LOCUS       NM_001396521            7084 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus taurine upregulated gene 1 (Tug1), transcript variant
            d, mRNA.
ACCESSION   NM_001396521
VERSION     NM_001396521.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7084)
  AUTHORS   Wang,H., Li,T., Jiang,Y., Chen,S., Wu,Z., Zeng,X., Yang,K., Duan,P.
            and Zou,S.
  TITLE     Long non-coding RNA LncTUG1 regulates favourable compression
            force-induced cementocytes mineralization via PU.1/TLR4/SphK1
            signalling
  JOURNAL   Cell Prolif 57 (6), e13604 (2024)
   PUBMED   38318762
  REMARK    GeneRIF: Long non-coding RNA LncTUG1 regulates favourable
            compression force-induced cementocytes mineralization via
            PU.1/TLR4/SphK1 signalling.
REFERENCE   2  (bases 1 to 7084)
  AUTHORS   Chen,J., Su,C., Ma,Z., Ou,X., Zhan,M. and Hu,J.
  TITLE     Aerobic exercise suppresses cognitive injury in patients with
            Alzheimer's disease by regulating long non-coding RNA TUG1
  JOURNAL   Neurosci Lett 826, 137732 (2024)
   PUBMED   38490634
  REMARK    GeneRIF: Aerobic exercise suppresses cognitive injury in patients
            with Alzheimer's disease by regulating long non-coding RNA TUG1.
REFERENCE   3  (bases 1 to 7084)
  AUTHORS   Wang,W., Miao,Z., Qi,X., Wang,B., Liu,Q., Shi,X. and Xu,S.
  TITLE     LncRNA Tug1 relieves the steatosis of SelenoF-knockout hepatocytes
            via sponging miR-1934-3p
  JOURNAL   Cell Biol Toxicol 39 (6), 3175-3195 (2023)
   PUBMED   37721623
  REMARK    GeneRIF: LncRNA Tug1 relieves the steatosis of SelenoF-knockout
            hepatocytes via sponging miR-1934-3p.
REFERENCE   4  (bases 1 to 7084)
  AUTHORS   Bharadhwaj,R.A. and Kumarswamy,R.
  TITLE     Long noncoding RNA TUG1 regulates smooth muscle cell
            differentiation via KLF4-myocardin axis
  JOURNAL   Am J Physiol Cell Physiol 325 (4), C940-C950 (2023)
   PUBMED   37642238
  REMARK    GeneRIF: Long noncoding RNA TUG1 regulates smooth muscle cell
            differentiation via KLF4-myocardin axis.
REFERENCE   5  (bases 1 to 7084)
  AUTHORS   Lewandowski,J.P., Dumbovic,G., Watson,A.R., Hwang,T.,
            Jacobs-Palmer,E., Chang,N., Much,C., Turner,K.M., Kirby,C.,
            Rubinstein,N.D., Groff,A.F., Liapis,S.C., Gerhardinger,C.,
            Bester,A., Pandolfi,P.P., Clohessy,J.G., Hoekstra,H.E.,
            Sauvageau,M. and Rinn,J.L.
  TITLE     The Tug1 lncRNA locus is essential for male fertility
  JOURNAL   Genome Biol 21 (1), 237 (2020)
   PUBMED   32894169
  REMARK    GeneRIF: The Tug1 lncRNA locus is essential for male fertility.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7084)
  AUTHORS   van Heesch,S., van Iterson,M., Jacobi,J., Boymans,S., Essers,P.B.,
            de Bruijn,E., Hao,W., MacInnes,A.W., Cuppen,E. and Simonis,M.
  TITLE     Extensive localization of long noncoding RNAs to the cytosol and
            mono- and polyribosomal complexes
  JOURNAL   Genome Biol 15 (1), R6 (2014)
   PUBMED   24393600
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7084)
  AUTHORS   Sauvageau,M., Goff,L.A., Lodato,S., Bonev,B., Groff,A.F.,
            Gerhardinger,C., Sanchez-Gomez,D.B., Hacisuleyman,E., Li,E.,
            Spence,M., Liapis,S.C., Mallard,W., Morse,M., Swerdel,M.R.,
            D'Ecclessis,M.F., Moore,J.C., Lai,V., Gong,G., Yancopoulos,G.D.,
            Frendewey,D., Kellis,M., Hart,R.P., Valenzuela,D.M., Arlotta,P. and
            Rinn,J.L.
