LOCUS       NM_009448               1977 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus tubulin, alpha 1C (Tuba1c), mRNA.
ACCESSION   NM_009448 XM_918562
VERSION     NM_009448.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1977)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1977)
  AUTHORS   Leca,I., Phillips,A.W., Ushakova,L., Cushion,T.D. and Keays,D.A.
  TITLE     Codon modification of Tuba1a alters mRNA levels and causes a severe
            neurodevelopmental phenotype in mice
  JOURNAL   Sci Rep 13 (1), 1215 (2023)
   PUBMED   36681692
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1977)
  AUTHORS   Niu,W. and Spradling,A.C.
  TITLE     Mouse oocytes develop in cysts with the help of nurse cells
  JOURNAL   Cell 185 (14), 2576-2590 (2022)
   PUBMED   35623357
REFERENCE   4  (bases 1 to 1977)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1977)
  AUTHORS   Zhao,M., Ko,S.Y., Liu,J.H., Chen,D., Zhang,J., Wang,B.,
            Harris,S.E., Oyajobi,B.O. and Mundy,G.R.
  TITLE     Inhibition of microtubule assembly in osteoblasts stimulates bone
            morphogenetic protein 2 expression and bone formation through
            transcription factor Gli2
  JOURNAL   Mol Cell Biol 29 (5), 1291-1305 (2009)
   PUBMED   19103752
REFERENCE   6  (bases 1 to 1977)
  AUTHORS   Peters,L.L., Zhang,W., Lambert,A.J., Brugnara,C., Churchill,G.A.
            and Platt,O.S.
  TITLE     Quantitative trait loci for baseline white blood cell count,
            platelet count, and mean platelet volume
  JOURNAL   Mamm Genome 16 (10), 749-763 (2005)
   PUBMED   16261417
REFERENCE   7  (bases 1 to 1977)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1977)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   9  (bases 1 to 1977)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
REFERENCE   10 (bases 1 to 1977)
  AUTHORS   Villasante,A., Wang,D., Dobner,P., Dolph,P., Lewis,S.A. and
            Cowan,N.J.
  TITLE     Six mouse alpha-tubulin mRNAs encode five distinct isotypes:
            testis-specific expression of two sister genes
  JOURNAL   Mol Cell Biol 6 (7), 2409-2419 (1986)
   PUBMED   3785200
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC157610.2.
            
            On Nov 17, 2006 this sequence version replaced NM_009448.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094022.1, AK145567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-534               AC157610.2         98132-98665         c
            535-757             AC157610.2         94240-94462         c
            758-906             AC157610.2         93959-94107         c
            907-1977            AC157610.2         90451-91521         c
FEATURES             Location/Qualifiers
     source          1..1977
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 55.61 cM"
     gene            1..1977
                     /gene="Tuba1c"
                     /gene_synonym="M[a]6; Tuba6"
                     /note="tubulin, alpha 1C"
                     /db_xref="GeneID:22146"
                     /db_xref="MGI:MGI:1095409"
     exon            1..534
                     /gene="Tuba1c"
                     /gene_synonym="M[a]6; Tuba6"
                     /inference="alignment:Splign:2.1.0"
     CDS             532..1881
                     /gene="Tuba1c"
                     /gene_synonym="M[a]6; Tuba6"
                     /note="tubulin, alpha 6; alpha-tubulin 6; tubulin alpha-6
                     chain; alpha-tubulin isotype M-alpha-6"
                     /codon_start=1
                     /product="tubulin alpha-1C chain"
                     /protein_id="NP_033474.1"
                     /db_xref="CCDS:CCDS37198.1"
