LOCUS       NM_028006               2929 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus tubulin, epsilon 1 (Tube1), mRNA.
ACCESSION   NM_028006
VERSION     NM_028006.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2929)
  AUTHORS   Simonson,L., Vold,S., Mowers,C., Massey,R.J., Ong,I.M.,
            Longley,B.J. and Chang,H.
  TITLE     Keratin 13 deficiency causes white sponge nevus in mice
  JOURNAL   Dev Biol 468 (1-2), 146-153 (2020)
   PUBMED   32758484
REFERENCE   2  (bases 1 to 2929)
  AUTHORS   Breslow,D.K., Hoogendoorn,S., Kopp,A.R., Morgens,D.W., Vu,B.K.,
            Kennedy,M.C., Han,K., Li,A., Hess,G.T., Bassik,M.C., Chen,J.K. and
            Nachury,M.V.
  TITLE     A CRISPR-based screen for Hedgehog signaling provides insights into
            ciliary function and ciliopathies
  JOURNAL   Nat Genet 50 (3), 460-471 (2018)
   PUBMED   29459677
REFERENCE   3  (bases 1 to 2929)
  AUTHORS   Zhang,L., Zhou,F., Garcia de Vinuesa,A., de Kruijf,E.M.,
            Mesker,W.E., Hui,L., Drabsch,Y., Li,Y., Bauer,A., Rousseau,A.,
            Sheppard,K.A., Mickanin,C., Kuppen,P.J., Lu,C.X. and Ten Dijke,P.
  TITLE     TRAF4 promotes TGF-beta receptor signaling and drives breast cancer
            metastasis
  JOURNAL   Mol Cell 51 (5), 559-572 (2013)
   PUBMED   23973329
REFERENCE   4  (bases 1 to 2929)
  AUTHORS   Ahmad,N., Aslam,M., Muenster,D., Horsch,M., Khan,M.A., Carlsson,P.,
            Beckers,J. and Graw,J.
  TITLE     Pitx3 directly regulates Foxe3 during early lens development
  JOURNAL   Int J Dev Biol 57 (9-10), 741-751 (2013)
   PUBMED   24307298
REFERENCE   5  (bases 1 to 2929)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK148039.1.
            
            On Jul 23, 2006 this sequence version replaced NM_028006.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148039.1, AK041416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2929
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 20.16 cM"
     gene            1..2929
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /note="tubulin, epsilon 1"
                     /db_xref="GeneID:71924"
                     /db_xref="MGI:MGI:1919174"
     exon            1..85
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1488
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /note="epsilon-tubulin 1"
                     /codon_start=1
                     /product="tubulin epsilon chain"
                     /protein_id="NP_082282.1"
                     /db_xref="CCDS:CCDS23787.1"
                     /db_xref="GeneID:71924"
                     /db_xref="MGI:MGI:1919174"
                     /translation="MTQSVVVQVGQCGNQIGCCFWDLALREHAAVNQKGIYDDAISSF
                     FRNVDTRAVGDGGSISKGRISSLKARAVLIDMEEGVVNEILQGPLRDVFDSKQLITDI
                     SGSGNNWAVGHKVFGCLYREQILEKLRKSAEQCDCLQCFFIIHSMGGGTGSGLGTFLL
                     KVLEDEFPEVYRFVTAVYPSSEDDVITSPYNSMLAMKELNEHADCVLPIDNQSLFDII
                     SKIDLVVNSGKLGSAVKPKSLITSNMGAVKKHHKKPFDAMNNIVANLLLSLTSSARFE
                     GSLNMDLNEISMNLVPFPKLHYLVSSLTPLYTLADVNIPPRRLDQMFSDAFSKDHQLI
                     QADPRHSLYLACALIVRGNVQISDLRRNIERLKPALQFVSWNQEGWKTSLCSVPPVGH
                     SHSLLALANNTCVKPTFMELRERFTRLYKKKAHLHHYLQVDGMEESTFTEAVSSLSAL
                     IQEYSDLDATKSLPVPDVPRLSVAL"
     exon            86..159
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /inference="alignment:Splign:2.1.0"
     exon            160..212
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /inference="alignment:Splign:2.1.0"
     exon            213..270
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /inference="alignment:Splign:2.1.0"
     exon            271..386
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /inference="alignment:Splign:2.1.0"
     exon            387..508
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /inference="alignment:Splign:2.1.0"
     exon            509..696
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /inference="alignment:Splign:2.1.0"
     exon            697..872
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1013
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1154
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1329
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..2929
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1599
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
     regulatory      2053..2058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /note="hexamer: AATAAA"
     polyA_site      2073
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /note="major polyA site"
