LOCUS       NM_011653               1591 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus tubulin, alpha 1A (Tuba1a), mRNA.
ACCESSION   NM_011653
VERSION     NM_011653.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1591)
  AUTHORS   Xiong,H., Lin,B., Liu,J., Lu,R., Lin,Z., Hang,C., Liu,W., Zhang,L.,
            Ding,J., Guo,H., Zhang,M., Wang,S., Gong,Z., Xie,D., Liu,Y.,
            Shi,D., Liang,D., Liu,Z., Chen,Y.H. and Yang,J.
  TITLE     SALL2 regulates neural differentiation of mouse embryonic stem
            cells through Tuba1a
  JOURNAL   Cell Death Dis 15 (9), 710 (2024)
   PUBMED   39349437
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1591)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1591)
  AUTHORS   Wen,J., Wang,Q., Zhang,W. and Wang,W.
  TITLE     TUBA1A licenses APC/C-mediated mitotic progression to drive
            glioblastoma growth by inhibiting PLK3
  JOURNAL   FEBS Lett 597 (24), 3072-3086 (2023)
   PUBMED   37873730
  REMARK    GeneRIF: TUBA1A licenses APC/C-mediated mitotic progression to
            drive glioblastoma growth by inhibiting PLK3.
REFERENCE   4  (bases 1 to 1591)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   5  (bases 1 to 1591)
  AUTHORS   Leca,I., Phillips,A.W., Ushakova,L., Cushion,T.D. and Keays,D.A.
  TITLE     Codon modification of Tuba1a alters mRNA levels and causes a severe
            neurodevelopmental phenotype in mice
  JOURNAL   Sci Rep 13 (1), 1215 (2023)
   PUBMED   36681692
  REMARK    GeneRIF: Codon modification of Tuba1a alters mRNA levels and causes
            a severe neurodevelopmental phenotype in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1591)
  AUTHORS   Kaminska,B., Kaczmarek,L. and Grzelakowska-Sztabert,B.
  TITLE     Inhibitors of polyamine biosynthesis affect the expression of genes
            encoding cytoskeletal proteins
  JOURNAL   FEBS Lett 304 (2-3), 198-200 (1992)
   PUBMED   1618323
REFERENCE   7  (bases 1 to 1591)
  AUTHORS   Birkenmeier,E.H., Gwynn,B., Howard,S., Jerry,J., Gordon,J.I.,
            Landschulz,W.H. and McKnight,S.L.
  TITLE     Tissue-specific expression, developmental regulation, and genetic
            mapping of the gene encoding CCAAT/enhancer binding protein
  JOURNAL   Genes Dev 3 (8), 1146-1156 (1989)
   PUBMED   2792758
REFERENCE   8  (bases 1 to 1591)
  AUTHORS   Villasante,A., Wang,D., Dobner,P., Dolph,P., Lewis,S.A. and
            Cowan,N.J.
  TITLE     Six mouse alpha-tubulin mRNAs encode five distinct isotypes:
            testis-specific expression of two sister genes
  JOURNAL   Mol Cell Biol 6 (7), 2409-2419 (1986)
   PUBMED   3785200
REFERENCE   9  (bases 1 to 1591)
  AUTHORS   Lewis,S.A., Lee,M.G. and Cowan,N.J.
  TITLE     Five mouse tubulin isotypes and their regulated expression during
            development
  JOURNAL   J Cell Biol 101 (3), 852-861 (1985)
   PUBMED   3839797
REFERENCE   10 (bases 1 to 1591)
  AUTHORS   Howe,C.C., Lugg,D.K. and Overton,G.C.
  TITLE     Post-transcriptional regulation of the abundance of mRNAs encoding
            alpha-tubulin and a 94,000-dalton protein in
            teratocarcinoma-derived stem cells versus differentiated cells
  JOURNAL   Mol Cell Biol 4 (11), 2428-2436 (1984)
   PUBMED   6513923
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC161165.5.
