LOCUS       NM_011655               2645 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus tubulin, beta 5 class I (Tubb5), mRNA.
ACCESSION   NM_011655
VERSION     NM_011655.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2645)
  AUTHORS   Zhang,W., Zhang,R., Wu,L., Zhu,C., Zhang,C., Xu,C., Zhao,S.,
            Liu,X., Guo,T., Lu,Y., Gao,Z., Yu,X., Li,L., Chen,Z.J., Qin,Y. and
            Jiao,X.
  TITLE     NLRP14 deficiency causes female infertility with oocyte maturation
            defects and early embryonic arrest by impairing cytoplasmic UHRF1
            abundance
  JOURNAL   Cell Rep 42 (12), 113531 (2023)
   PUBMED   38060382
REFERENCE   2  (bases 1 to 2645)
  AUTHORS   Ranjbar,R., Zamanzadeh,Z. and Ahadi,A.M.
  TITLE     Effects of Venlafaxine on the Size of Brain and Expression of
            SHANK3, TUBB5 and DDC Genes in BALB/c Mice
  JOURNAL   Psychopharmacol Bull 53 (3), 22-34 (2023)
   PUBMED   37601086
  REMARK    GeneRIF: Effects of Venlafaxine on the Size of Brain and Expression
            of SHANK3, TUBB5 and DDC Genes in BALB/c Mice.
REFERENCE   3  (bases 1 to 2645)
  AUTHORS   Liu,H., He,L., Cheng,Q., Luo,W., Zhao,T. and Yang,D.
  TITLE     Validation of superior reference genes in mouse submandibular
            glands under developmental and functional regeneration states
  JOURNAL   Int J Mol Med 50 (5) (2022)
   PUBMED   36069228
REFERENCE   4  (bases 1 to 2645)
  AUTHORS   Tripathy,R., Leca,I., van Dijk,T., Weiss,J., van Bon,B.W.,
            Sergaki,M.C., Gstrein,T., Breuss,M., Tian,G., Bahi-Buisson,N.,
            Paciorkowski,A.R., Pagnamenta,A.T., Wenninger-Weinzierl,A.,
            Martinez-Reza,M.F., Landler,L., Lise,S., Taylor,J.C., Terrone,G.,
            Vitiello,G., Del Giudice,E., Brunetti-Pierri,N., D'Amico,A.,
            Reymond,A., Voisin,N., Bernstein,J.A., Farrelly,E., Kini,U.,
            Leonard,T.A., Valence,S., Burglen,L., Armstrong,L., Hiatt,S.M.,
            Cooper,G.M., Aldinger,K.A., Dobyns,W.B., Mirzaa,G., Pierson,T.M.,
            Baas,F., Chelly,J., Cowan,N.J. and Keays,D.A.
  TITLE     Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with
            Cerebellar Hypoplasia and Cortical Malformations
  JOURNAL   Neuron 100 (6), 1354-1368 (2018)
   PUBMED   30449657
REFERENCE   5  (bases 1 to 2645)
  AUTHORS   Stoupa,A., Adam,F., Kariyawasam,D., Strassel,C., Gawade,S.,
            Szinnai,G., Kauskot,A., Lasne,D., Janke,C., Natarajan,K.,
            Schmitt,A., Bole-Feysot,C., Nitschke,P., Leger,J., Jabot-Hanin,F.,
            Tores,F., Michel,A., Munnich,A., Besmond,C., Scharfmann,R.,
            Lanza,F., Borgel,D., Polak,M. and Carre,A.
  TITLE     TUBB1 mutations cause thyroid dysgenesis associated with abnormal
            platelet physiology
  JOURNAL   EMBO Mol Med 10 (12) (2018)
   PUBMED   30446499
REFERENCE   6  (bases 1 to 2645)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   7  (bases 1 to 2645)
  AUTHORS   Gao,Y., Vainberg,I.E., Chow,R.L. and Cowan,N.J.
  TITLE     Two cofactors and cytoplasmic chaperonin are required for the
            folding of alpha- and beta-tubulin
  JOURNAL   Mol Cell Biol 13 (4), 2478-2485 (1993)
   PUBMED   8096061
REFERENCE   8  (bases 1 to 2645)
  AUTHORS   Wang,D., Villasante,A., Lewis,S.A. and Cowan,N.J.
