LOCUS       NM_021478               2085 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus TUB like protein 1 (Tulp1), mRNA.
ACCESSION   NM_021478
VERSION     NM_021478.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2085)
  AUTHORS   Ebke,L.A., Sinha,S., Pauer,G.J.T. and Hagstrom,S.A.
  TITLE     Photoreceptor Compartment-Specific TULP1 Interactomes
  JOURNAL   Int J Mol Sci 22 (15), 8066 (2021)
   PUBMED   34360830
  REMARK    GeneRIF: Photoreceptor Compartment-Specific TULP1 Interactomes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2085)
  AUTHORS   Remez,L., Cohen,B., Nevet,M.J., Rizel,L. and Ben-Yosef,T.
  TITLE     TULP1 and TUB Are Required for Specific Localization of PRCD to
            Photoreceptor Outer Segments
  JOURNAL   Int J Mol Sci 21 (22), 8677 (2020)
   PUBMED   33213002
  REMARK    GeneRIF: TULP1 and TUB Are Required for Specific Localization of
            PRCD to Photoreceptor Outer Segments.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2085)
  AUTHORS   Palfi,A., Yesmambetov,A., Humphries,P., Hokamp,K. and Farrar,G.J.
  TITLE     Non-photoreceptor Expression of Tulp1 May Contribute to Extensive
            Retinal Degeneration in Tulp1-/- Mice
  JOURNAL   Front Neurosci 14, 656 (2020)
   PUBMED   32655363
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2085)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2085)
  AUTHORS   Wahl,S., Magupalli,V.G., Dembla,M., Katiyar,R., Schwarz,K.,
            Koblitz,L., Alpadi,K., Krause,E., Rettig,J., Sung,C.H.,
            Goldberg,A.F. and Schmitz,F.
  TITLE     The Disease Protein Tulp1 Is Essential for Periactive Zone
            Endocytosis in Photoreceptor Ribbon Synapses
  JOURNAL   J Neurosci 36 (8), 2473-2493 (2016)
   PUBMED   26911694
  REMARK    GeneRIF: Tulp1 is essential to keep endocytotic proteins enriched
            at the periactive zone in photoreceptor ribbon synapses.
REFERENCE   6  (bases 1 to 2085)
  AUTHORS   Hagstrom,S.A., Adamian,M., Scimeca,M., Pawlyk,B.S., Yue,G. and
            Li,T.
  TITLE     A role for the Tubby-like protein 1 in rhodopsin transport
  JOURNAL   Invest Ophthalmol Vis Sci 42 (9), 1955-1962 (2001)
   PUBMED   11481257
REFERENCE   7  (bases 1 to 2085)
  AUTHORS   Heikenwalder,M.F., Koritschoner,N.P., Pajer,P., Chaboissier,M.C.,
            Kurz,S.M., Briegel,K.J., Bartunek,P. and Zenke,M.
  TITLE     Molecular cloning, expression and regulation of the avian
            tubby-like protein 1 (tulp1) gene
  JOURNAL   Gene 273 (1), 131-139 (2001)
   PUBMED   11483369
REFERENCE   8  (bases 1 to 2085)
  AUTHORS   Ikeda,S., Shiva,N., Ikeda,A., Smith,R.S., Nusinowitz,S., Yan,G.,
            Lin,T.R., Chu,S., Heckenlively,J.R., North,M.A., Naggert,J.K.,
            Nishina,P.M. and Duyao,M.P.
  TITLE     Retinal degeneration but not obesity is observed in null mutants of
            the tubby-like protein 1 gene
  JOURNAL   Hum Mol Genet 9 (2), 155-163 (2000)
   PUBMED   10607826
REFERENCE   9  (bases 1 to 2085)
  AUTHORS   Hagstrom,S.A., Duyao,M., North,M.A. and Li,T.
  TITLE     Retinal degeneration in tulp1-/- mice: vesicular accumulation in
            the interphotoreceptor matrix
  JOURNAL   Invest Ophthalmol Vis Sci 40 (12), 2795-2802 (1999)
   PUBMED   10549638
REFERENCE   10 (bases 1 to 2085)
  AUTHORS   North,M.A., Naggert,J.K., Yan,Y., Noben-Trauth,K. and Nishina,P.M.
  TITLE     Molecular characterization of TUB, TULP1, and TULP2, members of the
            novel tubby gene family and their possible relation to ocular
            diseases
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 3128-3133 (1997)
   PUBMED   9096357
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154912.3 and CT025652.7.
