LOCUS       NM_019756               1882 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus tubulin, delta 1 (Tubd1), transcript variant 2, mRNA.
ACCESSION   NM_019756
VERSION     NM_019756.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1882)
  AUTHORS   Patel,J., Xun,D., Creswell,K., Kim,D.K., Wu,M., Hwang,J.W.,
            Kim,T.S., Bansal,S., Hong,S.H., Galli,S., Kim,H.J., Deng,C.,
            Byers,S.W. and Lee,M.H.
  TITLE     Loss of RARRES1 function Promotes Follicular Lymphomagenesis and
            Inhibits B cell Differentiation in Mice
  JOURNAL   Int J Biol Sci 18 (7), 2670-2682 (2022)
   PUBMED   35541897
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1882)
  AUTHORS   Latremoliere,A., Cheng,L., DeLisle,M., Wu,C., Chew,S.,
            Hutchinson,E.B., Sheridan,A., Alexandre,C., Latremoliere,F.,
            Sheu,S.H., Golidy,S., Omura,T., Huebner,E.A., Fan,Y., Whitman,M.C.,
            Nguyen,E., Hermawan,C., Pierpaoli,C., Tischfield,M.A., Woolf,C.J.
            and Engle,E.C.
  TITLE     Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal
            Function but Is Essential for Timely Axon Regeneration
  JOURNAL   Cell Rep 24 (7), 1865-1879 (2018)
   PUBMED   30110642
REFERENCE   3  (bases 1 to 1882)
  AUTHORS   Breslow,D.K., Hoogendoorn,S., Kopp,A.R., Morgens,D.W., Vu,B.K.,
            Kennedy,M.C., Han,K., Li,A., Hess,G.T., Bassik,M.C., Chen,J.K. and
            Nachury,M.V.
  TITLE     A CRISPR-based screen for Hedgehog signaling provides insights into
            ciliary function and ciliopathies
  JOURNAL   Nat Genet 50 (3), 460-471 (2018)
   PUBMED   29459677
REFERENCE   4  (bases 1 to 1882)
  AUTHORS   Pusapati,G.V., Kong,J.H., Patel,B.B., Krishnan,A., Sagner,A.,
            Kinnebrew,M., Briscoe,J., Aravind,L. and Rohatgi,R.
  TITLE     CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity
            to the Morphogen Sonic Hedgehog
  JOURNAL   Dev Cell 44 (1), 113-129 (2018)
   PUBMED   29290584
  REMARK    GeneRIF: Loss-of-function mutations in Tubd1 prevent cells from
            assembling primary cilia and consequently lead to the failure to
            respond to Hedgehog ligands.
            Erratum:[Dev Cell. 2018 Jan 22;44(2):271. doi:
            10.1016/j.devcel.2018.01.002.. PMID: 29401421]
REFERENCE   5  (bases 1 to 1882)
  AUTHORS   Storbeck,M., Hupperich,K., Gaspar,J.A., Meganathan,K., Martinez
            Carrera,L., Wirth,R., Sachinidis,A. and Wirth,B.
  TITLE     Neuronal-specific deficiency of the splicing factor Tra2b causes
            apoptosis in neurogenic areas of the developing mouse brain
  JOURNAL   PLoS One 9 (2), e89020 (2014)
   PUBMED   24586484
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1882)
  AUTHORS   Kato,A., Nagata,Y. and Todokoro,K.
  TITLE     Delta-tubulin is a component of intercellular bridges and both the
            early and mature perinuclear rings during spermatogenesis
  JOURNAL   Dev Biol 269 (1), 196-205 (2004)
   PUBMED   15081367
REFERENCE   7  (bases 1 to 1882)
  AUTHORS   Sidjanin,D.J., Zangerl,B., Johnson,J.L., Xue,F., Mellersh,C.,
            Ostrander,E.A., Acland,G. and Aguirre,G.D.
