LOCUS       NM_023716               1922 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus tubulin, beta 2B class IIB (Tubb2b), mRNA.
ACCESSION   NM_023716
VERSION     NM_023716.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1922)
  AUTHORS   Niu,W. and Spradling,A.C.
  TITLE     Mouse oocytes develop in cysts with the help of nurse cells
  JOURNAL   Cell 185 (14), 2576-2590 (2022)
   PUBMED   35623357
REFERENCE   2  (bases 1 to 1922)
  AUTHORS   Bittermann,E., Abdelhamed,Z., Liegel,R.P., Menke,C., Timms,A.,
            Beier,D.R. and Stottmann,R.W.
  TITLE     Differential requirements of tubulin genes in mammalian forebrain
            development
  JOURNAL   PLoS Genet 15 (8), e1008243 (2019)
   PUBMED   31386652
  REMARK    GeneRIF: Study shows that loss of Tubb2a or Tubb2b does not impair
            survival but does lead to relatively mild cortical malformation
            phenotypes. In contrast, loss of Tuba1a is perinatal lethal and
            leads to significant forebrain dysmorphology. The ability of the
            mouse to survive in the absence of some tubulin genes known to
            cause disease in humans suggests future intervention strategies for
            these devastating tubulinopathy diseases.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1922)
  AUTHORS   Stoupa,A., Adam,F., Kariyawasam,D., Strassel,C., Gawade,S.,
            Szinnai,G., Kauskot,A., Lasne,D., Janke,C., Natarajan,K.,
            Schmitt,A., Bole-Feysot,C., Nitschke,P., Leger,J., Jabot-Hanin,F.,
            Tores,F., Michel,A., Munnich,A., Besmond,C., Scharfmann,R.,
            Lanza,F., Borgel,D., Polak,M. and Carre,A.
  TITLE     TUBB1 mutations cause thyroid dysgenesis associated with abnormal
            platelet physiology
  JOURNAL   EMBO Mol Med 10 (12) (2018)
   PUBMED   30446499
REFERENCE   4  (bases 1 to 1922)
  AUTHORS   Latremoliere,A., Cheng,L., DeLisle,M., Wu,C., Chew,S.,
            Hutchinson,E.B., Sheridan,A., Alexandre,C., Latremoliere,F.,
            Sheu,S.H., Golidy,S., Omura,T., Huebner,E.A., Fan,Y., Whitman,M.C.,
            Nguyen,E., Hermawan,C., Pierpaoli,C., Tischfield,M.A., Woolf,C.J.
            and Engle,E.C.
  TITLE     Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal
            Function but Is Essential for Timely Axon Regeneration
  JOURNAL   Cell Rep 24 (7), 1865-1879 (2018)
   PUBMED   30110642
REFERENCE   5  (bases 1 to 1922)
  AUTHORS   Hoffmeister,M., Krieg,J., Ehrke,A., Seigfried,F.A., Wischmann,L.,
            Dietmann,P., Kuhl,S.J. and Oess,S.
  TITLE     Developmental neurogenesis in mouse and Xenopus is impaired in the
            absence of Nosip
  JOURNAL   Dev Biol 429 (1), 200-212 (2017)
   PUBMED   28663132
REFERENCE   6  (bases 1 to 1922)
  AUTHORS   Stottmann,R.W., Moran,J.L., Turbe-Doan,A., Driver,E., Kelley,M. and
            Beier,D.R.
  TITLE     Focusing forward genetics: a tripartite ENU screen for
            neurodevelopmental mutations in the mouse
  JOURNAL   Genetics 188 (3), 615-624 (2011)
   PUBMED   21515572
REFERENCE   7  (bases 1 to 1922)
  AUTHORS   Guzun,R., Karu-Varikmaa,M., Gonzalez-Granillo,M., Kuznetsov,A.V.,
            Michel,L., Cottet-Rousselle,C., Saaremae,M., Kaambre,T., Metsis,M.,
            Grimm,M., Auffray,C. and Saks,V.
  TITLE     Mitochondria-cytoskeleton interaction: distribution of
            beta-tubulins in cardiomyocytes and HL-1 cells
  JOURNAL   Biochim Biophys Acta 1807 (4), 458-469 (2011)
   PUBMED   21296049
REFERENCE   8  (bases 1 to 1922)
  AUTHORS   Braun,A., Breuss,M., Salzer,M.C., Flint,J., Cowan,N.J. and
            Keays,D.A.
  TITLE     Tuba8 is expressed at low levels in the developing mouse and human
            brain
  JOURNAL   Am J Hum Genet 86 (5), 819-22 (2010)
   PUBMED   20466094
REFERENCE   9  (bases 1 to 1922)
  AUTHORS   Tachikawa,K., Sasaki,S., Maeda,T. and Nakajima,K.
  TITLE     Identification of molecules preferentially expressed beneath the
            marginal zone in the developing cerebral cortex
  JOURNAL   Neurosci Res 60 (2), 135-146 (2008)
   PUBMED   18055048
REFERENCE   10 (bases 1 to 1922)
  AUTHORS   Arden,S.D., Zahn,T., Steegers,S., Webb,S., Bergman,B., O'Brien,R.M.
            and Hutton,J.C.
  TITLE     Molecular cloning of a pancreatic islet-specific
            glucose-6-phosphatase catalytic subunit-related protein
  JOURNAL   Diabetes 48 (3), 531-542 (1999)
   PUBMED   10078553
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK010786.1.
