LOCUS       NM_053273               3456 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Mus musculus tweety family member 2 (Ttyh2), mRNA.
ACCESSION   NM_053273
VERSION     NM_053273.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3456)
  AUTHORS   Melvin,E., Kalaninova,Z., Shlush,E., Man,P., Giladi,M. and
            Haitin,Y.
  TITLE     TTYH family members form tetrameric complexes at the cell membrane
  JOURNAL   Commun Biol 5 (1), 886 (2022)
   PUBMED   36042377
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3456)
  AUTHORS   Li,B., Hoel,C.M. and Brohawn,S.G.
  TITLE     Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a
            Ca2+-dependent switch from intra- to intermembrane dimerization
  JOURNAL   Nat Commun 12 (1), 6913 (2021)
   PUBMED   34824283
  REMARK    GeneRIF: Structures of tweety homolog proteins TTYH2 and TTYH3
            reveal a Ca(2+)-dependent switch from intra- to intermembrane
            dimerization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3456)
  AUTHORS   Han,Y.E., Kwon,J., Won,J., An,H., Jang,M.W., Woo,J., Lee,J.S.,
            Park,M.G., Yoon,B.E., Lee,S.E., Hwang,E.M., Jung,J.Y., Park,H.,
            Oh,S.J. and Lee,C.J.
  TITLE     Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of
            the Swelling-dependent Volume-regulated Anion Channel (VRACswell)
            in the Brain
  JOURNAL   Exp Neurobiol 28 (2), 183-215 (2019)
   PUBMED   31138989
REFERENCE   4  (bases 1 to 3456)
  AUTHORS   Hupe,M., Li,M.X., Kneitz,S., Davydova,D., Yokota,C., Kele,J.,
            Hot,B., Stenman,J.M. and Gessler,M.
  TITLE     Gene expression profiles of brain endothelial cells during
            embryonic development at bulk and single-cell levels
  JOURNAL   Sci Signal 10 (487) (2017)
   PUBMED   28698213
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3456)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   6  (bases 1 to 3456)
  AUTHORS   Rae,F.K., Hooper,J.D., Eyre,H.J., Sutherland,G.R., Nicol,D.L. and
            Clements,J.A.
  TITLE     TTYH2, a human homologue of the Drosophila melanogaster gene
            tweety, is located on 17q24 and upregulated in renal cell carcinoma
  JOURNAL   Genomics 77 (3), 200-207 (2001)
   PUBMED   11597145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY352523.1, BY740853.1, AF329682.1, BY731753.1 and AL663079.9.
            
            On Jul 6, 2005 this sequence version replaced NM_053273.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154835.1, AK155166.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               BY352523.1         39-198
            161-568             BY740853.1         141-548
            569-1102            AF329682.1         512-1045
            1103-1331           BY731753.1         414-642
            1332-1675           AF329682.1         1272-1615
            1676-3456           AL663079.9         38371-40151
FEATURES             Location/Qualifiers
     source          1..3456
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 79.85 cM"
     gene            1..3456
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /note="tweety family member 2"
                     /db_xref="GeneID:117160"
                     /db_xref="MGI:MGI:2157091"
     exon            1..205
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1675