            
            On Jan 4, 2017 this sequence version replaced NM_021478.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014820.1, AF105711.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AC154912.3         183008-183153
            147-198             AC154912.3         183267-183318
            199-280             AC154912.3         183658-183739
            281-433             AC154912.3         183841-183993
            434-586             AC154912.3         184386-184538
            587-682             CT025652.7         51-146
            683-802             CT025652.7         228-347
            803-924             CT025652.7         548-669
            925-930             CT025652.7         3718-3723
            931-1101            CT025652.7         3810-3980
            1102-1214           CT025652.7         4380-4492
            1215-1326           CT025652.7         6592-6703
            1327-1425           CT025652.7         6780-6878
            1426-1597           CT025652.7         9188-9359
            1598-2085           CT025652.7         11040-11527
FEATURES             Location/Qualifiers
     source          1..2085
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.66 cM"
     gene            1..2085
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /note="TUB like protein 1"
                     /db_xref="GeneID:22157"
                     /db_xref="MGI:MGI:109571"
     exon            1..146
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1731
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /note="tubby like protein 1 like; tubby-like protein 1"
                     /codon_start=1
                     /product="tubby-related protein 1"
                     /protein_id="NP_067453.1"
                     /db_xref="CCDS:CCDS28578.1"
                     /db_xref="GeneID:22157"
                     /db_xref="MGI:MGI:109571"
                     /translation="MPLQEETLREVWASDSGHEEDCLSPEPPLRPKQRPAQGQKLRKK
                     KPETPDSLESKPRKAGAGRRKHEEPPADSAEPRAAQTVYAKFLRDPEAKKRDPRENFL
                     VARAPDLGGEENSEEDSDDDDNDDDEEEEEKKEGKKEKSSLPPKKAPKEREKKAKALG
                     PRGDVGSPDAPRKPLRTKKKEVGEGTKLRKAKKKGPGETDKDPAGSPAALRKEFPAAM
                     FLVGEGGAAEKGVKKKGPPKGSEEEKKEEEEEVEEEVASAVMKNSNQKGRAKGKGKKK
                     VKEERASSPPVEVGEPREFVLQPAPQGRAVRCRLTRDKKGMDRGMYPSYFLHLDTEKK
                     VFLLAGRKRKRSKTANYLISSDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRG
                     GGGDVGSLRQELAAVVYETNVLGFRGPRRMTVIIPGMNSDNERVPIRPRNASDGLLVR
                     WQNKTLESLIELHNKPPIWNEDSGSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFG
                     RVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE"
     exon            147..198
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            199..280
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            281..433
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            434..586
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            587..682
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            683..802
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            803..924
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            925..930
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1101
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1214
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1326
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1425
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1597
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..2085
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2058..2063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /note="hexamer: AATAAA"
     polyA_site      2085
                     /gene="Tulp1"
                     /gene_synonym="Tulp1l"
                     /note="major polyA site"
ORIGIN      
        1 agctgagccg agattagcta ggaaggaagg gaggctgggg agcggcgagt caccagagag
       61 agagagaggg gtggtggccg tgacaggcac acagacgcaa tgccactgca ggaggagacc
      121 cttcgggaag tgtgggcctc agacagcggc catgaagagg actgcttgag ccccgagccc
      181 ccgctgcgcc ccaaacagcg acccgcccag ggacagaagt tgaggaaaaa gaaacccgag
      241 acccccgact ccctggaatc caaaccccgt aaagctgggg ctgggcgcag gaagcacgag
      301 gagccgcccg cagactcggc agagccgcgc gctgcgcaga cagtctacgc caagttcctg
      361 agggaccccg aggccaagaa gcgggacccc cgggaaaact tcctagttgc ccgcgcccca
      421 gacctgggag gcgaggagaa ttcggaagag gattcggatg atgatgacaa tgatgatgat
      481 gaggaggagg aggagaagaa agaggggaaa aaagagaaaa gctctctgcc ccccaagaaa
      541 gcacccaagg agagagagaa gaaagccaag gctctgggcc caagggggga tgtaggaagc
      601 ccggatgccc ctcggaaacc gctccgaacc aagaagaagg aggtagggga gggaaccaaa
      661 ctgagaaagg caaagaaaaa agggcctggg gagactgaca aggaccccgc ggggagccca
      721 gcagccttga ggaaggagtt tccagcagcc atgttcctgg ttggggaagg tggcgcggct
      781 gagaagggtg tgaagaagaa aggacctcct aaaggttcag aggaagagaa gaaggaggag
      841 gaggaagaag tggaagagga ggttgcatcc gcagtgatga agaacagcaa ccagaagggc
      901 agagctaaag ggaaaggcaa aaagaaagtg aaggaggaga gagcctcttc gccccctgtg
      961 gaagtgggtg aaccccggga gtttgtgctg cagccagcac cccagggccg ggcagtccgc
     1021 tgccggctga cacgggacaa gaagggcatg gatcgcggca tgtacccgtc ctacttcctg
     1081 cacctggaca ctgagaagaa ggtgtttctc ctggccggca ggaaacgcaa gcggagtaag
     1141 acagccaact atctcatctc cagtgacccc accaacctgt cccggggagg cgagaatttc
     1201 atcgggaagc tgaggtctaa tctcttgggg aaccgcttca cggtctttga caacgggcag
     1261 aacccacagc gagggggagg tggtgacgtg ggaagcctgc gccaggagct ggccgctgtg
     1321 gtctatgaaa ccaatgtttt aggcttccga ggaccccgcc gtatgactgt catcattcct
     1381 ggaatgaact cggacaacga gagggtccct atccggcccc gaaacgccag cgatgggctg
     1441 ctagtgcgct ggcagaacaa gaccctggag agtctcatcg agctccataa caagccgccc
     1501 atctggaatg aagacagtgg ctcctacacc ctcaacttcc agggccgcgt cacccaggcc
     1561 tccgtcaaga actttcagat tgtgcacgct gatgaccctg actatatagt gctgcagttc
     1621 ggccgcgtgg ctgaggacgc cttcacccta gactaccggt acccgctgtg tgctctgcag
     1681 gccttcgcca tcgccctctc cagcttcgac gggaagctgg cctgcgagtg accccccaca
     1741 gctcctcagc gctgggaaag cattcggttg ggggtggcaa ggtccctccc ccacagctcc
     1801 catggaaggg ctcacccctc tccgtgacct ccgggcattt cccccctcca ctcccccagc
     1861 ctggcaccgg ctgaggcaga ggggatggag atgaacatct ggtcgcccaa aagtacttgc
     1921 ctcgccccct cctccccagt cacttcctgt cagagagccg gagtcagatg ttcgaggccc
     1981 ctccgacccc gcgctggggg gtttgtaggg ggtggggagg ggacgatggt gaagcagagc
     2041 cagggaccca catccccaat aaagtcacgt ccgaggctga acgca
//
