LOCUS       NM_134028               1777 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus tubulin, gamma 2 (Tubg2), mRNA.
ACCESSION   NM_134028 XM_905285
VERSION     NM_134028.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1777)
  AUTHORS   Gabriel,G.C., Yagi,H., Tan,T., Bais,A., Glennon,B.J.,
            Stapleton,M.C., Huang,L., Reynolds,W.T., Shaffer,M.G.,
            Ganapathiraju,M., Simon,D., Panigrahy,A., Wu,Y.L. and Lo,C.W.
  TITLE     Mitotic block and epigenetic repression underlie neurodevelopmental
            defects and neurobehavioral deficits in congenital heart disease
  JOURNAL   Nat Commun 16 (1), 469 (2025)
   PUBMED   39774941
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1777)
  AUTHORS   DeSpenza,T. Jr., Singh,A., Allington,G., Zhao,S., Lee,J.,
            Kiziltug,E., Prina,M.L., Desmet,N., Dang,H.Q., Fields,J.,
            Nelson-Williams,C., Zhang,J., Mekbib,K.Y., Dennis,E., Mehta,N.H.,
            Duy,P.Q., Shimelis,H., Walsh,L.K., Marlier,A., Deniz,E.,
            Lake,E.M.R., Constable,R.T., Hoffman,E.J., Lifton,R.P.,
            Gulledge,A., Fiering,S., Moreno-De-Luca,A., Haider,S., Alper,S.L.,
            Jin,S.C., Kahle,K.T. and Luikart,B.W.
  TITLE     Pathogenic variants in autism gene KATNAL2 cause hydrocephalus and
            disrupt neuronal connectivity by impairing ciliary microtubule
            dynamics
  JOURNAL   Proc Natl Acad Sci U S A 121 (27), e2314702121 (2024)
   PUBMED   38916997
REFERENCE   3  (bases 1 to 1777)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   4  (bases 1 to 1777)
  AUTHORS   Stansak,K.L., Baum,L.D., Ghosh,S., Thapa,P., Vanga,V. and
            Walters,B.J.
  TITLE     PCP auto count: a novel Fiji/ImageJ plug-in for automated
            quantification of planar cell polarity and cell counting
  JOURNAL   Front Cell Dev Biol 12, 1394031 (2024)
   PUBMED   38827526
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1777)
  AUTHORS   Xing,L., Gkini,V., Nieminen,A.I., Zhou,H.C., Aquilino,M.,
            Naumann,R., Reppe,K., Tanaka,K., Carmeliet,P., Heikinheimo,O.,
            Paabo,S., Huttner,W.B. and Namba,T.
  TITLE     Functional synergy of a human-specific and an ape-specific
            metabolic regulator in human neocortex development
  JOURNAL   Nat Commun 15 (1), 3468 (2024)
   PUBMED   38658571
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1777)
  AUTHORS   Yuba-Kubo,A., Kubo,A., Hata,M. and Tsukita,S.
  TITLE     Gene knockout analysis of two gamma-tubulin isoforms in mice
  JOURNAL   Dev Biol 282 (2), 361-373 (2005)
   PUBMED   15893303
REFERENCE   7  (bases 1 to 1777)
  AUTHORS   Chang,C.C., Ma,Y., Jacobs,S., Tian,X.C., Yang,X. and Rasmussen,T.P.
  TITLE     A maternal store of macroH2A is removed from pronuclei prior to
            onset of somatic macroH2A expression in preimplantation embryos
  JOURNAL   Dev Biol 278 (2), 367-380 (2005)
   PUBMED   15680357
REFERENCE   8  (bases 1 to 1777)
  AUTHORS   Illenye,S. and Heintz,N.H.
