LOCUS       NM_019742               1661 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus tumor suppressor 2, mitochondrial calcium regulator
            (Tusc2), mRNA.
ACCESSION   NM_019742
VERSION     NM_019742.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1661)
  AUTHORS   Farris,T., Gonzalez-Ochoa,S., Mohammed,M., Rajakaruna,H.,
            Tonello,J., Kanagasabai,T., Korolkova,O., Shimamoto,A., Ivanova,A.
            and Shanker,A.
  TITLE     Loss of Mitochondrial Tusc2/Fus1 Triggers a Brain Pro-Inflammatory
            Microenvironment and Early Spatial Memory Impairment
  JOURNAL   Int J Mol Sci 25 (13), 7406 (2024)
   PUBMED   39000512
  REMARK    GeneRIF: Loss of Mitochondrial Tusc2/Fus1 Triggers a Brain
            Pro-Inflammatory Microenvironment and Early Spatial Memory
            Impairment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1661)
  AUTHORS   Kim,I., Kim,J.H., Kim,K., Seong,S. and Kim,N.
  TITLE     Tusc2/Fus1 regulates osteoclast differentiation through NF-kappaB
            and NFATc1
  JOURNAL   BMB Rep 50 (9), 454-459 (2017)
   PUBMED   28391779
  REMARK    GeneRIF: results suggest that Tusc2 acts as a positive regulator of
            RANKL-mediated osteoclast differentiation
REFERENCE   3  (bases 1 to 1661)
  AUTHORS   Uzhachenko,R., Boyd,K., Olivares-Villagomez,D., Zhu,Y.,
            Goodwin,J.S., Rana,T., Shanker,A., Tan,W.J., Bondar,T.,
            Medzhitov,R. and Ivanova,A.V.
  TITLE     Mitochondrial protein Fus1/Tusc2 in premature aging and age-related
            pathologies: critical roles of calcium and energy homeostasis
  JOURNAL   Aging (Albany NY) 9 (3), 627-649 (2017)
   PUBMED   28351997
REFERENCE   4  (bases 1 to 1661)
  AUTHORS   Uzhachenko,R., Ivanov,S.V., Yarbrough,W.G., Shanker,A.,
            Medzhitov,R. and Ivanova,A.V.
  TITLE     Fus1/Tusc2 is a novel regulator of mitochondrial calcium handling,
            Ca2+-coupled mitochondrial processes, and Ca2+-dependent NFAT and
            NF-kappaB pathways in CD4+ T cells
  JOURNAL   Antioxid Redox Signal 20 (10), 1533-1547 (2014)
   PUBMED   24328503
  REMARK    GeneRIF: Fus1 achieves its protective role in inflammation,
            autoimmunity, and cancer via the regulation of mitochondrial
            calcium and calcium-coupled parameters.
REFERENCE   5  (bases 1 to 1661)
  AUTHORS   Hood,M.I., Uzhachenko,R., Boyd,K., Skaar,E.P. and Ivanova,A.V.
  TITLE     Loss of mitochondrial protein Fus1 augments host resistance to
            Acinetobacter baumannii infection
  JOURNAL   Infect Immun 81 (12), 4461-4469 (2013)
   PUBMED   24042119
REFERENCE   6  (bases 1 to 1661)
  AUTHORS   Uzhachenko,R., Issaeva,N., Boyd,K., Ivanov,S.V., Carbone,D.P. and
            Ivanova,A.V.
  TITLE     Tumour suppressor Fus1 provides a molecular link between
            inflammatory response and mitochondrial homeostasis
  JOURNAL   J Pathol 227 (4), 456-469 (2012)
   PUBMED   22513871
REFERENCE   7  (bases 1 to 1661)
  AUTHORS   Jadin,L., Wu,X., Ding,H., Frost,G.I., Onclinx,C., Triggs-Raine,B.
            and Flamion,B.
  TITLE     Skeletal and hematological anomalies in HYAL2-deficient mice: a
            second type of mucopolysaccharidosis IX?
  JOURNAL   FASEB J 22 (12), 4316-4326 (2008)
   PUBMED   18772348
REFERENCE   8  (bases 1 to 1661)
  AUTHORS   Ivanova,A.V., Ivanov,S.V., Pascal,V., Lumsden,J.M., Ward,J.M.,
            Morris,N., Tessarolo,L., Anderson,S.K. and Lerman,M.I.
  TITLE     Autoimmunity, spontaneous tumourigenesis, and IL-15 insufficiency
            in mice with a targeted disruption of the tumour suppressor gene
            Fus1
  JOURNAL   J Pathol 211 (5), 591-601 (2007)
   PUBMED   17318811
REFERENCE   9  (bases 1 to 1661)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res 60 (21), 6116-6133 (2000)
   PUBMED   11085536
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL672219.7.