  TITLE     The mammalian beta-tubulin repertoire: hematopoietic expression of
            a novel, heterologous beta-tubulin isotype
  JOURNAL   J Cell Biol 103 (5), 1903-1910 (1986)
   PUBMED   3782288
REFERENCE   9  (bases 1 to 2645)
  AUTHORS   Sullivan,K.F. and Cleveland,D.W.
  TITLE     Identification of conserved isotype-defining variable region
            sequences for four vertebrate beta tubulin polypeptide classes
  JOURNAL   Proc Natl Acad Sci U S A 83 (12), 4327-4331 (1986)
   PUBMED   3459176
REFERENCE   10 (bases 1 to 2645)
  AUTHORS   Lewis,S.A., Lee,M.G. and Cowan,N.J.
  TITLE     Five mouse tubulin isotypes and their regulated expression during
            development
  JOURNAL   J Cell Biol 101 (3), 852-861 (1985)
   PUBMED   3839797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY111488.1, AK146567.1 and CR974451.9.
            
            On Apr 18, 2009 this sequence version replaced NM_011655.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146567.1, AK169210.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                BY111488.1         1-69
            70-1862             AK146567.1         2-1794
            1863-2645           CR974451.9         58315-59097         c
FEATURES             Location/Qualifiers
     source          1..2645
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.7 cM"
     gene            1..2645
                     /gene="Tubb5"
                     /gene_synonym="B130022C14Rik; M(beta)5"
                     /note="tubulin, beta 5 class I"
                     /db_xref="GeneID:22154"
                     /db_xref="MGI:MGI:107812"
     exon            1..305
                     /gene="Tubb5"
                     /gene_synonym="B130022C14Rik; M(beta)5"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1583
                     /gene="Tubb5"
                     /gene_synonym="B130022C14Rik; M(beta)5"
                     /codon_start=1
                     /product="tubulin beta-5 chain"
                     /protein_id="NP_035785.1"
                     /db_xref="CCDS:CCDS28706.1"
                     /db_xref="GeneID:22154"
                     /db_xref="MGI:MGI:107812"
                     /translation="MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQL
                     DRISVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWA
                     KGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYP
                     DRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLT
                     TPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSR
                     GSQQYRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQ
                     NKNSSYFVEWIPNNVKTAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRK
                     AFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEEDFGEEAEEEA"
     exon            306..414
                     /gene="Tubb5"
                     /gene_synonym="B130022C14Rik; M(beta)5"
                     /inference="alignment:Splign:2.1.0"
     exon            415..525
                     /gene="Tubb5"
                     /gene_synonym="B130022C14Rik; M(beta)5"
                     /inference="alignment:Splign:2.1.0"
     exon            526..2645
                     /gene="Tubb5"
                     /gene_synonym="B130022C14Rik; M(beta)5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1740..1745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tubb5"
                     /gene_synonym="B130022C14Rik; M(beta)5"
                     /note="hexamer: AATAAA"
     polyA_site      1760
                     /gene="Tubb5"
                     /gene_synonym="B130022C14Rik; M(beta)5"
                     /note="major polyA site"