  TITLE     Multiple knockout mouse models reveal lincRNAs are required for
            life and brain development
  JOURNAL   Elife 2, e01749 (2013)
   PUBMED   24381249
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7084)
  AUTHORS   Ozgur,E., Mert,U., Isin,M., Okutan,M., Dalay,N. and Gezer,U.
  TITLE     Differential expression of long non-coding RNAs during genotoxic
            stress-induced apoptosis in HeLa and MCF-7 cells
  JOURNAL   Clin Exp Med 13 (2), 119-126 (2013)
   PUBMED   22487937
REFERENCE   9  (bases 1 to 7084)
  AUTHORS   Rapicavoli,N.A. and Blackshaw,S.
  TITLE     New meaning in the message: noncoding RNAs and their role in
            retinal development
  JOURNAL   Dev Dyn 238 (9), 2103-2114 (2009)
   PUBMED   19191220
  REMARK    Review article
REFERENCE   10 (bases 1 to 7084)
  AUTHORS   Young,T.L., Matsuda,T. and Cepko,C.L.
  TITLE     The noncoding RNA taurine upregulated gene 1 is required for
            differentiation of the murine retina
  JOURNAL   Curr Biol 15 (6), 501-512 (2005)
   PUBMED   15797018
  REMARK    GeneRIF: taurine upregulated gene 1 is necessary for the proper
            formation of photoreceptors in the developing rodent retina
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL691413.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927934.2967713.1,
                                           SRR11927932.2654888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate            :: translation inferred from conservation
            non-AUG initiation codon :: PMID: 32894169
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2465              AL691413.5         99611-102075        c
            2466-3217           AL691413.5         97826-98577         c
            3218-7084           AL691413.5         92367-96233         c
FEATURES             Location/Qualifiers
     source          1..7084
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.56 cM"
     gene            1..7084
                     /gene="Tug1"
                     /note="taurine upregulated gene 1"
                     /db_xref="GeneID:544752"
                     /db_xref="MGI:MGI:2144114"
     exon            1..2465
                     /gene="Tug1"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..521
                     /gene="Tug1"
                     /note="non-AUG (CUG) translation initiation codon"
                     /codon_start=1
                     /product="taurine up-regulated 1"
                     /protein_id="NP_001383450.1"
                     /db_xref="GeneID:544752"
                     /db_xref="MGI:MGI:2144114"
                     /translation="MARPPPLPGLVGRRSGRAVDRAIGWRLFLLLWHPALGAQARPPR
                     RAPGGRWRSRRVFLLVRRTRAAAYAFAIRRGVVRVVGGGGQLRPAPGEAAGEAGVAGA
                     GLEAWRHPSGPARTQLEGQEGAGGWLVVGFLLCLFLLMPP"
     exon            2466..3217
                     /gene="Tug1"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..7084
                     /gene="Tug1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3953..3958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tug1"
                     /note="hexamer: ATTAAA"
