LOCUS       NM_026473               1807 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tubulin, beta 6 class V (Tubb6), mRNA.
ACCESSION   NM_026473
VERSION     NM_026473.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1807)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1807)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1807)
  AUTHORS   Guerit,D., Marie,P., Morel,A., Maurin,J., Verollet,C.,
            Raynaud-Messina,B., Urbach,S. and Blangy,A.
  TITLE     Primary myeloid cell proteomics and transcriptomics: importance of
            beta-tubulin isotypes for osteoclast function
  JOURNAL   J Cell Sci 133 (10) (2020)
   PUBMED   32265273
  REMARK    GeneRIF: Primary myeloid cell proteomics and transcriptomics:
            importance of beta-tubulin isotypes for osteoclast function.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1807)
  AUTHORS   Stoupa,A., Adam,F., Kariyawasam,D., Strassel,C., Gawade,S.,
            Szinnai,G., Kauskot,A., Lasne,D., Janke,C., Natarajan,K.,
            Schmitt,A., Bole-Feysot,C., Nitschke,P., Leger,J., Jabot-Hanin,F.,
            Tores,F., Michel,A., Munnich,A., Besmond,C., Scharfmann,R.,
            Lanza,F., Borgel,D., Polak,M. and Carre,A.
  TITLE     TUBB1 mutations cause thyroid dysgenesis associated with abnormal
            platelet physiology
  JOURNAL   EMBO Mol Med 10 (12) (2018)
   PUBMED   30446499
REFERENCE   5  (bases 1 to 1807)
  AUTHORS   Latremoliere,A., Cheng,L., DeLisle,M., Wu,C., Chew,S.,
            Hutchinson,E.B., Sheridan,A., Alexandre,C., Latremoliere,F.,
            Sheu,S.H., Golidy,S., Omura,T., Huebner,E.A., Fan,Y., Whitman,M.C.,
            Nguyen,E., Hermawan,C., Pierpaoli,C., Tischfield,M.A., Woolf,C.J.
            and Engle,E.C.
  TITLE     Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal
            Function but Is Essential for Timely Axon Regeneration
  JOURNAL   Cell Rep 24 (7), 1865-1879 (2018)
   PUBMED   30110642
REFERENCE   6  (bases 1 to 1807)
  AUTHORS   Bhattacharya,R., Frankfurter,A. and Cabral,F.
  TITLE     A minor beta-tubulin essential for mammalian cell proliferation
  JOURNAL   Cell Motil Cytoskeleton 65 (9), 708-720 (2008)
   PUBMED   18553364
  REMARK    GeneRIF: The results provide the first evidence that a specific
            isoform of beta-tubulin is required for mitosis.[beta5 tubulin]
REFERENCE   7  (bases 1 to 1807)
  AUTHORS   Knox,K. and Baker,J.C.
  TITLE     Genomic evolution of the placenta using co-option and duplication
            and divergence
  JOURNAL   Genome Res 18 (5), 695-705 (2008)
   PUBMED   18340042
REFERENCE   8  (bases 1 to 1807)
  AUTHORS   van Tuyl,M., Groenman,F., Kuliszewski,M., Ridsdale,R., Wang,J.,
            Tibboel,D. and Post,M.
  TITLE     Overexpression of lunatic fringe does not affect epithelial cell
            differentiation in the developing mouse lung
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 288 (4), L672-L682 (2005)
   PUBMED   15591414
REFERENCE   9  (bases 1 to 1807)
  AUTHORS   Bhattacharya,R. and Cabral,F.
  TITLE     A ubiquitous beta-tubulin disrupts microtubule assembly and
            inhibits cell proliferation
  JOURNAL   Mol Biol Cell 15 (7), 3123-3131 (2004)
   PUBMED   15121885
REFERENCE   10 (bases 1 to 1807)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC008225.1.
