LOCUS       NM_011876               1594 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus twinfilin actin binding protein 2 (Twf2), mRNA.
ACCESSION   NM_011876
VERSION     NM_011876.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1594)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1594)
  AUTHORS   Krey,J.F., Chatterjee,P., Dumont,R.A., O'Sullivan,M., Choi,D.,
            Bird,J.E. and Barr-Gillespie,P.G.
  TITLE     Mechanotransduction-Dependent Control of Stereocilia Dimensions and
            Row Identity in Inner Hair Cells
  JOURNAL   Curr Biol 30 (3), 442-454 (2020)
   PUBMED   31902726
REFERENCE   3  (bases 1 to 1594)
  AUTHORS   Tadenev,A.L.D., Akturk,A., Devanney,N., Mathur,P.D., Clark,A.M.,
            Yang,J. and Tarchini,B.
  TITLE     GPSM2-GNAI Specifies the Tallest Stereocilia and Defines Hair
            Bundle Row Identity
  JOURNAL   Curr Biol 29 (6), 921-934 (2019)
   PUBMED   30827920
REFERENCE   4  (bases 1 to 1594)
  AUTHORS   Stritt,S., Beck,S., Becker,I.C., Vogtle,T., Hakala,M., Heinze,K.G.,
            Du,X., Bender,M., Braun,A., Lappalainen,P. and Nieswandt,B.
  TITLE     Twinfilin 2a regulates platelet reactivity and turnover in mice
  JOURNAL   Blood 130 (15), 1746-1756 (2017)
   PUBMED   28743718
  REMARK    GeneRIF: Twf2a-controlled actin rearrangements dampen platelet
            activation responses.
REFERENCE   5  (bases 1 to 1594)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   6  (bases 1 to 1594)
  AUTHORS   Desai,J., Shannon,M.E., Johnson,M.D., Ruff,D.W., Hughes,L.A.,
            Kerley,M.K., Carpenter,D.A., Johnson,D.K., Rinchik,E.M. and
            Culiat,C.T.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
REFERENCE   7  (bases 1 to 1594)
  AUTHORS   Vartiainen,M.K., Sarkkinen,E.M., Matilainen,T., Salminen,M. and
            Lappalainen,P.
  TITLE     Mammals have two twinfilin isoforms whose subcellular localizations
            and tissue distributions are differentially regulated
  JOURNAL   J Biol Chem 278 (36), 34347-34355 (2003)
   PUBMED   12807912
REFERENCE   8  (bases 1 to 1594)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1594)
  AUTHORS   Palmgren,S., Vartiainen,M. and Lappalainen,P.
  TITLE     Twinfilin, a molecular mailman for actin monomers
  JOURNAL   J Cell Sci 115 (Pt 5), 881-886 (2002)
   PUBMED   11870207
  REMARK    Review article
REFERENCE   10 (bases 1 to 1594)
  AUTHORS   Rohwer,A., Kittstein,W., Marks,F. and Gschwendt,M.
  TITLE     Cloning, expression and characterization of an A6-related protein
  JOURNAL   Eur J Biochem 263 (2), 518-525 (1999)
   PUBMED   10406962
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC164430.3.
            
            On Mar 21, 2007 this sequence version replaced NM_011876.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK084026.1, AK170441.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC164430.3         135631-135807
            178-255             AC164430.3         139412-139489
            256-434             AC164430.3         144242-144420
            435-530             AC164430.3         144779-144874
            531-635             AC164430.3         145255-145359
            636-761             AC164430.3         145461-145586
            762-912             AC164430.3         146624-146774
            913-1034            AC164430.3         146879-147000
            1035-1594           AC164430.3         147351-147910
FEATURES             Location/Qualifiers
     source          1..1594
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 57.46 cM"
     gene            1..1594
                     /gene="Twf2"
                     /gene_synonym="A6-related; Ptk9l; Ptk9r"
                     /note="twinfilin actin binding protein 2"
                     /db_xref="GeneID:23999"
                     /db_xref="MGI:MGI:1346078"
     exon            1..177
                     /gene="Twf2"
                     /gene_synonym="A6-related; Ptk9l; Ptk9r"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1202
                     /gene="Twf2"
                     /gene_synonym="A6-related; Ptk9l; Ptk9r"
                     /note="protein tyrosine kinase 9-like (A6-related
                     protein); PTK9 protein typrotein tyrosine kinase 9-like
                     (A6-related protein); mA6RP; twinfilin-1-like protein;
