LOCUS       NM_008807               1767 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus TUB like protein 2 (Tulp2), transcript variant 1,
            mRNA.
ACCESSION   NM_008807
VERSION     NM_008807.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1767)
  AUTHORS   Wang,W., Xing,J., Zhang,X., Liu,H., Liu,X., Jiang,H., Xu,C.,
            Zhao,X. and Hu,Z.
  TITLE     Control of ciliary transcriptional programs during spermatogenesis
            by antagonistic transcription factors
  JOURNAL   Elife 13, 94754 (2025)
   PUBMED   40009443
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1767)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1767)
  AUTHORS   Oyama,Y., Miyata,H., Shimada,K., Larasati,T., Fujihara,Y. and
            Ikawa,M.
  TITLE     TULP2 deletion mice exhibit abnormal outer dense fiber structure
            and male infertility
  JOURNAL   Reprod Med Biol 21 (1), e12467 (2022)
   PUBMED   35619658
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1767)
  AUTHORS   Zheng,M., Chen,X., Cui,Y., Li,W., Dai,H., Yue,Q., Zhang,H.,
            Zheng,Y., Guo,X. and Zhu,H.
  TITLE     TULP2, a New RNA-Binding Protein, Is Required for Mouse Spermatid
            Differentiation and Male Fertility
  JOURNAL   Front Cell Dev Biol 9, 623738 (2021)
   PUBMED   33763418
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1767)
  AUTHORS   Mukhopadhyay,S. and Jackson,P.K.
  TITLE     The tubby family proteins
  JOURNAL   Genome Biol 12 (6), 225 (2011)
   PUBMED   21722349
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1767)
  AUTHORS   Li,Q.Z., Wang,C.Y., Shi,J.D., Ruan,Q.G., Eckenrode,S.,
            Davoodi-Semiromi,A., Kukar,T., Gu,Y., Lian,W., Wu,D. and She,J.X.
  TITLE     Molecular cloning and characterization of the mouse and human TUSP
            gene, a novel member of the tubby superfamily
  JOURNAL   Gene 273 (2), 275-284 (2001)
   PUBMED   11595174
REFERENCE   7  (bases 1 to 1767)
  AUTHORS   Ikeda,S., He,W., Ikeda,A., Naggert,J.K., North,M.A. and
            Nishina,P.M.
  TITLE     Cell-specific expression of tubby gene family members (tub,
            Tulp1,2, and 3) in the retina
  JOURNAL   Invest Ophthalmol Vis Sci 40 (11), 2706-2712 (1999)
   PUBMED   10509669
REFERENCE   8  (bases 1 to 1767)
  AUTHORS   North,M.A., Naggert,J.K., Yan,Y., Noben-Trauth,K. and Nishina,P.M.
  TITLE     Molecular characterization of TUB, TULP1, and TULP2, members of the
            novel tubby gene family and their possible relation to ocular
            diseases
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 3128-3133 (1997)
   PUBMED   9096357
REFERENCE   9  (bases 1 to 1767)
  AUTHORS   Vambutas,V. and Wolgemuth,D.J.
  TITLE     Identification and characterization of the developmentally
            regulated pattern of expression in the testis of a mouse gene
            exhibiting similarity to the family of phosphodiesterases
  JOURNAL   Biochim Biophys Acta 1217 (2), 203-206 (1994)
   PUBMED   7509194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY087813.1, BB617192.1, AC151602.4 and BC048740.1.
            
            On Apr 1, 2015 this sequence version replaced NM_008807.2.
            
            Transcript Variant: This variant (1) differs in the 3' UTR and
            coding sequence compared to variant 2. The resulting isoform (1) is
            the same length but has a distinct C-terminus compared to isoform
            2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF105712.1, SRR5189685.125754.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               BY087813.1         2-182
            182-736             BB617192.1         150-704
            737-803             AC151602.4         72497-72563         c
            804-902             AC151602.4         71780-71878         c
            903-1760            BC048740.1         1-858
            1761-1767           AC151602.4         68077-68083         c
FEATURES             Location/Qualifiers
     source          1..1767
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.33 cM"
     gene            1..1767
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /note="TUB like protein 2"
                     /db_xref="GeneID:56734"
                     /db_xref="MGI:MGI:1861600"
     exon            1..82
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1736
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tubby-related protein 2; protein P4-6; testis specific
                     phosphodiesterase; tubby-like protein 2"
                     /codon_start=1
