LOCUS       NM_026210               1807 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus trans-golgi network vesicle protein 23B (Tvp23b),
            transcript variant 1, mRNA.
ACCESSION   NM_026210 XM_916933 XM_924575
VERSION     NM_026210.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1807)
  AUTHORS   Song,R., McAlpine,W., Fond,A.M., Nair-Gill,E., Choi,J.H.,
            Nystrom,E.E.L., Arike,L., Field,S., Li,X., SoRelle,J.A.,
            Moresco,J.J., Moresco,E.M.Y., Yates,J.R. 3rd, Azadi,P., Ni,J.,
            Birchenough,G.M.H., Beutler,B. and Turer,E.E.
  TITLE     Trans-Golgi protein TVP23B regulates host-microbe interactions via
            Paneth cell homeostasis and Goblet cell glycosylation
  JOURNAL   Nat Commun 14 (1), 3652 (2023)
   PUBMED   37339972
  REMARK    GeneRIF: Trans-Golgi protein TVP23B regulates host-microbe
            interactions via Paneth cell homeostasis and Goblet cell
            glycosylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1807)
  AUTHORS   Bussink,A.P., Speijer,D., Aerts,J.M. and Boot,R.G.
  TITLE     Evolution of mammalian chitinase(-like) members of family 18
            glycosyl hydrolases
  JOURNAL   Genetics 177 (2), 959-970 (2007)
   PUBMED   17720922
REFERENCE   3  (bases 1 to 1807)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   4  (bases 1 to 1807)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050027.1, AK150936.1, AK007707.1 and BP757155.1.
            
            On Oct 6, 2017 this sequence version replaced NM_026210.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077277.1, AK150936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AK050027.1         2-45
            45-1379             AK150936.1         2-1336
            1380-1784           AK007707.1         1261-1665
            1785-1807           BP757155.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1807
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 38.81 cM"
     gene            1..1807
                     /gene="Tvp23b"
                     /gene_synonym="1810036I24Rik; Fam18b; Fam18b1"
                     /note="trans-golgi network vesicle protein 23B"
                     /db_xref="GeneID:67510"
                     /db_xref="MGI:MGI:1914760"
     exon            1..141
                     /gene="Tvp23b"
                     /gene_synonym="1810036I24Rik; Fam18b; Fam18b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..747
                     /gene="Tvp23b"
                     /gene_synonym="1810036I24Rik; Fam18b; Fam18b1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ortholog of human family with sequence similarity 18
                     member B FAM18B; protein FAM18B1; family with sequence
                     similarity 18, member B; Golgi apparatus membrane protein
                     TVP23 homolog B"
                     /codon_start=1
                     /product="Golgi apparatus membrane protein TVP23 homolog B
                     isoform 1"
                     /protein_id="NP_080486.1"
                     /db_xref="CCDS:CCDS24834.1"
                     /db_xref="GeneID:67510"
                     /db_xref="MGI:MGI:1914760"
                     /translation="MLSQDSNDDTEDVSLFDAEEETTNRPRKSKIRHPVASFFHLFFR
                     VSAVVVYLLCELLSSSFIACMVTIILLLSCDFWAVKNVTGRLMVGLRWWNHIDEDGKS
                     HWVFESRKSTPQDNKTISEAESRIFWLGLIACPVLWVIFAFSALFSFRVKWLAVVIMG
                     VVLQGANLYGYIRCKVGSKKNLTSMATSYLGKQFLRQNTGDGQTS"
     exon            142..224
                     /gene="Tvp23b"
                     /gene_synonym="1810036I24Rik; Fam18b; Fam18b1"
                     /inference="alignment:Splign:2.1.0"
     exon            225..369
                     /gene="Tvp23b"