                     protein tyrosine kinase 9 related protein; twinfilin,
                     actin-binding protein, homolog 2"
                     /codon_start=1
                     /product="twinfilin-2"
                     /protein_id="NP_036006.1"
                     /db_xref="CCDS:CCDS23473.1"
                     /db_xref="GeneID:23999"
                     /db_xref="MGI:MGI:1346078"
                     /translation="MAHQTGIHATEELKEFFAKARAGSIRLIKVIIEDEQLVLGASQE
                     PVGRWDQDYDRAVLPLLDAQEPCYLLFRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYA
                     ATRATVKKEFGGGHIKDELFGTVKDDLSLAGYQKHLSSCAAPAPLTSAERELQQIRIN
                     EVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKTVNYIQLKLDLERETIELVHTE
                     PTNVAQLPSRIPRDAARYHFFLYKHTHEGDALESVVFIYSMPGYKCSIKERMLYSSCK
                     SRLLDSVEQDFQLEIAKKIEIGDGAELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRG
                     HKRLIRGPGENGEDS"
     exon            178..255
                     /gene="Twf2"
                     /gene_synonym="A6-related; Ptk9l; Ptk9r"
                     /inference="alignment:Splign:2.1.0"
     exon            256..434
                     /gene="Twf2"
                     /gene_synonym="A6-related; Ptk9l; Ptk9r"
                     /inference="alignment:Splign:2.1.0"
     exon            435..530
                     /gene="Twf2"
                     /gene_synonym="A6-related; Ptk9l; Ptk9r"
                     /inference="alignment:Splign:2.1.0"
     exon            531..635
                     /gene="Twf2"
                     /gene_synonym="A6-related; Ptk9l; Ptk9r"
                     /inference="alignment:Splign:2.1.0"
     exon            636..761
                     /gene="Twf2"
                     /gene_synonym="A6-related; Ptk9l; Ptk9r"
                     /inference="alignment:Splign:2.1.0"
     exon            762..912
                     /gene="Twf2"
                     /gene_synonym="A6-related; Ptk9l; Ptk9r"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1034
                     /gene="Twf2"
                     /gene_synonym="A6-related; Ptk9l; Ptk9r"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1594
                     /gene="Twf2"
                     /gene_synonym="A6-related; Ptk9l; Ptk9r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggcgggt cctgcggcac cgcccgggaa gctgcgcgag gctcggtgcc gtcgccacat
       61 cctccggagc tctgggtcca ggcgagccga gtcgagccgg gccaggacca agaggagaac
      121 tccgacggca cgggcgagcc gaaagctgag ccatggcgca ccagaccggc atccacgcca
      181 ctgaagagct aaaggaattc tttgccaagg cccgggctgg ctccatccga cttatcaaag
      241 tcatcattga ggacgaacag ctcgtgctgg gtgcctcaca ggagccagtg ggacgctggg
      301 accaggacta cgaccgggct gtgctgccac tgctagacgc ccaagagccc tgctacctcc
      361 tcttccgact tgattcgcag aatgctcagg gtttcgagtg gcttttcctg gcctggtcac
      421 ctgacaattc gccggtgcgg ctgaagatgc tatatgcagc cacacgcgcc accgtgaaga
      481 aggagtttgg aggcggccac atcaaggatg agctcttcgg gacagtaaag gatgacctct
      541 ccttggctgg gtaccagaag cacctgtcat cgtgtgccgc acctgcccca ctgacttctg
      601 ccgagagaga actccagcag atccgaatca atgaggtgaa gactgagatc agcgtggaaa
      661 gtaaacacca gacgctgcag ggcctggcct tccctctgca gcctgaggcc cagagggcac
      721 ttcagcaact caaacagaag acggtcaact atatccagct gaagctggac ctggaacggg
      781 agaccatcga gctggtacac acagaaccca caaatgtggc ccagctgccc tcacggattc
      841 ctcgagatgc tgcccgctac cacttcttcc tatacaagca tactcatgag ggtgatgccc
      901 ttgaatctgt ggtgttcatc tactccatgc ccgggtacaa gtgcagcatc aaggagcgga
      961 tgctctactc cagctgcaag agccgcctcc ttgactccgt agagcaagac ttccagctgg
     1021 agatagctaa gaagattgag atcggcgatg gagcagagct gacagctgag ttcctctatg
     1081 acgaggtaca tcccaagcaa cacgcgttca agcaggcgtt cgccaagccc aaaggccccg
     1141 ggggcaagcg gggccacaag cgcctcatcc ggggccccgg ggagaacggg gaagacagct
     1201 aggtgtctgg actgggaaca gggccgggca cgtggactac agggttgcca ctctgccacc
     1261 cctggacttc cttcctcccc agcctgggct ctaaggaatt gctttcctgt gggacaagga
     1321 gggcaggtgg ctgaccatat ctgagggcct gcctctggac cagcactgtg tgaccttgcc
     1381 ctgtcactgt ccctgcctct catctgtgtg tacagggtgg ctggcgaaac cccaccttgg
     1441 cacaaaccta gcctccagaa aatttcgtgc tgtggttgca gcccagccca aaagcctttg
     1501 gctacagtgg gtggggacgg ttggcagggg ccagatgtca caggaaggga tggttgaatg
     1561 ctgtattttg taaagaataa aatattttta aatc
//