     polyA_site      3973
                     /gene="Tug1"
                     /note="major polyA site"
     regulatory      6577..6582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tug1"
                     /note="hexamer: AATAAA"
     polyA_site      6609
                     /gene="Tug1"
                     /note="major polyA site"
     regulatory      7063..7068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tug1"
                     /note="hexamer: AATAAA"
     polyA_site      7084
                     /gene="Tug1"
ORIGIN      
        1 gagagacgca gccgggacgg tagctgcaga gcagagcgga ggagccatct tgtcttgtcg
       61 ccggggagtc aggcccctaa ctcgaagaag ccctggcgcg ccctcccccc ctccccggtc
      121 tggtagggcg aaggagcggg cgtgcggtcg atcgagcgat cggttggcgg ctctttctcc
      181 tgctctggca tccagctctt ggggcgcagg cccggccgcc gcggcgcgcg cccggtggcc
      241 gttggcgctc gcgccgcgtc tttcttctcg tacgcagaac tcgggcggcg gcctatgctt
      301 ttgcgatccg acgaggggtc gtccgggtgg ttggcggcgg cgggcaactc cgccccgctc
      361 ccggggaggc ggcgggggaa gctggggtgg ccggggctgg cctggaggcc tggcgccacc
      421 cctcggggcc tgctaggacc cagttggagg gtcaagaggg agctggagga tggttggtgg
      481 tgggcttcct cctttgcctt ttcctactta tgccacctta gtggggagcg agagcgctgg
      541 cggcagctcc ggggtgggga ttcgagctcc ggagtcggaa gatctgggtt tgcttccggg
      601 cctagccact cgctggccga gtgaccttag gcaagtcact ctgtaatctg tctgcgcctc
      661 agtttcctcc tctgcctatc agtgtgtgta tggaattgga agctctcttc aaaagtgtcg
      721 gtttacagaa agatgattat tgtttttttt tcctttgagt tgcaagaagt cataacaatt
      781 gctcattccc tgaaattaaa ttcgggaacc ttttattgga gttggagatg ggaaggttcc
      841 ctgaacttct tctgtacaga aacacgtggg aaagtgtttt ctagggggat gagtagatcc
      901 ttcagtagcg agttttcaaa gggggctatg acccagaaga gtttagaaca gtttttgcca
      961 ccgggaggaa actgaggcct acatgtcatc tgggaccctt cacaaccaat atgaagcccc
     1021 catttgagtc cctggtatat gtgagctgct tcttactgca taatggctgt ttcaggtacc
     1081 atcacttcac tgcttggctt ttagtcaaag ccctttcctt tcaccatagg gtgcctgaag
     1141 ggtggctgat gcctatggta caatggcacc cactagaaag cagctacaat taggagtgaa
     1201 tgtgtcctcg agtaacaaga agtgtaatct ctggcccagc gattgttttc tgctgctcgt
     1261 actggtgcct gactactttt ctctcgttaa ctattttttt acaaccatga ttgacaccca
     1321 ttatttgctc ctattttata tccctggttt tcgtggttga tagtgaacag gattattttt
     1381 aaatggtgct gccaaaacca gttaatagtg cacatggatt tttagcaaga gggctacttg
     1441 gaacagactg aaccaggcgt tggattcctg aaaatgtttg gggttttttt tttttttttt
     1501 tttttttttt ttttgggggg gttttttgtt ttgtttttta aattgaaggc taaagttttt
     1561 gaaaaaactt tgttggactc tggctgggac acaaaatcag atatttggaa tcattttgaa
     1621 gcttaacttt ttcctaacca gccttgtatt ctaattgctt gcaaatgtga gactgaatgg
     1681 ccaaaatgcc gtttgtttgt ttgtttattg tcagctgctt ttatcaaatt ccaggccatt
     1741 atccagcaaa cactattaaa atgtttgaac agttgggttt caaacatttt tgttttgtgg
     1801 agtggtgctt attaagtggt acagctctct aagcaagtga acacaaacat atttaagtgt
     1861 attttgtatg attagatgtt accaattctg atattttatt caaatgtcta aaaaaataag
     1921 ttgacttatt ccctttacca aagggccaga gacaaatggt ttcctttcaa gagaaatgac
     1981 tgttttgaag aaaaactctg ttggtcttag ctcttttgta attaaatctg gatgtacctc
     2041 aaaagactct ttaagactgt ggtgttaaaa ggctttcctc tggagaagga gaaaaaataa
