LOCUS       NM_172799               3223 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Mus musculus tubulin tyrosine ligase-like family, member 6 (Ttll6),
            mRNA.
ACCESSION   NM_172799
VERSION     NM_172799.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3223)
  AUTHORS   Ho,K.H., Candat,A., Scarpetta,V., Faucourt,M., Weill,S., Salio,C.,
            D'Este,E., Meschkat,M., Wurm,C.A., Kneussel,M., Janke,C.,
            Magiera,M.M., Genovesio,A., Meunier,A., Sassoe-Pognetto,M.,
            Brill,M.S., Spassky,N. and Patrizi,A.
  TITLE     Choroid plexuses carry nodal-like cilia that undergo axoneme
            regression from early adult stage
  JOURNAL   Dev Cell 58 (23), 2641-2651 (2023)
   PUBMED   37890489
REFERENCE   2  (bases 1 to 3223)
  AUTHORS   Janeckova,E., Feng,J., Guo,T., Han,X., Ghobadi,A.,
            Araujo-Villalba,A., Rahman,M.S., Ziaei,H., Ho,T.V., Pareek,S.,
            Alvarez,J. and Chai,Y.
  TITLE     Canonical Wnt signaling regulates soft palate development by
            mediating ciliary homeostasis
  JOURNAL   Development 150 (5) (2023)
   PUBMED   36825984
REFERENCE   3  (bases 1 to 3223)
  AUTHORS   Zhu,X., Song,G., Zhang,S., Chen,J., Hu,X., Zhu,H., Jia,X., Li,Z.,
            Song,W., Chen,J., Jin,C., Zhou,M., Zhao,Y., Xie,H., Zheng,S. and
            Song,P.
  TITLE     Asialoglycoprotein Receptor 1 Functions as a Tumor Suppressor in
            Liver Cancer via Inhibition of STAT3
  JOURNAL   Cancer Res 82 (21), 3987-4000 (2022)
   PUBMED   36043912
REFERENCE   4  (bases 1 to 3223)
  AUTHORS   Mahalingan,K.K., Keith Keenan,E., Strickland,M., Li,Y., Liu,Y.,
            Ball,H.L., Tanner,M.E., Tjandra,N. and Roll-Mecak,A.
  TITLE     Structural basis for polyglutamate chain initiation and elongation
            by TTLL family enzymes
  JOURNAL   Nat Struct Mol Biol 27 (9), 802-813 (2020)
   PUBMED   32747782
  REMARK    GeneRIF: Structural basis for polyglutamate chain initiation and
            elongation by TTLL family enzymes.
            Erratum:[Nat Struct Mol Biol. 2020 Aug 13;:. PMID: 32792670]
REFERENCE   5  (bases 1 to 3223)
  AUTHORS   Ye,B., Liu,B., Hao,L., Zhu,X., Yang,L., Wang,S., Xia,P., Du,Y.,
            Meng,S., Huang,G., Qin,X., Wang,Y., Yan,X., Li,C., Hao,J., Zhu,P.,
            He,L., Tian,Y. and Fan,Z.
  TITLE     Klf4 glutamylation is required for cell reprogramming and early
            embryonic development in mice
  JOURNAL   Nat Commun 9 (1), 1261 (2018)
   PUBMED   29593216
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3223)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Ttll6 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   7  (bases 1 to 3223)
  AUTHORS   van Dijk,J., Rogowski,K., Miro,J., Lacroix,B., Edde,B. and Janke,C.
  TITLE     A targeted multienzyme mechanism for selective microtubule
            polyglutamylation
  JOURNAL   Mol Cell 26 (3), 437-448 (2007)
   PUBMED   17499049
REFERENCE   8  (bases 1 to 3223)
  AUTHORS   Janke,C., Rogowski,K., Wloga,D., Regnard,C., Kajava,A.V.,
            Strub,J.M., Temurak,N., van Dijk,J., Boucher,D., van Dorsselaer,A.,
            Suryavanshi,S., Gaertig,J. and Edde,B.
  TITLE     Tubulin polyglutamylase enzymes are members of the TTL domain
            protein family
  JOURNAL   Science 308 (5729), 1758-1762 (2005)
   PUBMED   15890843
REFERENCE   9  (bases 1 to 3223)
  AUTHORS   Sousa-Nunes,R., Rana,A.A., Kettleborough,R., Brickman,J.M.,
            Clements,M., Forrest,A., Grimmond,S., Avner,P., Smith,J.C.,
            Dunwoodie,S.L. and Beddington,R.S.
  TITLE     Characterizing embryonic gene expression patterns in the mouse
            using nonredundant sequence-based selection
  JOURNAL   Genome Res 13 (12), 2609-2620 (2003)
   PUBMED   14613977
REFERENCE   10 (bases 1 to 3223)
  AUTHORS   Mohlke,K.L., Purkayastha,A.A., Westrick,R.J. and Ginsburg,D.
