LOCUS       NM_017379               1479 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tubulin, alpha 8 (Tuba8), mRNA.
ACCESSION   NM_017379
VERSION     NM_017379.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1479)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1479)
  AUTHORS   Ramos,S.I., Makeyev,E.V., Salierno,M., Kodama,T., Kawakami,Y. and
            Sahara,S.
  TITLE     Tuba8 Drives Differentiation of Cortical Radial Glia into Apical
            Intermediate Progenitors by Tuning Modifications of Tubulin C
            Termini
  JOURNAL   Dev Cell 52 (4), 477-491 (2020)
   PUBMED   32097653
REFERENCE   3  (bases 1 to 1479)
  AUTHORS   Stoupa,A., Adam,F., Kariyawasam,D., Strassel,C., Gawade,S.,
            Szinnai,G., Kauskot,A., Lasne,D., Janke,C., Natarajan,K.,
            Schmitt,A., Bole-Feysot,C., Nitschke,P., Leger,J., Jabot-Hanin,F.,
            Tores,F., Michel,A., Munnich,A., Besmond,C., Scharfmann,R.,
            Lanza,F., Borgel,D., Polak,M. and Carre,A.
  TITLE     TUBB1 mutations cause thyroid dysgenesis associated with abnormal
            platelet physiology
  JOURNAL   EMBO Mol Med 10 (12) (2018)
   PUBMED   30446499
REFERENCE   4  (bases 1 to 1479)
  AUTHORS   Rein-Fischboeck,L., Bajraktari,G., Pohl,R., Feder,S., Eisinger,K.,
            Mages,W., Haberl,E.M. and Buechler,C.
  TITLE     Alpha-syntrophin dependent expression of tubulin alpha 8 protein in
            hepatocytes
  JOURNAL   J Physiol Biochem 74 (4), 511-521 (2018)
   PUBMED   30033487
  REMARK    GeneRIF: Data (including data from studies conducted in knockout
            mice) suggest that Snta1 is involved in regulation of expression of
            Tuba8 in hepatocytes (but not in hepatic stellate cells); here,
            Snta1 protein levels are inversely related to Tuba8 protein
            expression in hepatocyte cell line. (Snta1 = syntrophin alpha-1;
            Tuba8 = tubulin alpha-8 chain)
REFERENCE   5  (bases 1 to 1479)
  AUTHORS   Diggle,C.P., Martinez-Garay,I., Molnar,Z., Brinkworth,M.H.,
            White,E., Fowler,E., Hughes,R., Hayward,B.E., Carr,I.M.,
            Watson,C.M., Crinnion,L., Asipu,A., Woodman,B., Coletta,P.L.,
            Markham,A.F., Dear,T.N., Bonthron,D.T., Peckham,M., Morrison,E.E.
            and Sheridan,E.
  TITLE     A tubulin alpha 8 mouse knockout model indicates a likely role in
            spermatogenesis but not in brain development
  JOURNAL   PLoS One 12 (4), e0174264 (2017)
   PUBMED   28388629
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1479)
  AUTHORS   Braun,A., Breuss,M., Salzer,M.C., Flint,J., Cowan,N.J. and
            Keays,D.A.
  TITLE     Tuba8 is expressed at low levels in the developing mouse and human
            brain
  JOURNAL   Am J Hum Genet 86 (5), 819-22 (2010)
   PUBMED   20466094
  REMARK    GeneRIF: Tuba8 is expressed at low levels in the developing mouse
            brain.
REFERENCE   7  (bases 1 to 1479)
  AUTHORS   Keays,D.A., Cleak,J., Huang,G.J., Edwards,A., Braun,A.,
            Treiber,C.D., Pidsley,R. and Flint,J.
  TITLE     The role of Tuba1a in adult hippocampal neurogenesis and the
            formation of the dentate gyrus
  JOURNAL   Dev Neurosci 32 (4), 268-277 (2010)
   PUBMED   21041996
REFERENCE   8  (bases 1 to 1479)
  AUTHORS   Abdollahi,M.R., Morrison,E., Sirey,T., Molnar,Z., Hayward,B.E.,
            Carr,I.M., Springell,K., Woods,C.G., Ahmed,M., Hattingh,L.,
            Corry,P., Pilz,D.T., Stoodley,N., Crow,Y., Taylor,G.R.,
            Bonthron,D.T. and Sheridan,E.
  TITLE     Mutation of the variant alpha-tubulin TUBA8 results in
            polymicrogyria with optic nerve hypoplasia
  JOURNAL   Am J Hum Genet 85 (5), 737-744 (2009)
   PUBMED   19896110
REFERENCE   9  (bases 1 to 1479)
  AUTHORS   Blacque,O.E., Perens,E.A., Boroevich,K.A., Inglis,P.N., Li,C.,
            Warner,A., Khattra,J., Holt,R.A., Ou,G., Mah,A.K., McKay,S.J.,
            Huang,P., Swoboda,P., Jones,S.J., Marra,M.A., Baillie,D.L.,
            Moerman,D.G., Shaham,S. and Leroux,M.R.
  TITLE     Functional genomics of the cilium, a sensory organelle
  JOURNAL   Curr Biol 15 (10), 935-941 (2005)
   PUBMED   15916950
REFERENCE   10 (bases 1 to 1479)
  AUTHORS   Stanchi,F., Corso,V., Scannapieco,P., Ievolella,C., Negrisolo,E.,
            Tiso,N., Lanfranchi,G. and Valle,G.
