LOCUS       NM_001080971            2004 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus tubulin, beta 1 class VI (Tubb1), mRNA.
ACCESSION   NM_001080971 XM_619851 XM_914077
VERSION     NM_001080971.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2004)
  AUTHORS   Kimmerlin,Q., Moog,S., Yakusheva,A., Ziessel,C., Eckly,A.,
            Freund,M., Zavodszky,G., Knapp,Y., Mangin,P. and Lanza,F.
  TITLE     Loss of alpha4A- and beta1-tubulins leads to severe platelet
            spherocytosis and strongly impairs hemostasis in mice
  JOURNAL   Blood 140 (21), 2290-2299 (2022)
   PUBMED   36026602
REFERENCE   2  (bases 1 to 2004)
  AUTHORS   Stoupa,A., Adam,F., Kariyawasam,D., Strassel,C., Gawade,S.,
            Szinnai,G., Kauskot,A., Lasne,D., Janke,C., Natarajan,K.,
            Schmitt,A., Bole-Feysot,C., Nitschke,P., Leger,J., Jabot-Hanin,F.,
            Tores,F., Michel,A., Munnich,A., Besmond,C., Scharfmann,R.,
            Lanza,F., Borgel,D., Polak,M. and Carre,A.
  TITLE     TUBB1 mutations cause thyroid dysgenesis associated with abnormal
            platelet physiology
  JOURNAL   EMBO Mol Med 10 (12) (2018)
   PUBMED   30446499
  REMARK    GeneRIF: In mice, Tubb1 knock-out disrupted microtubule integrity
            by preventing beta1-tubulin incorporation and impaired thyroid
            migration and thyroid hormone secretion.
REFERENCE   3  (bases 1 to 2004)
  AUTHORS   Latremoliere,A., Cheng,L., DeLisle,M., Wu,C., Chew,S.,
            Hutchinson,E.B., Sheridan,A., Alexandre,C., Latremoliere,F.,
            Sheu,S.H., Golidy,S., Omura,T., Huebner,E.A., Fan,Y., Whitman,M.C.,
            Nguyen,E., Hermawan,C., Pierpaoli,C., Tischfield,M.A., Woolf,C.J.
            and Engle,E.C.
  TITLE     Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal
            Function but Is Essential for Timely Axon Regeneration
  JOURNAL   Cell Rep 24 (7), 1865-1879 (2018)
   PUBMED   30110642
REFERENCE   4  (bases 1 to 2004)
  AUTHORS   Haque,K., Pandey,A.K., Zheng,H.W., Riazuddin,S., Sha,S.H. and
            Puligilla,C.
  TITLE     MEKK4 Signaling Regulates Sensory Cell Development and Function in
            the Mouse Inner Ear
  JOURNAL   J Neurosci 36 (4), 1347-1361 (2016)
   PUBMED   26818521
REFERENCE   5  (bases 1 to 2004)
  AUTHORS   Garg,A., O'Rourke,J., Long,C., Doering,J., Ravenscroft,G.,
            Bezprozvannaya,S., Nelson,B.R., Beetz,N., Li,L., Chen,S.,
            Laing,N.G., Grange,R.W., Bassel-Duby,R. and Olson,E.N.
  TITLE     KLHL40 deficiency destabilizes thin filament proteins and promotes
            nemaline myopathy
  JOURNAL   J Clin Invest 124 (8), 3529-3539 (2014)
   PUBMED   24960163
REFERENCE   6  (bases 1 to 2004)
  AUTHORS   Bhattacharya,R. and Cabral,F.
  TITLE     A ubiquitous beta-tubulin disrupts microtubule assembly and
            inhibits cell proliferation
  JOURNAL   Mol Biol Cell 15 (7), 3123-3131 (2004)
   PUBMED   15121885
REFERENCE   7  (bases 1 to 2004)
  AUTHORS   Italiano,J.E. Jr., Bergmeier,W., Tiwari,S., Falet,H., Hartwig,J.H.,
            Hoffmeister,K.M., Andre,P., Wagner,D.D. and Shivdasani,R.A.
