LOCUS       NM_009446               1552 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tubulin, alpha 3A (Tuba3a), mRNA.
ACCESSION   NM_009446
VERSION     NM_009446.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1552)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1552)
  AUTHORS   Akter,M.S., Hada,M., Shikata,D., Watanabe,G., Ogura,A. and
            Matoba,S.
  TITLE     CRISPR/Cas9-based genetic screen of SCNT-reprogramming resistant
            genes identifies critical genes for male germ cell development in
            mice
  JOURNAL   Sci Rep 11 (1), 15438 (2021)
   PUBMED   34326397
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1552)
  AUTHORS   Dahlet,T., Truss,M., Frede,U., Al Adhami,H., Bardet,A.F., Dumas,M.,
            Vallet,J., Chicher,J., Hammann,P., Kottnik,S., Hansen,P., Luz,U.,
            Alvarez,G., Auclair,G., Hecht,J., Robinson,P.N., Hagemeier,C. and
            Weber,M.
  TITLE     E2F6 initiates stable epigenetic silencing of germline genes during
            embryonic development
  JOURNAL   Nat Commun 12 (1), 3582 (2021)
   PUBMED   34117224
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1552)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1552)
  AUTHORS   Wanner,N., Vornweg,J., Combes,A., Wilson,S., Plappert,J.,
            Rafflenbeul,G., Puelles,V.G., Rahman,R.U., Liwinski,T., Lindner,S.,
            Grahammer,F., Kretz,O., Wlodek,M.E., Romano,T., Moritz,K.M.,
            Boerries,M., Busch,H., Bonn,S., Little,M.H., Bechtel-Walz,W. and
            Huber,T.B.
  TITLE     DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal
            and Differentiation
  JOURNAL   J Am Soc Nephrol 30 (1), 63-78 (2019)
   PUBMED   30518531
REFERENCE   6  (bases 1 to 1552)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   7  (bases 1 to 1552)
  AUTHORS   Pohlers,M., Truss,M., Frede,U., Scholz,A., Strehle,M., Kuban,R.J.,
            Hoffmann,B., Morkel,M., Birchmeier,C. and Hagemeier,C.
  TITLE     A role for E2F6 in the restriction of male-germ-cell-specific gene
            expression
  JOURNAL   Curr Biol 15 (11), 1051-1057 (2005)
   PUBMED   15936277
REFERENCE   8  (bases 1 to 1552)
  AUTHORS   Blacque,O.E., Perens,E.A., Boroevich,K.A., Inglis,P.N., Li,C.,
            Warner,A., Khattra,J., Holt,R.A., Ou,G., Mah,A.K., McKay,S.J.,
            Huang,P., Swoboda,P., Jones,S.J., Marra,M.A., Baillie,D.L.,
            Moerman,D.G., Shaham,S. and Leroux,M.R.
  TITLE     Functional genomics of the cilium, a sensory organelle
  JOURNAL   Curr Biol 15 (10), 935-941 (2005)
   PUBMED   15916950
REFERENCE   9  (bases 1 to 1552)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
REFERENCE   10 (bases 1 to 1552)
  AUTHORS   Villasante,A., Wang,D., Dobner,P., Dolph,P., Lewis,S.A. and
            Cowan,N.J.
  TITLE     Six mouse alpha-tubulin mRNAs encode five distinct isotypes:
            testis-specific expression of two sister genes
  JOURNAL   Mol Cell Biol 6 (7), 2409-2419 (1986)
   PUBMED   3785200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV656074.1, AK132775.1 and AV259496.1.
