LOCUS       NM_001081423            4871 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus tubulin tyrosine ligase-like family, member 5 (Ttll5),
            transcript variant 1, mRNA.
ACCESSION   NM_001081423 XM_988689
VERSION     NM_001081423.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4871)
  AUTHORS   Wu,H.Y., Rong,Y., Bansal,P.K., Wei,P., Guo,H. and Morgan,J.I.
  TITLE     TTLL1 and TTLL4 polyglutamylases are required for the
            neurodegenerative phenotypes in pcd mice
  JOURNAL   PLoS Genet 18 (4), e1010144 (2022)
   PUBMED   35404950
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4871)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4871)
  AUTHORS   Ye,B., Liu,B., Hao,L., Zhu,X., Yang,L., Wang,S., Xia,P., Du,Y.,
            Meng,S., Huang,G., Qin,X., Wang,Y., Yan,X., Li,C., Hao,J., Zhu,P.,
            He,L., Tian,Y. and Fan,Z.
  TITLE     Klf4 glutamylation is required for cell reprogramming and early
            embryonic development in mice
  JOURNAL   Nat Commun 9 (1), 1261 (2018)
   PUBMED   29593216
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4871)
  AUTHORS   Bedoni,N., Haer-Wigman,L., Vaclavik,V., Tran,V.H., Farinelli,P.,
            Balzano,S., Royer-Bertrand,B., El-Asrag,M.E., Bonny,O.,
            Ikonomidis,C., Litzistorf,Y., Nikopoulos,K., Yioti,G.G.,
            Stefaniotou,M.I., McKibbin,M., Booth,A.P., Ellingford,J.M.,
            Black,G.C., Toomes,C., Inglehearn,C.F., Hoyng,C.B., Bax,N.,
            Klaver,C.C., Thiadens,A.A., Murisier,F., Schorderet,D.F., Ali,M.,
            Cremers,F.P., Andreasson,S., Munier,F.L. and Rivolta,C.
  TITLE     Mutations in the polyglutamylase gene TTLL5, expressed in
            photoreceptor cells and spermatozoa, are associated with cone-rod
            degeneration and reduced male fertility
  JOURNAL   Hum Mol Genet 25 (20), 4546-4555 (2016)
   PUBMED   28173158
  REMARK    GeneRIF: Mouse models carrying truncating mutations in TTLL5 gene
            display reduced fertility in male animals.
REFERENCE   5  (bases 1 to 4871)
  AUTHORS   Sun,X., Park,J.H., Gumerson,J., Wu,Z., Swaroop,A., Qian,H.,
            Roll-Mecak,A. and Li,T.
  TITLE     Loss of RPGR glutamylation underlies the pathogenic mechanism of
            retinal dystrophy caused by TTLL5 mutations
  JOURNAL   Proc Natl Acad Sci U S A 113 (21), E2925-E2934 (2016)
   PUBMED   27162334
  REMARK    GeneRIF: study uncovers the pathogenic mechanism whereby absence of
            RPGR(ORF15) glutamylation leads to retinal pathology in patients
            with TTLL5 gene mutations and connects these two genes into a
            common disease pathway.
REFERENCE   6  (bases 1 to 4871)
  AUTHORS   Sergouniotis,P.I., Chakarova,C., Murphy,C., Becker,M., Lenassi,E.,
            Arno,G., Lek,M., MacArthur,D.G., Bhattacharya,S.S., Moore,A.T.,
            Holder,G.E., Robson,A.G., Wolfrum,U., Webster,A.R. and Plagnol,V.
  CONSRTM   UCL-Exomes Consortium
  TITLE     Biallelic variants in TTLL5, encoding a tubulin glutamylase, cause
            retinal dystrophy
  JOURNAL   Am J Hum Genet 94 (5), 760-769 (2014)
   PUBMED   24791901
REFERENCE   7  (bases 1 to 4871)
  AUTHORS   Lee,G.S., He,Y., Dougherty,E.J., Jimenez-Movilla,M., Avella,M.,
            Grullon,S., Sharlin,D.S., Guo,C., Blackford,J.A. Jr., Awasthi,S.,
            Zhang,Z., Armstrong,S.P., London,E.C., Chen,W., Dean,J. and
            Simons,S.S. Jr.
