LOCUS       NM_001396015            3259 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus tubulin tyrosine ligase-like family, member 13
            (Ttll13), transcript variant 1, mRNA.
ACCESSION   NM_001396015 XM_006540919
VERSION     NM_001396015.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3259)
  AUTHORS   Ho,K.H., Candat,A., Scarpetta,V., Faucourt,M., Weill,S., Salio,C.,
            D'Este,E., Meschkat,M., Wurm,C.A., Kneussel,M., Janke,C.,
            Magiera,M.M., Genovesio,A., Meunier,A., Sassoe-Pognetto,M.,
            Brill,M.S., Spassky,N. and Patrizi,A.
  TITLE     Choroid plexuses carry nodal-like cilia that undergo axoneme
            regression from early adult stage
  JOURNAL   Dev Cell 58 (23), 2641-2651 (2023)
   PUBMED   37890489
REFERENCE   2  (bases 1 to 3259)
  AUTHORS   Ye,B., Liu,B., Hao,L., Zhu,X., Yang,L., Wang,S., Xia,P., Du,Y.,
            Meng,S., Huang,G., Qin,X., Wang,Y., Yan,X., Li,C., Hao,J., Zhu,P.,
            He,L., Tian,Y. and Fan,Z.
  TITLE     Klf4 glutamylation is required for cell reprogramming and early
            embryonic development in mice
  JOURNAL   Nat Commun 9 (1), 1261 (2018)
   PUBMED   29593216
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3259)
  AUTHORS   van Dijk,J., Rogowski,K., Miro,J., Lacroix,B., Edde,B. and Janke,C.
  TITLE     A targeted multienzyme mechanism for selective microtubule
            polyglutamylation
  JOURNAL   Mol Cell 26 (3), 437-448 (2007)
   PUBMED   17499049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109232.17.
            
            On Sep 15, 2021 this sequence version replaced XM_006540919.5.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC145749.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849381, SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-281               AC109232.17        148607-148887
            282-549             AC109232.17        149508-149775
            550-590             AC109232.17        150519-150559
            591-709             AC109232.17        152344-152462
            710-840             AC109232.17        154725-154855
            841-997             AC109232.17        155265-155421
            998-1141            AC109232.17        155803-155946
            1142-1227           AC109232.17        156306-156391
            1228-1459           AC109232.17        156695-156926
            1460-1644           AC109232.17        157536-157720
            1645-1830           AC109232.17        159069-159254
            1831-2011           AC109232.17        160401-160581
            2012-2191           AC109232.17        160867-161046
            2192-2510           AC109232.17        161599-161917
            2511-3259           AC109232.17        162297-163045
FEATURES             Location/Qualifiers
     source          1..3259
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.57 cM"
     gene            1..3259
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /note="tubulin tyrosine ligase-like family, member 13"
                     /db_xref="GeneID:269954"
                     /db_xref="MGI:MGI:1920845"
     exon            1..281
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /inference="alignment:Splign:2.1.0"
     exon            282..549
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..2770
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tubulin polyglutamylase TTLL13; tubulin--tyrosine
