LOCUS       NP_001344146             887 aa            linear   ROD 09-FEB-2025
DEFINITION  tubulin polyglutamylase TTLL7 isoform 3 [Mus musculus].
ACCESSION   NP_001344146 XP_006502151
VERSION     NP_001344146.1
DBSOURCE    REFSEQ: accession NM_001357217.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 887)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 887)
  AUTHORS   Ping,Y., Ohata,K., Kikushima,K., Sakamoto,T., Islam,A., Xu,L.,
            Zhang,H., Chen,B., Yan,J., Eto,F., Nakane,C., Takao,K.,
            Miyakawa,T., Kabashima,K., Watanabe,M., Kahyo,T., Yao,I.,
            Fukuda,A., Ikegami,K., Konishi,Y. and Setou,M.
  TITLE     Tubulin Polyglutamylation by TTLL1 and TTLL7 Regulate Glutamate
            Concentration in the Mice Brain
  JOURNAL   Biomolecules 13 (5), 784 (2023)
   PUBMED   37238654
  REMARK    GeneRIF: Tubulin Polyglutamylation by TTLL1 and TTLL7 Regulate
            Glutamate Concentration in the Mice Brain.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 887)
  AUTHORS   Genova,M., Grycova,L., Puttrich,V., Magiera,M.M., Lansky,Z.,
            Janke,C. and Braun,M.
  TITLE     Tubulin polyglutamylation differentially regulates
            microtubule-interacting proteins
  JOURNAL   EMBO J 42 (5), e112101 (2023)
   PUBMED   36636822
REFERENCE   4  (residues 1 to 887)
  AUTHORS   Wu,H.Y., Rong,Y., Bansal,P.K., Wei,P., Guo,H. and Morgan,J.I.
  TITLE     TTLL1 and TTLL4 polyglutamylases are required for the
            neurodegenerative phenotypes in pcd mice
  JOURNAL   PLoS Genet 18 (4), e1010144 (2022)
   PUBMED   35404950
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 887)
  AUTHORS   Bodakuntla,S., Yuan,X., Genova,M., Gadadhar,S., Leboucher,S.,
            Birling,M.C., Klein,D., Martini,R., Janke,C. and Magiera,M.M.
  TITLE     Distinct roles of alpha- and beta-tubulin polyglutamylation in
            controlling axonal transport and in neurodegeneration
  JOURNAL   EMBO J 40 (17), e108498 (2021)
   PUBMED   34309047
  REMARK    GeneRIF: Distinct roles of alpha- and beta-tubulin
            polyglutamylation in controlling axonal transport and in
            neurodegeneration.
            Erratum:[EMBO J. 2022 Jun 1;41(11):e111373. doi:
            10.15252/embj.2022111373.. PMID: 35642378]
REFERENCE   6  (residues 1 to 887)
  AUTHORS   Mukai,M., Ikegami,K., Sugiura,Y., Takeshita,K., Nakagawa,A. and
            Setou,M.
  TITLE     Recombinant mammalian tubulin polyglutamylase TTLL7 performs both
            initiation and elongation of polyglutamylation on beta-tubulin
            through a random sequential pathway
  JOURNAL   Biochemistry 48 (5), 1084-1093 (2009)
   PUBMED   19152315
  REMARK    GeneRIF: TTLL7 performs both the initiation and elongation of
            polyglutamylation on beta-tubulin; the mechanism of binding of
            three substrates glutamate, ATP, and tubulin to the enzyme is a
            random sequential pathway.
REFERENCE   7  (residues 1 to 887)
  AUTHORS   van Dijk,J., Rogowski,K., Miro,J., Lacroix,B., Edde,B. and Janke,C.
  TITLE     A targeted multienzyme mechanism for selective microtubule
            polyglutamylation
  JOURNAL   Mol Cell 26 (3), 437-448 (2007)
   PUBMED   17499049
REFERENCE   8  (residues 1 to 887)
  AUTHORS   Ikegami,K., Heier,R.L., Taruishi,M., Takagi,H., Mukai,M.,
            Shimma,S., Taira,S., Hatanaka,K., Morone,N., Yao,I., Campbell,P.K.,
            Yuasa,S., Janke,C., Macgregor,G.R. and Setou,M.