  TITLE     Mechanisms and implications of platelet discoid shape
  JOURNAL   Blood 101 (12), 4789-4796 (2003)
   PUBMED   12586623
  REMARK    GeneRIF: findings highlight the essential requirements of the
            megakaryocyte/platelet-restricted beta1-tubulin isoform in platelet
            structure
REFERENCE   8  (bases 1 to 2004)
  AUTHORS   Schwer,H.D., Lecine,P., Tiwari,S., Italiano,J.E. Jr., Hartwig,J.H.
            and Shivdasani,R.A.
  TITLE     A lineage-restricted and divergent beta-tubulin isoform is
            essential for the biogenesis, structure and function of blood
            platelets
  JOURNAL   Curr Biol 11 (8), 579-586 (2001)
   PUBMED   11369202
REFERENCE   9  (bases 1 to 2004)
  AUTHORS   Lecine,P., Italiano,J.E. Jr., Kim,S.W., Villeval,J.L. and
            Shivdasani,R.A.
  TITLE     Hematopoietic-specific beta 1 tubulin participates in a pathway of
            platelet biogenesis dependent on the transcription factor NF-E2
  JOURNAL   Blood 96 (4), 1366-1373 (2000)
   PUBMED   10942379
REFERENCE   10 (bases 1 to 2004)
  AUTHORS   Wang,D., Villasante,A., Lewis,S.A. and Cowan,N.J.
  TITLE     The mammalian beta-tubulin repertoire: hematopoietic expression of
            a novel, heterologous beta-tubulin isotype
  JOURNAL   J Cell Biol 103 (5), 1903-1910 (1986)
   PUBMED   3782288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844534.4.
            
            On Feb 1, 2013 this sequence version replaced NM_001080971.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147698.1, CJ093893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               AL844534.4         94432-94638
            208-316             AL844534.4         99494-99602
            317-427             AL844534.4         100427-100537
            428-2004            AL844534.4         100641-102217
FEATURES             Location/Qualifiers
     source          1..2004
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 97.95 cM"
     gene            1..2004
                     /gene="Tubb1"
                     /gene_synonym="2810484G07Rik; M(beta)1"
                     /note="tubulin, beta 1 class VI"
                     /db_xref="GeneID:545486"
                     /db_xref="MGI:MGI:107814"
     exon            1..207
                     /gene="Tubb1"
                     /gene_synonym="2810484G07Rik; M(beta)1"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1506
                     /gene="Tubb1"
                     /gene_synonym="2810484G07Rik; M(beta)1"
                     /codon_start=1
                     /product="tubulin beta-1 chain"
                     /protein_id="NP_001074440.1"
                     /db_xref="CCDS:CCDS38359.1"
                     /db_xref="GeneID:545486"
                     /db_xref="MGI:MGI:107814"
                     /translation="MREIVHIQIGQCGNQIGAKFWEVIGEEHGIDCAGSYCGTSALQL
                     ERISVYYNEAYGKKYVPRAVLVDLEPGTMDSIRSSRLGVLFQPDSFVHGNSGAGNNWA
                     KGHYTEGAELIENVMDVVRRESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYP
                     DRILNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENTDACFCIDNEALYDICFRTLRLT
                     TPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQ
