LOCUS       NM_001416144            3048 bp    mRNA    linear   ROD 02-MAR-2025
DEFINITION  Mus musculus Tcl1 upstream neural differentiation associated RNA
            (Tunar), transcript variant 1, mRNA.
ACCESSION   NM_001416144
VERSION     NM_001416144.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3048)
  AUTHORS   Simmers,M.D., Jima,D.D., Tsuji,Y. and Cowley,M.
  TITLE     LncRNA Tuna is activated in cadmium-induced placental insufficiency
            and drives the NRF2-mediated oxidative stress response
  JOURNAL   Front Cell Dev Biol 11, 1151108 (2023)
   PUBMED   37325564
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3048)
  AUTHORS   Senis,E., Esgleas,M., Najas,S., Jimenez-Sabado,V., Bertani,C.,
            Gimenez-Alejandre,M., Escriche,A., Ruiz-Orera,J.,
            Hergueta-Redondo,M., Jimenez,M., Giralt,A., Nuciforo,P., Alba,M.M.,
            Peinado,H., Del Toro,D., Hove-Madsen,L., Gotz,M. and Abad,M.
  TITLE     TUNAR lncRNA Encodes a Microprotein that Regulates Neural
            Differentiation and Neurite Formation by Modulating Calcium
            Dynamics
  JOURNAL   Front Cell Dev Biol 9, 747667 (2021)
   PUBMED   35036403
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3048)
  AUTHORS   Lin,N., Chang,K.Y., Li,Z., Gates,K., Rana,Z.A., Dang,J., Zhang,D.,
            Han,T., Yang,C.S., Cunningham,T.J., Head,S.R., Duester,G.,
            Dong,P.D. and Rana,T.M.
  TITLE     An evolutionarily conserved long noncoding RNA TUNA controls
            pluripotency and neural lineage commitment
  JOURNAL   Mol Cell 53 (6), 1005-1019 (2014)
   PUBMED   24530304
  REMARK    GeneRIF: The lincRNA TUNA plays a vital role in pluripotency and
            neural differentiation of ESCs and is associated with neurological
            function of adult vertebrates.
            Erratum:[Mol Cell. 2014 Mar 20;53(6):1067]
REFERENCE   4  (bases 1 to 3048)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   5  (bases 1 to 3048)
  AUTHORS   Moran,I., Akerman,I., van de Bunt,M., Xie,R., Benazra,M., Nammo,T.,
            Arnes,L., Nakic,N., Garcia-Hurtado,J., Rodriguez-Segui,S.,
            Pasquali,L., Sauty-Colace,C., Beucher,A., Scharfmann,R., van
            Arensbergen,J., Johnson,P.R., Berry,A., Lee,C., Harkins,T.,
            Gmyr,V., Pattou,F., Kerr-Conte,J., Piemonti,L., Berney,T.,
            Hanley,N., Gloyn,A.L., Sussel,L., Langman,L., Brayman,K.L.,
            Sander,M., McCarthy,M.I., Ravassard,P. and Ferrer,J.
