LOCUS       NM_009447               2096 bp    mRNA    linear   ROD 28-MAR-2023
DEFINITION  Mus musculus tubulin, alpha 4A (Tuba4a), transcript variant 1,
            mRNA.
ACCESSION   NM_009447
VERSION     NM_009447.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2096)
  AUTHORS   Leca I, Phillips AW, Ushakova L, Cushion TD and Keays DA.
  TITLE     Codon modification of Tuba1a alters mRNA levels and causes a severe
            neurodevelopmental phenotype in mice
  JOURNAL   Sci Rep 13 (1), 1215 (2023)
   PUBMED   36681692
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2096)
  AUTHORS   Filova I, Pysanenko K, Tavakoli M, Vochyanova S, Dvorakova M,
            Bohuslavova R, Smolik O, Fabriciova V, Hrabalova P, Benesova S,
            Valihrach L, Cerny J, Yamoah EN, Syka J, Fritzsch B and Pavlinkova
            G.
  TITLE     ISL1 is necessary for auditory neuron development and contributes
            toward tonotopic organization
  JOURNAL   Proc Natl Acad Sci U S A 119 (37), e2207433119 (2022)
   PUBMED   36074819
REFERENCE   3  (bases 1 to 2096)
  AUTHORS   Hausrat TJ, Janiesch PC, Breiden P, Lutz D, Hoffmeister-Ullerich S,
            Hermans-Borgmeyer I, Failla AV and Kneussel M.
  TITLE     Disruption of tubulin-alpha4a polyglutamylation prevents
            aggregation of hyper-phosphorylated tau and microglia activation in
            mice
  JOURNAL   Nat Commun 13 (1), 4192 (2022)
   PUBMED   35858909
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2096)
  AUTHORS   Shah K, King GD and Jiang H.
  TITLE     A chromatin modulator sustains self-renewal and enables
            differentiation of postnatal neural stem and progenitor cells
  JOURNAL   J Mol Cell Biol 12 (1), 4-16 (2020)
   PUBMED   31065682
REFERENCE   5  (bases 1 to 2096)
  AUTHORS   Rutledge EA, Parvez RK, Short KM, Smyth IM and McMahon AP.
  TITLE     Morphogenesis of the kidney and lung requires branch-tip directed
            activity of the Adamts18 metalloprotease
  JOURNAL   Dev Biol 454 (2), 156-169 (2019)
   PUBMED   31242448
REFERENCE   6  (bases 1 to 2096)
  AUTHORS   Saito TT, Lui DY, Kim HM, Meyer K and Colaiacovo MP.
  TITLE     Interplay between structure-specific endonucleases for crossover
            control during Caenorhabditis elegans meiosis
  JOURNAL   PLoS Genet 9 (7), e1003586 (2013)
   PUBMED   23874210
REFERENCE   7  (bases 1 to 2096)
  AUTHORS   Yamamoto M, Matsuzaki T, Takahashi R, Adachi E, Maeda Y, Yamaguchi
            S, Kitayama H, Echizenya M, Morioka Y, Alexander DB, Yagi T,
            Itohara S, Nakamura T, Akiyama H and Noda M.
  TITLE     The transformation suppressor gene Reck is required for postaxial
            patterning in mouse forelimbs
  JOURNAL   Biol Open 1 (5), 458-466 (2012)
   PUBMED   23213437
REFERENCE   8  (bases 1 to 2096)
  AUTHORS   Azakir BA, Di Fulvio S, Therrien C and Sinnreich M.
  TITLE     Dysferlin interacts with tubulin and microtubules in mouse skeletal
            muscle
  JOURNAL   PLoS One 5 (4), e10122 (2010)
   PUBMED   20405035
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2096)
  AUTHORS   Holmberg M, Leonardsson G and Ny T.
  TITLE     The species-specific differences in the cAMP regulation of the
            tissue-type plasminogen activator gene between rat, mouse and human
            is caused by a one-nucleotide substitution in the cAMP-responsive
            element of the promoters
  JOURNAL   Eur J Biochem 231 (2), 466-474 (1995)
   PUBMED   7543410
REFERENCE   10 (bases 1 to 2096)
  AUTHORS   Villasante,A., Wang,D., Dobner,P., Dolph,P., Lewis,S.A. and
            Cowan,N.J.
  TITLE     Six mouse alpha-tubulin mRNAs encode five distinct isotypes:
            testis-specific expression of two sister genes
  JOURNAL   Mol Cell Biol 6 (7), 2409-2419 (1986)
   PUBMED   3785200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK620957.1, AK078355.1 and AK158934.1.
            
            [WARNING] On May 9, 2023 this sequence was replaced by NM_009447.5.