  TITLE     Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like
            protein 5/SRC-1 and TIF2-associated modulatory protein gene) in
            male mice causes sperm malformation and infertility
  JOURNAL   J Biol Chem 288 (21), 15167-15180 (2013)
   PUBMED   23558686
  REMARK    GeneRIF: STAMP appears to participate in a unique, tissue-selective
            TTLL-mediated pathway for alpha-tubulin polyglutamylation that is
            required for sperm maturation and motility and may be relevant for
            male fertility.
REFERENCE   8  (bases 1 to 4871)
  AUTHORS   Lacroix,B., van Dijk,J., Gold,N.D., Guizetti,J.,
            Aldrian-Herrada,G., Rogowski,K., Gerlich,D.W. and Janke,C.
  TITLE     Tubulin polyglutamylation stimulates spastin-mediated microtubule
            severing
  JOURNAL   J Cell Biol 189 (6), 945-954 (2010)
   PUBMED   20530212
REFERENCE   9  (bases 1 to 4871)
  AUTHORS   van Dijk,J., Rogowski,K., Miro,J., Lacroix,B., Edde,B. and Janke,C.
  TITLE     A targeted multienzyme mechanism for selective microtubule
            polyglutamylation
  JOURNAL   Mol Cell 26 (3), 437-448 (2007)
   PUBMED   17499049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138303.4, AK085566.1, BY140783.1, AM690748.1, AK009255.1 and
            BQ031122.1.
            
            On Jun 26, 2018 this sequence version replaced NM_001081423.2.
            
            CCDS Note: The coding region has been updated to represent an
            alternate splice pattern that is more supported by the available
            transcript and protein data.  The update includes extension of the
            5' CDS, affects splicing in the 3' CDS, and changes the protein
            length from 1355 aa to 1328 aa.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB093278.1, SRR1660815.227765.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC138303.4         156843-156855       c
            14-30               AK085566.1         228-244
            31-265              BY140783.1         2-236
            266-4252            AM690748.1         1-3987
            4253-4414           AK009255.1         2601-2762
            4415-4843           AK009255.1         2764-3192
            4844-4871           BQ031122.1         18-45               c
FEATURES             Location/Qualifiers
     source          1..4871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.81 cM"
     gene            1..4871
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /note="tubulin tyrosine ligase-like family, member 5"
                     /db_xref="GeneID:320244"
                     /db_xref="MGI:MGI:2443657"
     exon            1..167
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            168..339
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            340..446
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            447..529
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            530..636
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            637..767
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            768..850
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            851..920
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1005
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1107
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1199
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1307
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1389
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1451
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1546
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1660
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1752
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1815