     regulatory      2624..2629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tubb5"
                     /gene_synonym="B130022C14Rik; M(beta)5"
                     /note="hexamer: AATAAA"
     polyA_site      2638
                     /gene="Tubb5"
                     /gene_synonym="B130022C14Rik; M(beta)5"
     polyA_site      2644
                     /gene="Tubb5"
                     /gene_synonym="B130022C14Rik; M(beta)5"
ORIGIN      
        1 gcccccggcc gcgcgaacgc gagccccgcc ctgcgcgcct tccctcctgc gctcgccggc
       61 ctcttctgcc tcttagaacc ttcctgcggt cgtgcttgca tctcgctgct gcagcctccc
      121 gggctccggt ccatcctttc agtctgagac cggcccagaa gaaaaaaacc ccaaaaacct
      181 taattttctt tcttgttcgg tacctacatt ggaaccatca aaaacaatta tttcagtaaa
      241 ccgtagccat gagggaaatc gtgcacatcc aggccggaca gtgtggcaac cagatcggtg
      301 ctaagttctg ggaggtgata agcgatgaac atggcatcga ccccaccggt acctaccacg
      361 gtgacagcga cctgcagctg gaccgaatct ctgtgtacta taatgaagcc acaggtggca
      421 agtatgtccc tcgagctatc ttggtggatc tagaacctgg gactatggac tccgttcgct
      481 caggtccttt tggccagatc ttcagaccag acaacttcgt tttcggtcag tctggggcag
      541 gcaacaactg ggctaaaggc cactacacag agggagctga gttggttgac tctgtcttgg
      601 atgtggtgcg gaaggaggcg gagagctgtg attgcctgca aggctttcag ctgacccact
      661 cactgggtgg aggcactggc tctggcatgg gcaccctgct catcagcaag atccgggaag
      721 aatatcctga ccgtatcatg aataccttca gtgtggtgcc ctcgcccaaa gtgtctgata
      781 ccgtggtcga gccctacaat gccaccctgt ctgtccatca gttggttgag aacacggatg
      841 agacctactg catcgacaac gaggccctct acgacatctg cttccgtacc ctcaagctca
      901 ccacgccaac ctacggagac ctgaaccatc tcgtctcggc caccatgagc ggcgtcacca
      961 cctgcctccg tttcccgggc cagcttaatg ctgaccttcg aaagctggct gtcaacatgg
     1021 tgccattccc acgtctccac ttcttcatgc ctggctttgc ccctctcacc agccgtggaa
     1081 gccagcagta ccgggccctc actgtgcctg aacttaccca gcaggtcttc gatgccaaga
     1141 acatgatggc cgcctgcgac ccgcgccacg gccggtacct cacagttgcc gccgtcttcc
     1201 gtggacggat gtccatgaag gaggtggatg agcagatgct caacgtgcag aacaagaata
     1261 gcagctactt cgtggaatgg atccccaaca atgtcaagac agctgtctgt gacatcccac
     1321 cgcgtggcct caagatggca gtcaccttca ttggaaacag cacagccatc caggagctct
     1381 tcaagcgcat ctctgagcag tttacggcta tgttccgccg gaaggctttc ctccactggt
     1441 atacgggtga gggcatggac gagatggagt tcaccgaagc tgagagcaac atgaacgacc
     1501 tcgtctctga gtaccagcag taccaggatg ccaccgcgga agaggaagag gatttcggag
     1561 aggaggcaga agaggaggcc taaggcagag agccctgcat cagctcaggc tgcttagatc
     1621 cctcagcttt ctccaactgc cctttgtcct ccagtttctt tctgctgcct ctgtcttgta
     1681 tttgttttgt tctgttttct cattgggggt aaatggtgcc tggcacatgg caggcactca
     1741 ataaatattt gtttgtggaa tgtctccttt ctctttccac tctgacaaac ttagatttct
     1801 gacattctgg ttgttaccct gtgcttccta ctggtatctt tttttttttt tttttttttt
     1861 ttttggtttt tccagacagg gtttctctgt atatatagcc caggctgtcc tggaactcag
     1921 aaatccgcct gcctctgcct cccaagtgtt gggattaaag gcgtgtgcca ctatcaccca
     1981 acaagtatcc atttttttaa attattattt gactgtccag ttaatattcc agaatattct
     2041 ccagaaacct gaggtctgct ccagatcctg tgtagaaccc agcccaattc taagaactcg
     2101 gatagtaacc atcatcttaa agcaaagtag tggatcaggg atgctaggta gagaccacca
     2161 ggaagagaag ggggtggggt tttccagtca gggccattta gaatccacct atgctttcag
     2221 tcagcagggc tttgttttgt ttttctcctg cctcatctct cagcctcagg agaggtatta
     2281 acagtattat ctccatttat atcctcccag ctgtcctgag ccaaatctgc cattggaagt
     2341 gtcttccctg tattggttct cctttctcgg agagatgggg gttgggggtg cggcaaggtc
     2401 ttggtcttgg tctctgaaca ctcccaattc ccgctgaaac tccacacttg ggaaagtatg
     2461 tttccacctg ggtctttcag acactgccca gatgggctgt caccacctct gccccatgct
     2521 cctcctgccc ttggcttggt catttcctac ctttctattt cgtgttgtac ctgctttttt
     2581 tttttttttc atattgaaaa gttgacatcg ccccagagcc aaaaataaat gggaattgga
     2641 aaaag
//
