LOCUS       NM_011657               3401 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus TUB like protein 3 (Tulp3), mRNA.
ACCESSION   NM_011657
VERSION     NM_011657.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3401)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3401)
  AUTHORS   Elliott,K.H., Balchand,S.K., Bonatto Paese,C.L., Chang,C.F.,
            Yang,Y., Brown,K.M., Rasicci,D.T., He,H., Thorner,K.,
            Chaturvedi,P., Murray,S.A., Chen,J., Porollo,A., Peterson,K.A. and
            Brugmann,S.A.
  TITLE     Identification of a heterogeneous and dynamic ciliome during
            embryonic development and cell differentiation
  JOURNAL   Development 150 (8) (2023)
   PUBMED   36971348
REFERENCE   3  (bases 1 to 3401)
  AUTHORS   Palicharla,V.R., Hwang,S.H., Somatilaka,B.N., Legue,E.,
            Shimada,I.S., Familiari,N.E., Tran,V.M., Woodruff,J.B., Liem,K.F.
            Jr. and Mukhopadhyay,S.
  TITLE     Interactions between TULP3 tubby domain and ARL13B amphipathic
            helix promote lipidated protein transport to cilia
  JOURNAL   Mol Biol Cell 34 (3), ar18 (2023)
   PUBMED   36652335
REFERENCE   4  (bases 1 to 3401)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3401)
  AUTHORS   Legue,E. and Liem,K.F. Jr.
  TITLE     Mutations in Ciliary Trafficking Genes affect Sonic
            Hedgehog-dependent Neural Tube Patterning Differentially along the
            Anterior-Posterior Axis
  JOURNAL   Neuroscience 450, 3-14 (2020)
   PUBMED   32682825
  REMARK    GeneRIF: Mutations in Ciliary Trafficking Genes affect Sonic
            Hedgehog-dependent Neural Tube Patterning Differentially along the
            Anterior-Posterior Axis.
REFERENCE   6  (bases 1 to 3401)
  AUTHORS   Patterson,V.L., Damrau,C., Paudyal,A., Reeve,B., Grimes,D.T.,
            Stewart,M.E., Williams,D.J., Siggers,P., Greenfield,A. and
            Murdoch,J.N.
  TITLE     Mouse hitchhiker mutants have spina bifida, dorso-ventral
            patterning defects and polydactyly: identification of Tulp3 as a
            novel negative regulator of the Sonic hedgehog pathway
  JOURNAL   Hum Mol Genet 18 (10), 1719-1739 (2009)
   PUBMED   19223390
  REMARK    GeneRIF: Tulp3 is a novel negative regulator of the Shh pathway.
REFERENCE   7  (bases 1 to 3401)
  AUTHORS   Li,Q.Z., Wang,C.Y., Shi,J.D., Ruan,Q.G., Eckenrode,S.,
            Davoodi-Semiromi,A., Kukar,T., Gu,Y., Lian,W., Wu,D. and She,J.X.
  TITLE     Molecular cloning and characterization of the mouse and human TUSP
            gene, a novel member of the tubby superfamily
  JOURNAL   Gene 273 (2), 275-284 (2001)
   PUBMED   11595174
REFERENCE   8  (bases 1 to 3401)
  AUTHORS   Heikenwalder,M.F., Koritschoner,N.P., Pajer,P., Chaboissier,M.C.,
            Kurz,S.M., Briegel,K.J., Bartunek,P. and Zenke,M.
  TITLE     Molecular cloning, expression and regulation of the avian
            tubby-like protein 1 (tulp1) gene
  JOURNAL   Gene 273 (1), 131-139 (2001)
   PUBMED   11483369
REFERENCE   9  (bases 1 to 3401)
  AUTHORS   Ikeda,A., Ikeda,S., Gridley,T., Nishina,P.M. and Naggert,J.K.
  TITLE     Neural tube defects and neuroepithelial cell death in Tulp3
            knockout mice
  JOURNAL   Hum Mol Genet 10 (12), 1325-1334 (2001)
   PUBMED   11406614
REFERENCE   10 (bases 1 to 3401)
  AUTHORS   Nishina,P.M., North,M.A., Ikeda,A., Yan,Y. and Naggert,J.K.
  TITLE     Molecular characterization of a novel tubby gene family member,
            TULP3, in mouse and humans
  JOURNAL   Genomics 54 (2), 215-220 (1998)
   PUBMED   9828123
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY347356.1 and BC060068.1.
