LOCUS       NM_021885               5941 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus TUB bipartite transcription factor (Tub), mRNA.
ACCESSION   NM_021885
VERSION     NM_021885.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5941)
  AUTHORS   de Oliveira Micheletti,T., Cassia Dos Santos,A., Rocha,G.Z.,
            Silva,V.R.R., Quaresma,P.G.F., Assalin,H.B., Junqueira,F.S.,
            Ropelle,E.R., Oliveira,A.G., Saad,M.J.A. and Prada,P.O.
  TITLE     Acute exercise reduces feeding by activating IL-6/Tubby axis in the
            mouse hypothalamus
  JOURNAL   Front Physiol 13, 956116 (2022)
   PUBMED   36452038
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5941)
  AUTHORS   Youn,S.Y., Min,H., Jeong,S.R., Lee,J., Moon,S.J., Bok,J. and
            Kim,C.H.
  TITLE     Microtubule-associated protein 1 A and tubby act independently in
            regulating the localization of stereocilin to the tips of inner ear
            hair cell stereocilia
  JOURNAL   Mol Brain 15 (1), 80 (2022)
   PUBMED   36104704
  REMARK    GeneRIF: Microtubule-associated protein 1 A and tubby act
            independently in regulating the localization of stereocilin to the
            tips of inner ear hair cell stereocilia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5941)
  AUTHORS   Remez,L., Cohen,B., Nevet,M.J., Rizel,L. and Ben-Yosef,T.
  TITLE     TULP1 and TUB Are Required for Specific Localization of PRCD to
            Photoreceptor Outer Segments
  JOURNAL   Int J Mol Sci 21 (22), 8677 (2020)
   PUBMED   33213002
  REMARK    GeneRIF: TULP1 and TUB Are Required for Specific Localization of
            PRCD to Photoreceptor Outer Segments.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5941)
  AUTHORS   Han,W., Shin,J.O., Ma,J.H., Min,H., Jung,J., Lee,J., Kim,U.K.,
            Choi,J.Y., Moon,S.J., Moon,D.W., Bok,J. and Kim,C.H.
  TITLE     Distinct roles of stereociliary links in the nonlinear sound
            processing and noise resistance of cochlear outer hair cells
  JOURNAL   Proc Natl Acad Sci U S A 117 (20), 11109-11117 (2020)
   PUBMED   32358189
REFERENCE   5  (bases 1 to 5941)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5941)
  AUTHORS   Heckenlively,J.R., Chang,B., Erway,L.C., Peng,C., Hawes,N.L.,
            Hageman,G.S. and Roderick,T.H.
  TITLE     Mouse model for Usher syndrome: linkage mapping suggests homology
            to Usher type I reported at human chromosome 11p15
  JOURNAL   Proc Natl Acad Sci U S A 92 (24), 11100-11104 (1995)
   PUBMED   7479945
REFERENCE   7  (bases 1 to 5941)
  AUTHORS   Ohlemiller,K.K., Hughes,R.M., Mosinger-Ogilvie,J., Speck,J.D.,
            Grosof,D.H. and Silverman,M.S.
  TITLE     Cochlear and retinal degeneration in the tubby mouse
  JOURNAL   Neuroreport 6 (6), 845-849 (1995)
   PUBMED   7612867
REFERENCE   8  (bases 1 to 5941)
  AUTHORS   Warden,C.H., Fisler,J.S., Shoemaker,S.M., Wen,P.Z., Svenson,K.L.,
            Pace,M.J. and Lusis,A.J.
  TITLE     Identification of four chromosomal loci determining obesity in a
            multifactorial mouse model
  JOURNAL   J Clin Invest 95 (4), 1545-1552 (1995)
   PUBMED   7706460
REFERENCE   9  (bases 1 to 5941)
  AUTHORS   Jones,J.M., Meisler,M.H., Seldin,M.F., Lee,B.K. and Eicher,E.M.
  TITLE     Localization of insulin-2 (Ins-2) and the obesity mutant tubby
            (tub) to distinct regions of mouse chromosome 7
  JOURNAL   Genomics 14 (1), 197-199 (1992)
   PUBMED   1358794
REFERENCE   10 (bases 1 to 5941)
  AUTHORS   Coleman,D.L. and Eicher,E.M.
  TITLE     Fat (fat) and tubby (tub): two autosomal recessive mutations
            causing obesity syndromes in the mouse
  JOURNAL   J Hered 81 (6), 424-427 (1990)
   PUBMED   2250094
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147700.1 and BC096554.1.
