LOCUS       NM_172745               1718 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Tu translation elongation factor, mitochondrial
            (Tufm), transcript variant 1, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_172745
VERSION     NM_172745.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1718)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1718)
  AUTHORS   Bi,Y., Xu,H., Wang,X., Zhu,H., Ge,J., Ren,J. and Zhang,Y.
  TITLE     FUNDC1 protects against doxorubicin-induced cardiomyocyte
            PANoptosis through stabilizing mtDNA via interaction with TUFM
  JOURNAL   Cell Death Dis 13 (12), 1020 (2022)
   PUBMED   36470869
  REMARK    GeneRIF: FUNDC1 protects against doxorubicin-induced cardiomyocyte
            PANoptosis through stabilizing mtDNA via interaction with TUFM.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1718)
  AUTHORS   Zhong,B.R., Zhou,G.F., Song,L., Wen,Q.X., Deng,X.J., Ma,Y.L.,
            Hu,L.T. and Chen,G.J.
  TITLE     TUFM is involved in Alzheimer's disease-like pathologies that are
            associated with ROS
  JOURNAL   FASEB J 35 (5), e21445 (2021)
   PUBMED   33774866
  REMARK    GeneRIF: TUFM is involved in Alzheimer's disease-like pathologies
            that are associated with ROS.
REFERENCE   4  (bases 1 to 1718)
  AUTHORS   Kim,D., Hwang,H.Y., Ji,E.S., Kim,J.Y., Yoo,J.S. and Kwon,H.J.
  TITLE     Activation of mitochondrial TUFM ameliorates metabolic
            dysregulation through coordinating autophagy induction
  JOURNAL   Commun Biol 4 (1), 1 (2021)
   PUBMED   33398033
  REMARK    GeneRIF: Activation of mitochondrial TUFM ameliorates metabolic
            dysregulation through coordinating autophagy induction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1718)
  AUTHORS   Chatla,S., Du,W., Wilson,A.F., Meetei,A.R. and Pang,Q.
  TITLE     Fancd2-deficient hematopoietic stem and progenitor cells depend on
            augmented mitochondrial translation for survival and proliferation
  JOURNAL   Stem Cell Res 40, 101550 (2019)
   PUBMED   31472450
REFERENCE   6  (bases 1 to 1718)
  AUTHORS   Lei,Y., Wen,H., Yu,Y., Taxman,D.J., Zhang,L., Widman,D.G.,
            Swanson,K.V., Wen,K.W., Damania,B., Moore,C.B., Giguere,P.M.,
            Siderovski,D.P., Hiscott,J., Razani,B., Semenkovich,C.F., Chen,X.
            and Ting,J.P.
  TITLE     The mitochondrial proteins NLRX1 and TUFM form a complex that
            regulates type I interferon and autophagy
  JOURNAL   Immunity 36 (6), 933-946 (2012)
   PUBMED   22749352
  REMARK    GeneRIF: By recruiting Atg5-Atg12 and NLRX1, TUFM serves as a nodal
            checkpoint of the RIG-I-MAVS axis. It acts similarly to NLRX1 by
            inhibiting RigI-like-receptor-induced IFN-I but promoting
            autophagy.
REFERENCE   7  (bases 1 to 1718)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   8  (bases 1 to 1718)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 1718)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 1718)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY246546.1, AK152858.1 and BC060959.1.
            
            On Jul 30, 2009 this sequence version replaced NM_172745.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100596.1, AK152858.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BY246546.1         1-6
            7-1681              AK152858.1         2-1676
            1682-1718           BC060959.1         1747-1783
FEATURES             Location/Qualifiers
     source          1..1718
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.08 cM"
     gene            1..1718
                     /gene="Tufm"
                     /gene_synonym="2300002G02Rik; EF-TuMT; EFTU"
                     /note="Tu translation elongation factor, mitochondrial"
                     /db_xref="GeneID:233870"
                     /db_xref="MGI:MGI:1923686"
     exon            1..136
                     /gene="Tufm"
                     /gene_synonym="2300002G02Rik; EF-TuMT; EFTU"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1452
                     /gene="Tufm"
                     /gene_synonym="2300002G02Rik; EF-TuMT; EFTU"
                     /note="isoform 1 is encoded by transcript variant 1;
                     elongation factor Tu, mitochondrial"
                     /codon_start=1
                     /product="elongation factor Tu, mitochondrial isoform 1"
                     /protein_id="NP_766333.1"
                     /db_xref="CCDS:CCDS21830.1"
                     /db_xref="GeneID:233870"
                     /db_xref="MGI:MGI:1923686"
                     /translation="MAAATLLRATPRFSGLCASPTPFLQGRLRPLKAPASPFLCRGLA
