LOCUS       NM_134024               1627 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus tubulin, gamma 1 (Tubg1), mRNA.
ACCESSION   NM_134024
VERSION     NM_134024.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1627)
  AUTHORS   Gabriel,G.C., Yagi,H., Tan,T., Bais,A., Glennon,B.J.,
            Stapleton,M.C., Huang,L., Reynolds,W.T., Shaffer,M.G.,
            Ganapathiraju,M., Simon,D., Panigrahy,A., Wu,Y.L. and Lo,C.W.
  TITLE     Mitotic block and epigenetic repression underlie neurodevelopmental
            defects and neurobehavioral deficits in congenital heart disease
  JOURNAL   Nat Commun 16 (1), 469 (2025)
   PUBMED   39774941
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1627)
  AUTHORS   Rehmani,T., Dias,A.P., Applin,B.D., Salih,M. and Tuana,B.S.
  TITLE     SLMAP3 is essential for neurulation through mechanisms involving
            cytoskeletal elements, ABP, and PCP
  JOURNAL   Life Sci Alliance 7 (12), e202302545 (2024)
   PUBMED   39366759
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1627)
  AUTHORS   DeSpenza,T. Jr., Singh,A., Allington,G., Zhao,S., Lee,J.,
            Kiziltug,E., Prina,M.L., Desmet,N., Dang,H.Q., Fields,J.,
            Nelson-Williams,C., Zhang,J., Mekbib,K.Y., Dennis,E., Mehta,N.H.,
            Duy,P.Q., Shimelis,H., Walsh,L.K., Marlier,A., Deniz,E.,
            Lake,E.M.R., Constable,R.T., Hoffman,E.J., Lifton,R.P.,
            Gulledge,A., Fiering,S., Moreno-De-Luca,A., Haider,S., Alper,S.L.,
            Jin,S.C., Kahle,K.T. and Luikart,B.W.
  TITLE     Pathogenic variants in autism gene KATNAL2 cause hydrocephalus and
            disrupt neuronal connectivity by impairing ciliary microtubule
            dynamics
  JOURNAL   Proc Natl Acad Sci U S A 121 (27), e2314702121 (2024)
   PUBMED   38916997
REFERENCE   4  (bases 1 to 1627)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   5  (bases 1 to 1627)
  AUTHORS   Stansak,K.L., Baum,L.D., Ghosh,S., Thapa,P., Vanga,V. and
            Walters,B.J.
  TITLE     PCP auto count: a novel Fiji/ImageJ plug-in for automated
            quantification of planar cell polarity and cell counting
  JOURNAL   Front Cell Dev Biol 12, 1394031 (2024)
   PUBMED   38827526
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1627)
  AUTHORS   de Lecea,L., Kilduff,T.S., Peyron,C., Gao,X., Foye,P.E.,
            Danielson,P.E., Fukuhara,C., Battenberg,E.L., Gautvik,V.T.,
            Bartlett,F.S. 2nd, Frankel,W.N., van den Pol,A.N., Bloom,F.E.,
            Gautvik,K.M. and Sutcliffe,J.G.
  TITLE     The hypocretins: hypothalamus-specific peptides with
            neuroexcitatory activity
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 322-327 (1998)
   PUBMED   9419374
REFERENCE   7  (bases 1 to 1627)
  AUTHORS   Kohda,K., Matsuda,Y., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     Structural analysis and chromosomal localization of the mouse Psmb5
            gene coding for the constitutively expressed beta-type proteasome
            subunit
  JOURNAL   Immunogenetics 47 (1), 77-87 (1997)
   PUBMED   9382924
REFERENCE   8  (bases 1 to 1627)
  AUTHORS   Kandil,E., Kohda,K., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     PA28 subunits of the mouse proteasome: primary structures and
            chromosomal localization of the genes
  JOURNAL   Immunogenetics 46 (4), 337-344 (1997)
   PUBMED   9218537
REFERENCE   9  (bases 1 to 1627)
  AUTHORS   Burns,R.G.
