LOCUS       NM_023279               1757 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus tubulin, beta 3 class III (Tubb3), mRNA.
ACCESSION   NM_023279
VERSION     NM_023279.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1757)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1757)
  AUTHORS   Tang,I., Nisal,A., Reed,A., Ware,T.B., Johansen,A., Zaki,M.S.,
            Cravatt,B.F. and Gleeson,J.G.
  TITLE     Lipidomic profiling of mouse brain and human neuron cultures
            reveals a role for Mboat7 in mTOR-dependent neuronal migration
  JOURNAL   Sci Transl Med 17 (779), eadp5247 (2025)
   PUBMED   39742503
REFERENCE   3  (bases 1 to 1757)
  AUTHORS   Feng,X., Du,X., Yang,X., Chen,C., Liang,Z., Xu,X., Wang,Y.,
            Zheng,J.C., Xia,X. and Liu,J.
  TITLE     miR-185-5p regulates the proliferation and differentiation of
            neural stem/progenitor cells
  JOURNAL   Front Cell Dev Biol 12, 1510746 (2024)
   PUBMED   39703696
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1757)
  AUTHORS   Fritzsch,B., Weng,X., Yamoah,E.N., Qin,T., Hui,C.C.,
            Lebron-Mora,L., Pavlinkova,G. and Sham,M.H.
  TITLE     Irx3/5 Null Deletion in Mice Blocks Cochlea-Saccule Segregation and
            Disrupts the Auditory Tonotopic Map
  JOURNAL   J Comp Neurol 532 (12), e70008 (2024)
   PUBMED   39655644
REFERENCE   5  (bases 1 to 1757)
  AUTHORS   Alvarez,S., Gupta,S., Mercado-Ayon,Y., Honeychurch,K.,
            Rodriguez,C., Kawaguchi,R. and Butler,S.J.
  TITLE     Netrin1 patterns the dorsal spinal cord through modulation of Bmp
            signaling
  JOURNAL   Cell Rep 43 (11), 114954 (2024)
   PUBMED   39547237
REFERENCE   6  (bases 1 to 1757)
  AUTHORS   Gassmann,M., Casagranda,F., Orioli,D., Simon,H., Lai,C., Klein,R.
            and Lemke,G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   7  (bases 1 to 1757)
  AUTHORS   Marcus,R.C. and Mason,C.A.
  TITLE     The first retinal axon growth in the mouse optic chiasm: axon
            patterning and the cellular environment
  JOURNAL   J Neurosci 15 (10), 6389-6402 (1995)
   PUBMED   7472403
REFERENCE   8  (bases 1 to 1757)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
REFERENCE   9  (bases 1 to 1757)
  AUTHORS   Wang,D., Villasante,A., Lewis,S.A. and Cowan,N.J.
  TITLE     The mammalian beta-tubulin repertoire: hematopoietic expression of
            a novel, heterologous beta-tubulin isotype
  JOURNAL   J Cell Biol 103 (5), 1903-1910 (1986)
   PUBMED   3782288
REFERENCE   10 (bases 1 to 1757)
  AUTHORS   Sullivan,K.F. and Cleveland,D.W.
  TITLE     Identification of conserved isotype-defining variable region
            sequences for four vertebrate beta tubulin polypeptide classes
  JOURNAL   Proc Natl Acad Sci U S A 83 (12), 4327-4331 (1986)
   PUBMED   3459176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK082942.1, BC031357.1 and CK780733.1.
