LOCUS       NM_011658               1665 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus twist basic helix-loop-helix transcription factor 1
            (Twist1), mRNA.
ACCESSION   NM_011658
VERSION     NM_011658.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1665)
  AUTHORS   Islam,M., Yang,Y., Simmons,A.J., Shah,V.M., Musale,K.P., Xu,Y.,
            Tasneem,N., Chen,Z., Trinh,L.T., Molina,P., Ramirez-Solano,M.A.,
            Sadien,I.D., Dou,J., Rolong,A., Chen,K., Magnuson,M.A.,
            Rathmell,J.C., Macara,I.G., Winton,D.J., Liu,Q., Zafar,H.,
            Kalhor,R., Church,G.M., Shrubsole,M.J., Coffey,R.J. and Lau,K.S.
  TITLE     Temporal recording of mammalian development and precancer
  JOURNAL   Nature 634 (8036), 1187-1195 (2024)
   PUBMED   39478207
REFERENCE   2  (bases 1 to 1665)
  AUTHORS   Geister,E., Ard,D., Patel,H., Findley,A., DeSouza,G., Martin,L.,
            Knox,H., Gavara,N., Lugea,A. and Sabbatini,M.E.
  TITLE     The Role of Twist1 in Chronic Pancreatitis-Associated Pancreatic
            Stellate Cells
  JOURNAL   Am J Pathol 194 (10), 1879-1897 (2024)
   PUBMED   39032603
  REMARK    GeneRIF: The Role of Twist1 in Chronic Pancreatitis-Associated
            Pancreatic Stellate Cells.
REFERENCE   3  (bases 1 to 1665)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   4  (bases 1 to 1665)
  AUTHORS   Zhang,Y., Wang,J., Sun,H., Xun,Z., He,Z., Zhao,Y., Qi,J., Sun,S.,
            Yang,Q., Gu,Y., Zhang,L., Zhou,C., Ye,Y., Wu,N., Zou,D. and Su,B.
  TITLE     TWIST1+FAP+ fibroblasts in the pathogenesis of intestinal fibrosis
            in Crohn's disease
  JOURNAL   J Clin Invest 134 (18), e179472 (2024)
   PUBMED   39024569
  REMARK    GeneRIF: TWIST1+FAP+ fibroblasts in the pathogenesis of intestinal
            fibrosis in Crohn's disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1665)
  AUTHORS   Yan,Z., Zhu,J., Liu,Y., Li,Z., Liang,X., Zhou,S., Hou,Y., Chen,H.,
            Zhou,L., Wang,P., Ao,X., Gao,S., Huang,X., Zhou,P.K. and Gu,Y.
  TITLE     DNA-PKcs/AKT1 inhibits epithelial-mesenchymal transition during
            radiation-induced pulmonary fibrosis by inducing ubiquitination and
            degradation of Twist1
  JOURNAL   Clin Transl Med 14 (5), e1690 (2024)
   PUBMED   38760896
  REMARK    GeneRIF: DNA-PKcs/AKT1 inhibits epithelial-mesenchymal transition
            during radiation-induced pulmonary fibrosis by inducing
            ubiquitination and degradation of Twist1.
REFERENCE   6  (bases 1 to 1665)
  AUTHORS   Stoetzel,C., Weber,B., Bourgeois,P., Bolcato-Bellemin,A.L. and
            Perrin-Schmitt,F.
  TITLE     Dorso-ventral and rostro-caudal sequential expression of M-twist in
            the postimplantation murine embryo
  JOURNAL   Mech Dev 51 (2-3), 251-263 (1995)
   PUBMED   7547472
REFERENCE   7  (bases 1 to 1665)
  AUTHORS   Murray,S.S., Glackin,C.A., Winters,K.A., Gazit,D., Kahn,A.J. and
            Murray,E.J.
  TITLE     Expression of helix-loop-helix regulatory genes during
            differentiation of mouse osteoblastic cells
  JOURNAL   J Bone Miner Res 7 (10), 1131-1138 (1992)
   PUBMED   1280901
REFERENCE   8  (bases 1 to 1665)
  AUTHORS   Glackin,C.A., Murray,E.J. and Murray,S.S.
  TITLE     Doxorubicin inhibits differentiation and enhances expression of the
            helix-loop-helix genes Id and mTwi in mouse osteoblastic cells
  JOURNAL   Biochem Int 28 (1), 67-75 (1992)
   PUBMED   1280141
REFERENCE   9  (bases 1 to 1665)
  AUTHORS   Wolf,C., Thisse,C., Stoetzel,C., Thisse,B., Gerlinger,P. and
            Perrin-Schmitt,F.
  TITLE     The M-twist gene of Mus is expressed in subsets of mesodermal cells
            and is closely related to the Xenopus X-twi and the Drosophila
            twist genes
  JOURNAL   Dev Biol 143 (2), 363-373 (1991)
   PUBMED   1840517
REFERENCE   10 (bases 1 to 1665)
  AUTHORS   Shedlovsky,A., Guenet,J.L., Johnson,L.L. and Dove,W.F.
  TITLE     Induction of recessive lethal mutations in the T/t-H-2 region of
            the mouse genome by a point mutagen
  JOURNAL   Genet Res 47 (2), 135-142 (1986)
   PUBMED   3710160
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC083139.1.
            
            On Oct 10, 2004 this sequence version replaced NM_011658.1.
            
            Summary: Basic helix-loop-helix (bHLH) transcription factors have
            been implicated in cell lineage determination and differentiation.
            This gene encodes a bHLH transcription factor that is
            evolutionarily conserved from invertebrates to humans, and was
            originally identified in Drosophila as an essential gene involved
            in early mesoderm development and dorsal-ventral patterning in the
            embryo. This protein plays a role in cancer by regulating the
            epithelial-mesenchymal transition (EMT), a process that is critical
            for metastasis initiation, and promoting tumor progression.