  TITLE     Comparative mapping of distal murine chromosome 11 and human
            17q21.3 in a region containing a modifying locus for murine plasma
            von Willebrand factor level
  JOURNAL   Genomics 54 (1), 19-30 (1998)
   PUBMED   9806826
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AM690749.1, BC132203.1 and CO043420.1.
            
            [WARNING] On Mar 20, 2024 this sequence was replaced by
            NM_172799.5.
            
            On Jan 1, 2010 this sequence version replaced NM_172799.3.
            
            CCDS Note: The coding region has been updated to represent an
            alternative splicing pattern, resulting in an extended N-terminus
            that is more supported by the available transcript and conservation
            data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AM690749.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849384, SAMN00849389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2469              AM690749.1         1-2469
            2470-3028           BC132203.1         2598-3156
            3029-3223           CO043420.1         1-195               c
FEATURES             Location/Qualifiers
     source          1..3223
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.48 cM"
     gene            1..3223
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /note="tubulin tyrosine ligase-like family, member 6"
                     /db_xref="GeneID:237930"
                     /db_xref="MGI:MGI:2683461"
     CDS             1..2469
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /note="polyglutamylase; tubulin--tyrosine ligase-like
                     protein 6; protein polyglutamylase TTLL6"
                     /codon_start=1
                     /product="tubulin polyglutamylase TTLL6"
                     /protein_id="NP_766387.2"
                     /db_xref="CCDS:CCDS25290.2"
                     /db_xref="GeneID:237930"
                     /db_xref="MGI:MGI:2683461"
                     /translation="MLQCLTSESEEGAEEREESSTEDLEELKEFVTLAFVRENTQKRL
                     QNAQQHGKKKRKKKRLVINLSNCRYDSVRRAAQQYGLREAGDNDDWTLYWTDYSVSLE
                     RVMEMKSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADWGDLQ
                     TYSRTRKNKTYICKPDSGCQGRGIFITRSVKEIKPGEDMICQLYISKPFIIDGFKFDL
                     RVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNLDNLDEICMHLTNYSINKHSSNFVQ
                     DAFSGSKRKLSTFNSYMKTHGYDVEQIWRGIEDVIIKTLISAHPVIKHNYHTCFPSHT
                     LNSACFEILGFDILLDRKLKPWLLEVNHSPSFSTDSKLDKEVKDSLLYDALVLINLGN
                     CDKKKVLEEERQRGRFLQQCPNREIRLEEVKGFQAMRLQKTEEYEKKNCGGFRLIYPG
                     LNLEKYDKFFQDNSSLFQNTVASRARELYARQLIQELRQKQEKKVFLKKARKEETQGE
                     SAGEQARDKVVRLQRQRQQPKCKTVATCPPKQSLHPVTLVSCTSGLLLNIRGLKKGEI
                     SESLEQKDTKEAMLIPCKPVSARNYSSVPDLRSANPSCFEPEFHVPNAKVKEVKSAFM
                     VNIESTAQPITSVESSRDATAPISTSLESLASMSLSTSPECSSPESVHMVSYNHKQQK
                     ASFHKPMQEKKSKPLMFSKSRHLDLNCTSMKNDINRQYLMSEILQKVQMKKKRPLFPA
                     PKSQYPTLSKERCPHSRSSSRKKEMNSPSVFVLQASHSRAESLNDLLVVATQARLDPR
                     PSRSHSGTTTRDSSTQDPKHTATA"
     exon            1..176
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /inference="alignment:Splign:2.1.0"
     exon            177..214
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /inference="alignment:Splign:2.1.0"
     exon            215..333
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /inference="alignment:Splign:2.1.0"
     exon            334..464
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /inference="alignment:Splign:2.1.0"
     exon            465..621
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /inference="alignment:Splign:2.1.0"
     exon            622..765
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /inference="alignment:Splign:2.1.0"
     exon            766..851
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1077
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1253
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1442
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1620
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1896
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2230
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2501