  TITLE     Human beta cell transcriptome analysis uncovers lncRNAs that are
            tissue-specific, dynamically regulated, and abnormally expressed in
            type 2 diabetes
  JOURNAL   Cell Metab 16 (4), 435-448 (2012)
   PUBMED   23040067
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122013.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059025.1, SRR7652917.662808.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AC122013.4         85189-85318         c
            131-460             AC122013.4         84587-84916         c
            461-3048            AC122013.4         38214-40801         c
FEATURES             Location/Qualifiers
     source          1..3048
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 55.45 cM"
     gene            1..3048
                     /gene="Tunar"
                     /gene_synonym="2810011L19Rik; BNLN; Mi-Lnc78; pTUNAR;
                     Tuna"
                     /note="Tcl1 upstream neural differentiation associated
                     RNA"
                     /db_xref="GeneID:69952"
                     /db_xref="MGI:MGI:1917202"
     exon            1..130
                     /gene="Tunar"
                     /gene_synonym="2810011L19Rik; BNLN; Mi-Lnc78; pTUNAR;
                     Tuna"
                     /inference="alignment:Splign:2.1.0"
     exon            131..460
                     /gene="Tunar"
                     /gene_synonym="2810011L19Rik; BNLN; Mi-Lnc78; pTUNAR;
                     Tuna"
                     /inference="alignment:Splign:2.1.0"
     CDS             449..646
                     /gene="Tunar"
                     /gene_synonym="2810011L19Rik; BNLN; Mi-Lnc78; pTUNAR;
                     Tuna"
                     /note="beta cell and neural cell-regulin"
                     /codon_start=1
                     /product="protein TUNAR"
                     /protein_id="NP_001403073.1"
                     /db_xref="GeneID:69952"
                     /db_xref="MGI:MGI:1917202"
                     /translation="MLFSVSLERKIKTFATKMVITSGNDEDRGGQEKESKEESVLAML
                     GIIGTILNLIVIIFVYIYTTL"
     exon            461..3048
                     /gene="Tunar"
                     /gene_synonym="2810011L19Rik; BNLN; Mi-Lnc78; pTUNAR;
                     Tuna"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2954..2959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tunar"
                     /gene_synonym="2810011L19Rik; BNLN; Mi-Lnc78; pTUNAR;
                     Tuna"
                     /note="hexamer: AATAAA"
     polyA_site      2975
                     /gene="Tunar"
                     /gene_synonym="2810011L19Rik; BNLN; Mi-Lnc78; pTUNAR;
                     Tuna"
                     /note="major polyA site"
     regulatory      3026..3031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tunar"
                     /gene_synonym="2810011L19Rik; BNLN; Mi-Lnc78; pTUNAR;
                     Tuna"
                     /note="hexamer: AATAAA"
     polyA_site      3048
                     /gene="Tunar"
                     /gene_synonym="2810011L19Rik; BNLN; Mi-Lnc78; pTUNAR;
                     Tuna"
                     /note="major polyA site"
ORIGIN      
        1 ctcagtcccc tccctggatg ccttaagggt ggctattgcc accgcggagt tgcccctccc
       61 ctgcggggac cccgacgtcg ccgccccctt ctcctcccac gctggtccgc accactctcc
      121 gcaccgccag ccaccctccg agatcttccc gccgagccca ggcgtggggc atgaggagcc
      181 cctgggtgtc gcctgcagac aacccagcct cgcgcacacc tcgccagtcg ctgacaggga