     2101 aatcaactgg aacttaaaag cttgaaattc catgacaaaa cacagatgtc caggattgga
     2161 ggttcataaa gtacatgcag tagttggagt ggattccatt ttcagtgtag ctgccaccat
     2221 ggactccagg ctcccagatt ttcaagaact ggacctgtga cccagaagag cttgtcaaga
     2281 tatgacagga actctggagg tggacgtttt gtattcaatt ttggaactgt tgatcttgcc
     2341 gtgagaaaag agagacacga ctcaccaagc actgccacca gcactgtcac tgggaacttg
     2401 aagatccaag tttctgtcca gaacctcagt gcaaactgac aacactccat ccaaagtgaa
     2461 ctacgtcccg tgcctcctga ttgctgaatg ttcacctgga cctgccaatg accttccttc
     2521 tgctactcca tcagcctaca gacctggtac ttggattttt gtccatggtg attccttcca
     2581 ccttactact gaagaagaca ccattccagt ggaccactgt gacccaagaa gcattcagcc
     2641 atcatgatgt ggcctttacc tccactcctg tcctactctg cccagattca gcacagccct
     2701 ttatagtgca gtcaagagtc ttcaagccaa ataactgaag ctattttatc acaacaaagg
     2761 ccaggtttat tccataaatg tacagttcat ttctgcagtt tattcttcag agacacatag
     2821 taaatttgga ccaggggatt ttgttttgtt tatattgtca acactgtctg aagaaaggca
     2881 tctctgagaa cagcattgga ccctactcca caatctcaaa tgattgaagt ttcataaact
     2941 gcctaggatc ctgtcaaggc cactggactc ttgttctttt cctacttcaa aatctgtagc
     3001 tgtctactaa atgacaaagc agatattctg acccattggg atcaaaacca aggcattttg
     3061 aattcctcat agtatcatct tcgggttact caggaaccaa aacttttcac accaatttaa
     3121 gaaattctac tgaggaatcc ctttacctaa ccatctcaca aggcttcaac cagattcctg
     3181 aaaaggcctc ttgatatatc aagatagaac ctacatgcat tttgtgaaca acttatcact
     3241 gattttccaa aggctttgtg ctcttgaagt tctttgaagg aaagctgtgt ggaagtccag
     3301 agtaaagtga agctgctctg gatgaagtag tgaagtggga gttgaggtct acaacctgcc
     3361 acaaccatct tcctttacca ccatggtgat gccaaaaggg acttccttaa agctcttcag
     3421 aaaatcctgc ttgaaaccac taccctagac aacatgtttg acctggatgg cattctcttc
     3481 aaaacaattc atattcagtt gatgctcaac atgtttggag atgctttatt cagagaatga
     3541 tgataattac agcattgtct aatgaagttt tattaatagc attccatcca aggtggactt
     3601 cctggagttg gatataacca gagagcaatt catatgtatc ctacactgaa gaacaccatt
     3661 aactttcagc aacctatagc tagtggtact agaagtacgt gtcttggaag tctatgagag
     3721 ctggtattga agctgatgcc tccttaaggc catcttagac caagttgttt gtttgacctc
     3781 tcctcattaa ctatggagca gaattgaaat acaaattttt cctaaaggga cttgcaacct
     3841 ggttatcatt cattatctca agtttcaagt catgttgatg caaccagtag ttattaaact
     3901 gctccatggt tttttgttat ttaatacttt ttccagggct taaaaaaaca aaattaaatt
     3961 tctccaacac gtctatactt gtctgttcaa aagtaactac tcaccactat atggaacaga
     4021 tgattctgaa gacactctga gcatccttta tgatatttgt gacttaaaat gtggctggaa
     4081 attttccttc tacccagtga aatatttaat gattagtctt catgcctgat accatcaact
     4141 gtatatgcgt gataggcaaa gtttgacata ggcatttgac tctaggctat gatagcttgc
     4201 tagtaacttc aagtagcata ttgtcaacct gtttgctgga aaagtagagt aacttggaaa
     4261 aaaaactaaa tggcagctaa ggattttttt cagtattcct gagtttctgt ccttgggata
     4321 tttcaatgaa attttcacct gtctcttcac ttaacagagt gactgactcc ttactatgaa
     4381 gtattcttaa gacattaaga ttacttttgt agaaaggata aaattcctga ccatccaaat
     4441 catcatagtg aacaagactt caatttgtga cctgagaaaa tctcatttct ctacttcgta
     4501 gtcaatgtaa gggccaatgc tatcagctac tctgagtgca ctgggtaaac gttggaactg