  TITLE     Loss of alpha-tubulin polyglutamylation in ROSA22 mice is
            associated with abnormal targeting of KIF1A and modulated synaptic
            function
  JOURNAL   Proc Natl Acad Sci U S A 104 (9), 3213-3218 (2007)
   PUBMED   17360631
REFERENCE   9  (residues 1 to 887)
  AUTHORS   Ikegami,K., Mukai,M., Tsuchida,J., Heier,R.L., Macgregor,G.R. and
            Setou,M.
  TITLE     TTLL7 is a mammalian beta-tubulin polyglutamylase required for
            growth of MAP2-positive neurites
  JOURNAL   J Biol Chem 281 (41), 30707-30716 (2006)
   PUBMED   16901895
  REMARK    GeneRIF: TTLL7 is a mammalian beta-tubulin polyglutamylase required
            for growth of MAP2-positive neurites
REFERENCE   10 (residues 1 to 887)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115889.13, AC165225.5 and BM899995.1.
            
            On Oct 24, 2017 this sequence version replaced XP_006502151.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.58455.1,
                                           SRR10223970.5896.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..887
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 72.28 cM"
     Protein         1..887
                     /product="tubulin polyglutamylase TTLL7 isoform 3"
                     /note="tubulin polyglutamylase TTLL7; tubulin--tyrosine
                     ligase-like protein 7"
                     /calculated_mol_wt=102576
     Region          91..376
                     /region_name="TTL"
                     /note="Tubulin-tyrosine ligase family; pfam03133"
                     /db_xref="CDD:397308"
     Region          <384..>474
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     CDS             1..887
                     /gene="Ttll7"
                     /gene_synonym="1110049N09Rik; 4921517B04Rik; C630030B20;
                     mTTLL7"
                     /coded_by="NM_001357217.1:398..3061"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS89701.1"
                     /db_xref="GeneID:70892"
                     /db_xref="MGI:MGI:1918142"
ORIGIN      
        1 mpslpqdgvi qgsspvdlgt elpyqctmkr kvrkkkkkgi itanvagtkf eivrlvidem
       61 gfmktpdede tsnliwcdaa vqqekitdlq nyqrinhfpg mgeicrkdfl arnmtkmiks
      121 rpmdytfvpr twifpseytq fqnyvkelkk krkqktfivk pangamghgi slirngdkvp
      181 sqdhlivqey iekpflmegy kfdlriyilv tscdplkifl yhdglvrmgt ekyippnesn
      241 ltqlymhltn ysvnkhnerf ernetedkgs krsikwftef lqanqhdvtk fwsdiselvv
      301 ktlivaephv lhayrmcrpg qppgsesvcf evlgfdilld rklkpwllei nrapsfgtdq
      361 kidydvkrgv llnalkllni rtsdkrknla kqkaeaqrrl ygqnpvrrls pgssdweqqr
      421 hqlerrkeel kerllqvrkq vsqeehenrh mgnyrriypp edkallekye gllavafqtf
      481 lsgraasfqr emnnplkkmr eedlldlleq ceiddeklmg ktgrvrgpkp lccmpecaev
      541 tkkqkyygss dssydsssss snseldenek elcqkrldqv pyslkhtshc kiiqqsnsmr
      601 rsvscprsis ahlpsrgdvr pfssqqvipl arptsasrsh slnrassyar hlphgsdtgs
      661 tntlneslrq lktkeqeddl tsqtlfvlkd mrirfpgksd aeselliedi mdnwkhyktk
      721 vasywlikld svkqrkvldi vkssirtvlp riwrvpdaee lslyrifnrv fnrllwshgq
      781 glwscfcdsg sswesifsks pevvtplqlq ccqrlvelck qcllvvykyt tetrgpisgi
      841 gpdwgnsryl lpgstqflmr splynmkyns pgmtrsnvlf tsrygrl
//