            
            On Jan 24, 2017 this sequence version replaced NM_009446.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089547.1, AK132775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                DV656074.1         12-50
            40-1531             AK132775.1         1-1492
            1532-1552           AV259496.1         308-328
FEATURES             Location/Qualifiers
     source          1..1552
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.32 cM"
     gene            1..1552
                     /gene="Tuba3a"
                     /gene_synonym="M[a]3; Tuba3"
                     /note="tubulin, alpha 3A"
                     /db_xref="GeneID:22144"
                     /db_xref="MGI:MGI:1095406"
     exon            1..114
                     /gene="Tuba3a"
                     /gene_synonym="M[a]3; Tuba3"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1464
                     /gene="Tuba3a"
                     /gene_synonym="M[a]3; Tuba3"
                     /note="tubulin, alpha 3; alpha-tubulin 3/7; alpha-tubulin
                     isotype M-alpha-3/7"
                     /codon_start=1
                     /product="tubulin alpha-3 chain"
                     /protein_id="NP_033472.1"
                     /db_xref="CCDS:CCDS39640.1"
                     /db_xref="GeneID:22144"
                     /db_xref="MGI:MGI:1095406"
                     /translation="MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGG
                     GDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANN
                     YARGHYTIGKEIVDLVLDRIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVD
                     YGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLD
                     IERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVI
                     SAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIAT
                     IKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLD
                     HKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSVEAEAEEGEEY
                     "
     exon            115..337
                     /gene="Tuba3a"
                     /gene_synonym="M[a]3; Tuba3"
                     /inference="alignment:Splign:2.1.0"
     exon            338..486
                     /gene="Tuba3a"
                     /gene_synonym="M[a]3; Tuba3"
                     /inference="alignment:Splign:2.1.0"
     exon            487..1167
                     /gene="Tuba3a"
                     /gene_synonym="M[a]3; Tuba3"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1552
                     /gene="Tuba3a"
                     /gene_synonym="M[a]3; Tuba3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1516..1521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tuba3a"
                     /gene_synonym="M[a]3; Tuba3"
                     /note="hexamer: AATAAA"
     polyA_site      1537
                     /gene="Tuba3a"
                     /gene_synonym="M[a]3; Tuba3"
                     /note="major polyA site"
ORIGIN      
        1 gcctggactc cacatccgtc ctggactgtt gagcgcgcag accagaggcg gttgaggacc
       61 agtggtgagg aacggccgag gcggcgtctg agcgggtctc cggagttcag catgcgtgag
      121 tgtatctcta tccacgtggg gcaggcaggt gtccagatcg gcaatgcctg ctgggaactg
      181 tactgccttg aacatggcat tcagcctgac ggtcagatgc caagcgacaa aaccattggc
      241 ggcggggacg actcattcaa cacattcttc agtgagactg gagccggcaa gcacgtgccc
      301 agggcagtgt ttgtggacct ggagcccact gtggtggatg aggtgcgcac gggaacctac
      361 cggcagcttt ttcacccaga gcagctgatc actggaaagg aagatgcagc caataattat
      421 gccagaggcc actacaccat cggcaaagag attgtcgacc tggtcctgga tcgaatccga
      481 aagctggccg atctgtgcac gggactgcag ggcttcctca tcttccacag ctttggagga
      541 ggcacagggt ctgggtttgc atcgctgctg atggagcggc tttcagtgga ctatggcaag
      601 aagtccaagc tggagtttgc catctaccca gccccccagg tttctacagc ggtcgtggag
      661 ccttacaact ccatcctgac cacgcacacc accctagagc attccgactg tgctttcatg
      721 gtggataacg aagccatcta cgacatctgc cggcgcaacc tggatattga acgtcccaca
      781 tacaccaacc tcaatcgtct gattgggcag attgtgtcgt ccattacagc ctccctgagg
      841 tttgatggcg ccctgaatgt ggacttaaca gaattccaga ccaacctggt gccataccct
      901 cgcatccact tcccactggc aacctacgcc ccggtcatct cagctgagaa ggcataccat
      961 gagcagctgt cagtggcaga gatcaccaat gcttgcttcg agccagccaa tcagatggtc
     1021 aagtgtgacc ctcgccacgg caaatacatg gcctgctgca tgttgtaccg gggggatgtg
     1081 gttcccaaag atgtcaacgc ggctattgca accatcaaga caaagcgcac catccagttt
     1141 gtagattggt gtccgactgg atttaaggtg ggtattaact accagcctcc cactgtggtc
     1201 cctgggggag acctggccaa agtgcagcgg gccgtgtgca tgctgagcaa taccacggcc
     1261 atcgcagagg cctgggcccg cctggaccac aaatttgacc tcatgtacgc caagcgagcc
     1321 tttgtgcatt ggtacgtggg agaaggcatg gaggaagggg agttctccga ggcccgggag
     1381 gacctggcag cgctggagaa ggactatgaa gaggtgggcg tggattccgt ggaagcagag
     1441 gcagaagaag gggaggagta ctgagcgcat gggtctggct ggcggccgtc catttatgtc
     1501 ttccccacca ttggaaataa aggatatatt attaaaattt ctagactgag gc
//