            
            On Feb 9, 2007 this sequence version replaced NM_011657.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060068.1, AB016963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                BY347356.1         4-73
            71-3401             BC060068.1         1-3331
FEATURES             Location/Qualifiers
     source          1..3401
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 62.96 cM"
     gene            1..3401
                     /gene="Tulp3"
                     /gene_synonym="2310022L06Rik"
                     /note="TUB like protein 3"
                     /db_xref="GeneID:22158"
                     /db_xref="MGI:MGI:1329045"
     exon            1..114
                     /gene="Tulp3"
                     /gene_synonym="2310022L06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1456
                     /gene="Tulp3"
                     /gene_synonym="2310022L06Rik"
                     /note="tubby-like protein 3"
                     /codon_start=1
                     /product="tubby-related protein 3"
                     /protein_id="NP_035787.1"
                     /db_xref="CCDS:CCDS39647.1"
                     /db_xref="GeneID:22158"
                     /db_xref="MGI:MGI:1329045"
                     /translation="MEAARCAPGPRGDSAFDDETLRLRQLKLDNQRALLEKKQRKKRL
                     EPLMVQPNPEARLRRLKPRGSEEHTPLVDPQMPRSDVILHGIDGPAAFLKPEAQDLES
                     KPQVLSVGSPAPEEGTEGSADGESPEETAPKPDLQEILQKHGILSSVNYDEEPDKEED
                     EGGNLSSPSARSEESAAASQKAASETGASGVTAQQGDAQLGEVENLEDFAYSPAPRGV
                     TVKCKVTRDKKGMDRGLFPTYYMHLEREENRKIFLLAGRKRKKSKTSNYLVSTDPTDL
                     SREGESYIGKLRSNLMGTKFTVYDHGVNPVKAQGLVEKAHTRQELAAICYETNVLGFK
                     GPRKMSVIIPGMNMNHERIPFRPRNEHESLLSKWQNKSMENLIELHNKAPVWNDDTQS
                     YVLNFHGRVTQASVKNFQIVHGNDPDYIVMQFGRVADDVFTLDYNYPLCALQAFAIGL
                     SSFDSKLACE"
     exon            115..166
                     /gene="Tulp3"
                     /gene_synonym="2310022L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            167..326
                     /gene="Tulp3"
                     /gene_synonym="2310022L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            327..503
                     /gene="Tulp3"
                     /gene_synonym="2310022L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            504..625
                     /gene="Tulp3"
                     /gene_synonym="2310022L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            626..823
                     /gene="Tulp3"
                     /gene_synonym="2310022L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            824..936
                     /gene="Tulp3"
                     /gene_synonym="2310022L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1051
                     /gene="Tulp3"
                     /gene_synonym="2310022L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1150
                     /gene="Tulp3"
                     /gene_synonym="2310022L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1322
                     /gene="Tulp3"
                     /gene_synonym="2310022L06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..3374
                     /gene="Tulp3"
                     /gene_synonym="2310022L06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3352..3357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tulp3"
                     /gene_synonym="2310022L06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3372
                     /gene="Tulp3"
                     /gene_synonym="2310022L06Rik"
                     /note="major polyA site"
ORIGIN      
        1 gatctcctcc atcctctcca gccgggcggc ggcgtctcgg ggtctggacg ctgatgccac
       61 cggtcgggcg ggtatggagg cggcgcgctg cgcacccgga ccccgcgggg acagtgcctt
      121 tgacgatgag accctgaggc ttcggcagct gaagctggac aatcagaggg cactgctgga
      181 gaagaagcag agaaagaagc gccttgagcc actcatggta cagccaaacc cagaagccag