     regulatory      2260..2265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /note="hexamer: AATAAT"
     polyA_site      2281
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
     regulatory      2587..2592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /note="hexamer: AATAAA"
     polyA_site      2626
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
     regulatory      2810..2815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /note="hexamer: ATTATA"
     regulatory      2826..2831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
                     /note="hexamer: AAGAAA"
     polyA_site      2831
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
     polyA_site      2847
                     /gene="Tube1"
                     /gene_synonym="2310061K05Rik; Tube"
ORIGIN      
        1 gagctcgaaa gctaaggcgg gagtttgggc gggagtgctc ctgctggtcc tcccggcgga
       61 atgacccagt cggtggtcgt acaggtcgga cagtgcggga accagatcgg ctgctgcttc
      121 tgggacctgg cgctgaggga gcacgcagcg gtcaaccaga aaggaattta tgacgacgct
      181 ataagcagct tcttcaggaa tgtggatacc agagctgttg gggatggtgg cagtatttcc
      241 aaaggaagaa tatcttctct aaaagcacgg gctgttttga ttgacatgga agaaggcgta
      301 gtgaatgaaa ttctccaagg cccactgaga gacgtgtttg atagcaaaca gctcatcact
      361 gatatctctg gctcgggaaa taattgggct gtgggtcaca aagtttttgg atgtctttac
      421 cgggaacaga ttttagagaa actgcggaag tcggcagagc agtgcgattg cttacagtgc
      481 ttcttcatca tccactccat gggcggagga acaggctctg ggcttggcac atttctgtta
      541 aaggttcttg aagatgaatt cccagaagtg taccggtttg tgacagcggt ttatccttcc
      601 agtgaagacg atgtcatcac ctcgccttat aacagtatgc tggccatgaa ggaactgaat
      661 gagcatgcag actgtgtgct gcccattgac aaccaatctt tatttgacat cattagcaaa
      721 attgatcttg tggtaaattc tggaaagttg ggctcagctg tgaagcctaa gagtctcatt
      781 acgtcgaaca tgggggctgt taaaaagcac cacaagaagc ccttcgacgc catgaacaac
      841 attgtggcga acctgctcct cagcctgaca agctctgcga ggtttgaggg ctccctcaat
      901 atggacctga atgagatcag catgaacttg gttcctttcc cgaagcttca ttatctcgtg
      961 tcaagcctga cacctctgta cacgctggcc gatgttaaca ttcccccccg aagactggat
     1021 cagatgtttt cagacgcctt tagtaaggat caccagctca tccaagcaga ccccagacat
     1081 agcctctacc ttgcctgtgc cctcatcgtt agaggaaacg tacagatttc cgatcttcgc
     1141 agaaatattg aaagattaaa acctgctctg cagtttgtct cctggaatca agaaggctgg
     1201 aagaccagcc tgtgttctgt accgcctgtg ggccactcgc attctctgtt agctttagca
     1261 aataacacgt gtgtgaagcc taccttcatg gagctgagag aaaggttcac aaggctctac
     1321 aagaaaaagg ctcacctcca tcactacctg caagttgatg ggatggagga aagcactttt
     1381 acggaagctg tgtcctctct gtcagcgctc atacaggagt acagtgacct cgatgccaca
     1441 aagagcctgc ctgtgccaga tgtgcccagg ttgagtgtgg ccttgtgagg ggagaagctg
     1501 agaaagcagt tgttctgtct gtcccctttc tgttgcagca ttttttctga ttcagaaagc
     1561 ccatgttttt cacagtatca ggaagtattt tatctaaaat ggtggtttct attttattac
     1621 agttttttat agcggtacat ggtatcactt taggcagttt gccaaaattg agatgagaga
     1681 gaacccaaca tggtgttaca caagtgtaat cccagtgtgg ctgacatgca ggagggcctg
     1741 cgttcagggc cagcctgggc tactcgtgca acaaaagccg acgcagaggg aaggagcagt
     1801 cgtccccttg ctttatttgt gtcttttgca gacatcttca cagtgatgaa cgcctcaggg
     1861 aagatgtaca tatctcttgt atatttacac tttatgctgt cctgctctat ttaaatgcta
     1921 gggacgtagg tccttggaat ggaggaacat aatatatata atatctggac ttttcagggt
     1981 agtttttgtt ctttgagtaa taatatgttt atggtccaaa gaatcacaac ttggcatcca
     2041 gtcccttttt ataataaacg gtttaaaagc aaatgtgtaa acggctgcta cggcggttga
     2101 gcatgtcacc gttgcacact gacgtctgca gctgaacttg taggaaacgg ttatcatgtg
     2161 ctgaggtgac tgcagccact gtgcctctct tctgaatcgt taatgttggt ttcagtacag
     2221 gtatgtttca aatccattgg ttggtttatc tttcaaggaa ataattttaa gggaaaaata
     2281 atcgggtgtg tgcttcctta cttctatcct ctgtttcttt tctttgctga gtgactgttc
     2341 tatgtttgtt ttttatctta gaagtttaaa cttttatagt atttggtata caaactgcaa
     2401 tattacagtt attaacagta tcacagacat tctattttcc cctttctaga agaatcaact
     2461 gatattcagg acagggcgat ggtgattata gatgcattta taataccatc ttagtaattt
     2521 taagaatctt gctgtccctc tactaattat gtggtaggat ctgatagact gtattgccaa
     2581 gtacagaata aaactttaaa ttatgtcttt ttatatctac ataaaatgtt ttttgagaca
     2641 gtgtttctct gtagccctgg ctgtcctgga acccactctg tagaccaggt tgacctcaaa
     2701 ctcacagaga tccgcctgtc tctgcctccc atgtgctggg gtcaaaggtg tgattttttt
     2761 cattatgtat gtaattttta cctggagcca tttgcctgta tattacttaa ttataggcta
     2821 tactcaagaa atgagttcta tttaaaattc ttcaagcatt cgtttttgtt ttattagtat
     2881 atgttttaga atcttctctt gtcacaaata tagcaagcta agaatggtc
//