            
            On Jan 15, 2003 this sequence version replaced NM_026473.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008225.1, AK144815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1807
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 39.96 cM"
     gene            1..1807
                     /gene="Tubb6"
                     /gene_synonym="2310057H16Rik"
                     /note="tubulin, beta 6 class V"
                     /db_xref="GeneID:67951"
                     /db_xref="MGI:MGI:1915201"
     exon            1..84
                     /gene="Tubb6"
                     /gene_synonym="2310057H16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1371
                     /gene="Tubb6"
                     /gene_synonym="2310057H16Rik"
                     /codon_start=1
                     /product="tubulin beta-6 chain"
                     /protein_id="NP_080749.2"
                     /db_xref="CCDS:CCDS29321.1"
                     /db_xref="GeneID:67951"
                     /db_xref="MGI:MGI:1915201"
                     /translation="MREIVHIQAGQCGNQIGTKFWEVISDEHGIDQAGGYVGDSALQL
                     ERISVYYNESSSKKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWA
                     KGHYTEGAELVDSVLDVVRKECEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYP
                     DRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLT
                     TPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAR
                     GSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQ
                     NKNSSYFVEWIPNNVKVAVCDIPPRGLKMASTFIGNSTAIQELFKRISEQFSAMFRRK
                     AFLHWFTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVNDGEEAFEDEDEEEINE"
     exon            85..193
                     /gene="Tubb6"
                     /gene_synonym="2310057H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            194..304
                     /gene="Tubb6"
                     /gene_synonym="2310057H16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            305..1744
                     /gene="Tubb6"
                     /gene_synonym="2310057H16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1726..1731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tubb6"
                     /gene_synonym="2310057H16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1744
                     /gene="Tubb6"
                     /gene_synonym="2310057H16Rik"
                     /note="major polyA site"
ORIGIN      
        1 cagcgcccga gcgcagacgc gcccgccatg agggagattg tgcacatcca ggcgggccag
       61 tgcgggaacc agatcggtac caagttttgg gaagtgatca gtgatgagca cggcatcgac
      121 caggccggag gctacgtggg cgactcagcg ctgcagctgg agaggatcag cgtctactac
      181 aatgagtcat cctctaagaa gtacgtaccc agggctgccc tggtggactt ggagcccggc
      241 accatggaca gtgtgaggtc tgggcctttt gggcaactct tccggcctga caacttcatc
      301 ttcggacaga cgggtgccgg aaacaactgg gccaagggtc actacacgga gggcgcggag
      361 ctggtggatt cggtgctgga tgtggtgcgc aaggagtgtg agcattgcga ctgtcttcag
      421 ggcttccagc tcacccactc gctgggcggt ggcacgggct caggcatggg cacactgctc
      481 atcagcaaga tccgagagga gtacccggac cgcatcatga acaccttcag cgtcatgccg
      541 tcacccaagg tctcagacac cgtggtggag ccctacaacg ccacattgtc agtgcaccag
      601 ctggtagaga acaccgacga gacctactgc atcgacaacg aggccctcta tgacatctgc
      661 ttccgcacgc tcaagctgac cacacccact tacggggacc tcaaccactt ggtatccgcc
      721 accatgagcg gtgtcaccac atcactgcgt ttccctggcc aactcaacgc cgacctgcgc
      781 aagctggctg tgaacatggt gccattccca cgtctccact tcttcatgcc cggctttgcc
      841 cccctcacag cccggggcag tcagcagtac cgtgccctga cagtgcctga gctcacacag
      901 cagatgttcg atgccaagaa catgatggct gcctgtgacc cacgccatgg ccgctacctg
      961 accgtcgcca ctgtcttccg gggccccatg tccatgaagg aggtggacga gcagatgctg
     1021 gccatccaga acaagaacag cagctacttt gtggagtgga tccccaacaa tgtcaaggta
     1081 gctgtgtgcg acatcccacc acggggcctg aagatggcct ccaccttcat tggcaatagc
     1141 actgccatcc aggagctatt caagcgcatc tccgagcagt tctcggccat gttccgccgc
     1201 aaggccttcc tgcactggtt caccggtgag ggcatggacg agatggagtt caccgaggcc
     1261 gagagtaaca tgaatgacct ggtgtccgag taccagcagt accaggacgc cacggtcaat
     1321 gatggggaag aggcatttga agacgaggat gaagaagaga tcaacgaata gggagccata
     1381 agatgctaca gtgaacgtct gctcttttct tagccttgat ggtgtgggaa tggtgccctg
     1441 gtctaagcat gtcactggcc cctctcaaac caaatgcacc acactgttct ccaggttacc
     1501 tggaacagtc ccagcagacc agggagatct catataggaa ccctgaaagc aaagtagggg
     1561 gctcacacag ggctaaagaa agtgaccacc ttttgttaag cccccttccc accccatcag
     1621 agttagaata gggatttgtt tttcatcctc ggtgataaaa actaaagcca cacagtgctg
     1681 ccttaagtga atgcacacta tggaacttta tgacaatcca ttcataataa aatgctaaac
     1741 ctgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1801 aaaaaaa
//