  TITLE     Analysis of the gamma-tubulin sequences: implications for the
            functional properties of gamma-tubulin
  JOURNAL   J Cell Sci 108 (Pt 6), 2123-2130 (1995)
   PUBMED   7673333
  REMARK    Review article
REFERENCE   10 (bases 1 to 1627)
  AUTHORS   Gueth-Hallonet,C., Antony,C., Aghion,J., Santa-Maria,A.,
            Lajoie-Mazenc,I., Wright,M. and Maro,B.
  TITLE     gamma-Tubulin is present in acentriolar MTOCs during early mouse
            development
  JOURNAL   J Cell Sci 105 (Pt 1), 157-166 (1993)
   PUBMED   8360270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX255926.10.
            
            On Jul 4, 2018 this sequence version replaced NM_134024.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154019.1, AK160125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               BX255926.10        52789-52914
            127-239             BX255926.10        53219-53331
            240-407             BX255926.10        53503-53670
            408-476             BX255926.10        55345-55413
            477-556             BX255926.10        56086-56165
            557-683             BX255926.10        56585-56711
            684-770             BX255926.10        56905-56991
            771-920             BX255926.10        57095-57244
            921-1073            BX255926.10        57642-57794
            1074-1235           BX255926.10        57875-58036
            1236-1627           BX255926.10        58704-59095
FEATURES             Location/Qualifiers
     source          1..1627
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 64.24 cM"
     gene            1..1627
                     /gene="Tubg1"
                     /gene_synonym="1500010O08Rik; GCP-1; Tubg"
                     /note="tubulin, gamma 1"
                     /db_xref="GeneID:103733"
                     /db_xref="MGI:MGI:101834"
     exon            1..126
                     /gene="Tubg1"
                     /gene_synonym="1500010O08Rik; GCP-1; Tubg"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1433
                     /gene="Tubg1"
                     /gene_synonym="1500010O08Rik; GCP-1; Tubg"
                     /note="gamma-tubulin complex component 1; tubulin, gamma
                     polypeptide"
                     /codon_start=1
                     /product="tubulin gamma-1 chain"
                     /protein_id="NP_598785.1"
                     /db_xref="CCDS:CCDS25451.1"
                     /db_xref="GeneID:103733"
                     /db_xref="MGI:MGI:101834"
                     /translation="MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEG
                     TDRKDVFFYQADDEHYIPRAVLLDLEPRVIHSILNSSYAKLYNPENIYLSEHGGGAGN
                     NWASGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDR
                     YPKKLVQTYSVFPNQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTALNLIATDRL
                     HIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPL
                     TTDQSVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVH
                     KSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFERTC
                     RQFDKLRKREAFMEQFRKEDIFKDNFDEMDTSREIVQQLIDEYHAATRPDYISWGTQE
                     Q"
     exon            127..239
                     /gene="Tubg1"
                     /gene_synonym="1500010O08Rik; GCP-1; Tubg"
                     /inference="alignment:Splign:2.1.0"
     exon            240..407
                     /gene="Tubg1"
                     /gene_synonym="1500010O08Rik; GCP-1; Tubg"
                     /inference="alignment:Splign:2.1.0"
     exon            408..476
                     /gene="Tubg1"
