LOCUS       NM_015767               3189 bp    mRNA    linear   ROD 05-MAR-2023
DEFINITION  Mus musculus tocopherol (alpha) transfer protein (Ttpa), transcript
            variant 1, mRNA.
ACCESSION   NM_015767
VERSION     NM_015767.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3189)
  AUTHORS   Ulatowski L, Ghelfi M, West R, Atkinson J, Finno CJ and Manor D.
  TITLE     The tocopherol transfer protein mediates vitamin E trafficking
            between cerebellar astrocytes and neurons
  JOURNAL   J Biol Chem 298 (3), 101712 (2022)
   PUBMED   35150738
  REMARK    GeneRIF: The tocopherol transfer protein mediates vitamin E
            trafficking between cerebellar astrocytes and neurons.
REFERENCE   2  (bases 1 to 3189)
  AUTHORS   Irias-Mata A, Sus N, Hug ML, Muller M, Vetter W and Frank J.
  TITLE     alpha-Tocomonoenol Is Bioavailable in Mice and May Partly Be
            Regulated by the Function of the Hepatic alpha-Tocopherol Transfer
            Protein
  JOURNAL   Molecules 25 (20), 4803 (2020)
   PUBMED   33086686
  REMARK    GeneRIF: alpha-Tocomonoenol Is Bioavailable in Mice and May Partly
            Be Regulated by the Function of the Hepatic alphaTocopherol
            Transfer Protein.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3189)
  AUTHORS   Collin GB, Gogna N, Chang B, Damkham N, Pinkney J, Hyde LF, Stone
            L, Naggert JK, Nishina PM and Krebs MP.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3189)
  AUTHORS   Takahashi K, Yanai S, Takisawa S, Kono N, Arai H, Nishida Y, Yokota
            T, Endo S and Ishigami A.
  TITLE     Vitamin C and vitamin E double-deficiency increased
            neuroinflammation and impaired conditioned fear memory
  JOURNAL   Arch Biochem Biophys 663, 120-128 (2019)
   PUBMED   30629958
REFERENCE   5  (bases 1 to 3189)
  AUTHORS   Marcos P, Gonzalez-Fuentes J, Castro-Vazquez L, Lozano MV,
            Santander-Ortega MJ, Rodriguez-Robledo V, Villaseca-Gonzalez N and
            Arroyo-Jimenez MM.
  TITLE     Vitamin transporters in mice brain with aging
  JOURNAL   J Anat 232 (4), 699-715 (2018)
   PUBMED   29315537
  REMARK    GeneRIF: The presence of alphaTTP and SVCT2 in brain regions
            implicated in learning, memory and motor control provides an
            anatomical basis that may explain the higher resistance of this
            animal model to brain oxidative stress, which is associated with
            better motor performance and learning abilities in old age.
REFERENCE   6  (bases 1 to 3189)
  AUTHORS   Kaempf-Rotzoll DE, Igarashi K, Aoki J, Jishage K, Suzuki H, Tamai
            H, Linderkamp O and Arai H.
  TITLE     Alpha-tocopherol transfer protein is specifically localized at the
            implantation site of pregnant mouse uterus
  JOURNAL   Biol Reprod 67 (2), 599-604 (2002)
   PUBMED   12135902
  REMARK    GeneRIF: alpha-tocopherol plays a role in the process of
            implantation
REFERENCE   7  (bases 1 to 3189)
  AUTHORS   Yokota T, Igarashi K, Uchihara T, Jishage K, Tomita H, Inaba A, Li
            Y, Arita M, Suzuki H, Mizusawa H and Arai H.
  TITLE     Delayed-onset ataxia in mice lacking alpha -tocopherol transfer
            protein: model for neuronal degeneration caused by chronic
            oxidative stress
  JOURNAL   Proc Natl Acad Sci U S A 98 (26), 15185-15190 (2001)
   PUBMED   11752462
REFERENCE   8  (bases 1 to 3189)
  AUTHORS   Jishage K, Arita M, Igarashi K, Iwata T, Watanabe M, Ogawa M, Ueda
            O, Kamada N, Inoue K, Arai H and Suzuki H.
  TITLE     Alpha-tocopherol transfer protein is important for the normal
            development of placental labyrinthine trophoblasts in mice
  JOURNAL   J Biol Chem 276 (3), 1669-1672 (2001)
   PUBMED   11076932
REFERENCE   9  (bases 1 to 3189)
  AUTHORS   Terasawa Y, Ladha Z, Leonard SW, Morrow JD, Newland D, Sanan D,
            Packer L, Traber MG and Farese RV Jr.