                     ligase-like protein 13"
                     /codon_start=1
                     /product="tubulin polyglutamylase TTLL13 isoform 1"
                     /protein_id="NP_001382944.1"
                     /db_xref="GeneID:269954"
                     /db_xref="MGI:MGI:1920845"
                     /translation="MEPNNCKTSESEEDDIEEEESEEECVREESTTPNSTQQALRKAD
                     YKEFENGVALSVVAKKIPKKILSATDTDDLEVGRRRRKRKRRPLAINLTNCKYESVRR
                     AAQMCGLKEVGEDEEWTVYWTDCSVSLERVMDMKRFQKINHFPGMTEICRKDLLARNL
                     NRMQKLYPTEYNIFPRTWCLPADYGDFQAYGRQRKTRTYICKPDSGCQGRGIFITRTP
                     KEIKPGEHMICQQYITKPFLIDGFKFDMRIYVLITSCDPLRIFMYEEGLARFATMPYV
                     EPSHNNLEEVCMHLTNYAINKHNENFVRDDAVGSKRKLSTLNAWLREHSHDPQELWGD
                     IEDIIIKTIISAHSVLRHNYRTCFPQYLCGGTCACFEILGFDILLDHKLKPWLLEVNH
                     SPSFTTDSRLDREVKDALLCDAMNLVNLRGCDKKKVIEEDKRRVKERLFPCHQQPRET
                     RREQFELSQAAMHDQERYEDSHLGGYRRIYPGPDSEKYAPFFKHNGSLFQETAASKAR
                     EECARQQLEEIRLKQEQQENPGTKKRKENKEQNQGESAGEKSRSRTATRVLATSLAYR
                     NRNREKELLPVQLDTTQPQDIVEEEELERMKLLLQRENLIRSLGIVEQLTRMLYPSHR
                     SHRKLHEYRPRFHQDGLSSQELQPVNLVPLVLLRGAASEQIPPHFLQPLRPHELIPRI
                     LGPLSSINPAIAQHSRYHLQPKNFNWIGDSAATGPCSLSMKKSGRHYISSSRVRLTSQ
                     GQASRRLEAINRALSGSVPPTLTPRQGYLLQPKRQENGSWTECCTLPSMVNSEHRGSK
                     AGDLPLCPASAPVLQHSSPLLNIIQHR"
     exon            550..590
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /inference="alignment:Splign:2.1.0"
     exon            591..709
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /inference="alignment:Splign:2.1.0"
     exon            710..840
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /inference="alignment:Splign:2.1.0"
     exon            841..997
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1141
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1227
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1459
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1644
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1830
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..2011
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2191
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2510
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..3259
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3235..3240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /note="hexamer: ATTAAA"
     polyA_site      3259
                     /gene="Ttll13"
                     /gene_synonym="1700111A04Rik; 4921538O11"
                     /note="major polyA site"
ORIGIN      
        1 gtgtccatag cgacggcggc ggcggcggcc gtctgcttgc ttaagaagtc gccgccgccg
       61 ccaggatctc ggagccagga gttaaccccg agggggagcg ggctccccct cgcgacagcg
      121 gggacagaca gtcctgtgga acgacgagaa ggtccccgac gtccagcaac gcccaggaag
      181 agccgcagcg aacgagcggc ggccatgagc gaccagctga gtccagcccc gagccgatag
      241 gggcagctcc agcagcccct gagctctcct cgaaacctcg gaatctgaga ggatggagcc
      301 caataactgt aagaccagtg aatctgagga agatgatatt gaggaagaag aatctgagga
      361 agaatgtgtt agagaggaat ctaccacccc caactctacc cagcaggcac ttagaaaggc
      421 tgactataaa gaatttgaga atggggttgc cttatcggtt gtagccaaga aaattccaaa
      481 gaaaatatta agtgcaacag acacagatga tttggaagtt gggaggagaa gaagaaagcg
