LOCUS       NM_001098267            1889 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Mus musculus tubulin tyrosine ligase-like family, member 2 (Ttll2),
            transcript variant 1, mRNA.
ACCESSION   NM_001098267 XM_011246172
VERSION     NM_001098267.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1889)
  AUTHORS   Ho,K.H., Candat,A., Scarpetta,V., Faucourt,M., Weill,S., Salio,C.,
            D'Este,E., Meschkat,M., Wurm,C.A., Kneussel,M., Janke,C.,
            Magiera,M.M., Genovesio,A., Meunier,A., Sassoe-Pognetto,M.,
            Brill,M.S., Spassky,N. and Patrizi,A.
  TITLE     Choroid plexuses carry nodal-like cilia that undergo axoneme
            regression from early adult stage
  JOURNAL   Dev Cell 58 (23), 2641-2651 (2023)
   PUBMED   37890489
REFERENCE   2  (bases 1 to 1889)
  AUTHORS   van Dijk,J., Rogowski,K., Miro,J., Lacroix,B., Edde,B. and Janke,C.
  TITLE     A targeted multienzyme mechanism for selective microtubule
            polyglutamylation
  JOURNAL   Mol Cell 26 (3), 437-448 (2007)
   PUBMED   17499049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117241.4.
            
            On or before Nov 18, 2022 this sequence version replaced
            XM_011246172.4, NM_001098267.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.154096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC117241.4         31607-31720
            115-217             AC117241.4         32360-32462
            218-317             AC117241.4         38799-38898
            318-1889            AC117241.4         39069-40640
FEATURES             Location/Qualifiers
     source          1..1889
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 4.72 cM"
     gene            1..1889
                     /gene="Ttll2"
                     /gene_synonym="EG625850"
                     /note="tubulin tyrosine ligase-like family, member 2"
                     /db_xref="GeneID:100216474"
                     /db_xref="MGI:MGI:3644030"
     exon            1..114
                     /gene="Ttll2"
                     /gene_synonym="EG625850"
                     /inference="alignment:Splign:2.1.0"
     exon            115..217
                     /gene="Ttll2"
                     /gene_synonym="EG625850"
                     /inference="alignment:Splign:2.1.0"
     exon            218..317
                     /gene="Ttll2"
                     /gene_synonym="EG625850"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1865
                     /gene="Ttll2"
                     /gene_synonym="EG625850"
                     /function="putative tubulin polyglutamylation"
                     /note="putative polyglutamylase; tubulin--tyrosine
                     ligase-like protein 2"
                     /codon_start=1
                     /product="probable tubulin polyglutamylase TTLL2"
                     /protein_id="NP_001091737.1"
                     /db_xref="CCDS:CCDS49941.1"
                     /db_xref="GeneID:100216474"
                     /db_xref="MGI:MGI:3644030"
                     /translation="MDGLQSLGDVTAEIFGLPLEGHSVQESKPLKTEDEPQGAPLKPL
                     VFRVDESTPGLVQSVLLERGWDKFDEQRQDVEDWNLYWRSSSFRRAEYVNVKPWQRLN