                     /product="tubby-related protein 2 isoform 1"
                     /protein_id="NP_032833.2"
                     /db_xref="CCDS:CCDS39954.1"
                     /db_xref="GeneID:56734"
                     /db_xref="MGI:MGI:1861600"
                     /translation="MDREGPRGPRSGASQENEQWKKETLEDEFSGVRLQKLEQQRQLF
                     EKKQRRKRQEPLMVQANPDATLRHRRPRRGEERFQSDSSWGLGVGSPFLQENVPQAHL
                     PSGAHSALVTMSYVADGSGERAPLLSPRGAVYTRGNGPAVRHHLCWLPDSSDSDVEEV
                     TMEDIPVISRPPQTNLANLRRGWLASPGPGISQEEKEEEVGSTDARVEDKTPSPDPDP
                     DPTVNSDGDHGDLAPCKVEENTAQKNTETASGIGDEDREKGEVTESTETNYAPVASKV
                     LQGDDGDASNHNAWNMTCPQPRIPGPRLGEDMEAYVLLPAPRDHMVQCRIVRNKHGMD
                     KGMFPSYYLYLEAEDGVAHFLLAGRKRKRSKTSNYLISLDPKDMSRNGSNFVGKVRSN
                     VLGTKFTIFDNGVNPERSYWVPDSARIREELGVVCYETNVLGFRGPRKMTVILPGMDS
                     RKQRMKVQPQNDQDSILSRVQKGAGHGLLLLQNKAPSWSDESGAYVLNFHGRVTRASV
                     KNFQIVHPDEPDHLVLQFGRVAPNIFTMDFRYPLCPLQAFAICLSSFDGKLACE"
     exon            83..115
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /inference="alignment:Splign:2.1.0"
     exon            116..167
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /inference="alignment:Splign:2.1.0"
     exon            168..306
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /inference="alignment:Splign:2.1.0"
     exon            307..444
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /inference="alignment:Splign:2.1.0"
     exon            445..615
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /inference="alignment:Splign:2.1.0"
     exon            616..803
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /inference="alignment:Splign:2.1.0"
     exon            804..1103
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1216
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1331
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1430
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1602
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1767
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1740..1745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /note="hexamer: AATAAA"
     polyA_site      1762
                     /gene="Tulp2"
                     /gene_synonym="Pdet"
                     /note="major polyA site"
ORIGIN      
        1 aagggatccg cctgccccag tgccctggga gcattactct gttggacatg gaccgtgagg
       61 ggccaagagg gccaagaagt ggagcgtctc aggagaatga acagtggaag aaagagaccc
      121 tggaggatga attctctggc gtgaggctgc agaagctaga acaacagcga cagctatttg
      181 agaagaagca gcgcaggaaa cgccaggagc ccctcatggt tcaggccaat cctgatgcta
      241 ccctgaggca ccggcgacca aggcgcgggg aggagcgctt ccagagtgac agcagctggg
      301 gccttggtgt tgggagccct ttcctccagg agaacgttcc gcaggcacat ctgccctcag
      361 gggcgcacag tgcccttgtc accatgagct atgtcgcaga tgggagtggt gagcgggccc
      421 ccctactgtc accccgagga gcagtataca ctcggggcaa cggccctgcg gtccgtcatc
      481 atctttgctg gcttccagac agctccgatt cagacgtgga ggaagtgacc atggaagaca
      541 tccccgtcat ctcccgacct ccccagacga atctggcaaa cctacgcagg ggctggttag
      601 cctccccagg acccgggatc agtcaagaag aaaaagaaga agaggttgga tccacggatg
      661 ccagagttga agacaagaca cccagcccag acccagaccc agaccctacc gtgaactctg
      721 acggagatca tggagacctg gcaccctgca aggtggaaga aaacacagcc cagaagaata
      781 cagaaacagc ctctggcatc ggggatgaag accgggagaa gggagaggtc acagagtcta
      841 cagagacaaa ctatgcccca gtggcatcca aggttttgca aggcgacgat ggtgacgcca
      901 gcaaccacaa tgcctggaac atgacctgcc cccagcctcg cattcccggc cctcggctcg
      961 gggaggacat ggaagcatac gtgttgctcc ctgcaccccg agaccacatg gtgcagtgcc
     1021 gcatcgtccg aaacaagcac ggcatggaca aggggatgtt cccttcctac tacctctacc
     1081 tggaggccga ggatggtgta gcacatttcc ttctggctgg gcggaaaagg aaaagaagca
     1141 aaacttcaaa ttatctcatc tccctggacc ccaaagacat gtctcgcaat gggagcaact
     1201 ttgtaggcaa agttagatcc aatgtcttgg gcacgaaatt caccatcttc gataatgggg
     1261 tgaaccctga gcggagttac tgggttccag acagtgcccg gatcagagag gagctgggag
     1321 tcgtctgtta tgagaccaat gtcttgggat tcagggggcc tcggaaaatg actgtgatcc
     1381 ttccaggaat ggacagccgg aagcagagga tgaaagtcca gccacaaaat gatcaggatt
     1441 ccatattgag tcgcgtacag aagggcgctg gacacgggct gcttctactg cagaacaagg
     1501 ccccatcgtg gagcgacgaa agcggcgcat acgtactcaa ttttcacggt cgcgtcacgc
     1561 gggcttcagt caagaacttc cagatagtgc acccggatga acccgaccac ctggtgctcc
     1621 agtttggccg tgtggcccca aacatattca cgatggattt ccgatatcct ctttgcccgc
     1681 tccaagcctt cgccatctgc ttatccagtt tcgatgggaa actggcgtgt gagtaactga
     1741 ataaaatacc atccctcacc aactctg
//