            Mutations in the human gene are associated with Saethre-Chotzen
            syndrome (SCS). Mice with heterozygous mutations in this gene
            exhibit cranofacial and structural defects similar to those seen in
            human SCS patients. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083139.1, M63650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1665              BC083139.1         1-1665
FEATURES             Location/Qualifiers
     source          1..1665
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 14.81 cM"
     gene            1..1665
                     /gene="Twist1"
                     /gene_synonym="bHLHa38; M-Twist; Pde; pdt; Ska10;
                     Ska<m10Jus>; Twist"
                     /note="twist basic helix-loop-helix transcription factor
                     1"
                     /db_xref="GeneID:22160"
                     /db_xref="MGI:MGI:98872"
     exon            1..968
                     /gene="Twist1"
                     /gene_synonym="bHLHa38; M-Twist; Pde; pdt; Ska10;
                     Ska<m10Jus>; Twist"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..928
                     /gene="Twist1"
                     /gene_synonym="bHLHa38; M-Twist; Pde; pdt; Ska10;
                     Ska<m10Jus>; Twist"
                     /note="polydactyly EMS; Pluridigite; charlie chaplin;
                     twist homolog 1; twist gene homolog 1"
                     /codon_start=1
                     /product="twist-related protein 1"
                     /protein_id="NP_035788.1"
                     /db_xref="CCDS:CCDS25879.1"
                     /db_xref="GeneID:22160"
                     /db_xref="MGI:MGI:98872"
                     /translation="MMQDVSSSPVSPADDSLSNSEEEPDRQQPASGKRGARKRRSSRR
                     SAGGSAGPGGATGGGIGGGDEPGSPAQGKRGKKSAGGGGGGGAGGGGGGGGGSSSGGG
                     SPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYI
                     DFLYQVLQSDELDSKMASCSYVAHERLSYAFSVWRMEGAWSMSASH"
     exon            969..1630
                     /gene="Twist1"
                     /gene_synonym="bHLHa38; M-Twist; Pde; pdt; Ska10;
                     Ska<m10Jus>; Twist"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1603..1608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Twist1"
                     /gene_synonym="bHLHa38; M-Twist; Pde; pdt; Ska10;
                     Ska<m10Jus>; Twist"
                     /note="hexamer: AATAAA"
     polyA_site      1630
                     /gene="Twist1"
                     /gene_synonym="bHLHa38; M-Twist; Pde; pdt; Ska10;
                     Ska<m10Jus>; Twist"
                     /note="major polyA site"
ORIGIN      
        1 cgcgggctcg ccagcaccgg caccggctgc gccaggccgg aacggggcgc gcttgcggcc
       61 gtcgggcgcc ttctttttgg acctcggggc cctccacacc gtcccctccc ccgcccgcct
      121 ccctccccgc ctccagcgcc ctccccgcgg aggtcccccc acccccatcc cgcctccctg
      181 cgtcctccgg gccgcaccgc ccgggccggc gccgagcgcg gggaagctgg cgggctaggg
      241 cgccccgctc ctctgctcta ccctcccccg tcccggctcc gcgaggccgc acgtcgccgc
      301 ccgcgagatg atgcaggacg tgtccagctc gccagtctct ccggccgacg acagcctgag
      361 caacagcgag gaggagccgg accggcagca gccggcgagc ggcaagcgcg gggctcgcaa
      421 gagacgcagc agtcggcgca gcgcgggcgg cagcgcgggg cccggcgggg ccacgggcgg
      481 gggcatcgga ggcggcgacg agccaggcag cccggcccag ggcaagcgcg gcaagaaatc
      541 tgcgggcgga ggcggcggcg gcggcgcggg cggaggtggt ggcggcggcg gcggcagcag
      601 cagcgggggc gggagcccgc agtcgtacga ggagctgcag acccagcggg tcatggctaa
      661 cgtgcgggag cgccagcgca cgcagtcgct gaacgaggcg ttcgccgccc tgcgcaagat
      721 catccccacg ctgccctcgg acaagctgag caagattcag accctcaaac tggcggccag
      781 gtacatcgac ttcctgtacc aggtcctgca gagcgacgag ctggactcca agatggcaag
      841 ctgcagctat gtggcccacg agcggctcag ctacgccttc tccgtctgga ggatggaggg
      901 ggcctggtcc atgtccgcgt cccactagca gcggagctcc ccaccccctc tgcaggccgg
      961 agacctagat gtcattgttt ccagagaagg agaaaatgga cagtctagag actctggagc
     1021 tggataacta aaaataaatc tatatgacaa agattttcat ggaaattaga agagcagaga
     1081 ccaaattcac aagaatcagg gcgtggggca cacttttaaa agagaaagcg agacaggccc
     1141 gtggacagag attcccagag gggcagcagc agacccccca cacctctgca ttctgataga
     1201 agtctgaaca ctcgtttgtg tccccccacc ccactttttg acgaagaatg ttttattttt
     1261 atttttcatg catgcattct caagaggtct tgccaatcag ccactgacag gaaaggcatc
     1321 cctgtggact ggctccattt taaaatggta acaatcagag gaattttaac acctttagaa
     1381 ataaaaacgc tgggatcaaa ctggcctgca aaatcatagt cagtgaattc cttaaaaacc
     1441 atacttcctc tgaaggaaaa gaaaaacata aattacaaaa gacaacattc tatttattta
     1501 ttgatgaccc atggtaaaat gcaaatagat ccggtgtcta aatgcattca tatttttatg
     1561 actgttttgt aaatatcttt tgtatattat ttttctgcaa taaataaata tgattgaaaa
     1621 attttaagaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