  TITLE     Functional analysis of bacterial artificial chromosomes in
            mammalian cells: mouse Cdc6 is associated with the mitotic spindle
            apparatus
  JOURNAL   Genomics 83 (1), 66-75 (2004)
   PUBMED   14667810
REFERENCE   9  (bases 1 to 1777)
  AUTHORS   Di Fiore,B., Ciciarello,M., Mangiacasale,R., Palena,A.,
            Tassin,A.M., Cundari,E. and Lavia,P.
  TITLE     Mammalian RanBP1 regulates centrosome cohesion during mitosis
  JOURNAL   J Cell Sci 116 (Pt 16), 3399-3411 (2003)
   PUBMED   12840069
  REMARK    Erratum:[J Cell Sci. 2003 Sep 1;116(Pt 17):3659]
REFERENCE   10 (bases 1 to 1777)
  AUTHORS   Pershouse,M., Li,J., Yang,C., Su,H., Brundage,E., Di,W.,
            Biggs,P.J., Bradley,A. and Chinault,A.C.
  TITLE     BAC contig from a 3-cM region of mouse chromosome 11 surrounding
            Brca1
  JOURNAL   Genomics 69 (1), 139-142 (2000)
   PUBMED   11013085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590969.12.
            
            On Aug 26, 2009 this sequence version replaced NM_134028.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019652.1, AB158481.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               AL590969.12        233358-233642       c
            286-398             AL590969.12        232966-233078       c
            399-566             AL590969.12        232606-232773       c
            567-635             AL590969.12        232006-232074       c
            636-715             AL590969.12        231664-231743       c
            716-842             AL590969.12        230391-230517       c
            843-929             AL590969.12        229383-229469       c
            930-1079            AL590969.12        229130-229279       c
            1080-1232           AL590969.12        228580-228732       c
            1233-1394           AL590969.12        228338-228499       c
            1395-1777           AL590969.12        227739-228121       c
FEATURES             Location/Qualifiers
     source          1..1777
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 64.3 cM"
     gene            1..1777
                     /gene="Tubg2"
                     /gene_synonym="Tubgl"
                     /note="tubulin, gamma 2"
                     /db_xref="GeneID:103768"
                     /db_xref="MGI:MGI:2144208"
     exon            1..285
                     /gene="Tubg2"
                     /gene_synonym="Tubgl"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1592
                     /gene="Tubg2"
                     /gene_synonym="Tubgl"
                     /note="gamma-2-tubulin"
                     /codon_start=1
                     /product="tubulin gamma-2 chain"
                     /protein_id="NP_598789.1"
                     /db_xref="CCDS:CCDS25452.1"
                     /db_xref="GeneID:103768"
                     /db_xref="MGI:MGI:2144208"
                     /translation="MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEG
                     TDRKDVFFYQADDEHYIPRAVLLDLEPRVIHSILNSSYAKLYNPENIYLSEHGGGAGN
                     NWGRGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDR
                     YPKKLVQTYSVFPNQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRL
                     HIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPL
                     TTDQSVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVH
                     KSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFESSC
                     QQYDKLWKRGAFLEQFRKEDIFKDNFEEMHRSREVVQELIDEYHAATRPDYISWGTQE
                     Q"
     exon            286..398
                     /gene="Tubg2"
                     /gene_synonym="Tubgl"
                     /inference="alignment:Splign:2.1.0"
     exon            399..566
                     /gene="Tubg2"
