LOCUS       NM_133923               3168 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus tubulin tyrosine ligase-like family, member 3 (Ttll3),
            transcript variant 1, mRNA.
ACCESSION   NM_133923
VERSION     NM_133923.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3168)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3168)
  AUTHORS   Bellchambers,H.M., Phatak,A.R., Nenni,M.J., Padua,M.B., Gao,H.,
            Liu,Y. and Ware,S.M.
  TITLE     Single cell RNA analysis of the left-right organizer transcriptome
            reveals potential novel heterotaxy genes
  JOURNAL   Sci Rep 13 (1), 10688 (2023)
   PUBMED   37393374
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3168)
  AUTHORS   Janeckova,E., Feng,J., Guo,T., Han,X., Ghobadi,A.,
            Araujo-Villalba,A., Rahman,M.S., Ziaei,H., Ho,T.V., Pareek,S.,
            Alvarez,J. and Chai,Y.
  TITLE     Canonical Wnt signaling regulates soft palate development by
            mediating ciliary homeostasis
  JOURNAL   Development 150 (5) (2023)
   PUBMED   36825984
REFERENCE   4  (bases 1 to 3168)
  AUTHORS   Zhu,X., Song,G., Zhang,S., Chen,J., Hu,X., Zhu,H., Jia,X., Li,Z.,
            Song,W., Chen,J., Jin,C., Zhou,M., Zhao,Y., Xie,H., Zheng,S. and
            Song,P.
  TITLE     Asialoglycoprotein Receptor 1 Functions as a Tumor Suppressor in
            Liver Cancer via Inhibition of STAT3
  JOURNAL   Cancer Res 82 (21), 3987-4000 (2022)
   PUBMED   36043912
REFERENCE   5  (bases 1 to 3168)
  AUTHORS   Gadadhar,S., Alvarez Viar,G., Hansen,J.N., Gong,A., Kostarev,A.,
            Ialy-Radio,C., Leboucher,S., Whitfield,M., Ziyyat,A., Toure,A.,
            Alvarez,L., Pigino,G. and Janke,C.
  TITLE     Tubulin glycylation controls axonemal dynein activity, flagellar
            beat, and male fertility
  JOURNAL   Science 371 (6525) (2021)
   PUBMED   33414192
  REMARK    GeneRIF: Tubulin glycylation controls axonemal dynein activity,
            flagellar beat, and male fertility.
REFERENCE   6  (bases 1 to 3168)
  AUTHORS   Adissu,H.A., Estabel,J., Sunter,D., Tuck,E., Hooks,Y.,
            Carragher,D.M., Clarke,K., Karp,N.A., Newbigging,S., Jones,N.,
            Morikawa,L., White,J.K. and McKerlie,C.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Histopathology reveals correlative and unique phenotypes in a
            high-throughput mouse phenotyping screen
  JOURNAL   Dis Model Mech 7 (5), 515-524 (2014)
   PUBMED   24652767
REFERENCE   7  (bases 1 to 3168)
  AUTHORS   Bosch Grau,M., Gonzalez Curto,G., Rocha,C., Magiera,M.M., Marques
            Sousa,P., Giordano,T., Spassky,N. and Janke,C.
  TITLE     Tubulin glycylases and glutamylases have distinct functions in
            stabilization and motility of ependymal cilia
  JOURNAL   J Cell Biol 202 (3), 441-451 (2013)
   PUBMED   23897886
  REMARK    GeneRIF: The TTLL3 was required for stability and maintenance of
            ependymal cilia, whereas the polyglutamylase TTLL6 was necessary
            for coordinated beating behavior.
REFERENCE   8  (bases 1 to 3168)
  AUTHORS   Rogowski,K., Juge,F., van Dijk,J., Wloga,D., Strub,J.M.,
            Levilliers,N., Thomas,D., Bre,M.H., Van Dorsselaer,A., Gaertig,J.
            and Janke,C.
  TITLE     Evolutionary divergence of enzymatic mechanisms for
            posttranslational polyglycylation
  JOURNAL   Cell 137 (6), 1076-1087 (2009)
   PUBMED   19524510
REFERENCE   9  (bases 1 to 3168)
  AUTHORS   van Dijk,J., Rogowski,K., Miro,J., Lacroix,B., Edde,B. and Janke,C.