            
            On Mar 21, 2007 this sequence version replaced NM_011653.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M13445.1, BC085256.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC161165.5         162800-162850       c
            52-274              AC161165.5         160818-161040       c
            275-423             AC161165.5         160537-160685       c
            424-1591            AC161165.5         159196-160363       c
FEATURES             Location/Qualifiers
     source          1..1591
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 55.29 cM"
     gene            1..1591
                     /gene="Tuba1a"
                     /gene_synonym="Tuba-1; Tuba1"
                     /note="tubulin, alpha 1A"
                     /db_xref="GeneID:22142"
                     /db_xref="MGI:MGI:98869"
     exon            1..51
                     /gene="Tuba1a"
                     /gene_synonym="Tuba-1; Tuba1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1404
                     /gene="Tuba1a"
                     /gene_synonym="Tuba-1; Tuba1"
                     /note="tubulin, alpha 1; alpha-tubulin 1; tubulin alpha-1
                     chain; alpha-tubulin isotype M-alpha-1; Talpha1
                     alpha-tubulin"
                     /codon_start=1
                     /product="tubulin alpha-1A chain"
                     /protein_id="NP_035783.1"
                     /db_xref="CCDS:CCDS37196.1"
                     /db_xref="GeneID:22142"
                     /db_xref="MGI:MGI:98869"
                     /translation="MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGG
                     GDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANN
                     YARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVD
                     YGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLD
                     IERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVI
                     SAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAT
                     IKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLD
                     HKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEE
                     Y"
     exon            52..274
                     /gene="Tuba1a"
                     /gene_synonym="Tuba-1; Tuba1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..423
                     /gene="Tuba1a"
                     /gene_synonym="Tuba-1; Tuba1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..1591
                     /gene="Tuba1a"
                     /gene_synonym="Tuba-1; Tuba1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcctcctc gcctccgcca tccacccggc agccgcgaag cagcaaccat gcgtgagtgc
       61 atctccatcc atgttggcca ggctggtgtc cagatcggca atgcctgctg ggagctctac
      121 tgcctggaac atggcatcca gcctgatggc cagatgccaa gtgacaagac cattggggga
      181 ggagatgact ccttcaacac cttcttcagt gagacaggag ctggcaagca tgtgccccgg
      241 gcagtgttcg tagacctgga acccacggtc atcgatgaag ttcgcaccgg cacctaccgc
      301 cagctcttcc accctgagca gctcatcaca ggcaaggagg atgctgccaa taactatgct
      361 cgtggccact acaccattgg caaggagatc attgaccttg tcctggacag gattcgcaag
      421 ctggctgacc agtgcacagg tctccagggc ttcttggttt tccacagctt tggcggggga
      481 actggctctg gcttcacctc cctgctgatg gagcggctct ctgtggatta cggaaagaag
      541 tccaagctgg agttctccat ttacccagcc ccccaggttt ccactgctgt ggttgagccc
      601 tacaattcca tcctcaccac ccacaccacc ctggagcact ctgattgtgc cttcatggta
      661 gacaatgagg ccatctatga tatctgtcgt agaaacctcg acattgagcg cccaacctac
      721 actaacctaa acaggttgat aggtcaaatt gtgtcttcca tcactgcttc cctcagattt
      781 gatggggccc tgaatgttga tctgacagaa ttccagacca acctggtacc ctaccctcgt
      841 atccacttcc ctctggccac ttatgcccct gtcatctctg ctgagaaagc ctaccacgag
      901 cagctttctg tagcagagat caccaatgcc tgctttgagc cagccaacca gatggtgaaa
      961 tgtgaccctc gccatggtaa atacatggct tgctgcctgc tgtaccgtgg tgatgtggtt
     1021 cccaaagatg tcaatgctgc cattgccacc atcaagacca agcgtaccat ccagtttgtg
     1081 gactggtgcc ccactggctt caaggttggc attaactacc agcctcccac tgtggtaccc
     1141 ggtggtgacc tggccaaggt gcagagagct gtgtgcatgc tgagcaacac cacagccatt
     1201 gctgaggcct gggctcgcct agatcacaag tttgatctga tgtatgccaa gcgtgccttt
     1261 gtgcactggt atgtgggtga gggcatggag gagggtgagt tctctgaggc ccgtgaggac
     1321 atggctgccc tagagaagga ttatgaggag gttggtgtgg attctgtgga aggcgagggg
     1381 gaggaagaag gagaggaata ctaaattaaa tgtcacaagg tgctgcttcc acagggatgt
     1441 ttattgtgtt ccaacacaga aagttgtggt ctgatcagtt aatttgtatg tggcaatgtg
     1501 tgctttcata cagttactga cttatgaatg attgatttga cagagaccca agctgcccat
     1561 ttcacttatg ggttttaaat aaaatactcc c
//