  TITLE     Increased atherosclerosis in hyperlipidemic mice deficient in alpha
            -tocopherol transfer protein and vitamin E
  JOURNAL   Proc Natl Acad Sci U S A 97 (25), 13830-13834 (2000)
   PUBMED   11095717
REFERENCE   10 (bases 1 to 3189)
  AUTHORS   Terasawa Y, Cases SJ, Wong JS, Jamil H, Jothi S, Traber MG, Packer
            L, Gordon DA, Hamilton RL and Farese RV Jr.
  TITLE     Apolipoprotein B-related gene expression and ultrastructural
            characteristics of lipoprotein secretion in mouse yolk sac during
            embryonic development
  JOURNAL   J Lipid Res 40 (11), 1967-1977 (1999)
   PUBMED   10553000
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY072913.1, AL732527.6, AK050374.1, AK004882.1 and AV026942.2.
            
            [WARNING] On Oct 18, 2023 this sequence was replaced by
            NM_015767.5.
            
            On Dec 4, 2015 this sequence version replaced NM_015767.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050374.1, AK004882.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BY072913.1         1-15
            16-64               AL732527.6         46040-46088         c
            65-99               BY072913.1         65-99
            100-2074            AK050374.1         2-1976
            2075-2459           AK004882.1         1957-2341
            2460-3152           AK050374.1         2365-3057
            3153-3189           AV026942.2         610-646
FEATURES             Location/Qualifiers
     source          1..3189
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 7.76 cM"
     gene            1..3189
                     /gene="Ttpa"
                     /gene_synonym="alpha-TTP"
                     /note="tocopherol (alpha) transfer protein"
                     /db_xref="GeneID:50500"
                     /db_xref="MGI:MGI:1354168"
     exon            1..315
                     /gene="Ttpa"
                     /gene_synonym="alpha-TTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..948
                     /gene="Ttpa"
                     /gene_synonym="alpha-TTP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-tocopherol transfer protein; alpha TTP"
                     /codon_start=1
                     /product="alpha-tocopherol transfer protein isoform 1"
                     /protein_id="NP_056582.1"
                     /db_xref="CCDS:CCDS17995.1"
                     /db_xref="GeneID:50500"
                     /db_xref="MGI:MGI:1354168"
                     /translation="MAEMRPGPLVGKQLNELPDHSPLLQPGLAELRRRVQEAGVPQTP
                     QPLTDAFLLRFLRARDFDLDLAWRLMKNYYKWRAECPELSADLRPRSILGLLKAGYHG
                     VLRSRDSTGSRVLIYRIAYWDPKVFTAYDVFRVSLITSELIVQEVETQRNGVKAIFDL
                     EGWQVSHAFQITPSVAKKIAAVLTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKI
                     KDRIHLHGNNYKSSMLQHFPDILPREYGGKEFSMEDICQEWTNFIMKSEDYLSSISET
                     IQ"
     exon            316..469
                     /gene="Ttpa"
                     /gene_synonym="alpha-TTP"
                     /inference="alignment:Splign:2.1.0"
     exon            470..663
                     /gene="Ttpa"
                     /gene_synonym="alpha-TTP"
                     /inference="alignment:Splign:2.1.0"
     exon            664..774
                     /gene="Ttpa"
                     /gene_synonym="alpha-TTP"
                     /inference="alignment:Splign:2.1.0"
     exon            775..3189
                     /gene="Ttpa"
                     /gene_synonym="alpha-TTP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagatcgggg cggcccgggt gagtgtgcgt ggggcggcgg ccacggcggg gggcggaggg
       61 tggctctggg cccgcacttt tcccccctgt cgccgggaca gcacggcggg catggcagag
      121 atgcggccgg ggccattggt tgggaaacag ctcaacgagc tgcccgacca ctcgccgctg
