LOCUS       NM_197993               2757 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus terminal uridylyl transferase 1, U6 snRNA-specific
            (Tut1), mRNA.
ACCESSION   NM_197993
VERSION     NM_197993.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2757)
  AUTHORS   Kim,J., Nakamura,J., Hamada,C., Taketomi,T., Yano,S., Okajima,T.,
            Kashiwabara,S.I., Baba,T., Sato,B., Chiba,T. and Tsuruta,F.
  TITLE     USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and
            Maintains Cerebellar Homeostasis
  JOURNAL   Mol Cell Biol 40 (21), e00098-20 (2020)
   PUBMED   32839293
  REMARK    GeneRIF: USP15 Deubiquitinates TUT1 Associated with RNA Metabolism
            and Maintains Cerebellar Homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2757)
  AUTHORS   Wang,X., Li,Z.T., Yan,Y., Lin,P., Tang,W., Hasler,D., Meduri,R.,
            Li,Y., Hua,M.M., Qi,H.T., Lin,D.H., Shi,H.J., Hui,J., Li,J., Li,D.,
            Yang,J.H., Lin,J., Meister,G., Fischer,U. and Liu,M.F.
  TITLE     LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and
            Spermatogenesis in Mice
  JOURNAL   Mol Cell 77 (5), 999-1013 (2020)
   PUBMED   32017896
REFERENCE   3  (bases 1 to 2757)
  AUTHORS   Dai,Q., Luan,G., Deng,L., Lei,T., Kang,H., Song,X., Zhang,Y.,
            Xiao,Z.X. and Li,Q.
  TITLE     Primordial dwarfism gene maintains Lin28 expression to safeguard
            embryonic stem cells from premature differentiation
  JOURNAL   Cell Rep 7 (3), 735-746 (2014)
   PUBMED   24768001
  REMARK    GeneRIF: TUT1 nucleotidyl transferase interacts with LARP7 protein
            to regulate Lin28 expression.
REFERENCE   4  (bases 1 to 2757)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2757)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130819.4.
            
            On Jan 10, 2023 this sequence version replaced NM_197993.3.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023900.2, SRR17253011.7495277.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               AC130819.4         185448-185634       c
            188-378             AC130819.4         183892-184082       c
            379-694             AC130819.4         180067-180382       c
            695-795             AC130819.4         179626-179726       c
            796-1274            AC130819.4         176647-177125       c
            1275-1384           AC130819.4         175340-175449       c
            1385-1495           AC130819.4         175095-175205       c
            1496-1588           AC130819.4         174816-174908       c
            1589-2757           AC130819.4         173267-174435       c
FEATURES             Location/Qualifiers
     source          1..2757
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.04 cM"
     gene            1..2757
                     /gene="Tut1"
                     /gene_synonym="2700038E08Rik; PAPD2; Rbm21; star-PAP;
                     Tent1; TUTase6; U6-TUTase"
                     /note="terminal uridylyl transferase 1, U6 snRNA-specific"
                     /db_xref="GeneID:70044"
                     /db_xref="MGI:MGI:1917294"
     exon            1..187
                     /gene="Tut1"
                     /gene_synonym="2700038E08Rik; PAPD2; Rbm21; star-PAP;
                     Tent1; TUTase6; U6-TUTase"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2715
                     /gene="Tut1"
                     /gene_synonym="2700038E08Rik; PAPD2; Rbm21; star-PAP;
                     Tent1; TUTase6; U6-TUTase"
                     /EC_number="2.7.7.19"
                     /EC_number="2.7.7.52"
                     /note="RNA binding motif protein 21"