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..3206
                     /gene="Ttll6"
                     /gene_synonym="4932418K24Rik; D11Moh43e; D11Moh44e;
                     t8130b59"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctacagt gcctgacttc ggaaagtgag gaaggggctg aagagaggga ggagagttcc
       61 acagaagatc tggaggagct aaaagaattt gtcaccctgg cttttgtgag agagaacaca
      121 caaaagaggc tccagaacgc acagcagcat ggtaagaaaa agaggaagaa aaaaagattg
      181 gtgatcaatc tatctaactg ccggtatgac agcgtgcgca gggccgccca gcaatatggc
      241 cttcgagagg cgggtgacaa tgatgactgg actctctatt ggaccgacta ctcagtgtca
      301 ctggagcgag tgatggaaat gaagagctac cagaaaatca atcattttcc tgggatgagt
      361 gagatctgcc gcaaggactt gctggcccgg aatatgagcc gcatgctaaa gctgtttcct
      421 aaggatttcc acttcttccc caggacttgg tgtcttcctg ccgactgggg agatttgcag
      481 acttacagca ggacaagaaa aaataagact tacatttgta agccggactc gggctgccaa
      541 gggagaggca tattcattac ccggtcggtg aaagaaatca agccagggga ggatatgatc
      601 tgccagcttt atatctcaaa gcccttcatc atcgacgggt tcaagtttga ccttcgggtt
      661 tatgtgctgg tgacctcctg tgaccctctc agggtttttg tgtacaatga aggactggct
      721 cgctttgcca ccacctctta ctcccaccct aacctagaca acctggatga gatctgtatg
      781 cacctgacta attattctat caataagcac agttccaact tcgttcaaga cgctttttct
      841 ggcagcaaga ggaaactctc caccttcaac tcgtacatga agacccacgg ctacgacgtg
      901 gagcagatct ggaggggcat cgaggacgtc atcatcaaga cgctcatatc cgctcacccg
      961 gtcatcaaac acaattacca tacctgcttc cccagccaca cgctcaacag tgcctgcttt
     1021 gaaatcctgg gctttgacat cttgttggac cggaaactca aaccctggct gctggaggtc
     1081 aaccattctc caagcttctc cactgactcc aagttggata aagaggtgaa agacagcctg
     1141 ctctatgatg cattggtcct catcaacctg gggaactgtg acaaaaagaa agtcttggag
     1201 gaggagagac agcggggacg attcttgcag cagtgtccaa atcgggagat caggctagag
     1261 gaagtcaagg gtttccaggc catgaggtta cagaaaacag aggaatatga gaagaaaaac
     1321 tgtgggggct tccggctcat ctaccctggt ctgaatttgg agaagtatga caagtttttc
     1381 caggacaaca gctccctctt ccagaacacc gttgcttcca gagcccggga gctgtatgca
     1441 cggcagctga tccaggagct gaggcagaaa caggaaaaaa aagtcttcct aaaaaaagcg
     1501 aggaaggaag agacgcaggg cgagtctgcg ggtgagcagg caagagacaa agtcgtgcgg
     1561 ctccagcgac agagacagca gcccaagtgc aagacggtgg ccacctgtcc ccccaaacaa
     1621 tccttacatc cagtgacctt agtatcctgc acatctggct tgctcttgaa catcagaggc
     1681 ctaaagaaag gtgaaatttc tgagagcctc gaacagaagg acaccaagga ggccatgctt
     1741 ataccctgca agcccgtgtc ggcaaggaac tacagttctg tccctgacct gaggagtgca
     1801 aaccccagct gcttcgagcc agagttccat gtgcccaatg ccaaagtcaa ggaagtcaag
     1861 tcggccttta tggtgaacat agagagcact gcccagccca taacgtctgt agaaagttcc
     1921 cgagatgcca cagcccccat ctcaacctct ctagaatccc tggcaagcat gagcctctcc
     1981 accagccctg agtgcagcag cccggagagt gtccatatgg tgtcctataa ccacaagcag
     2041 cagaaggctt ccttccacaa gccgatgcag gagaagaaat ccaagcctct catgttttcc
     2101 aaatccaggc atttggacct gaactgtacc tcaatgaaga atgacattaa taggcagtat
     2161 ctgatgtcag agatactgca gaaggttcaa atgaagaaga aacgcccctt gttcccggct
     2221 cccaagtcac aatacccaac cctgtccaag gagcggtgcc cccacagccg cagctccagc
     2281 aggaagaaag agatgaattc gccctccgtc ttcgtcctgc aggcttctca cagccgtgct
     2341 gaatctctga atgaccttct ggtagttgcc actcaagctc gcctggaccc tcggcccagc
     2401 agaagccatt cgggcactac gacaagggac tccagcacac aggacccaaa gcacactgcc
     2461 actgcctgag gtctggtcag aaaggatgtg agaggaatca gaatcagact ggatcttcgc
     2521 catttccttt tcctacctct tactccagga aatgatttgt ctcttcctgc agcgtctgca
     2581 acatctacag aatggactgg aagtttcatt tccgcatcta gaaattctgg tctgataact
     2641 atgtcccgtt ggcaccgtcg agggcagtga ccttcccttc tgtgctctct ctgttagttc
     2701 acagcgctgt gtgtgtggga ccaggaccgg cagggatcga gcgctgcttc cctaggacaa
     2761 agtccacttg ccttagctgt ggtgctcccc ccaaccccgg agttaagcaa cttgaagcag
     2821 gagtgagggg aggactcacg atttccagga gtccagagcc ctcattccac ctgcaaacct
     2881 gtgccagtcc cgccctcctc tctaaagaaa aagaaggcag agtcgggact aagtgtggag
     2941 gaattctggg tcttggtgga aagaagaagc aggacagttt caaattcgcc agtggaagag
     3001 agaccacgcc ctctccacca acccaaaggc cttccgcccc agccccggga ctgcctcttg
     3061 ctgctatctt cccttcagtc ttgctggcaa agacaggtaa tgtaagagag tacctagcct
     3121 gcaggtgttt cttccattga cctgaaggca ttatttgtct gcccacatgt atacattgat
     3181 aaaataaatt gccatgccca atgctaaaaa aaaaaaaaaa aaa
//