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /note="mTTY2; tweety homolog 2; volume-regulated anion
                     channel subunit Ttyh2"
                     /codon_start=1
                     /product="protein tweety homolog 2"
                     /protein_id="NP_444503.2"
                     /db_xref="CCDS:CCDS25608.1"
                     /db_xref="GeneID:117160"
                     /db_xref="MGI:MGI:2157091"
                     /translation="MPAARVEYIAPWWVVWLHSVPHLGLRLQRVDSTFSPGDETYQES
                     LLFLGVLAAIGLGLNLIFLTVYLVCTCCCRRDHTVQTKQQESCCVTWTAVVAGLLCCA
                     AVGVGFYGNSETNDGMHQLIYSLDNANHTFSGMDELVSANTQRMKVDLEQHLARLSEI
                     IAARGDYIQTLKFMQQMAGNVVSQLSGLPVWREVTTQLTKLSHQTAYVEYYRWLSYLL
                     LFILDLVICLVTCLGLARRSKCLLASMLCCGILTLILSWASLAADAAAAVGTSDFCMA
                     PDIYILNNTGSQINSEVTRYYLHCSQSLISPFQQSLTTFQRSLTTMQIQVGGLLQFAV
                     PLFPTAEKDLLGIQLLLNNSEISLHQLTAMLDCRGLHKDYLDALTGICYDGIEGLLFL
                     GLFSLLAALAFSTLTCAGPRAWKYFINRDRDYDDIDDDDPFNPQARRIAAHNPTRGQL
                     HSFCSYSSGLGSQCSLQPPSQTISNAPVSEYMNQAILFGGNPRYENVPLIGRGSPPPT
                     YSPSMRPTYMSVADEHLRHYEFPS"
     exon            206..378
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            379..490
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            491..711
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            712..807
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            808..880
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            881..950
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1006
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1099
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1192
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1335
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1521
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1600
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..3456
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3431..3436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3449
                     /gene="Ttyh2"
                     /gene_synonym="1110001A03Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgggtcgctt ccgagccggg tagtggtggt agcggcgttg gcaggggcag tggacccgct
       61 gcagcttgtg caagccatgc cggcggcgcg agtggagtac atcgcgccct ggtgggtcgt
      121 gtggctgcac agcgttccgc acctcggcct gcgcctgcag cgagtagaca gcaccttcag
      181 ccccggcgac gaaacttacc aggagtcgct gctcttcctg ggggtgttgg ctgccattgg
      241 cctgggcctg aatctcatct tcctcaccgt ctacctggtg tgcacatgct gctgccggcg
      301 ggaccacacg gtgcagacca agcagcagga atcatgctgc gtgacctgga cggcggtggt
      361 ggctgggctc ctctgctgtg ctgcggtggg cgttggtttc tatggaaaca gcgagaccaa
      421 cgatgggatg catcagctga tctactccct ggacaacgcg aaccacacct tctctggaat
      481 ggatgagctg gtgtctgcaa acacccagag gatgaaggta gacctagaac agcacctggc
      541 ccggctcagc gagatcattg ctgcccgggg tgactacatc cagaccctga agtttatgca
      601 acagatggca ggcaatgtcg tcagccagct ctcggggctg cccgtgtgga gggaggtcac
      661 cacgcagctg accaagctgt cccaccagac tgcctatgtg gaatactaca ggtggctgtc
      721 ctacctcctg cttttcatcc ttgacctggt catctgcctt gtcacctgcc tgggactggc
      781 caggcggtcc aagtgtctcc tagcctccat gctgtgctgt ggaatactga ccctgatcct