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1854
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2012
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2319
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2440
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2587
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2691
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2819
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2903
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3296
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3481
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            3482..3636
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..3832
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            3833..4047
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            4048..4130
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            4131..4253
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     exon            4254..4871
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4851..4856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /note="hexamer: AATAAA"
     polyA_site      4870
                     /gene="Ttll5"
                     /gene_synonym="1700048H13Rik; 2310009M18Rik;
                     4930556H18Rik; D630041K24Rik; mKIAA0998; Stamp"
                     /note="major polyA site"
ORIGIN      
        1 cgggcgcctg cgcagtggct cttagcgggc ggttgcttgt tggttgttgt agtaacgggg
       61 gaagcagcct tcggcggctg cgttgattcg ggctggggaa ggaggaggga ggtgaagcag
      121 agcgtggtcc ccgcctgccg gccccgagcc gtgagaagat gagacaggag tctgtgccat
      181 ccaaattgtt tgatccagtg agactgcaag gaagaaaggt ctctgaggcc tctgtgtgct
      241 gactgtatga cagaccccaa aggagatgcc agttgtgatg gcccgggacc tggaggagac
      301 agcatcgtcc tcagaggacg aggacctggc caaccaagag gatcacccat gtattatgtg
      361 gactggaggc tgcaggagaa ttccagtttt ggttttccat gctgaggcta ttttgacaaa
      421 ggacaacaat attcgagtaa ttggagagcg ttatcatttg tcttataaga ttgtgagaac
      481 ggacagtcgc ctggtgcgaa gcattctgac agcccatgga tttcatgaag ttcacccgag
      541 cagcactgac tataatttga tgtggacagg atcccaccta aaaccgttct tacttcgaac
      601 cctctctgaa gcacaaaagg ttaatcattt ccccaggtct tatgaactaa cccgcaagga
      661 ccgactgtac aaaaacatca ttcggatgca gcacactcat ggattcaaag cattccacat
      721 cctccctcag acctttctcc tgccagctga gtatgcagaa ttctgtaatt catattcaaa
      781 ggaccgagga ccttggatag taaaaccagt ggcctcttct agggggcggg gcgtctactt
      841 gatcaacaac ccaaaccaga tctccctgga agagaacatc ttggtctccc gttacattaa
      901 caaccccctg ctcatagatg atttcaagtt tgacgtgcgc ctctatgtgc tcgtgacttc
      961 ctatgatccc cttgtcatct atctctatga ggaaggactg gctaggtttg caactgtgcg
     1021 ttatgatcaa ggctccaaga acatccgcaa ccagttcatg cacctgacga actacagcgt
     1081 gaacaagaag agtggagact atgtgagttg tgatgaccca gaagtggagg attatgggaa
     1141 caagtggagc atgagtgcca tgcttaggta cctgaaacaa gaaggcaagg acacaactgc
     1201 attgatggcc catgtggaag acctgatcat taagacaata atctctgctg aactagctat
     1261 cgccactgcc tgtaaaacct ttgttccaca ccgcagcagt tgttttgaac tgtatggctt
     1321 tgatgtgctc atagataata ctctgaagcc atggttgttg gaagtgaatc tctctccttc
     1381 tttggcctgt gatgctcctc tggatctaaa gattaaagcc agtatgatct cagacatgtt
     1441 cactgttgta ggatttgtgt gccaagatcc tgcccagcgg acatccaacc ggtcaattta
     1501 tcccagtttt gagtcttcca ggcggaaccc ttttcagaaa cctcagcgca cccgtccact
     1561 ctctgccagt gatgcagaaa tgaaaaacct tgtggcctca gcccgggaga aggtaccggg
     1621 gaagttaggc ggttctgtgc ttggtctgtc aatggaggag atcaaagttc tccggagggt
     1681 aaaggaggag aatgatcgga gaggagggtt tattcgcata tttcctacat cggagacatg
     1741 ggaaatatat gggtcctacc ttgaacacaa aacctccatg aactacatgc tggcaacacg
     1801 cctattccag gacagaggaa accccagaag gagcttgctg acaggaagag cacgagtgag