                     GSQQYRALSVAELTQQMFDARNIMAACDPRRGRYLTVACIFRGKMSTKEVDQQLLSIQ
                     TRNSNCFVEWIPNNVKVAVCDIPPRGLNMAATFLGNNTAIQELFTRVSEHFSAMFRRR
                     AFVHWYTSEGMDISEFGEAESDIHDLVSEYQQFQDVRAGLEDSEEDVEEAEVEAEDKD
                     H"
     exon            208..316
                     /gene="Tubb1"
                     /gene_synonym="2810484G07Rik; M(beta)1"
                     /inference="alignment:Splign:2.1.0"
     exon            317..427
                     /gene="Tubb1"
                     /gene_synonym="2810484G07Rik; M(beta)1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..2004
                     /gene="Tubb1"
                     /gene_synonym="2810484G07Rik; M(beta)1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccctcagc cagacacacc cctgggccaa ttgggagagc agttgggtgg gctggtccca
       61 ccaagaccat gaaactgcac ccagctcaca ctggtgaccc aggctcttcc agactctgcg
      121 acctaactga ctcttgggtt caaggctagg atgagagaga tcgtgcacat ccagattggc
      181 cagtgtggca accagatcgg agccaagttc tgggaggtga tcggggaaga acatgggatt
      241 gactgcgctg ggagctactg tgggacgtct gctctccagc tggagaggat cagcgtttac
      301 tacaacgaag cctacggtaa gaagtatgtg ccgcgagccg tccttgtgga cctggaaccc
      361 gggacaatgg acagcatccg atccagcaga ttgggagtcc tctttcagcc tgacagtttt
      421 gttcatggta actctggtgc tggtaacaac tgggcgaagg gccactacac agagggagcg
      481 gagctgatcg aaaatgtcat ggatgtggta aggagggaga gcgagagctg cgactgccta
      541 cagggtttcc agatcgtgca ttctctgggt ggaggcacgg gctcaggcat gggcaccctg
      601 ctcatgaaca agatcaggga ggagtacccg gatcggatct tgaactcctt tagcgtcatg
      661 ccatcaccca aggtatcaga cacggtggta gagccctaca atgccgtgct atccatccac
      721 cagctgatag agaacacaga tgcctgcttc tgcatcgaca acgaagcgct ctatgacatt
      781 tgtttccgca ccctgaggct gacgacaccc acctacgggg atctcaacca cctggtgtcc
      841 ttgaccatga gcggaatcac gacttcactg cgctttcccg gtcagctcaa tgcagacctg
      901 cgcaagctgg ccgtgaatat ggtgcccttt cctcgtcttc acttcttcat gcctggcttc
      961 gctccactca cagcccaggg tagccagcag taccgagccc tctcagtagc ggagctcacc
     1021 caacagatgt tcgatgcccg caacatcatg gctgcctgtg accctcgccg cggccgctac
     1081 ctgactgtgg cttgtatatt ccggggtaag atgtccacca aggaagtgga ccaacagctg
     1141 ctgtccattc agacaaggaa cagcaactgc tttgtggaat ggattcccaa caatgtcaag
     1201 gtagctgtgt gtgacatccc gccccgtggg ctgaacatgg cagctacctt cctgggcaac
     1261 aatacagcca tccaagagct cttcaccagg gtctctgagc acttctcagc tatgttcaga
     1321 aggagagctt ttgtgcactg gtacaccagt gaagggatgg acataagtga atttggggaa
     1381 gctgagagtg atatccatga cctggtgtct gagtaccaac aattccaaga tgtcagagca
     1441 gggctagagg acagtgaaga ggatgtggag gaggcagagg tggaggcaga agacaaagat
     1501 cattagctag gagagaagct atagggcagc cgatgcttgc ttttccttct tcctttttaa
     1561 atagtgagtg agtttactgt agtgagccct atttattttt tattagttgt aggatagaca
     1621 tgcagacaaa gtgtgcaagt ttgccaggag ccgtttagca gtgttgctgg gtacccaggg
     1681 cagctaggat gcttcagagt cctctctctc aaagccagca gaactgggtg tctgaagagt
     1741 gtgtgggagg gaggttcagg gccaacggaa gtatgactct gcctctatgg ccaagctgtg
     1801 tggaccttat gtaccattcg gcaggctgac tggaaaaaga caaagggagg caagaaaagc
     1861 cacgtctctt ctctcggctc ccaccgtcca aaagaccatc aagagcaaag cattccagtc
     1921 cccaggcctt tgtttcccag taaccagctt ccaacctatt tctctgtgtt ttcttaatag
     1981 aacgagatgc cagtagttcg ctaa
//