      841 cagctgggct tctctggctg ctgatgctgc tgcagcagtg ggcaccagtg acttctgcat
      901 ggctcctgac atctacatcc tgaacaacac agggagccag atcaactcag aggtgacccg
      961 gtactacctc cattgcagtc agagcctaat cagcccgttc cagcagtcac tgaccacctt
     1021 ccagcgctca ttgaccacca tgcagatcca ggttggaggc ctgctgcagt ttgccgtgcc
     1081 cctcttccct acagcagaga aagaccttct tggcatccag cttctgctaa acaactccga
     1141 gatcagcctg caccagttga ccgccatgtt ggattgccga gggctgcaca aggactacct
     1201 agacgccctc actggcatct gctatgatgg cattgagggc ctgctcttcc ttggtctctt
     1261 ctccctcttg gctgccctgg ctttctccac cctgacctgt gccggacctc gtgcctggaa
     1321 atacttcatc aacagggaca gagattatga tgacatcgac gacgatgacc ctttcaaccc
     1381 ccaagctcgg cgcatcgcgg cccataaccc cacgaggggg caactgcaca gtttctgcag
     1441 ctacagcagc ggccttggca gccagtgcag ccttcagcct ccctcccaga ccatctccaa
     1501 tgccccagtc tctgagtaca tgaaccaggc catactcttt ggtgggaacc cacgatacga
     1561 aaatgtgcca ctcatcggga gaggttcccc tccgcccaca tactctccca gcatgagacc
     1621 cacctacatg tccgtggcgg atgaacacct gagacactac gagttcccgt cctaggggct
     1681 ttcagtgtac ctgcctcttc tgccagctcg gttctcagca gatgcagaac ccagctgtgt
     1741 ttctggaata gaaaccgaag gttcctggac acgaacaggc tcctgtggct gcagagacac
     1801 agctgggact cctgaccaaa gccacaggtg gacgtgaggc ctgtgactgg accagcctct
     1861 ccggccttaa ctcccccagg actcagctgt tgtccctgag gcagctgccc gcttcagccc
     1921 accttaagtc ccaccctcag cagatgaaaa atggtaattg aggaggggac caccagcctg
     1981 agagcccttt tctctaaagg cccttccatt gggctcctgc ctcttgttag cgtggcccta
     2041 actaagtcca ggccacaccc tccagttact tggtccttgg tttctaggcg gtggcaattg
     2101 gaggtgtgtt aggagaacac ctggtccagg atctacgttc tgggaccaca gggactctgc
     2161 ctagatgcca gaaggacagc atcaagagat ctccccagag gggatgggtg gcttcaagct
     2221 gggcactgca gcctggcagc catgggcaca attctctaac ctccaccagc caaccccatt
     2281 ctggaaccag gtgtcagctg caggtgggga cagtctcagg tatgaacaga cactttgaaa
     2341 gcacctgaac aggttcccag tgttttaaaa caggttgatg atccaaagac tcacgcctcc
     2401 cgcaggcacg gccaatactt gcaatagact caggctcggt tgggttttat acccgatgtt
     2461 ctactgtggc tctcacacaa gccatcttac agatctggag gagaggccaa ggagtgagct
     2521 gtggggtttt tggggttttg ttttgctgcg gtctccttat ataccctgac tggccctggc
     2581 ctagaactca tagagatctg cctgcctctg tctgcagagt actgggctca aaggcgtgtg
     2641 ctaccacacc acaccaggcc aggagcagat ttgctttgat tttttttttt tttttttttt
     2701 ttttgagaca gggtttctct gtgtagccct agcttgtcct tgaactcatt ctatagacca
     2761 gactaacctc aaattcagag atcacctgcc tctgccttga gagtgccagg attaaagggt
     2821 gcgccatgat gccacatcct ggtcttttgg cttttttttt ttttttttaa taagatatca
     2881 gtgagacatt ctaccccaca cggctagaga aggacatctg gagccttgta aagggaaaga
     2941 catgatagct aagaaggccg agggacttca ttctgaggaa cagccacttc tggccaggag
     3001 aaaataataa cccctgtcct gcctgccaag ggacaggtta ggggtctttg gtgcttccaa
     3061 cctctgacca acccagagta cactacacac cgaagccccg tggccttgtg cagccaagcg
     3121 aggccctact gatggtgcgg gacagggatg tgtccatttc agaagagcca cattgtcatt
     3181 gtactggcag ctcccagcca agccaccggc gtcactgtgt ctcatattaa cctgtgcata
     3241 ctgtgagcga cctttgtatg cctgtgtcct gtgcagactc ggagctttga cctcaggcct
     3301 tgctcctgat gtctcctctg cagcagctga aggacttttt aatgcatgta cattaaacta
     3361 aaactcctcc gggttctaca agagtcgggt gggcaaacct cttcttgatc catgttcgcc
     3421 ctcccccaga aataaaccac ttcccttaag atgtgc
//