  TITLE     TUBA8: A new tissue-specific isoform of alpha-tubulin that is
            highly conserved in human and mouse
  JOURNAL   Biochem Biophys Res Commun 270 (3), 1111-1118 (2000)
   PUBMED   10772959
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153584.5, AJ245923.1 and
            BC017631.1.
            
            On Sep 29, 2015 this sequence version replaced NM_017379.1.
            
            Summary: This gene encodes a member of the tubulin family of
            cytoskeletal proteins that form the integral component of
            microtubules. This gene is preferentially expressed in heart,
            skeletal muscle and testis. The encoded protein may play a role in
            liver tumorigenesis in mice. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017631.1, GU591980.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC153584.5         73315-73350         c
            37-1468             AJ245923.1         1-1432
            1469-1479           BC017631.1         1412-1422
FEATURES             Location/Qualifiers
     source          1..1479
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.15 cM"
     gene            1..1479
                     /gene="Tuba8"
                     /note="tubulin, alpha 8"
                     /db_xref="GeneID:53857"
                     /db_xref="MGI:MGI:1858225"
     exon            1..103
                     /gene="Tuba8"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1450
                     /gene="Tuba8"
                     /note="alpha tubulin 8"
                     /codon_start=1
                     /product="tubulin alpha-8 chain"
                     /protein_id="NP_059075.1"
                     /db_xref="CCDS:CCDS39615.1"
                     /db_xref="GeneID:53857"
                     /db_xref="MGI:MGI:1858225"
                     /translation="MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFGTQASKIN
                     DDDSFTTFFSETGNGKHVPRAVMVDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANN
                     YARGHYTVGKESIDLVLDRIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLD
                     YGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLD
                     IERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPII
                     SAEKAYHEQLSVAEITSSCFEPNSQMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAA
                     IKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLD
                     HKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGTDSFEEENEGEEF"
     exon            104..326
                     /gene="Tuba8"
                     /inference="alignment:Splign:2.1.0"
     exon            327..475
                     /gene="Tuba8"
                     /inference="alignment:Splign:2.1.0"
     exon            476..1156
                     /gene="Tuba8"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1469
                     /gene="Tuba8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1450..1455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tuba8"
                     /note="hexamer: AATATA"
     polyA_site      1469
                     /gene="Tuba8"
                     /note="major polyA site"
ORIGIN      
        1 ctccctcgca gtgtgtcaca accgcggagg cggccgtatc tggagcagtt ggggtgggca
       61 ggcccagctg ggaggcgagc gggcgaagag agcggccacg atgagggaat gcatatcggt
      121 ccatgtgggt caagccggag ttcagattgg caatgcctgc tgggagctct tctgcttgga
      181 gcacggcatc caggcggatg gaacctttgg cactcaggcc agcaagatca acgatgacga
      241 ctcctttacc accttcttca gtgagactgg caacgggaaa cacgtgcccc gggctgtcat
      301 ggtggacctg gagcctaccg tagtagatga ggtgcgggca ggaacctacc gccagctctt
      361 ccatcctgag cagctgatca caggcaagga ggatgcagct aacaattacg cccgcgggca
      421 ctatacggtg ggcaaggaga gtatcgatct ggtgctggac cgaatccgta aactgactga
      481 tgcctgctcc ggcttgcagg gcttcctcat cttccacagc tttggtgggg gcacaggatc
      541 tggctttact tctctgctga tggagcgcct ttccctagac tatggcaaga agtccaagct
      601 ggaatttgcc atctacccag ccccccaggt ctccacagca gtggtggagc cttacaactc
      661 catcctgacc acccatacca ccctggaaca ttccgactgt gctttcatgg tggataacga
      721 agccatctac gacatctgcc gcaggaacct ggatattgaa cgccccacct ataccaacct
      781 caaccgcctc atcagccaga ttgtgtcctc catcactgcc tctctccgct ttgatggcgc
      841 cctcaatgtg gacctcacag agtttcagac caacctggta ccctaccccc gaatccactt
      901 cccgctggtc acttacgccc ccatcatttc tgctgagaaa gcctaccacg agcagctgtc
      961 tgtggcagag ataactagct cctgtttcga gcccaacagc cagatggtga agtgtgaccc
     1021 acgtcatggc aaatacatgg cctgctgcat gctctaccgc ggtgatgtgg tacccaagga
     1081 cgtgaatgtc gccattgctg ccatcaagac caagagaact attcagtttg ttgactggtg
     1141 tcccacaggt ttcaaggtgg gcatcaacta ccagccacct actgtcgtgc caggagggga
     1201 cctggccaaa gtccagcgag ccgtgtgcat gctgagcaac accacagcaa tcgcagaggc
     1261 ctgggcccgc cttgaccata agtttgacct catgtacgcc aagcgggcct ttgtacattg
     1321 gtatgttgga gagggtatgg aagaaggaga gttttctgag gccagggagg acctggctgc
     1381 tctggagaag gattatgaag aagtggggac tgattcgttt gaagaagaga atgaggggga
     1441 ggaattttaa atatacactt gccccatgaa aaaaaaaaa
//