            
            On Dec 23, 2005 this sequence version replaced NM_021885.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147700.1, BC096554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AK147700.1         56-150
            96-5809             BC096554.1         77-5790
            5810-5941           AK147700.1         5865-5996
FEATURES             Location/Qualifiers
     source          1..5941
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.21 cM"
     gene            1..5941
                     /gene="Tub"
                     /gene_synonym="rd5"
                     /note="TUB bipartite transcription factor"
                     /db_xref="GeneID:22141"
                     /db_xref="MGI:MGI:2651573"
     exon            1..259
                     /gene="Tub"
                     /gene_synonym="rd5"
                     /inference="alignment:Splign:2.1.0"
     exon            260..311
                     /gene="Tub"
                     /gene_synonym="rd5"
                     /inference="alignment:Splign:2.1.0"
     exon            312..474
                     /gene="Tub"
                     /gene_synonym="rd5"
                     /inference="alignment:Splign:2.1.0"
     exon            475..618
                     /gene="Tub"
                     /gene_synonym="rd5"
                     /inference="alignment:Splign:2.1.0"
     exon            619..786
                     /gene="Tub"
                     /gene_synonym="rd5"
                     /inference="alignment:Splign:2.1.0"
     exon            787..905
                     /gene="Tub"
                     /gene_synonym="rd5"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1103
                     /gene="Tub"
                     /gene_synonym="rd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1216
                     /gene="Tub"
                     /gene_synonym="rd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1334
                     /gene="Tub"
                     /gene_synonym="rd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1433
                     /gene="Tub"
                     /gene_synonym="rd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1605
                     /gene="Tub"
                     /gene_synonym="rd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..5941
                     /gene="Tub"
                     /gene_synonym="rd5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5787..5792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tub"
                     /gene_synonym="rd5"
                     /note="hexamer: AATAAA"
     polyA_site      5809
                     /gene="Tub"
                     /gene_synonym="rd5"
                     /note="major polyA site"
ORIGIN      
        1 gcactcccgc cgcctctccc gagcgctgca ccgcgcacag acaaccgttc tgggagcccg
       61 cggccggggc cctggcgtgc agagagggcc tcggcggggc ccagcggtcg ggccggggag
      121 gatgcggccc ggggcggccc gagagttgag cagggtcccc gcgccagccc cgagcggtcc
      181 cggccaccgg agccgcagcc gccgccccgc ccccgggaga catgacttcc aagccgcatt
      241 ccgactggat tccttacagt gtcctagatg atgagggcag caacctgagg cagcagaagc
      301 tcgaccggca gcgggccctg ttggaacaga agcagaagaa gaagcgccaa gagcccttga
      361 tggtacaggc caatgcagat ggacggcccc ggagtcggcg agcccggcag tcagaggagc
      421 aagcccccct ggtggagtcc tacctcagca gcagtggcag caccagctac caagttcaag
      481 aggccgactc gattgccagt gtacagctgg gagccacccg cccaccagca ccagcctcag