      241 gctgcgaagg ttaaagccac gaggcagtga ggagcacacg cctctggtgg accctcagat
      301 gcctcgcagc gacgtcatcc tacacggcat cgacggtcca gctgctttcc ttaagccaga
      361 ggctcaggat ttggaaagca agcctcaggt tctctctgtg ggctcccctg ccccagaaga
      421 aggcacggaa gggagtgcag atggggaaag ccccgaggag acagccccca agccagacct
      481 tcaggagatt ctccaaaaac acggcatctt gagtagtgtg aactatgacg aggagcctga
      541 caaggaggaa gatgaggggg gaaacctcag ctccccgtcg gctcgctcag aggagagtgc
      601 tgcagccagc cagaaagcag cctcggagac aggagcttcc ggtgtgacag cccagcaggg
      661 tgacgcccag cttggagaag tggagaattt agaggacttt gcgtatagcc ctgcccctcg
      721 gggtgtcacg gtgaagtgta aagtaaccag ggataagaaa ggcatggacc gtggcctctt
      781 ccccacctac tatatgcacc tggaacggga ggagaaccgc aagatatttc ttctagccgg
      841 tagaaagcgg aaaaagagca aaacgtccaa ctacctggtc tccacagacc cgacagattt
      901 gtctcgtgaa ggggaaagtt acattggcaa actcagatcc aatctcatgg ggaccaagtt
      961 cacagtgtat gaccatggtg tcaacccagt caaggcccag ggtctggtgg agaaggccca
     1021 cacccgccag gagctggctg ctatctgtta tgaaacaaat gtcctcggtt tcaaaggtcc
     1081 caggaaaatg tctgtgatca tcccggggat gaacatgaac catgagcgca tccctttcag
     1141 gccacgaaat gaacacgaga gcttgctttc aaaatggcaa aacaaatcca tggagaacct
     1201 gatcgagctg cacaacaagg ccccggtgtg gaatgacgac acccagtcct acgtgctgaa
     1261 ctttcacggc agagtcaccc aggcatccgt gaaaaacttc cagatcgtcc acgggaatga
     1321 ccctgactac atcgtcatgc agtttggacg cgtggctgat gacgtgttca cactggacta
     1381 taactaccca ctgtgcgcac ttcaagcctt cgccatcggg ctgtccagct ttgacagcaa
     1441 gctggcgtgt gaatgagaag cagcaagcag gggatttctt caccacagag ccttcaagag
     1501 cagaaagctg ctgcctctgc ccctgcccct gcccctgccc ctgcccctgc ccctgcccct
     1561 gcccctgccc ctgcccctgc ccctgcccct gcccctgccc tagcacaaga agagcaacat
     1621 tctgcccctc tggtgaatga tccagtgtgt gtgtgtgtgt gaatgtgcat gtgtgtgttt
     1681 gtttatacat gcatacacat tcacacatgg atgcatgctt ccacgtactc gttcatgcct
     1741 tctctgaact tcagagacct ggtcatagat tacaacttct catgtgtgag agatggctta
     1801 aagcacaggg aagtagacac ccaggcacac tggtgtctcc tgatcgcaca acagactctg
     1861 tgtggtgagt gtagctttca tgtgctcggg cacttccaac agaatcaggt tctaatgatt
     1921 taatacttgg gcctcctgtt ttgaaggccc tttcaaaagg gggcttttcc cttggatgcc
     1981 tttagcccag gagcctgcag ccttcctcag ccaatggtct gatagtgtct cttgcactga
     2041 ccccagtcag gtcctttagc acaaaacagc cataactagt tggtgcacaa agagtgtagc
     2101 tgtgtcccaa taaaacttta tttacaaagt gggcattggc ctagtttggc ctgtgactct
     2161 ggttcgcagg cctgccttgg ctgtgtccct gtcctccaag gctggagcat cttccaggct
     2221 agatgtggag aggcgggggg tggtttactt ttcagtagca gcagactgac attttatttt
     2281 tatttttact ttattttttt ttcccatgga tctctgtgta gccctggcta tcctggaact
     2341 tattctgtag accaggctgg cctcagagat ccacctgcct ctgcccccca agtgctggaa
     2401 ttaaaggctt acactactgt gcctggccat agacagactc ttaagaggaa ttcttgccga
     2461 atctactctt ggtagctttt gcctcatgga gattatggct gcagagtgtc atatatcatc
     2521 ttgggacatg tgacactagt ttgttcgtgg gtctgaaagg ctctgctgtc cccagcctgc
     2581 ctcttgctta ttctcagagt aggttggtgg gcagccatct cagaagcatg actgtggcca
     2641 gatcttcgga atctttgctc tctggaatct taatctagtg tctccttaga ggcagcaaga
     2701 gtcttggtga ggaggtcacc tcgccgacac tccacaggct ttgcctgtca gctttgtcct
     2761 ccagcctcga aacctggccc acaccagtgg agacactgcc ctgcatgctg agtctttgag
     2821 atcttgaaca tctcgaacat ctcccagcga atcatgacaa attcctcaag gtccccagcc
     2881 tacagtgtac ctgaacttaa gaattcaaaa actttgggtc tacattcagt ggtcccccac
     2941 tctcaaactg gcaactgctc cgtggttttt cctgtatgga ggaggtccct gcatccctgc
     3001 atcctgttgc tccatgctca cagctgtgtg acgactacag cgtgagatct gggaggtgag
     3061 acctgtgcta aggccagtgt cttgcctgtc ccttcagatg tcactgtctc tgcctctggc
     3121 aggcgtccca tcaagtgcct tgttcataaa tgtgctctga aacctgacac acctctgctt
     3181 tcccagacga gccacctttg ttgagtgaaa actgctctct gtctccactt gaagggggtg
     3241 gggctatgac tttctgccca gcctagagag ctgtatactc ccatttcatg gactctgctt
     3301 gagtgtgcag gttttacatg aattctattt ataccttttg tatgccacat aaataaagat
     3361 aatttatata aagaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