                     /codon_start=1
                     /product="speckle targeted PIP5K1A-regulated poly(A)
                     polymerase"
                     /protein_id="NP_932110.1"
                     /db_xref="CCDS:CCDS29562.1"
                     /db_xref="GeneID:70044"
                     /db_xref="MGI:MGI:1917294"
                     /translation="MAAVDSDVVSLPRGRFRCCLCDVTTANRPSLDAHLKGRKHRDLV
                     QLRATRKAQGLRSVFVSGFPRDVGSAQLSEYFQTFGPVANIVMDKDKGVFAIVEMGDI
                     SAREAVLSQPKHSLGGHGLRVRPREQKEFQSPASKSPKGVDSSSHQLVQALAEAADVG
                     AQMVKLVELRELSEAERQLRNLVVALMQEVFTEFFPGCVVHPFGSTVNSFDVHGCDLD
                     LFLDMGDMEETEPDPKAPKVPETSSLDSALASSLDPQALACTPASPLDSLSPTSVQES
                     ESLDFDTPSSLAPQTPDSALGSDTVTSPQSLPPVSPLQEDRKEGKQGKELELAEEASK
                     DEKEEAAAVLELVGSILRGCVPGVYRVQTVPSARRPVVKFCHRPSGLHGDVSLSNRLA
                     LYNSRFLNLCSEMDGRVRPLVYTLRCWAQHNGLSGGGPLLNNYALTLLVIYFLQTRDP
                     PVLPTVAQLTQRAGEGEQVEVDGWDCSFPKDASRLEPSTNVEPLSSLLAQFFSCVSCL
                     DLSGSLLSLREGRPLMVAEGLPSDLWEGLRLGPMNLQDPFDLSHNVAANVTGRVAKRL
                     QSCCGAAASYCRSLQYQQRSSRGRDWGLLPLLQPSSPSSLLSAKLIPLPSAPFPQVIM
                     ALVDVLREALGCHIEQGTKRRRSEGARIKDSPLGGVNKRQRLGGQEKSFEEGKEEPQG
                     CAGDHSENEVEEMVIEVRETPQDWALLHSGPPEEELPLMTANCLDKAAEHNPMKPEVA
                     GEGSQGETGKEASHPSSVSWRCALWHQVWQGRRRARRRLQQQTKEEGRGGPTTGAEWL
                     AMEARVTQELKGPNSEQERPPGEPLLSFVASASQAEQTLTVAPLQDSQGLFPGLHHFL
                     QGFIPQALKNLLK"
     exon            188..378
                     /gene="Tut1"
                     /gene_synonym="2700038E08Rik; PAPD2; Rbm21; star-PAP;
                     Tent1; TUTase6; U6-TUTase"
                     /inference="alignment:Splign:2.1.0"
     exon            379..694
                     /gene="Tut1"
                     /gene_synonym="2700038E08Rik; PAPD2; Rbm21; star-PAP;
                     Tent1; TUTase6; U6-TUTase"
                     /inference="alignment:Splign:2.1.0"
     exon            695..795
                     /gene="Tut1"
                     /gene_synonym="2700038E08Rik; PAPD2; Rbm21; star-PAP;
                     Tent1; TUTase6; U6-TUTase"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1274
                     /gene="Tut1"
                     /gene_synonym="2700038E08Rik; PAPD2; Rbm21; star-PAP;
                     Tent1; TUTase6; U6-TUTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1384
                     /gene="Tut1"
                     /gene_synonym="2700038E08Rik; PAPD2; Rbm21; star-PAP;
                     Tent1; TUTase6; U6-TUTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1495
                     /gene="Tut1"
                     /gene_synonym="2700038E08Rik; PAPD2; Rbm21; star-PAP;
                     Tent1; TUTase6; U6-TUTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1588
                     /gene="Tut1"
                     /gene_synonym="2700038E08Rik; PAPD2; Rbm21; star-PAP;
                     Tent1; TUTase6; U6-TUTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..2757
                     /gene="Tut1"
                     /gene_synonym="2700038E08Rik; PAPD2; Rbm21; star-PAP;
                     Tent1; TUTase6; U6-TUTase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2735..2740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tut1"
                     /gene_synonym="2700038E08Rik; PAPD2; Rbm21; star-PAP;
                     Tent1; TUTase6; U6-TUTase"
                     /note="hexamer: AATAAA"
     polyA_site      2757
                     /gene="Tut1"