  TITLE     Cloning of the canine delta tubulin cDNA (TUBD) and mapping to CFA9
  JOURNAL   Anim Genet 33 (2), 161-162 (2002)
   PUBMED   12047234
REFERENCE   8  (bases 1 to 1882)
  AUTHORS   Smrzka,O.W., Delgehyr,N. and Bornens,M.
  TITLE     Tissue-specific expression and subcellular localisation of
            mammalian delta-tubulin
  JOURNAL   Curr Biol 10 (7), 413-416 (2000)
   PUBMED   10753753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK169454.1 and AB024329.1.
            
            On Nov 19, 2010 this sequence version replaced NM_019756.2.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            coding region and differs in the 5' UTR, compared to variant 1. It
            encodes a shorter isoform (2), compared to isoform 1. Variants 2
            and 4 encode the same isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026465.1, AK169454.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1856              AK169454.1         2-1857
            1857-1882           AB024329.1         1631-1656
FEATURES             Location/Qualifiers
     source          1..1882
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.82 cM"
     gene            1..1882
                     /gene="Tubd1"
                     /gene_synonym="4930550G19Rik; Tubd"
                     /note="tubulin, delta 1"
                     /db_xref="GeneID:56427"
                     /db_xref="MGI:MGI:1891826"
     exon            1..240
                     /gene="Tubd1"
                     /gene_synonym="4930550G19Rik; Tubd"
                     /inference="alignment:Splign:2.1.0"
     exon            241..460
                     /gene="Tubd1"
                     /gene_synonym="4930550G19Rik; Tubd"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..1656
                     /gene="Tubd1"
                     /gene_synonym="4930550G19Rik; Tubd"
                     /note="isoform 2 is encoded by transcript variant 2;
                     delta-tubulin; tubulin delta chain"
                     /codon_start=1
                     /product="tubulin delta chain isoform 2"
                     /protein_id="NP_062730.1"
                     /db_xref="CCDS:CCDS25202.1"
                     /db_xref="GeneID:56427"
                     /db_xref="MGI:MGI:1891826"
                     /translation="MSIVTVQLGQCGNQIGFEVFDALFRDSHCSQGLCSKRDNEAYQA
                     SCRERFFREEENGVPVARAVLVDMEPKVINQTLSKAAQSGRWNYGQHTSFCQKQGSGN
                     NWAYGYSVHGPKHEESIMNLIQTEVEKCDSLSGFFIIMSMAGGTGSGLGAFVTQKLQD
                     QYSSSLKMNQIIWPYGTGEVIVQNYNSILTLSHLYRSSDALLIHENDAVHKICAKRMN
                     IKQISFRDLNQVLAHQLGSVFQPTYSEDSSFHYRRNPLGDLMEHLVPHPEFKMLGVRN
                     IPQMSAASLAYSAFTWAGLLKHLRQMLISSAKMEEGINWQVRPPLTGLPPIGKASAHK
                     EHHFNTSLANLVVLRGREVHSADVEGFKDPALYTSWLEPVDAFSVWKTQRAFDKYEKS
                     AALVSNSQLLVKPLDMIVGKAWNMFSSKAFIHQYTKFGMEEEDFLDSFALLEQVVASY
                     GSLGP"
     exon            461..608
                     /gene="Tubd1"
                     /gene_synonym="4930550G19Rik; Tubd"
                     /inference="alignment:Splign:2.1.0"
     exon            609..825
                     /gene="Tubd1"
                     /gene_synonym="4930550G19Rik; Tubd"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1057
                     /gene="Tubd1"