      241 catgaacagc atgattgggt tccggtgtcc ggcggccagc ctcagccgga ggcggccagt
      301 gggtctgcgc tgtttgggag aatgaggcag gaacccacgg caacctctct ctcctccttc
      361 tcctcgcctt cctctggctc ccgctccccg gacccgggcc gggctgtggc tctgctgcgt
      421 gccctgcgcg ccccccacct gcctccggat gctcttctcg gttagcctgg agaggaagat
      481 aaagacattt gcaaccaaga tggtaatcac gagtggaaac gatgaagacc ggggaggcca
      541 agagaaagag agcaaagagg agagcgtgtt ggccatgctg ggcatcatcg ggaccatcct
      601 gaacctgatc gttatcatct ttgtatacat atataccact ctatgaaagg ccccattcag
      661 acctcggtgg cctcaggatg gccacgagac aagggtcctg tgcatccgtc tatcagcgac
      721 cacacactgc ggggggacca gcaggtttga agaccacaca atgctccatc aatgcacctt
      781 cgaactttct gacgggtcac ctgatggacc cgtccttctg tgaggagcag acactctgaa
      841 gcacaatgaa tccagtggga ctccttcagg ccacaaggaa ctcccacagg ggacccagcg
      901 ggatgctgga aaggccagcc ttctgcaccg gcggtgagca cgagggtgag gaagtgcttc
      961 accctggagt gctgaccaca tctcacactg gaaagaggat gcgtggggta gtcgcagctc
     1021 cgctgacctc ctcccaggac tggcaagata aataagctct aggtgcggtt cgttgacagg
     1081 cattgcattc atcaaatgtt tccagctgtt tgatatggga gataacttat ttttcctttt
     1141 tcattggctt gatatgtgta tctgttcata tcgaggttta taaatctata tttttaataa
     1201 atgtgctcta ttttttagca tgaaccaaat atttggagaa gcacttctgg acccatagct
     1261 cttcttggtt ttaatcgctt ttgctccatc agctgcaaga cgtctttgtc tgtagtcatc
     1321 cggttgcctc agctcatctc aagccttgtc gtacctcagg ttcttcttcc ttcccatccc
     1381 tgcccctccc ttctctcctc tctctttccc ctgtctctcc cttccatctc ttaattcccc
     1441 tatccttccc catctcccca ccccccatct cctctctccc ctcctcctca cctcttgtct
     1501 agaggacatt ttcccataat accagctgtg gtcttggctg gtgtgtgctt caagattgtc
     1561 gagcggcttt tcattgttct gtcagagata taaaccgatt gtgggcatgc agaccttaga
     1621 tgcaccctgt ctttattgag aattatgcat gaacaagggc tgagtggcag gccagcatct
     1681 ccagttttta aagggactac caaggaggaa gatgagcagc cctgcctgca ggccaccctt
     1741 gggacagagc agtcaccagc tcaagtgcag tattgcttat ttgctcctgt aaccatccaa
     1801 ttatcagatt ctgatttatt tatttattta tttatttatt tatttattta tttatttatt
     1861 tttgtgacca tgagagatgg aaacggggcg agctcgatgt tcagtgcacc agccgtcatc
     1921 ccttccttgg tgagctgcct ggggaggtgg agggtgggat ctcttcagaa gtcagtggga
     1981 tatgagggaa gtgagacctc cccgctgtga gaatgcacac acagttcctg ctgtaaaaac
     2041 actgctggga cgagtgaccc ttcaagggca ttgggagggg acttaatggt ctctgttaag
     2101 gagccctgca cattttaaag ctgtttttcc actcacacaa agctcttttt ttctctgagg
     2161 ggatggttga ataaatacaa atttgccctg ctctctggct ccgtaacaca gccccaacct
     2221 ggatgcagtg tacagcttta aggagagggt ccgcattcat tctgccaagg gcagaagtgg
     2281 cagcagcccc ccctttggat tcagatgaca ctaagggggg gcatgtctca gcttgccccc
     2341 ttccttaaat ggcaccatga aggagtcatt tcttgggctt cactaaggga ccagtctctt
     2401 ttataaatca aatacccatg agcacctggc tctgcccaga gatgtctcct cttccccacc
     2461 agaaggacag ataccgtgta cacaagtaac caggctttca tagttgctgg tgagagggag
     2521 agtctttctc tctcacctgt gtggtagaag gaagaagaaa ggacagctcg gaccaggaat
     2581 cttccctgag gtttcctggc acccagtgga gtcagattct agcctcacct ggccagttcc
     2641 ttatcccagc gaggacttgg atgctgttgt gggatgctga tgaggatagt gactgtggct
     2701 ggaaagcctg tcgctttgct gaggatcaac ccagcacaca cacacacaca cacacacaca
     2761 cacacacacc acaccacacc acaccacaac aggaaacaac cttagaactc cttggacact
     2821 ggcagaattt gacacaaata aaagacagta gagaggctgg ttaggaaggt gggaggcacc
     2881 ccggggcgag cactacctac caggctgtgt gattcttgac aaactgtaat tctgcacagt
     2941 ggactaaaca aacaataaag gtgcagtggg ggaaactatt ggtgtcgcca acttcctcgt
     3001 gagcccgtgt gtaattgttt gatttaataa aacttgaccg tggctgta
//