                     /gene_synonym="2700038E08Rik; PAPD2; Rbm21; star-PAP;
                     Tent1; TUTase6; U6-TUTase"
                     /note="major polyA site"
ORIGIN      
        1 attgacggaa gtggcttccc cgcacgcacg ttacaatttt tagttgtgtg ttccggtgtg
       61 tttccggcga aataggctgt aggcgttccg taccggagag tggctatggc ggcggtggat
      121 tcggacgttg tatcgctgcc gcgtggccgc tttcgctgct gcctctgcga tgttactaca
      181 gccaaccgac ccagcctcga tgcccacttg aaaggccgga agcaccggga tttggtgcaa
      241 ctccgagcta ccaggaaggc acagggactc cgaagtgtgt ttgtcagtgg cttccccagg
      301 gatgtgggtt ctgctcagct ctctgagtac ttccagacat ttggccctgt ggccaatatt
      361 gtcatggaca aggacaaggg ggtgtttgcc atcgtggaga tgggagacat aagtgctcgg
      421 gaggctgtct tatcacagcc caagcacagc cttgggggac atggacttcg agtccggcca
      481 agggagcaga aggagttcca gagcccagct tccaagtctc ccaaaggagt ggactcaagt
      541 agtcaccagc tggtccaagc actggctgag gctgcggatg tgggggccca gatggtgaag
      601 cttgtggaac tgagggagtt gtctgaggct gagcggcagc ttcggaacct tgttgtggcc
      661 ctgatgcagg aggtcttcac agagttcttc cctggctgtg tggtccatcc ttttggctct
      721 actgtaaata gctttgatgt tcatggctgt gatctcgacc tcttcttgga catgggtgat
      781 atggaagaga ccgagccaga cccaaaggct ccaaaggttc cagagacttc atccttggac
      841 tcagcccttg cttcttccct ggatcctcag gcgctggcct gcaccccagc ttctcctcta
      901 gactcactgt ctccaacttc tgttcaagag tctgagtccc tggactttga caccccatct
      961 tctctggcac cacagacacc cgactctgct ttgggctctg acactgtcac ctctcctcag
     1021 tctctgcctc cagtttcacc actgcaggag gacaggaaag aggggaaaca ggggaaagag
     1081 ctagaattag cagaagaagc ctcaaaggac gagaaggagg aggcagcagc agtgttagag
     1141 ctggtgggat ctattctccg tggctgtgtc cctggagtgt accgagtcca aactgtgccc
     1201 tctgcccggc gtcctgtggt caagttctgt catcggcctt caggtcttca tggagatgta
     1261 tccctcagta accggttggc cttatataat tcacgtttcc tgaatctctg ctctgagatg
     1321 gatggtcgag tccggcccct tgtgtatacc ttacgctgct gggctcagca taatgggctg
     1381 tcaggaggtg gcccccttct caataactac gccttgacgt tgttagtgat ctacttcctt
     1441 cagaccagag accctccagt acttcctact gtggcccagc ttacccagag agcaggtgaa
     1501 ggggaacagg tagaagttga tggctgggac tgtagcttcc ctaaggatgc ctcaagattg
     1561 gagcccagca ccaacgtgga gcctctcagt tccctgctgg cccagttctt ctcctgcgta
     1621 tcttgcttgg atctttctgg ctccctgctg tccctgcggg aaggtcggcc attgatggtg
     1681 gcagagggcc tgccttctga tctctgggaa gggctgcgcc ttggccccat gaatctccag
     1741 gacccctttg acctgagtca caatgttgca gccaatgtga ccggccgggt ggctaaacgt
     1801 ctgcagagct gttgtggggc agcagccagt tactgccgaa gtctccagta ccagcagcgt
     1861 tcctcccggg gccgggactg gggactgctc ccgcttttgc agcccagctc ccctagctcc
     1921 ctgctgtctg ccaagctcat ccccttaccc tctgccccct ttccacaggt cattatggct
     1981 ttggtggatg tgttaaggga agcactagga tgccacatag aacagggaac caagagacga
     2041 cggtcagaag gtgccagaat taaagactct cccttgggag gggtgaacaa aagacagaga
     2101 cttggtgggc aagaaaagag cttcgaggaa gggaaagagg agccacaggg atgtgcaggg
     2161 gaccacagtg aaaatgaggt agaagaaatg gtaatagagg ttcgagagac acctcaggac
     2221 tgggccttgt tgcactcggg accaccagag gaggagttgc ccctgatgac tgcaaactgt
     2281 ctagacaagg cagctgagca taatcccatg aaacctgaag tggctggaga agggtctcag
     2341 ggtgagacag ggaaggaggc atcacaccca tcatcagtga gctggcgctg tgccttgtgg
     2401 caccaagtat ggcaggggag gcggcgtgcc cggagacgat tacagcaaca aaccaaggaa
     2461 gaaggtagag gaggtcccac cacaggagca gagtggctgg caatggaagc tcgtgtgacc
     2521 caggaactaa aaggacccaa tagtgagcaa gagaggccgc cgggggagcc cctcctcagc
     2581 tttgtggcat ctgcctccca ggctgagcag acactcactg tggccccact ccaggactcc
     2641 caaggcctgt tccctggtct tcatcatttt ctacagggtt ttatccctca agcacttaaa
     2701 aatctcctca agtgaggaac caaacctcaa aaacaataaa gctgctagtt tatttca
//