            
            On Apr 6, 2007 this sequence version replaced NM_023716.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010786.1, AK168908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1922              AK010786.1         2-1923
FEATURES             Location/Qualifiers
     source          1..1922
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 14.04 cM"
     gene            1..1922
                     /gene="Tubb2b"
                     /gene_synonym="2410129E14Rik; brdp"
                     /note="tubulin, beta 2B class IIB"
                     /db_xref="GeneID:73710"
                     /db_xref="MGI:MGI:1920960"
     exon            1..178
                     /gene="Tubb2b"
                     /gene_synonym="2410129E14Rik; brdp"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1459
                     /gene="Tubb2b"
                     /gene_synonym="2410129E14Rik; brdp"
                     /codon_start=1
                     /product="tubulin beta-2B chain"
                     /protein_id="NP_076205.1"
                     /db_xref="CCDS:CCDS26445.1"
                     /db_xref="GeneID:73710"
                     /db_xref="MGI:MGI:1920960"
                     /translation="MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQL
                     ERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWA
                     KGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYP
                     DRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLT
                     TPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSR
                     GSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQ
                     NKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRK
                     AFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA"
     exon            179..287
                     /gene="Tubb2b"
                     /gene_synonym="2410129E14Rik; brdp"
                     /inference="alignment:Splign:2.1.0"
     exon            288..398
                     /gene="Tubb2b"
                     /gene_synonym="2410129E14Rik; brdp"
                     /inference="alignment:Splign:2.1.0"
     exon            399..1922
                     /gene="Tubb2b"
                     /gene_synonym="2410129E14Rik; brdp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1690..1695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tubb2b"
                     /gene_synonym="2410129E14Rik; brdp"
                     /note="hexamer: CATAAA"
     polyA_site      1709
                     /gene="Tubb2b"
                     /gene_synonym="2410129E14Rik; brdp"
                     /note="major polyA site"
     regulatory      1854..1859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tubb2b"
                     /gene_synonym="2410129E14Rik; brdp"
                     /note="hexamer: AATATA"
     polyA_site      1873
                     /gene="Tubb2b"
                     /gene_synonym="2410129E14Rik; brdp"
ORIGIN      
        1 ctcagcccgt agcccgtcgg ttccggagta agttccaggt ggcccagcag tgggtgtgga
       61 aggggaggat catcagaccc actgacacag acccaagaca gcaagaagct aaccaggcac
      121 catgcgagag atcgtgcaca ttcaggcggg ccagtgcggc aaccagatcg gtgccaagtt
      181 ttgggaggtc atcagtgatg agcatggtat agaccccact ggaagttacc atggagacag
      241 tgatttgcaa ctggaaagaa tcaatgtata ctacaatgaa gcaactggta ataaatatgt
      301 gcctagggcc atcctggtgg acctggagcc aggcacaatg gactcagtca ggtctggacc
      361 atttgggcag atcttcaggc cggacaactt cgtgttcggc cagagtggtg caggaaataa
      421 ctgggcaaag ggccactaca cagagggggc cgagctggtg gactctgtcc tggacgtggt
      481 gaggaaggag tcagaaagct gtgactgtct tcagggcttc cagctgaccc actcactggg
      541 gggaggcact ggctcaggca tggggaccct gctcatcagc aagatcagag aggagtaccc
      601 agaccgcatc atgaacacct tcagcgtcat gccctcaccc aaggtctctg acactgtggt
      661 ggagccctat aatgccaccc tctcagtgca ccagctggta gagaacacag atgaaaccta
      721 ctgcatcgat aatgaggctc tgtatgacat ctgtttccgc accctgaagc tgaccacacc
      781 cacctatggc gatctcaacc acctggtgtc agccaccatg agtggagtga ccacctgcct
      841 gcgcttccca ggccagctga acgcagacct gcgcaagctg gccgtgaaca tggtgccatt
      901 cccacgcctg cacttcttca tgccaggctt tgcacctctg accagccggg gcagccagca
      961 gtaccgagcc ctgacggtgc ccgagctgac ccagcagatg ttcgactcca agaacatgat
     1021 ggctgcctgc gaccctcgcc atggccgcta cctgaccgtg gccgccattt tccgtggccg
     1081 catgtccatg aaggaggtgg atgagcagat gctcaacgtg cagaacaaga acagcagcta
     1141 cttcgtggag tggatcccca acaacgtcaa gacggccgtg tgtgacatcc ctcctcgtgg
     1201 cctcaagatg tcagccacct tcattggcaa cagcactgcc atccaggagc tgttcaagcg
     1261 catctcggag cagttcactg ctatgttccg gcgcaaggct ttcctgcact ggtacacggg
     1321 tgagggcatg gacgagatgg agttcaccga ggcggagagc aacatgaatg acctggtgtc
     1381 tgagtaccag cagtaccagg atgccacggc tgatgagcag ggcgagttcg aggaggaaga
     1441 gggcgaggat gaggcttgag ttccccaggc caagcaggtt agggaaagct gagatgaaag
     1501 gagggggtgg gggggcttaa tctgtgaaaa taccttggca gttgaaggaa ggagaatggt
     1561 cttaggtttg tgctgggtct ctggtgctct tcactgttgc ctgtcacttt ttttctcttt
     1621 ttgtaatacc gataacatca atgtaacact tgagatcttt ctgaactcct gttgtaatgg
     1681 ctaaaatcac ataaaccttt gtgtcctaac ggtgtcctct tttctttctc ttcctttctc
     1741 cctatcaagc tctttgttat caacttaaat ccacctttct gaacacagaa aattttcttc
     1801 ctttagaaaa gactgaaagc tcaggtgttt gtttcttctt tgggtatgct attaatataa
     1861 gttgaaccaa aaatggcctt actcaatcca acaatgagaa gaaacaatgg attttaagat
     1921 gt
//