      181 ctccagcccg gcctggcgga gctcaggcgc cgggtgcagg aggcaggcgt cccgcagacc
      241 ccgcagcctc tcacagacgc tttcctgctg cgcttcctgc gcgcccggga tttcgatctg
      301 gatctggcct ggcgcttaat gaaaaactat tataaatggc gagcagaatg cccagaatta
      361 agtgcagatc tacgccctag aagtatcctt ggacttctga aagctggcta ccatggcgtg
      421 ctcaggtccc gggattctac tggcagtaga gttctcattt acagaattgc atactgggac
      481 ccaaaagttt ttacagctta tgatgtattt cgtgtaagtc tgatcacatc agagctcatt
      541 gtacaggagg tggaaactca acgcaatgga gttaaagcta tatttgacct ggaaggctgg
      601 caggtttctc atgctttcca aattacccca tctgtagcca agaagattgc tgctgtactt
      661 acagattcct ttccactgaa agttcgtggg atccatttga taaatgagcc agtcattttc
      721 catgctgtct tctccatgat taaaccattt ctgactgaaa agattaagga ccggattcat
      781 ctgcacggga acaactacaa atcaagcatg cttcagcact tcccagacat tcttcctcgg
      841 gaatatggcg gtaaagagtt ctccatggag gatatttgtc aggagtggac aaattttata
      901 atgaagtctg aagattatct cagcagcatt tctgagacca tccaatgaga agttatttcc
      961 tgcaaatgac ttcatttaaa attcaaggat gggatcctat ctggtttcta aactaaaggg
     1021 caaaccttct aaactaattg atgcttattt gatcttaaaa catgcaacat ggatatttgg
     1081 ggaatgtttt aacttctaca atgctgctcc ttttaaatta attaaatgtt aggaaagaag
     1141 atattcctgt ttgaacttga agagcaaaca tagctacatg taaagcagct gttccagtgt
     1201 gtctctgtat ggttcaggaa attttatctt aaacaaaacg ttatgatcac actgtttaat
     1261 actagattga tggctaccta ctggaaagaa atactgtatg tatcaactga tggtgaaaca
     1321 atatcgatgc tcagataagg ttggcgtcag catataaatc agactgtcct gaatacaatc
     1381 tcatctcagg acagttcatc tcaggtaaat cctactctag caaatgcaca atagaagcct
     1441 gtgaatgtaa gtctacacac acgataatgt tgtcatcagt gaaatcacaa tagaagccct
     1501 tgaatgtaag tctgcacaca cactattgtt gtcatcagtg aaatcactat gtttgataaa
     1561 aatgatctaa aacttaggac atttttctgg ggacagttga gaggtttctc acactgtttt
     1621 gtattttcaa ataagaatat aagtatggct tctgtttata gacagggaag tagaggaata
     1681 tgtcttttac attgacattt atacttgaaa acttaacaca actacatcaa tgaagggtgc
     1741 ttacatttta aaccatcagc aattatactc tagtattttt caaatattca taaaatgctt
     1801 tcattttatt ctgagataat ctactattat ttcagaatat tctgagtccc acgatttaat
     1861 ttaaacagtc agtagctggg atgtgctgtc tctaacacag tgtggttcat ttctaagact
     1921 tccattcatt gagaaagatg taatcttatc ccatattcag cacagccttc aacttctggc
     1981 ataatgttta tacttaatgt ttataattaa ttttatttta aactggaaag aacacaagta
     2041 gagaacttat tgaatttgtg ttcaagtagt tcaatttcta cattaattac actagagtaa
     2101 ctttgtacaa ggatcttttt cattgcacaa gggtgttttt ctttataaga aaataagtct
     2161 aatcagatga gctgatactt acgattctca gtacatatac ctctgacaaa agtgaaagga
     2221 gggccagatg ttctttagag aacgtgttta attttcactt agcaactaga cgctaccttt
     2281 actatttaat tttactaaaa aaatcttgcc tttttcttta aaaaagcctt cgttactaaa
     2341 ttatgaaatt gaaattgtat acataagaat aataaaaatc agttaaagaa atgaacagta
     2401 acaaaacacc tctggcttat caacctttta tgatagaagg aaactcagat gtcactttat
     2461 ttatagagag ctattaagtc acgtgccatg actctgtgaa ggaatggcac attacaataa
     2521 aggctaatgt tttgaatgtg tatactagta aagcaattaa cagtaacctg aatttaaatg
     2581 tcagtcgatg gaagtacagc ctatgacagg gctttgaaaa cgtttctaca gtgaagcagt
     2641 tctacagaga acactaatga gcaatgtgta aactgtttgg aaggtgctgg tgaataactg
     2701 gaactttcca catggcttca ccacacttgt gccagaaaca tattctgaaa gttgagctcc
     2761 ataggtgctc accgtgctgc tgaatttcac aataatttgc tttactattg ttaaaaataa
     2821 acatctttcc tcacaaacca tggtgtttat atttttctaa aatggaaagg aagcattctt
     2881 ttcagaaaag agaaatgttt ttttctttca gaaaaatgca gtaaaaacat attatccatt
     2941 atccgaatgc agtaaaaaca tcttagccgt tatccgaatg ttggttctgt tgtttaggtg
     3001 caggtgcttt ccctgttgtt ctgcttcctt cagtgtcttt gctagatcaa gtgcagacgc
     3061 tgcacacaat ctctagttcc tctagttctg gatttgagaa atctgtcttt ggaattcatg
     3121 ttcagtttta cttggatagt aaaattatcc cgaaaaatta aaatctatta aagaaacaca
     3181 cattatctg
//