                     /gene_synonym="1500010O08Rik; GCP-1; Tubg"
                     /inference="alignment:Splign:2.1.0"
     exon            477..556
                     /gene="Tubg1"
                     /gene_synonym="1500010O08Rik; GCP-1; Tubg"
                     /inference="alignment:Splign:2.1.0"
     exon            557..683
                     /gene="Tubg1"
                     /gene_synonym="1500010O08Rik; GCP-1; Tubg"
                     /inference="alignment:Splign:2.1.0"
     exon            684..770
                     /gene="Tubg1"
                     /gene_synonym="1500010O08Rik; GCP-1; Tubg"
                     /inference="alignment:Splign:2.1.0"
     exon            771..920
                     /gene="Tubg1"
                     /gene_synonym="1500010O08Rik; GCP-1; Tubg"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1073
                     /gene="Tubg1"
                     /gene_synonym="1500010O08Rik; GCP-1; Tubg"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1235
                     /gene="Tubg1"
                     /gene_synonym="1500010O08Rik; GCP-1; Tubg"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1627
                     /gene="Tubg1"
                     /gene_synonym="1500010O08Rik; GCP-1; Tubg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1600..1605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tubg1"
                     /gene_synonym="1500010O08Rik; GCP-1; Tubg"
                     /note="hexamer: AATAAA"
     polyA_site      1623
                     /gene="Tubg1"
                     /gene_synonym="1500010O08Rik; GCP-1; Tubg"
                     /note="major polyA site"
ORIGIN      
        1 gcgtcttgcc ggcgagcgcg ctagcggtcg gcggtgttgc tggcgggaga gactgcaacg
       61 ccgatgtctg aggagcgatg ccgagagaaa tcatcaccct acagttgggc cagtgcggca
      121 atcagattgg gttcgagttc tggaaacagc tatgtgccga gcatggcatc agtcccgagg
      181 gcatcgtaga agagttcgcc acggagggca ctgaccgaaa ggacgtcttt ttctaccagg
      241 cagatgatga gcactacatc ccccgggctg tgctgctgga cctggagccc cgggtgatcc
      301 attccatcct aaactcctcc tatgctaagc tctacaaccc agagaacatc tacctgtcgg
      361 agcatggcgg aggagctggc aacaactggg ccagcggatt ctcccaggga gaaaaaatcc
      421 acgaggacat ttttgacatc atagatcggg aggcagatgg cagtgacagt ctagagggat
      481 ttgtactgtg tcattccatt gctgggggga caggctctgg cttgggctcc tacctcctgg
      541 aacggctaaa tgacaggtac cccaaaaaac tagtgcagac atactctgtg ttccccaacc
      601 aggatgagat gagtgacgtg gtggtccaac cctacaactc cctcctcaca ctaaagaggc
      661 tgacccagaa cgcggactgt gtggtggtgc tggacaacac ggccctgaac ctgatagcca
      721 cagaccgcct acacatccag aacccatcct tctcccagat caaccagctg gtgtccacca
      781 tcatgtcagc cagcaccacc accctgcgct accctggata catgaacaat gacctcatcg
      841 gcctcatcgc ctcgctcatt cccacccctc ggctccactt tctcatgact ggctataccc
      901 ccctcaccac ggaccagtca gtggccagtg tgaggaagac aacagtcctg gatgtcatga
      961 ggcgcctgct acagcccaag aatgtgatgg tgtccacagg ccgggatcgt cagaccaacc
     1021 actgctacat cgccatcctc aacatcatcc agggagaggt ggaccccacc caggtccaca
     1081 agagcctgca gaggatccgg gaaaggaaac tggccaactt catcccctgg ggcccagcca
     1141 gcatccaggt ggccctgtca aggaagtctc cctacctacc ctcagcccac cgggtcagcg
     1201 ggctcatgat ggccaaccac accagtatct cctcgctctt cgaacggacc tgtcgccagt
     1261 ttgacaagct gcggaaacgg gaggccttca tggagcagtt ccgcaaggag gacatcttca
     1321 aggacaattt tgacgagatg gacacctcca gggagattgt gcagcagctg attgacgagt
     1381 accacgcggc cacacggcca gactatatct cctggggcac ccaggagcag tgagtcacgg
     1441 acgacaggga ccctcatctg ccttaccggt tagcccaggc cctgccaggc tgacttcccc
     1501 tcggagcaca gatcagggac ctcacaagtc ctcgcgtaca cacgcaccgt ctgtcggctt
     1561 gggggtgggt ttacttcttc tctgagagta tttatcttta ataaagcact ggatgtaaac
     1621 caagcca
//