            
            On Jun 12, 2018 this sequence version replaced NM_023279.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AU036037.1, BC088749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AK082942.1         2-12
            12-1734             BC031357.1         1-1723
            1735-1757           CK780733.1         526-548
FEATURES             Location/Qualifiers
     source          1..1757
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.1 cM"
     gene            1..1757
                     /gene="Tubb3"
                     /gene_synonym="3200002H15Rik; M(beta)3; M(beta)6"
                     /note="tubulin, beta 3 class III"
                     /db_xref="GeneID:22152"
                     /db_xref="MGI:MGI:107813"
     exon            1..110
                     /gene="Tubb3"
                     /gene_synonym="3200002H15Rik; M(beta)3; M(beta)6"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1406
                     /gene="Tubb3"
                     /gene_synonym="3200002H15Rik; M(beta)3; M(beta)6"
                     /note="betaIII-tubulin"
                     /codon_start=1
                     /product="tubulin beta-3 chain"
                     /protein_id="NP_075768.1"
                     /db_xref="CCDS:CCDS22757.1"
                     /db_xref="GeneID:22152"
                     /db_xref="MGI:MGI:107813"
                     /translation="MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQL
                     ERISVYYNEASSHKYVPRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWA
                     KGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYP
                     DRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLA
                     TPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAR
                     GSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQ
                     SKNSSYFVEWIPNNVKVAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRK
                     AFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEMYEDDDEESEAQGPK
                     "
     exon            111..219
                     /gene="Tubb3"
                     /gene_synonym="3200002H15Rik; M(beta)3; M(beta)6"
                     /inference="alignment:Splign:2.1.0"
     exon            220..330
                     /gene="Tubb3"
                     /gene_synonym="3200002H15Rik; M(beta)3; M(beta)6"
                     /inference="alignment:Splign:2.1.0"
     exon            331..1739
                     /gene="Tubb3"
                     /gene_synonym="3200002H15Rik; M(beta)3; M(beta)6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1708..1713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tubb3"
                     /gene_synonym="3200002H15Rik; M(beta)3; M(beta)6"
                     /note="hexamer: AATAAA"
     polyA_site      1734
                     /gene="Tubb3"
                     /gene_synonym="3200002H15Rik; M(beta)3; M(beta)6"
                     /note="major polyA site"
ORIGIN      
        1 ctccgcagcc tgctgtccgc ctgccttttc gtctctagcc gcgtgaagtc agcatgaggg
       61 agatcgtgca catccaggcc ggccagtgcg gcaaccagat aggggccaag ttctgggagg
      121 tcatcagcga tgagcacggc atagacccca gcggcaacta tgtaggggac tcagacctgc
      181 agctggagcg catcagcgta tactacaatg aggcctcctc tcacaagtat gtgcccaggg
      241 ccattctggt ggacttggaa cctggaacca tggacagtgt tcggtctggc gcctttggac
      301 acctattcag gcccgacaac tttatctttg gtcagagtgg tgctggcaac aactgggcca
      361 aagggcacta tacggagggc gcggagctgg tggactcagt cctagatgtc gtgcggaaag
      421 agtgtgagaa ttgtgactgc ctgcagggct tccagctgac acactcactg ggtgggggca
      481 caggctcagg catgggcaca ctgctcatca gcaaggtgcg tgaggagtac cccgaccgca
      541 tcatgaacac cttcagcgtg gtgccttcac ccaaagtgtc ggacactgtg gtggagccct
      601 acaacgccac cctgtccatc caccagctag tggagaacac agacgagacc tactgcatcg
      661 acaatgaagc cctctacgac atctgcttcc gcaccctcaa gctggccaca cccacctatg
      721 gggacctcaa ccaccttgtg tctgccacca tgagtggagt caccacctcc cttcgattcc
      781 ctggtcagct caatgccgac ctccgcaagc tggctgtgaa catggtgccg ttcccacgtc
      841 tccacttctt catgcccggc ttcgccccac ttacagcccg gggcagccag cagtaccgtg
      901 ccctgacggt gcctgagctc acgcagcaga tgttcgatgc caagaacatg atggctgcct
      961 gtgacccgcg ccacggtcgc tacctgaccg tggccactgt cttccgtggg cgcatgtcta
     1021 tgaaggaggt ggacgagcag atgctggcca tccagagtaa gaacagcagc tacttcgtgg
     1081 agtggatccc caacaacgtc aaggtagccg tgtgtgacat cccaccccgt gggctcaaaa
     1141 tgtcatccac cttcattggc aacagcacgg ccatccagga gctgttcaaa cgcatctcgg
     1201 agcagttcac agccatgttc cggcgcaagg ccttcctgca ctggtacacg ggcgagggca
     1261 tggatgagat ggagttcacc gaggccgaga gcaacatgaa tgacctggtg tccgagtacc
     1321 agcagtacca ggacgccact gcggaggagg agggggagat gtatgaagat gatgacgagg
     1381 aatcggaagc ccaggggccc aagtgaagtt gctcgcagct ggggtgtggg gccaagtggc
     1441 agccagggcc aagacaagca gcatctgtcc cccccagagc catctagcta ctgacactgc
     1501 ccccagcttt gcttctcacc agctcattag ggctcccagg ttaaagtcct tcagtattta
     1561 tggccacccc cactccatgt gagtccactt ggctctgtcc tccccatttt agccacctct
     1621 gtatttatgt tgcttattcg tctgttttta tggtttgttt tgttttttta ctgggttgtg
     1681 tttatattcg gggggagggg tatacttaat aaagttactg ctgtctgtca gatacctcta
     1741 aaaaaaaaaa aaaaaaa
//