            
            On Apr 29, 2007 this sequence version replaced NM_019742.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082684.1, AF123387.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               AL672219.7         136404-136681
            279-399             AL672219.7         137725-137845
            400-1661            AL672219.7         137996-139257
FEATURES             Location/Qualifiers
     source          1..1661
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 58.12 cM"
     gene            1..1661
                     /gene="Tusc2"
                     /gene_synonym="1190001E22Rik; Fus1; Lgcc; PAP; Pdap2"
                     /note="tumor suppressor 2, mitochondrial calcium
                     regulator"
                     /db_xref="GeneID:80385"
                     /db_xref="MGI:MGI:1931086"
     exon            1..278
                     /gene="Tusc2"
                     /gene_synonym="1190001E22Rik; Fus1; Lgcc; PAP; Pdap2"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..465
                     /gene="Tusc2"
                     /gene_synonym="1190001E22Rik; Fus1; Lgcc; PAP; Pdap2"
                     /note="PDGFA associated protein 2; lung cancer candidiate,
                     FUS; fus-1 protein; fusion 1 protein"
                     /codon_start=1
                     /product="tumor suppressor candidate 2"
                     /protein_id="NP_062716.1"
                     /db_xref="CCDS:CCDS23495.1"
                     /db_xref="GeneID:80385"
                     /db_xref="MGI:MGI:1931086"
                     /translation="MGASGSKARGLWPFASTPGGGGPEAAGSEQSLVRSRARAVPPFV
                     FTRRGSMFYDEDGDLAHEFYEETIVTKNGQKRAKLRRVHKNLIPQGIVKLDPPRIHVD
                     FPVILYEV"
     exon            279..399
                     /gene="Tusc2"
                     /gene_synonym="1190001E22Rik; Fus1; Lgcc; PAP; Pdap2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..1661
                     /gene="Tusc2"
                     /gene_synonym="1190001E22Rik; Fus1; Lgcc; PAP; Pdap2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      577..582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tusc2"
                     /gene_synonym="1190001E22Rik; Fus1; Lgcc; PAP; Pdap2"
                     /note="hexamer: ACTAAA"
     polyA_site      598
                     /gene="Tusc2"
                     /gene_synonym="1190001E22Rik; Fus1; Lgcc; PAP; Pdap2"
ORIGIN      
        1 ggagacagca gagcctgcgg aaggcggcgg cggcggcacc tgcgagtgga agctggggca
       61 gggcatggtc gcgcccgccg cgctgtgaga gcggagcggc cgctgggtcc gccatgcgcc
      121 cgcggcgctg acatgggcgc cagcggctcc aaagctcggg gcctctggcc ctttgcctcc
      181 actccggggg gcggcggccc agaggcggca ggctccgagc agtctctggt gcggtctcga
      241 gcccgagcag tgcctccctt cgtattcacg cgccgcggct ccatgttcta cgatgaagat
      301 ggagatctgg ctcacgaatt ctatgaggag acaatcgtca ccaagaatgg gcagaagcga
      361 gccaagctga ggcgggtaca taagaatctg attcctcagg gcatcgtgaa gctggatcct
      421 ccccgaatcc acgtggattt ccccgtgatc ctctatgaag tatgaacctg tgtgtggcat
      481 ggcagacacg agcacccact gccccagcaa gaaactccca ggatcaaggt gtagcttcca
      541 ttcaggagtc caggctggtg ccacaacctt gaataaacta aactccgttg gcccagaacc
      601 ttcagttgta agaggggttg tccctcagtg ttaactggta ttggcggatg tctgaacaat
      661 aagaggttgg tggctggtga gggctaagga cagaattacc agcccgtctc ccccagccgc
      721 ttgtgggaga agcatgacag gagacacgtg ccggtcagga atgcctggtt cctggttacc
      781 tgcctgacct gctttcttcc aagcttgcct agggcccagc cctcctagaa gctacagcac
      841 tttacaagca gagtctgcct tcttccagcc cctgggctgt aggggctcta cccaagtggg
      901 aacttccttt tcctcactcc ccttcccccc tagtcagagc atttcagccg tttgctacct
      961 cgattcctcc tgtatcggac agactggaga tacataccag cctcaccctt cctgcctacc
     1021 taccacatgc tcccgctctt aagctggaca ctttgctggc tgttcaataa gaatgaggac
     1081 cagtgtggga ggcttctcct ttcacccagg gctggactga tctctcttga tttcaaccag
     1141 ttgccctcaa gttgagaggg tacaggccgg ggtcaggaca ggctactgac gcctgtacct
     1201 gtggggactt gccccaaacc acatattcgt cgtctccctt gtctttgcac cagtcccaca
     1261 aatccccagt tgtaggggag aggcagtcca ccacctagtg gtaagaaacg actggggctg
     1321 gtgccagtag ctatgaggag cccatccccc cccttctcct tacagtatct ttaccccttc
     1381 agggtctgtt aagagaaagt actggagctc cttggtaagg atagaaagga ggggaaaata
     1441 cttaagaggc ataattaaaa tgtgaaggtt tgtaaatagt ctagactatg ataatgttgg
     1501 ggcagagtct gatttctata cagagatggc tttaaaaaaa tacttccttg tggaagctct
     1561 gtgcttctag agtgtgggaa atggcttggg acgagtgatc cccagcacag gaaggctgtt
     1621 gtgttatttg ttcaatttca ataaaagtta tttgtagacc c
//