      541 ccaagaaatc caagggagcg gctgcatctg ggggccaggg tggagcccct aggaaggaga
      601 agaagggaaa gcataaaggc accagcgggc cagcaactct ggcagaagac aagtctgagg
      661 cccaaggccc agtgcagatc ttgactgtgg gacagtcaga ccacgacaag gatgcgggag
      721 agacagcagc cggcgggggc gcacagccca gtgggcagga cctccgtgcc acgatgcaga
      781 ggaagggcat ctccagcagc atgagctttg acgaggacga ggatgaggat gaaaacagct
      841 ccagctcctc ccagctaaac agcaacaccc gccctagttc tgccactagc agaaagtcca
      901 tccgggaggc agcttcagcc cccagcccag ccgccccaga gccaccagtg gatattgagg
      961 tccaggatct agaggagttt gcactgaggc cagccccaca agggatcacc atcaaatgcc
     1021 gcatcactcg ggacaagaag gggatggacc gcggcatgta ccccacctac tttctgcacc
     1081 tagaccgtga ggatggcaag aaggtgttcc tcctggcggg caggaagaga aagaagagta
     1141 aaacttccaa ttacctcatc tctgtggacc caacagactt gtctcgggga ggcgatagct
     1201 atatcgggaa attgcggtcc aacctgatgg gcaccaagtt caccgtttat gacaatggcg
     1261 tcaaccctca gaaggcatcc tcttccacgc tggaaagcgg aaccttgcgc caggagctgg
     1321 cagcggtgtg ctatgagaca aatgtcctag gcttcaaggg acctcggaag atgagtgtga
     1381 tcgtcccagg catgaacatg gttcatgaga gagtctgtat ccgcccccgc aatgaacatg
     1441 agaccctgtt agcacgctgg cagaacaaga acacggagag catcattgag ctgcagaaca
     1501 agacgccagt ctggaatgat gacacacagt cctatgtact taacttccac ggccgtgtca
     1561 cacaggcttc tgtgaagaac ttccagatca tccacggcaa tgacccggac tacatcgtca
     1621 tgcagtttgg ccgggtagca gaagatgtgt tcaccatgga ttacaactac ccactgtgtg
     1681 cactgcaggc ctttgccatt gctctgtcca gctttgacag caagctggcc tgcgagtaga
     1741 ggccccccac tgcctttagg tggcccagtc cggagtggag cttgcctgcc tgccaagaca
     1801 gccctgccta ccctctgttc ataggccctc tatgggcttt ctggccttac caaccagaga
     1861 ctggctgctc tgcctctgct gctgaagcag gggggacagc aaatgggtat gacaggagaa
     1921 gaatatttct gtgccccaag gtcaacacac atgcccagtc ctgggtcagt cccctgctgc
     1981 agtggtgtta tcacaccgga aagcctcttc acctggaggt acagagggag aggaagcaca
     2041 agcctggctg ctgtggctca gccatccact cagcctacga gtcagagaca gtgggtgtcc
     2101 cgggaagcag gggtacagtg agtgtgtgtg tatgtacagg gcactcaagc tgtatgtaga
     2161 aaaagctctg gtggtcagca gaaagcactc ccacttcaaa agggcccatt aggcccaaag
     2221 ggggttagga gtggtaggga taggtgcgtg gcaggtccct gctaggattg caggggcctg
     2281 gccatgtgta ttagctggag gcttagaatg ctagctcatt tgttgctaca gatttgccca
     2341 gtgcttgcac acgtaagaac ccagctctca aggccaaata tctgagtgga tggggatgat
     2401 aggagtcatc cagtagactc cctacatcag ggctctcagc agccccagca caacacctat
     2461 gacacacaca caggatctag gtcaccattc aagtaatggt atgcttcagg aagaatgtcc
     2521 tctctgggaa gactcagctc ccattattgc cagcatgcca tgatcagtga gggctgtgtg
     2581 ccatgcttag ggggatggcg cagggtgagg ggagcagagg atattttagg gccacaagag
     2641 ctcagaggta gcggacctct gtgtggttca ccaacagcaa tgctgatccc tgagtatagg
     2701 gcacatgtct cttggttacc tcactggtta atggcagagt tgagaacctc aaattctttt
     2761 gttcctactg ttgcccagaa actagactct ctgacctgct agggtctatt ctgcatgtcc
     2821 tttctcttcc cagttccaga gatgaaaccc ctccgagtta atgtataagg ttggaaacct
     2881 ttcagtaggg aatcaggcag ttccctgttg aaagttgtct gagtttttgc acaccattct
     2941 gatctgatgt ggcctgtgcc tggctcctct atgaggactt cgagctgtgc acagacctta
     3001 gcaggaccac tgcacacttt gtgtctgtgt gacaggcagc ccaagggttc tggggctggg
     3061 cttggacacg ccctccattg ggatggcacc actcatctgg tgggcttggg aactccaagc
     3121 tcttgcctgt gtgccatctg tgagaagctt cttggagctg agacaccaga gggaagcaaa
     3181 gagcatttag acattgcttt ttgctttgaa atagatatgt ttggaaacgc taagtagaag