            
            On Aug 27, 2015 this sequence version replaced NM_009447.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK620957.1, AK078355.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                CK620957.1         1-41
            42-2094             AK078355.1         2-2054
            2095-2096           AK158934.1         2083-2084
FEATURES             Location/Qualifiers
     source          1..2096
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..2096
                     /gene="Tuba4a"
                     /gene_synonym="M[a]4; Tuba4"
                     /note="tubulin, alpha 4A"
                     /db_xref="GeneID:22145"
                     /db_xref="MGI:MGI:1095410"
     exon            1..102
                     /gene="Tuba4a"
                     /gene_synonym="M[a]4; Tuba4"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1446
                     /gene="Tuba4a"
                     /gene_synonym="M[a]4; Tuba4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tubulin alpha-4A chain; tubulin alpha-4 chain;
                     alpha-tubulin isotype M-alpha-4"
                     /codon_start=1
                     /product="tubulin alpha-4A chain isoform 1"
                     /protein_id="NP_033473.1"
                     /db_xref="CCDS:CCDS35623.1"
                     /db_xref="GeneID:22145"
                     /db_xref="MGI:MGI:1095410"
                     /translation="MRECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGG
                     GDDSFTTFFCETGAGKHVPRAVFVDLEPTVIDEIRNGPYRQLFHPEQLITGKEDAANN
                     YARGHYTIGKEIIDPVLDRIRKLSDQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVD
                     YGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLD
                     IERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVI
                     SAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAA
                     IKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLD
                     HKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGIDSYEDEDEGEE"
     exon            103..325
                     /gene="Tuba4a"
                     /gene_synonym="M[a]4; Tuba4"
                     /inference="alignment:Splign:2.1.0"
     exon            326..474
                     /gene="Tuba4a"
                     /gene_synonym="M[a]4; Tuba4"
                     /inference="alignment:Splign:2.1.0"
     exon            475..2096
                     /gene="Tuba4a"
                     /gene_synonym="M[a]4; Tuba4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcctcctgc ctataagagc ggtgcggcac tgcagctccg cagatctcac cgagacccgt
       61 gaccccgact ctacgtgaga cgtacagccc aaactcatca tgcgcgagtg catttcagtc
      121 catgtggggc aggcaggtgt ccagatgggc aatgcctgct gggagctcta ctgtctggaa
      181 catgggattc agcctgatgg gcagatgccc agcgataaga ccattggtgg aggggacgac
      241 tccttcacca ccttcttctg tgaaactgga gctggaaaac atgtgcctcg ggcagtcttt
      301 gtggacctgg agcctactgt aatcgatgag atccgaaatg gcccataccg tcagctcttc
      361 cacccagagc agcttatcac tgggaaagaa gatgcagcca acaactatgc ccgtggtcat
      421 tacaccattg gcaaggagat catcgaccca gtgctggacc ggatccgcaa gctgtctgat
      481 cagtgcacag gacttcaggg cttcctagta ttccacagct ttggaggggg caccggctct
      541 ggcttcacct ctctgctgat ggagcggctt tctgttgact atggcaaaaa gtccaagctg
      601 gaattctcca tctacccagc cccccaagtg tccacggctg tagtggagcc ctacaactcc
      661 atcctgacca cccataccac cctggaacac tcagactgtg ccttcatggt ggacaacgaa
      721 gccatttatg atatctgccg ccgtaaccta gatattgagc gtccaaccta taccaacctc
      781 aaccgcctca tcagccaaat tgtctcctcc atcacagctt ccttgcgctt tgatggggcc
      841 ctcaatgtgg acctgacaga gttccagacc aacctggtgc cctaccctcg catccacttc
      901 cccttggcta cctatgcacc agtcatttct gcagagaagg cctaccatga gcagctgtca
      961 gtggcagaga tcaccaatgc ctgttttgag cctgccaacc agatggtgaa atgtgaccct
     1021 cggcacggca agtacatggc ctgctgcctg ctgtaccgtg gagatgtggt gcccaaagat
     1081 gtgaatgctg ccatagctgc catcaagacg aagcgcagca tccagtttgt ggactggtgc
     1141 cccacaggct tcaaggttgg catcaactac caaccaccca ctgtggtgcc tgggggtgac
     1201 ctggccaagg tgcagcgtgc tgtgtgcatg ctgagcaaca caaccgccat tgctgaagcc
     1261 tgggcccgtc tggaccacaa gtttgacttg atgtatgcca agagggcttt tgtacactgg
     1321 tatgtgggtg agggaatgga ggagggggag ttctctgagg ctcgagagga tatggctgcc
     1381 ctggaaaaag attatgagga agtaggcatc gactcctatg aggacgagga tgagggagaa
     1441 gagtagaccg ctacttggag cctgttcact gtgtttattg caaaatcctt tcgaaataaa
     1501 cagtctcctt gcatggtttc ttgtcccctt tgtaactgct tgagcctctg cttgtccccc
     1561 tttctgcttt ggctgctacc tcccgctatt ggccgcttgt gaccttttaa ttttaccttc
     1621 acatggctga cagtgagact tgccaagggg gccccatatt gagccccaga aagcaggaac
     1681 ccaaggactt caatgtaagg tcctaaggac tcgcagaata ggaaagaaac aaggaccaaa
     1741 ccctggacct gtctgtctag ctacaagcta ttgcaagata caagtcttca ctttctgaaa
     1801 tatctgatag tctgtgttgg atgattggac tactttattc ttcttgctgc tgcttcactc
     1861 aacagctcta gaaggcttgg cccaggcgtc attgaacact gaggatttgg gaatgggggc
     1921 tgggcgggcc caaagttccc gggcatacag ccacctcaca aacttggggg atgggcagga
     1981 acaagggcaa tctagttgtt tgtgccacag cacctctggc agctttgcat agcttgctgt
     2041 ctatcttgct ttctggggct ggagccatgc tattaaaagt caggtcgtct cccctc
//