                     VEAKKTYVRDKPHVNVGTIGHVDHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEER
                     ARGITINAAHVEYSTAARHYAHTDCPGHADYVKNMITGTAPLDGCILVVAANDGPMPQ
                     TREHLLLAKQIGVEHVVVYVNKADAVQDSEMVELVELEIRELLTEFGYKGEETPVIVG
                     SALCALEQRDPELGVKSVQKLLDAVDTYIPVPTRDLDKPFLLPVESVYSIPGRGTVVT
                     GTLERGILKKGDECELLGHNKNIRTVVTGIEMFHKSLERAEAGDNLGALVRGLKREDL
                     RRGLVMVKPGSIQPHQKVEAQVYILSKEEGGRHKPFVSHFMPVMFSLTWDMACRVILP
                     PGKELAMPGEDLKLSLILRQPMILEKGQRFTLRDGNKTIGTGLVTDVPAMTEEDKNIK
                     WS"
     exon            137..331
                     /gene="Tufm"
                     /gene_synonym="2300002G02Rik; EF-TuMT; EFTU"
                     /inference="alignment:Splign:2.1.0"
     exon            332..498
                     /gene="Tufm"
                     /gene_synonym="2300002G02Rik; EF-TuMT; EFTU"
                     /inference="alignment:Splign:2.1.0"
     exon            499..603
                     /gene="Tufm"
                     /gene_synonym="2300002G02Rik; EF-TuMT; EFTU"
                     /inference="alignment:Splign:2.1.0"
     exon            604..768
                     /gene="Tufm"
                     /gene_synonym="2300002G02Rik; EF-TuMT; EFTU"
                     /inference="alignment:Splign:2.1.0"
     exon            769..901
                     /gene="Tufm"
                     /gene_synonym="2300002G02Rik; EF-TuMT; EFTU"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1006
                     /gene="Tufm"
                     /gene_synonym="2300002G02Rik; EF-TuMT; EFTU"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1158
                     /gene="Tufm"
                     /gene_synonym="2300002G02Rik; EF-TuMT; EFTU"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1278
                     /gene="Tufm"
                     /gene_synonym="2300002G02Rik; EF-TuMT; EFTU"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1689
                     /gene="Tufm"
                     /gene_synonym="2300002G02Rik; EF-TuMT; EFTU"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1664..1669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tufm"
                     /gene_synonym="2300002G02Rik; EF-TuMT; EFTU"
                     /note="hexamer: AATAAA"
     polyA_site      1689
                     /gene="Tufm"
                     /gene_synonym="2300002G02Rik; EF-TuMT; EFTU"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgatc tgcagtccca agtgcccgtc cttccctgca cgcgcgggcc ccgggtgcct
       61 agttcccggt cccggtcacc gagtactacc acaatggcgg cagccactct attgcgagcg
      121 acgccccgct tcagcggtct ctgcgccagc ccgaccccat ttctgcaagg tcggctgcgg
      181 ccgctgaagg ctcccgcatc acccttcttg tgtcgcggcc tagctgtgga ggccaagaag
      241 acttatgtac gcgacaagcc ccatgtgaat gtgggtacca tcggacatgt ggaccatggc
      301 aagaccaccc tgactgcagc catcacgaaa attctagccg agggaggtgg agctaagttc
      361 aagaagtacg aggagataga caatgcccca gaggagcgag ctcggggcat caccatcaat
      421 gcagcccatg tggagtatag cactgctgcc cgacactatg cccacacaga ctgtcctggt
      481 catgcagatt atgttaagaa tatgatcaca ggcactgccc ccctggatgg ctgtatcctg
      541 gtggtggcag ctaatgatgg ccccatgccc cagacccgag agcacttact gctagctaaa
      601 cagattgggg tagaacatgt tgtggtgtac gtgaacaagg cagacgctgt ccaggactca
      661 gagatggtgg agttagtcga gctggagatc cgggagctgc tcaccgagtt tggctataaa
      721 ggagaggaaa ctccagtcat cgtaggctcg gctctctgtg cccttgagca acgtgaccct
      781 gagctaggcg tgaagtcagt gcagaagctc ctggatgctg tggacaccta catcccagtg
      841 cccacccggg acctggacaa gcccttcctg ctccctgtag agtcagtcta ctctattcct
      901 ggccggggca cagtggtgac aggtacatta gagcgtggca ttttgaagaa aggagatgag
      961 tgtgagttgc tgggacataa caagaacatc cgcactgtgg tgacaggcat tgagatgttc
     1021 cacaagagcc tggagagggc tgaggcaggg gataacctgg gtgctctggt ccgaggctta
     1081 aagcgcgaag atttgaggcg tggcttggtc atggtcaagc caggctccat ccaaccccac
     1141 cagaaggtgg aggcccaggt ttatatcctc agcaaggagg aaggtggccg ccacaaaccc
     1201 tttgtatctc atttcatgcc cgtcatgttc tccctgacct gggacatggc ctgtcgagtc
     1261 atcttgcctc cagggaagga acttgccatg cctggagagg acttgaagct tagtctaatc
     1321 ttgcggcagc ccatgatctt agagaaaggc caacgtttca ccttgaggga tggcaacaag
     1381 accattggca ctggccttgt tactgatgta ccagccatga ctgaggagga caagaacatc
     1441 aagtggagct gagtctggac ttctgctcag gttattgagc ttcaggctgc cctggtcagc
     1501 gttcccactg tgggcataag gctgccctgg tcagcattcc cactgtgggc ataaggctgc
     1561 cctggtcagc gttcccactg tggacacagg ctgtatccag gcagagtaca cctctggaca
     1621 tttctcctgc tcacaatgag tggcctgtca ggagagggag gcaaataaaa ctgtcccatg
     1681 gataactcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