                     HHPGMTNLTRKDCLAKHLARMRSRYGESLYEFTPLTFIMPTDYTKFVAKYFKEKQDLG
                     TKPSYWICKPAELSRGRGIIIFSDIRDLMFKGTYVVQKYICNPLLVGRYKCDLRIYVC
                     ITGFKPLTIYMYQEGLVRFATEKFDLRNLEDYYSHLTNSSINKLGASYQKIKEVVGQG
                     CKWTLSRFFSYLRNWDVDDLLLRQKISHMVILTVLAMAPSVPVTYNCFELFGFDILID
                     DNLKPWLLEVNYNPALTLDCSTDESVKRSLVHDVIELLYLNGLRSEEKKCGRTSPGNS
                     VVSLARSHHHEFCATPNSSSYASLIEFTTGSKSDPAVQNICPKHTRTSQLREMMSRRD
                     RLLTKEAAKSKPRHKAWHLPRKMVFPYASQSQPHKMKGPAGDLPEAGSTPNDHAGNFV
                     LIFPFNKATFRASRNGLNVKRIIQELQKLMNK"
     exon            318..1889
                     /gene="Ttll2"
                     /gene_synonym="EG625850"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcttggca tctctgaccc aaagagaggc cattcctata cattaggctg gggacagatc
       61 tgcagaagtg acatgtagag tccagcacct tctgaagagg gcacaggcta ttcaggatcc
      121 atccgacctg ggatggagac atcatacact ggaagctaac gcgaactttc cctcctttca
      181 acggtgtctt ccgagtgttt gttacaggac tgaaaaatgc tgatcccaga ggcaggacta
      241 caatggatgg tctgcagagt ttgggtgatg tgactgcaga gatttttgga ctgccactag
      301 agggacattc tgtacaggaa agcaagcctt tgaagacaga agatgaaccc caaggggccc
      361 ccttgaagcc actggtgttc cgagtggatg agagcacccc tgggctcgta cagagtgtcc
      421 tcctggagcg tgggtgggac aagtttgatg agcaacgtca ggatgtggag gactggaatc
      481 tgtactggag gtcgtcctcc ttccggaggg cggaatatgt caatgtcaaa ccctggcaga
      541 ggctcaacca tcacccaggg atgaccaatc tcaccaggaa ggactgcctg gccaaacacc
      601 tggcgcgcat gagaagtcgc tatggtgagt ctctctatga gttcacaccc ctgacattca
      661 tcatgcccac tgactacacc aagtttgtgg ccaagtactt caaggaaaag caggatttgg
      721 gtaccaagcc aagctactgg atctgcaagc cagcagagct gtctcgaggg agggggataa
      781 tcattttcag tgacatccga gacctcatgt tcaagggcac gtatgtagta cagaagtaca
      841 tctgtaaccc cttactcgtg ggtaggtaca aatgcgacct ccgcatctat gtctgcatca
      901 ctggctttaa gcctttgacc atttacatgt accaggaagg gttagtgcgg tttgccacgg
      961 agaagtttga tctcaggaat ttggaagact attattccca tttgaccaac agcagcatca
     1021 acaaattggg ggcctcgtat cagaagatca aagaggtggt gggtcaaggc tgcaagtgga
     1081 ccctcagcag gttcttctct tacctccgca actgggatgt ggatgacctg ttactgaggc
     1141 agaagatcag ccacatggtg attctcacag tcctggccat ggctccctca gtccccgtca
     1201 cctacaactg cttcgagctt tttggatttg acatccttat tgatgataac ctgaaaccgt
     1261 ggcttttgga agtcaactac aaccctgctt tgaccttgga ctgttccacg gatgagtcgg
     1321 tcaagagaag ccttgtccat gatgttattg agctattata cttaaacggc ctcagaagtg
     1381 aggagaaaaa gtgtgggaga acttctccag gaaactccgt ggtctccctt gccaggagcc
     1441 atcaccatga gttttgtgcg acccccaatt cctcttccta tgcatctctc atagagttta
     1501 cgacgggcag taaaagcgac ccagctgtcc agaacatctg tcccaagcac actcgaacct
     1561 cccagttgag agaaatgatg agcaggcggg acagacttct gacaaaagag gcagccaaaa
     1621 gcaagccaag gcacaaggct tggcacttgc ctcgcaagat ggtcttcccg tatgcgtctc
     1681 agtcacagcc tcacaagatg aaggggcctg cgggcgacct cccggaagct ggaagcacac
     1741 caaacgacca cgccggcaac tttgtcctca tcttcccgtt caacaaggct actttcagag
     1801 cctccaggaa tgggttaaat gtcaaaagaa tcattcaaga gctccagaag ctaatgaata
     1861 aataactctt taagtgataa aagctaaaa
//