     1861 cacggaagga gcaccagagc taaaggtgga gagcatgaac tccaaggcca agctgcatgc
     1921 cgctctctat gagaggaagc tactgtctct ggaggtgcga aaacgtagac gacggagtgg
     1981 cagattgagg gcaatgaggc caaaataccc agtgattgcc caaccagctg aaatgaatat
     2041 taaaaccgag acagagagtg aagaggagga agaagttgga ttagacaatg acgatgaaga
     2101 gcaggaagca tcccaggagg agtctgcagg gtctcttgga gaaaatcaag ccaagtacac
     2161 accttcattg actgttatag tagaaaattc gcccagagac aatgcaatga aagttgccga
     2221 gtggactaat aaaggtgaac cgtgctgcaa aatcgaggct caggagccag agtctaaatt
     2281 caacctgatg cagattctcc aggacaatgg caatctaagc aaagtacagg cccggttagc
     2341 attctctgcc tatcttcagc atgtgcaaat ccgtctgaca aaagacagtg gtggtcagac
     2401 actcagtccc agctgggctg ccaaagagga tgaacagatg gaactggtgg ttcgttttct
     2461 caagcgagcg tcaagtaacc tccagcactc gctgaggatg gtattgccta gtcggcggtt
     2521 ggcacttctg gagcgcagga gaatccttgc ccaccagcta ggagacttta tcggtgtgta
     2581 caacaaggaa acagaacaaa tggctgaaaa gaaatcaaag aagaaacttg aagaagagga
     2641 agaagatggg gtgaacgcag aaagctttca ggagtttatt cgacaagcaa gtgaggctga
     2701 actggaggag gtgttgactt tttataccca aaaaaacaag tctgccagtg tcttcctggg
     2761 gactcactcg aaaagctcta agaacagcag tagttactct gatagtgggg caaaaggtga
     2821 tcaccctgag accatacaag aagtgaaaat aaagcaaccc aaacagcaac aggcaacaga
     2881 aatccacgcc gataaattat ctcgatttac cacttcatca ggaaaagagg cgaaactagt
     2941 gtataccaat tgctcttctt tctgcagtcc tgctgctgtt cttctgcaga gactccccag
     3001 ctcccatctg tcgtccgtga tcacaacctc tgccctctcg gcaggccctg gccaccatgc
     3061 ttctctatct caaatccctc cagctgtccc cagcctgcct caccagccag cactgctact
     3121 gagccccgtt cctgacaatg cccctccctc catacactct ggaacccaga atgtaagccc
     3181 tgcggggctg ccacgctgtc gatccggcag ctacaccatt ggcccctttt cctctttcca
     3241 aagtgccgca catatctata gccagaaact gtctcgtccc tcctcagcaa aggcagcagg
     3301 gtcatgtcat ccacacaagc atcattcagg aattgccaaa acacaaaaag agggtgaaga
     3361 tgtttcatta aacaggaggt acaaccaaag tctggttacg gctgaactcc agcggctcgc
     3421 ggagaagcag gcagccaggc agtattctcc agccagtcac atcagtctcc tcactcagca
     3481 ggtgacaaac ctgaatttgg ccagcagtgt cataaacaga agcagtgcat ccaccccccc
     3541 tacccttcgg cctgtcatca gtcctagtgg cccaacgtgg tctatacagc cagacctcca
     3601 cgcttctgag acccactcca gcccccctgg aagcaggagc ctccagacag gtggctttgc
     3661 ctgggagggc gaggtagaga acaacgcata cagcaagact acaggggtgg tcccccagca
     3721 caagtaccac cccacagcag gcagctacca gctccacttt gctctccagc aactcgagca
     3781 acaaaaactt cagtcccggc aacttctgga ccagagtcga gcccggcacc aggcaatctt
     3841 tggcagccag acactaccta actccagttt atggacaatg aataatggtc caggctgcag
     3901 aatttcaagt gccacaactg gtggccagaa gccaaacacc ctgccacaaa aagtagtggc
     3961 acctccaaat tcatccacct tggtctccaa gcctgcatcc aatcacaagc aagtgctcag
     4021 aaagccggca tcccagaggg cttccaaagg gtcctctgca gaagggcagc tgaacggtct
     4081 ccagagcagc cttaaccctg cagccttcat gcccatcacc aactccacag gatctttgga
     4141 agctccccaa gttattttcg caagatccaa acccttaccc acacagtctg gagcccttgc
     4201 tacagttata ggacagagaa aatcaaagtc ggtgaagtca gggacaattt aagaccctgc
     4261 tcacactaac agatgaacca gagactccaa gggaagaaga acctgctgtg cgctcctggg
     4321 agcttgacgg aggctaagcc tccacggtgc tgtgaggggt ccatagtatt tttttgctgc
     4381 ctctgagtcc ccaaggcctt taagcagaag tgacagtaga tgcttgccat cagccagccc
     4441 agacttttac caggacaaca gggaacagac cctgtgggtt tggatgagat tggcagtggg
     4501 gactgtcgcc tgatgcgtgt ccccagcaga acacctttca gagtgtgcct ttccctgccc
     4561 tccccctgcc ctgctaggtc cctctgtctc tcctcctgct gctcacagat ggtataaagg
     4621 aggctctttg gctatttgca tctggctttt gctgcttttc cagattgaaa tattaagttt
     4681 attttatttt gtacaagctt cagatcccaa catcaaccac caaacttgat cttccctttc
     4741 ccgagagtgt ggggggtggg gagccaacag caccggctcc ccagagtggg gaggcaagta
     4801 ggcggctgcc atggtccagg cgccatttgg aattactgac ttctaagatt aataaagtaa
     4861 ttcaactttt c
//