     3241 tttaaaaagt agagtcatgt agagtcatgc tttgaatatg tgggtcatgc tttagatatg
     3301 aagaggctat gcaggtaagg aggctggatt gatgtaaatg gaagtagtac tttaagaaag
     3361 ctctagattt cccaggttgg acactcgacg aaaggcacac ctgctgcagc aggttctgac
     3421 acacctgagc catacattgc catcagagaa ccctcagcga ggtagccttt gtttacagtc
     3481 tagtttctag agggcagtag gacttccatg ctggggctgg cctatctcct gatgaaagat
     3541 tacagtgcca tctccttccc atagttctgt gtctgccctc cctccctgac tttataggga
     3601 gaaatctcct gacattagag gtgatagaaa ccagagcttt agtctagtca ggctgtttct
     3661 ctgggttgac aagtttaagg ttgaacaggc tgatttctgg aatctcatga gtggagggga
     3721 ccctggtggt taagagcgga actggaagca caatggaaaa ctcttggact ctgctctctg
     3781 ctttaccaca cacaaaaaag agggttcttg gctatttgaa tataaagttg gtagcaccag
     3841 gaaataggct gaactttgta gcccactgtg gaaaggagca gcctcagcac aaacccctct
     3901 gtcgggccct gagtgacaag accagcctca caaggtcaga ttttaagact cagctcctgg
     3961 tgataatgcc ttttcttgac cactggcgct gtgaacacag gctaatggac ttcagatacc
     4021 agggccccgg gatcacctgg gttagcctct cccacaggaa gatcccttac ccctcatccc
     4081 ctcttctttt tggtccttgg ctgggtagca aattggtgag aagagcagcc tagtctgtaa
     4141 gagtgcaggg cagctggaac cttaggcagc tcctctgtat gctaccggct ccacacccta
     4201 acactctcca ccctctgctc caaaccagtt cttctgcaga gtggtgatgt tagcttcccc
     4261 agctcctctc caagtctagc tttttctgtc cttctggctc caaggtgctc tgtgtctgtg
     4321 tgtgtgtgtc tgtctgtgtg tgtgtgtgtc gaggaaaggg caatctgcaa acaatgaaca
     4381 gaagtttaag atcacatcag agtagggaaa gacaacggag gcagtggtga ccactgtgga
     4441 ctgtggatgg tgccccttca ttccatgctc tttctcccat ggttctgagc aggcgactgt
     4501 caaggaagtg tgttgtcagt tcactggagg aggagctgag atgtgcaccc ttttaaatga
     4561 acatggggtg gtgatggtgc cttaacaatc ttgacactaa ggtgaagcaa gcaagtaagg
     4621 tgtgtgcctc tgggaagaca ggagtcggaa gccaaggtgt gtggcaacag tctggaagag
     4681 agcttttggt aatcataccg tcttcagtga caaggcaaca atgctgtaaa gtgggtttgt
     4741 ttggttttgt tttttctttc tcttttatgg aaatggcagg tctatttgcc tcaaacgtta
     4801 tgtagaagta gttctaagtt taacaagcaa tagagatgac tgcttagcta ggatctgcag
     4861 ggagctctgc tctgcaagca caacacctgt ctcatagatg gacagcctgg tttcccttct
     4921 cagcagtcct ggcctcccct tctctgtatt ccttgcccca gctacgatat cctcatggga
     4981 tttcaggatg ccaggtgcca tcaaagcatg cttttttgtg gtgcctagca ctgtgactgg
     5041 ggcccaactg ccctgcagag ttgggacctt gcactgccct agaccctggc tttagatctg
     5101 cttcagtctc cagaacaggc tatgggatag atttttcttt cagtttatgg ccacctgccc
     5161 aaattgactt ccagcttaca atcttctgtc atttcaagat cgtaagaagt actgggatgg
     5221 gtttgagttt tcagcacaga ggcgagttga tctaggagca tacaactgta ctgagcagct
     5281 agagcatttg agcaacccat gtaatctttg tgtttccctc cctgtaagaa ggcctgtcag
     5341 agcttgctgt aggagttagg gtaaatgaaa gttagtcctg gctctcatca ccacctttcc
     5401 tagctcatca ctgtgccttc tttcttccct aagaaagaca atgcacccct ctcttctgtt
     5461 ctcctgcccc ttcgccccca ctgaggtcca ggtagagcag atgaggctga aatgtagagt
     5521 gttctataga gcatctcagt agcatagaag gagaagccca gctccaacct cctggacccc
     5581 atactggtga ccagcttggt gaggacaggc aaaatttctc tagctgagag cacacttagc
     5641 cagttttcac gcctagaaca tatatgtcga tttgcacatg attgtctttt cctattttgg
     5701 agtggtcaga cattttattt ttgttcaaaa ttatctggag ttttagacaa acttgcaaaa
     5761 ctgtgctttt attaagtgac tttttgaata aactttttgg tattctgaag caaatgtatt
     5821 tatttattgg tatgtgcaat gacaaacttg gtattttccc ataatgacat tatgtatgtt
     5881 gtagaattta gtgtttgtct aagtacagac atgtatcaac acattaaact tgaactgttt
     5941 g
//