      541 gaaacgaaga cccctggcca tcaacctgac caactgcaag tatgagagtg tgcgccgggc
      601 agcccaaatg tgtggcctga aggaagtagg ggaggatgag gagtggacgg tgtactggac
      661 agactgctct gtctcactgg aacgagtcat ggacatgaag aggtttcaga aaatcaacca
      721 cttccctggc atgacggaaa tctgccgcaa agatctgctg gctcggaacc tcaaccgcat
      781 gcagaagctc taccctactg agtacaacat cttcccacgc acctggtgcc tccctgcgga
      841 ctatggggac ttccaggcct acggtcgtca gcggaaaacc cgcacttata tctgcaagcc
      901 agatagcggc tgtcaggggc gtggcatctt tatcaccaga acccccaagg aaatcaagcc
      961 aggagagcat atgatctgcc agcagtacat caccaagccc ttccttattg atggcttcaa
     1021 gtttgacatg cgaatctatg ttctgatcac ttcctgtgac cctctccgga tcttcatgta
     1081 cgaggaaggc ctggctcgtt ttgccactat gccgtatgtg gaacctagcc ataacaacct
     1141 ggaggaggtc tgcatgcacc tgaccaacta tgccatcaat aaacacaatg agaattttgt
     1201 ccgagatgat gctgtgggca gtaagaggaa gctgtcgaca ctcaatgcct ggctgcgaga
     1261 gcacagccat gatccccaag agctgtgggg ggacatcgag gacatcatca tcaaaaccat
     1321 catctcagcc cactctgtgc ttcgccacaa ctaccgaacc tgtttccccc aatatctgtg
     1381 tggaggtaca tgcgcctgct ttgagatcct ggggtttgac atcttactgg accacaaact
     1441 caagccctgg cttctagagg taaaccactc cccaagcttc accacagact cccgcctgga
     1501 tcgagaggtg aaagatgcac ttctctgtga tgctatgaac cttgtcaacc tccggggctg
     1561 tgacaaaaag aaggtgattg aagaagacaa acgtcgagtc aaggagcggc ttttcccgtg
     1621 ccaccaacag ccacgagaaa ccaggcgaga acagtttgag ttatcccagg ctgccatgca
     1681 tgaccaggag cgctatgaag actcccacct agggggatac cggcggatct acccggggcc
     1741 cgactccgag aaatacgcac ctttcttcaa gcacaatggc tccctcttcc aggagacagc
     1801 tgcctccaag gccagagagg agtgtgccag gcagcaactg gaagagattc gcctaaagca
     1861 ggaacagcag gagaacccag gcaccaagaa gcgcaaggaa aacaaggagc agaatcaggg
     1921 agaatcggcg ggggagaaaa gccgatcccg aacagctact cgggtccttg ccaccagctt
     1981 ggcatacagg aaccggaacc gggagaaaga gctgctgcca gtacaactgg acactacgca
     2041 gcctcaggac atcgtggaag aggaggagct cgagcggatg aagctcctgc tacagagaga
     2101 gaacctcatc cgcagcctgg gcattgtaga gcagctcacc cgcatgctgt accctagcca
     2161 ccggagccac agaaagcttc atgagtatcg gcctagattt caccaggacg ggctgagcag
     2221 tcaagaactg caacctgtga atttggtccc attggtgctt ctgagagggg ctgcctcaga
     2281 gcagatccct cctcatttcc tgcaaccact tcggccccac gagttgatcc ccaggatctt
     2341 agggccgcta tcaagcatca atcccgcaat tgcacagcat tcccggtacc atcttcagcc
     2401 caagaacttc aactggatag gagattcagc agccacgggc ccctgttcat tgtcaatgaa
     2461 gaaatctggg aggcactata tttccagctc tagagtcagg ctcactagcc aaggccaagc
     2521 cagcagaagg ctagaagcca taaacagagc cctgtcagga tcagtgccac ccactctaac
     2581 cccaaggcag ggctatcttc tgcagcccaa aagacaggaa aatggctcat ggactgaatg
     2641 ctgcaccttg ccctccatgg taaactctga acacagagga agcaaggctg gggatcttcc
     2701 cctatgccct gcctctgcac cagtactgca gcattccagc ccactcctca acatcatcca
     2761 acacaggtaa aagaaggaaa gcccagcact caaccaaaac agcaaatggt cttcaatctt
     2821 tgctaattga aagactgcca acaagttcca gattgaaaag ctctggccag gacctttgtt
     2881 tgcaaaaggc aaaaaacacg gagacaccaa gagttcttca acattctaag attctttggg
     2941 gatcggtaaa gactaaaaga tgaagagcta aggccagctt gtatgcatcg ctgctcacca
     3001 agccttaggc tgagtttatc cctaagcgat gggtctgaac cctgggtatg gcttggggct
     3061 ggaggtcact gggcaacaag gaattccttt cccggaggag tcaaaagcga ctacggtgta
     3121 gtcgccatca gaagattgct gagggtacgc ccttcctgcc acagtggcag aatcaggcag
     3181 gcctgggcag cctgtgccag aggggcggct ctgggcaact gaacccgtct ttttattaaa
     3241 gtttatgtcg ttttccagg
//