                     /gene_synonym="Tubgl"
                     /inference="alignment:Splign:2.1.0"
     exon            567..635
                     /gene="Tubg2"
                     /gene_synonym="Tubgl"
                     /inference="alignment:Splign:2.1.0"
     exon            636..715
                     /gene="Tubg2"
                     /gene_synonym="Tubgl"
                     /inference="alignment:Splign:2.1.0"
     exon            716..842
                     /gene="Tubg2"
                     /gene_synonym="Tubgl"
                     /inference="alignment:Splign:2.1.0"
     exon            843..929
                     /gene="Tubg2"
                     /gene_synonym="Tubgl"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1079
                     /gene="Tubg2"
                     /gene_synonym="Tubgl"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1232
                     /gene="Tubg2"
                     /gene_synonym="Tubgl"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1394
                     /gene="Tubg2"
                     /gene_synonym="Tubgl"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1777
                     /gene="Tubg2"
                     /gene_synonym="Tubgl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1755..1760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tubg2"
                     /gene_synonym="Tubgl"
                     /note="hexamer: AATAAA"
     polyA_site      1777
                     /gene="Tubg2"
                     /gene_synonym="Tubgl"
                     /note="major polyA site"
ORIGIN      
        1 tgcgcctgtg ctgaattcca gctgcaattg ctaagagaga aaatgatgcc caggatgggc
       61 tctgccgccc gccggctgcg gagaggccca cactgcacac gcgcagaccc agcgcccgcg
      121 tcaaaacatc agtcgacagc gcgttcccca tgtcctgcgc ctccggctgg caggagttcc
      181 tctcagtcgt gacccccgcc gccaggccgg ggcggacgag ctaggtctga tcggcgatgc
      241 cccgggagat catcaccctg cagctgggcc agtgcggcaa ccagattggg ttcgagttct
      301 ggaaacagct gtgtgctgaa catggaatca gccccgaggg catcgtagag gagttcgcca
      361 ccgagggcac tgaccgaaag gatgtctttt tctaccaggc agatgatgag cactacatcc
      421 cccgggctgt gctgctggac ctggagcccc gggtgatcca ttccatcctc aactcctcct
      481 atgctaagct ctacaacccg gagaacatct acctgtcgga gcatggcgga ggagctggca
      541 acaactgggg cagaggattc tcccagggtg agaaaattca cgaggacatc tttgacatta
      601 tagaccgaga agcagatgga agtgacagtc tagagggatt tgtgctatgt cactccattg
      661 ctggggggac aggttctggt ctgggctcct acctcttaga gcgactgaac gacaggtacc
      721 ccaagaaatt ggtgcagaca tactcagtgt ttcccaacca ggacgagatg agtgatgtag
      781 tggtccagcc ctacaactcc ctcctcacac taaagaggct gacccagaat gcggactgcg
      841 tggtggtgct ggacaacaca gccctgaacc ggatcgccac agaccgccta cacatccaga
      901 acccatcctt ctcccagatc aaccagctgg tgtccaccat catgtcagcc agcaccacca
      961 ccctgcgcta ccctggatac atgaacaatg acctcatcgg cctcatcgcc tcgctcattc
     1021 ccacccctcg gctccacttc ctcatgactg gctacacccc cctcaccacg gaccagtcag
     1081 tggccagtgt gaggaagaca acagtcctgg atgtcatgag gcgcctgcta cagcccaaga
     1141 atgtgatggt gtccacaggt cgggatcgtc agaccaacca ctgctacatc gccatcctca
     1201 acatcatcca gggagaggta gaccccaccc aggtccacaa gagcctgcag aggatccggg
     1261 aaaggaaact ggccaacttc attccctggg gcccagccag catccaggtg gccctgtcaa
     1321 ggaagtctcc ctacctgccc tcagcccacc gggtcagcgg gctcatgatg gccaaccaca
     1381 ccagtatctc ctcgcttttt gaaagttcct gccagcagta tgacaaactg tggaagcggg
     1441 gggccttcct ggaacagttt cgcaaggagg acatcttcaa ggacaacttt gaggagatgc
     1501 acagatcgag ggaggtggtg caggaactca ttgacgagta ccacgcggcc acccggccgg
     1561 actacatctc ctggggtacc caggagcagt gactctactc tctgctgtcc cctggacaag
     1621 aagcacagtc cccaccacgc ccagaccctc tgacccaact tcgcctcaca tttttgtgtt
     1681 catgtgcaat ttaggaactg ttcctgtctt ccttttcacc cctggcgctt ggctggcttg
     1741 gttaagttct aataaataaa gcgtgatgat gcattga
//