                     /db_xref="GeneID:22146"
                     /db_xref="MGI:MGI:1095409"
                     /translation="MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGG
                     GDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANN
                     YARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVD
                     YGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLD
                     IERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVI
                     SAEKAYHEQLTVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAT
                     IKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLD
                     HKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGADSAEGDDEGEEY"
     exon            535..757
                     /gene="Tuba1c"
                     /gene_synonym="M[a]6; Tuba6"
                     /inference="alignment:Splign:2.1.0"
     exon            758..906
                     /gene="Tuba1c"
                     /gene_synonym="M[a]6; Tuba6"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1977
                     /gene="Tuba1c"
                     /gene_synonym="M[a]6; Tuba6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagctgtcg cagtcaccac cctgccggca gccccgggtc acctctctgg ctcactcttc
       61 cgggctccaa ggcctgggtg gggcgaccga gccacaagtg cggcggcgat cagctgtgag
      121 tccccggtgg ctgagccagg ccgcccccct ctctacctgg gactttcttc cggccagagc
      181 tccacaaaga tctcgctgtc ctccaacttc caatcgcctt ccccaccttc ttccccgccc
      241 cacctggccc tggcgtggac cctgggtgtc tcctcccctt cccacttcca gctccttcta
      301 cggagtttga tttgaacttt cgaacccgcc aatcatcggc ttcgctgcgg cccggggcgg
      361 ggtccggtgt ccgccctccc gacgcgtggc ccggccaggg tatataagcc ctgtcctgga
      421 ggcggacctt acacagcttc tcccccggac tccttggtag tctgttagtg ggagatcttc
      481 gtcacccttt ttcacttcct cagttttcgc ggaccacttc aaggactaaa tatgcgtgag
      541 tgcatctcca tccacgttgg ccaggctggt gtccagatcg gcaatgcctg ctgggagctc
      601 tactgcctgg aacatggcat ccagcctgat ggccagatgc caagtgacaa gaccattggg
      661 ggaggagatg actccttcaa caccttcttc agtgagacag gagctggcaa gcatgtgccc
      721 cgggcagtgt tcgtagacct ggaacccacg gtcatcgatg aagttcgcac cggcacctac
      781 cgccagctct tccatcctga gcagctcatc acaggcaagg aggatgctgc caataactat
      841 gcccgtggcc actacaccat tggcaaggag atcattgacc ttgtcctgga caggattcgc
      901 aagctggctg accagtgcac gggtctccag ggcttcttgg ttttccacag ctttggtggg
      961 ggaactggct ctggcttcac ctccctgctg atggagcggc tctctgtgga ttacggaaag
     1021 aagtccaagc tggagttctc catttaccca gccccccagg tttccactgc tgtggttgag
     1081 ccctacaatt ccatcctcac cacccacacc accctggagc actctgattg tgccttcatg
     1141 gtagacaatg aggccatcta tgacatctgt cgtagaaacc tcgacattga gcgcccaacc
     1201 tacaccaacc ttaaccgcct tattagccag attgtgtctt ccatcactgc ttccctcaga
     1261 tttgatgggg ccctgaatgt tgatctgaca gaattccaga ccaacctggt accctaccct
     1321 cgcatccact tccctctggc cacttatgcc cctgtcatct ctgctgagaa agcctaccat
     1381 gagcagctta cagtagcaga gatcaccaat gcctgctttg agccagccaa ccagatggtg
     1441 aaatgtgacc ctcgccatgg taaatacatg gcttgctgcc tgctgtaccg tggtgatgtg
     1501 gttcccaaag atgtcaatgc tgccattgcc accatcaaga ccaagcgtac catccagttt
     1561 gtggactggt gccccactgg cttcaaggtt ggcattaact accagcctcc cactgtggta
     1621 cccggtggtg acctggccaa ggtgcagaga gctgtgtgca tgctgagcaa caccacagcc
     1681 attgctgagg cctgggctcg cctagatcac aagtttgatc tgatgtatgc caagcgtgcc
     1741 tttgtgcact ggtatgtggg tgagggcatg gaggagggtg agttctctga ggcccgtgag
     1801 gacatggctg ccctagagaa ggattatgag gaggttgggg cagatagtgc tgaaggagac
     1861 gatgagggtg aggaatatta actcatgtgc tgccattcta tacttctgtg gtctcatctt
     1921 tgtctttgtg tgtgctctaa ctgtcctaaa ctgtcaataa aggtgtttcc gttgtaa
//