                     /gene_synonym="4930550G19Rik; Tubd"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1222
                     /gene="Tubd1"
                     /gene_synonym="4930550G19Rik; Tubd"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1363
                     /gene="Tubd1"
                     /gene_synonym="4930550G19Rik; Tubd"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1547
                     /gene="Tubd1"
                     /gene_synonym="4930550G19Rik; Tubd"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1871
                     /gene="Tubd1"
                     /gene_synonym="4930550G19Rik; Tubd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1848..1853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tubd1"
                     /gene_synonym="4930550G19Rik; Tubd"
                     /note="hexamer: AATAAA"
     polyA_site      1871
                     /gene="Tubd1"
                     /gene_synonym="4930550G19Rik; Tubd"
                     /note="major polyA site"
ORIGIN      
        1 atatctgaag ttgataaatt gaaattgaac atgcgtgatt agccttccta aatagaagaa
       61 gggaaacgag ggtcgaaaaa agacaagccc tcagcagagc tcttcgcata aggagcgagc
      121 gcatttattt gttctaagta gttttttttt ttaaagtatt gaaagtgagc atgcgcgtag
      181 tgagagggtt ggtcttctga agtttgaacc gaactgaaac tgccggtcgc agagctgtca
      241 gtgacccacc ctctggtgtt ttagactaag cctcctttgt ggcttggcat gtcgatagtg
      301 acagtacagc tggggcagtg tggcaaccag attggctttg aagtgtttga tgctttattt
      361 agagactcac actgttccca gggactctgt tctaagaggg acaacgaggc atatcaagct
      421 tcctgcagag aaagattttt cagagaggaa gaaaatggag ttccagttgc ccgggctgtt
      481 cttgttgaca tggaacctaa agttatcaat caaacactat caaaagctgc ccagtctggc
      541 cgatggaatt atggtcagca cacgagtttt tgtcagaaac aaggatctgg gaacaactgg
      601 gcatacggtt actctgtgca tggaccgaag catgaagaat ctataatgaa cttaatccaa
      661 acagaggtgg agaaatgtga ctctttgagt ggatttttca tcataatgag tatggccggg
      721 ggaacaggat cagggctggg agccttcgtt acacagaagc tacaagatca gtactccagt
      781 tccttgaaaa tgaaccagat tatatggcct tatggaacgg gtgaggtcat tgtgcagaac
      841 tacaactcca tcttgactct ctctcacctg taccggtctt cagatgccct tctcattcac
      901 gagaatgacg ctgtccataa gatctgtgcc aaacggatga acatcaagca gatctccttc
      961 agagacttaa atcaagttct tgcccaccag ctggggagtg tgttccagcc tacatactct
     1021 gaggacagct catttcacta ccgcagaaat ccactaggag acttaatgga gcatttagtt
     1081 cctcaccctg aatttaagat gctgggtgtc cgtaacattc ctcagatgtc tgcggcgtct
     1141 ctggcgtaca gcgcgtttac ctgggctggc ctcctcaagc acttaagaca gatgcttatt
     1201 tccagtgcaa aaatggaaga aggtatcaac tggcaggtgc ggcctcctct gacaggcctt
     1261 ccacccattg gcaaagcgtc tgcccacaag gagcatcatt ttaacacttc tcttgctaac
     1321 ttggtggtcc tccgagggag agaggtgcac agtgcagacg tagagggatt taaagaccca
     1381 gctctctaca cttcctggtt ggagcctgtt gatgctttca gtgtatggaa aacccagcga
     1441 gcctttgaca agtatgagaa gtctgcagcc ctggtcagca acagccagct cttagtaaag
     1501 ccactggata tgattgtggg caaggcgtgg aatatgttct catccaaagc ctttatccat
     1561 cagtacacaa aatttggaat ggaggaggaa gactttttgg acagctttgc attgttggag
     1621 caagttgttg ccagttatgg tagtcttgga ccctaagcca agaggaaaag ctctttacag
     1681 gatttttgga ctaaaatatt ttcaaaactg agctgtgctc agtggtgctt gcctgtgacc
     1741 gagctctctg gagtcaggag caggagtcag gggctcaggt cgtccttgac tacactgaaa
     1801 gttccaggcc aacctggacg acatgagaca ctgtctcagg ctagataaat aaatacaaat
     1861 atctgctttc aaaaaaaaaa aa
//