     4561 ccttctttat atcattactt tttatcctct aaattaatca tggttatgta attctcgcca
     4621 caaatcagca aatcagactc agatctggtt attctagact gctcacagtt aacaaatcaa
     4681 actctggatg acttctgctt gtatatgcaa ctactatttg taaagaaatt gcaaattcac
     4741 ttttctatta cctctacatt gctagctctt tcttttgtgt ttgtattaaa aacaaaaata
     4801 agctacactg ccagctattc cctcctgcca tactcagtta aaatgaagaa tcgggaatct
     4861 aaccagtgaa tggataagta gaaaaaacta aaacttaagg caaaagcctt aatctagggc
     4921 cttttctact atcttcatgt cttggatttc atctaaaatc aacagtgcca cccaaccagt
     4981 ctgaggtctt gacttgcttt taagatgatt cttagagatg ggctgtatta cagaaggtga
     5041 agacttgatt accaaagaaa gtagagccaa ctttgacaaa cctggctcta caatcctatt
     5101 gcttccagat gtagcataga ctcataacta gaacctcaag tctgcattga ggatatagcc
     5161 ttctaagctg acagttcttg caacaggtga gcaagaaaat gaaagctgtt atacccaact
     5221 ggccctttaa gatccaaaaa taatgtctgg actaaaccct atggagtacc caggacaaaa
     5281 actaatttac agagcttcat tattaatctg cctgttcttc tagcttaatt attggtatgg
     5341 ctggccctac tgaagtagtt tgtctgttta cctgtcttca gctcttaacc tggctatttt
     5401 gacatgctac tgcaattaga ctaactggct ttgagaagac tacaatcagt ttcagcctct
     5461 cctttgccca atttcaccaa ggaattttga taagaggaac ccatacctca ccccaccaga
     5521 acagaaagga ccatgctgca tattccttga ccagcaactt taagtagaga acaaccctgc
     5581 ttgttttcaa catctgaaac accatttgat ctaataggag tatagaaggt tgacagcaga
     5641 gtacactact tacttctttc ataactcaga aatgaatatg actggcccag aagttgtaag
     5701 ttcaccttga caagaaacag caacaccaga agtttactgc tgaacttaac ttgccactta
     5761 ctcgaatagt ctcacagacc tgcttgccaa gtaggaggct agttttcctg cttcatatca
     5821 ccattggagt ggggctcaat ggggtcaatg ttaatactga cttgaatggg gaccttatgg
     5881 tgaatcctag actatgaggc taatggaaat tattgtctat tcaagtggat tatagatttc
     5941 ctgaggacag aacagacatc actcctggtg atttttagaa cttgattacc aaggaagaaa
     6001 taccagctgc taacagtcaa cttcatgggc aaagattaag ctctctatat ctggtcgtat
     6061 cctggatgct agttttttat tgcccagtga ccatttccat ctcacgctta acttcctgat
     6121 gttttttgga accatctctt ccaattttca gtcctggtga tttagacagt cttttcatgc
     6181 tggacatttt gttgcaacct catcaatcac agcaaagtcc atcttgactt tagtgattag
     6241 ttcaggaatg gatgcatgat tcaagtttgt ccaatgataa tcaaccctag gtgttttctc
     6301 agttgtggag aagttctctt agatgcttta gctttgtagg agaaaactca aaccaacagg
     6361 gcctacctac tatgttgaat gattgtagga gaaaactcaa accaaccagg cctacctact
     6421 atgttgaatg agccaggcag aaaatgaagc cagtacagag ggaaatggag ccaaaagagg
     6481 aagagacttg agttctgatg atcacattta tgcccctgta tccaactgtg cctgaagcta
     6541 atagtacatc acctggactt ttcagttatg tgaaccaata aattcccctt tttgtttaag
     6601 ttactttgag ttgggtttct attacttgaa attgagtcct ggctaataac actatttagc
     6661 agcaatggaa cttggcatat tcaagttatt aagctatagg tcaaggacac attagaatta
     6721 ttttctaaag gcacaacaga aaatgagaat aatacactac ggaaacataa aacttactgg
     6781 tacaaagatt caagtgaaaa tgatgaatac aatatagttc actgataaaa gaaaacctac
     6841 atagttaaca ttaaaaaggt acatttattg tgaccagaca tagaaaaatg ttcacaatgg
     6901 gtaaagcaaa acagttgata gaagtgtatg gtgtgaacaa atttaaggtg tgtgtttatc
     6961 tttgtaaatg catagaaagg tttatcattg gcttgagcag tagattacat agtattaaaa
     7021 ttctctatga ctagactaca ttaattttaa actttattta aaaataaata atttttaaaa
     7081 tgcc
//