                     /gene_synonym="1810036I24Rik; Fam18b; Fam18b1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..459
                     /gene="Tvp23b"
                     /gene_synonym="1810036I24Rik; Fam18b; Fam18b1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..591
                     /gene="Tvp23b"
                     /gene_synonym="1810036I24Rik; Fam18b; Fam18b1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..720
                     /gene="Tvp23b"
                     /gene_synonym="1810036I24Rik; Fam18b; Fam18b1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..1785
                     /gene="Tvp23b"
                     /gene_synonym="1810036I24Rik; Fam18b; Fam18b1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1668..1673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tvp23b"
                     /gene_synonym="1810036I24Rik; Fam18b; Fam18b1"
                     /note="hexamer: AATACA"
     polyA_site      1699
                     /gene="Tvp23b"
                     /gene_synonym="1810036I24Rik; Fam18b; Fam18b1"
                     /note="major polyA site"
     regulatory      1762..1767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tvp23b"
                     /gene_synonym="1810036I24Rik; Fam18b; Fam18b1"
                     /note="hexamer: TATAAA"
     polyA_site      1785
                     /gene="Tvp23b"
                     /gene_synonym="1810036I24Rik; Fam18b; Fam18b1"
                     /note="major polyA site"
ORIGIN      
        1 ctctggagtt gcgccctccc accaagtggc ttcctggtgc gcttgtgacg tcggctgtag
       61 agctggatcg cgtggcagct ttgctgtcgt ggctctcgga agtggggggc gggttggcgc
      121 agggtcgtca tgttgtcgca ggacagtaat gatgacactg aagatgtctc actgtttgat
      181 gcagaagagg agacaaccaa tagaccaaga aaatccaaaa tcaggcaccc cgtggcatcc
      241 ttcttccatc tgttcttccg ggtcagtgcg gttgtggtct atctcctttg cgagctgctc
      301 agtagcagct ttatcgcctg catggtgaca attatcttgc tgctgtcatg cgacttttgg
      361 gcagtaaaga atgtcacagg tagactaatg gtcggcctgc gttggtggaa tcatattgat
      421 gaggatggga agagccactg ggtgtttgag tccagaaagt caacgcctca agacaacaaa
      481 acaatttctg aggccgagtc aagaatcttt tggctaggac tcatcgcctg ccccgtcctg
      541 tgggtgatct ttgcctttag tgccctcttt tccttccgag tgaagtggct ggctgtggtg
      601 atcatgggtg tggtgctgca aggtgccaac ctatatggtt atatccggtg taaagtgggc
      661 agcaagaaga acttaaccag catggctacg tcgtatcttg gaaagcagtt tctaagacaa
      721 aacactggag atggtcagac ttcgtgagta aagatgaaga ctgtcatgga ctctgggagc
      781 aatggacacg attcttagtg tttagagctc agtctgttgc agagtggggt gtgtttgtta
      841 cttagaagct tatttaaaag aaggaaaccc catggggcca ggaagtctgt gtgtctggaa
      901 acagtgtcag gtgtgccttg ggtgtctgtc tggatagatg gtcctgtagc agcagcaagt
      961 cctttgcacg tgtgagtgga ccttcgcatc ctgacccata gactgtagga atgggtgttc
     1021 agtctgtctc aaattctgtg tttgcatagc attcctgtac atggtttttg gggtaagttt
     1081 tgattcagtg gtaagggtga acatgttggt ttatgtatga gttagaaaca gttattaatt
     1141 ttaatgtgtt ctgtatggta aagttcctta tcttagactt gtataagcaa gtaaaagcta
     1201 aatttgggca ctaatgttaa ctgatttcta aaattttggt tttagttggt aatgagtcat
     1261 tcactcaagg tccatttggc ataagtggga cctttgtagt tgtggtggat atacaggggc
     1321 tgctgttgct gtgtttcttt gtgaccatag atctctctgg aactatctaa aatctcttag
     1381 tggtcttttc gttaagttaa tgaaatacta ccttttaata agaatatcat tcttatgaaa
     1441 taatgagagt aattacttaa gtacttggca tagtaaatgc ctataaaaca ttgtatgaat
     1501 ttattttttc ttttataatg gggatattgt aaatcacata tttgtattaa ggttatttcc
     1561 taagacaaag caatatacta tagactaaac caaatgtaaa ctattgtagg cagctggatt
     1621 cttttgtagt attgtaaatt ttgttggaat ctttatatta tgtcatgaat acacttgtcc
     1681 attgttggca cattttaaat gtcttgttta ttaagtatct ttattagagt gtagcttggc
     1741 aggtgtatag ctttatattt atataaaact gctgtttaca aagcaaaaaa aaaaaaaaaa
     1801 aaaaaaa
//