  TITLE     A targeted multienzyme mechanism for selective microtubule
            polyglutamylation
  JOURNAL   Mol Cell 26 (3), 437-448 (2007)
   PUBMED   17499049
REFERENCE   10 (bases 1 to 3168)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153910.6, AM690746.1, AK080321.1 and AA285487.1.
            
            On Jun 19, 2019 this sequence version replaced NM_133923.6.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM690746.1, SRR17784650.1249117.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC153910.6         67604-67637
            35-2818             AM690746.1         1-2784
            2819-3138           AK080321.1         2199-2518
            3139-3159           AA285487.1         294-314
            3160-3168           AC153910.6         89725-89733
FEATURES             Location/Qualifiers
     source          1..3168
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.76 cM"
     gene            1..3168
                     /gene="Ttll3"
                     /gene_synonym="4833441J24Rik"
                     /note="tubulin tyrosine ligase-like family, member 3"
                     /db_xref="GeneID:101100"
                     /db_xref="MGI:MGI:2141418"
     exon            1..434
                     /gene="Ttll3"
                     /gene_synonym="4833441J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            435..526
                     /gene="Ttll3"
                     /gene_synonym="4833441J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            527..695
                     /gene="Ttll3"
                     /gene_synonym="4833441J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            696..793
                     /gene="Ttll3"
                     /gene_synonym="4833441J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            794..922
                     /gene="Ttll3"
                     /gene_synonym="4833441J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1037
                     /gene="Ttll3"
                     /gene_synonym="4833441J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1142
                     /gene="Ttll3"
                     /gene_synonym="4833441J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1338
                     /gene="Ttll3"
                     /gene_synonym="4833441J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1487
                     /gene="Ttll3"
                     /gene_synonym="4833441J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1731
                     /gene="Ttll3"
                     /gene_synonym="4833441J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..2167
                     /gene="Ttll3"
                     /gene_synonym="4833441J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2438
                     /gene="Ttll3"
                     /gene_synonym="4833441J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..3168
                     /gene="Ttll3"
                     /gene_synonym="4833441J24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3143..3148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttll3"
                     /gene_synonym="4833441J24Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3168
                     /gene="Ttll3"
                     /gene_synonym="4833441J24Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcactgtggg gcactgcgag ctggctaaag gcgcatgcag ggtgtcagct cggcgcttct
       61 cctgagcgcg gggcagctgg ggcccggggc cgcctggtac cgccaggagg gcagctccga
      121 gtgtagctgg ctccggaggt cgcagccatc cgagctccgc accaatttct cgtcccgctg
      181 gccctggccg cgcaactccg agtcccggcg gtctgagagg ctacaatggc ctggtcccgc
      241 ctccgccaag ccggaggtgg cgagctgtgg cgacagccgt cgggattaca gctcattgcc
      301 tgcgcgccac ctaagcagcg ctcgcgagtc gtccatgccc ggtgctctgg gcactgtgaa
      361 cccccaaccc gtccgcaccc tggtcccccc gaccctggat gagccccttc ctgatgccct
      421 acggccgcct gatgattccc tactcctctg gcgaggactc accaagggac ctaaccacat
      481 gggccgactc agaaacgcca aaatccacgt agagagagcc gtcaagcaga agaagatctt
      541 tatgattcat ggccgatacc cagtgatccg gtgtctcttg cgtcagaggg gctgggtaga
      601 gaagaagatg gtgcatcccc caggcacagc cctgccagca ccccagaagg atctcgatag
      661 ctccatgctg ggtgatagcg atgccacgga ggatgaggat gaggaagaga acgaaatgtt
      721 tcgggagtcg cagctgttgg acttggatgg tttcctggaa tttgatgacc tagatgggat
      781 acatgctttg atgtcccgca tggttcgaaa tgagaccccc tacctcatct ggaccactcg
      841 gcgggatgtg ctggattgtc gcttcctttc caaggatcag atgataaacc attatgcccg
      901 tgcaggctcc ttcaccacaa aggtgggcct ttgtctcaac ctccggaatc tgccgtggtt
      961 tgatgaggcc gatgctgact ctttcttccc acgatgctac cgattggggg cagaggatga
     1021 caagaaagcc ttcatagagg acttctggct gacagctgcc cgcaacgtcc tcaagctggt
     1081 ggtgaagttg gaagagaagt cacagtccat ctccatccag gcaagagagg aagaggcccc
     1141 agaagataca cagcccaaga aacaggaaaa gaagctagtg accgtgtcct cagactttgt
     1201 cgatgaggct ctgagtgcat gccaggagca ccttagcagc atagcccaca aagacattga
     1261 caaggacccc aactccccgc tctacctcag ccccgatgat tggtcccagt tccttcagcg
     1321 ctactaccaa atagttcatg aaggggcaga gctcagatac ctggaggtcc aagtccagcg
     1381 ctgtgaagac atcctacagc agcttcagaa cgtggtaccc cagttagaca tggaggggga
     1441 tcggaacatc tggatcgtga agcccggagc caagtcccga ggccgaggga ttatgtgcat
     1501 gaaccgcctg gatgagatgc tgaagctggt ggactgcaac cccatgctca tgaaggatgg
     1561 caagtggatc gtgcagaagt acattgagcg gcccctgctt atcttcggca ccaagtttga
     1621 cctgagacag tggttcctgg tgactgactg gaacccactc accgtgtggt tctaccgaga
     1681 cagctacatt cgcttctcca cacagccctt ctccctgaag aacctggaca actctgtgca
     1741 cctgtgtaac aactccatcc agagacactt ggaggcttcc tgtcaccggc acccgatgct
     1801 gcccccagat aacatgtggt ccagccagag gtttcaggcc cacttgcagg aggtagatgc
     1861 cccaaaggcc tggtccagcg tcatcgtgcc aggcatgaag gctgctgtga tccatgccct
     1921 gcagacctcc caagataacg tgcagtgccg gaaggccagc tttgagctct atggggcaga
     1981 ctttgtgttt ggggaagact tccagccctg gttgattgaa atcaatgcca gccccaccat
     2041 ggcaccttcc acggctgtca ctgcccgcct ctgtgccggt gtgcaggcag ataccctgcg
     2101 tgtggtcatc gaccggcgcc tggaccgcag ctgtgatacg ggagcctttg agctcatcta
     2161 taagcagcct gctgtggagg tgcctcagta cgtgggtatc cggctcctag tggagggctc
     2221 taccatcaag aagcccgtgc ccgtgggtca tcggcggaca ggggtccgct catcactccc
     2281 tcatctgctg acccagcaag gctctgggga aagcaaggac tcaggctccc ctacccacag
     2341 gtcagcttct aggaaaaatg ctagggccga gagcctggag cacaccgaga agccggaacc
     2401 tgcggccgtc gcctctgtct ccggaaaggg gaagaaagcc cctttccact tccctagcct
     2461 ccattccaag gcctggctgc cttctccccg tgtgcaccga ccccagggcc gggtcctcag
     2521 actccaacat gaccagctgg tgggctctaa ggctctgtca accacaggca aggccttgat
     2581 gactcttcct actgccaagg ttctgatgtc cttcccacct caccctgatc tcaagctggc
     2641 acctagcatg ctgaaaccag gaaaggtggg cttcgagctg tgctgcacaa cctggcgggt
     2701 agtgctgagt ggtgggatcg gggaagaagg gcacagacag agggcagcac ccagaccaag
     2761 cagcgcacca gggaagggct tatcttccac agaaccctgt tccaagacag agacctgatc
     2821 atctctctct tcctcccctc ctttacgccg aggctgctat tccccagcac cttcgaggcc
     2881 cccactttgg aagtgcctcg tggcctctgc cctttgaagc cggacttctt cctagcaccc
     2941 acaggaaagt caagggcaaa ggcaagttca aggccagact cggcagcaca cccagggctg
     3001 aggcataccc caagaagagg ctgagcctcc ctaatccctt cactcttact ttggcgtccc
     3061 aaaacctgag gctcataggg gctgcgaggc tagagaaacc actgctctga tcttcactgg
     3121 cctattctgg atccagcatc aaattaaaaa aaaaaaaaag caagtaaa
//
