LOCUS       NM_029774               3373 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus tubulin tyrosine ligase-like family, member 11
            (Ttll11), mRNA.
ACCESSION   NM_029774
VERSION     NM_029774.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3373)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3373)
  AUTHORS   Ho,K.H., Candat,A., Scarpetta,V., Faucourt,M., Weill,S., Salio,C.,
            D'Este,E., Meschkat,M., Wurm,C.A., Kneussel,M., Janke,C.,
            Magiera,M.M., Genovesio,A., Meunier,A., Sassoe-Pognetto,M.,
            Brill,M.S., Spassky,N. and Patrizi,A.
  TITLE     Choroid plexuses carry nodal-like cilia that undergo axoneme
            regression from early adult stage
  JOURNAL   Dev Cell 58 (23), 2641-2651 (2023)
   PUBMED   37890489
REFERENCE   3  (bases 1 to 3373)
  AUTHORS   Wu,H.Y., Rong,Y., Bansal,P.K., Wei,P., Guo,H. and Morgan,J.I.
  TITLE     TTLL1 and TTLL4 polyglutamylases are required for the
            neurodegenerative phenotypes in pcd mice
  JOURNAL   PLoS Genet 18 (4), e1010144 (2022)
   PUBMED   35404950
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3373)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3373)
  AUTHORS   Ye,B., Liu,B., Hao,L., Zhu,X., Yang,L., Wang,S., Xia,P., Du,Y.,
            Meng,S., Huang,G., Qin,X., Wang,Y., Yan,X., Li,C., Hao,J., Zhu,P.,
            He,L., Tian,Y. and Fan,Z.
  TITLE     Klf4 glutamylation is required for cell reprogramming and early
            embryonic development in mice
  JOURNAL   Nat Commun 9 (1), 1261 (2018)
   PUBMED   29593216
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3373)
  AUTHORS   Lacroix,B., van Dijk,J., Gold,N.D., Guizetti,J.,
            Aldrian-Herrada,G., Rogowski,K., Gerlich,D.W. and Janke,C.
  TITLE     Tubulin polyglutamylation stimulates spastin-mediated microtubule
            severing
  JOURNAL   J Cell Biol 189 (6), 945-954 (2010)
   PUBMED   20530212
REFERENCE   7  (bases 1 to 3373)
  AUTHORS   van Dijk,J., Rogowski,K., Miro,J., Lacroix,B., Edde,B. and Janke,C.
  TITLE     A targeted multienzyme mechanism for selective microtubule
            polyglutamylation
  JOURNAL   Mol Cell 26 (3), 437-448 (2007)
   PUBMED   17499049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL773525.5, AL845477.8 and AL732413.4.
            
            On Jun 21, 2019 this sequence version replaced NM_029774.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM690755.1, SRR7974084.6535.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-649               AL773525.5         30296-30944         c
            650-746             AL845477.8         97888-97984         c
            747-880             AL845477.8         93699-93832         c
            881-1456            AL845477.8         55595-56170         c
            1457-1552           AL845477.8         43297-43392         c
            1553-1668           AL845477.8         42290-42405         c
            1669-1767           AL732413.4         31155-31253
            1768-2013           AL732413.4         53374-53619
            2014-2120           AL732413.4         64781-64887
            2121-3373           AL732413.4         96484-97736
FEATURES             Location/Qualifiers
     source          1..3373
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 23.9 cM"
     gene            1..3373
                     /gene="Ttll11"
                     /gene_synonym="4932702F08Rik; 4933424A20Rik; D2Ertd624e"
                     /note="tubulin tyrosine ligase-like family, member 11"
                     /db_xref="GeneID:74410"
                     /db_xref="MGI:MGI:1921660"
     exon            1..649
                     /gene="Ttll11"
                     /gene_synonym="4932702F08Rik; 4933424A20Rik; D2Ertd624e"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..2380
                     /gene="Ttll11"
                     /gene_synonym="4932702F08Rik; 4933424A20Rik; D2Ertd624e"
                     /note="polyglutamylase; tubulin--tyrosine ligase-like
                     protein 11"
                     /codon_start=1
                     /product="tubulin polyglutamylase TTLL11"
                     /protein_id="NP_084050.1"
                     /db_xref="CCDS:CCDS50579.1"
                     /db_xref="GeneID:74410"
                     /db_xref="MGI:MGI:1921660"
                     /translation="MRRSSPEKKPEAEWEADAAAAAAATAAATESLPAETEKQQGVDA
                     GAAGDPERLELEEQPKDVGRIPTPTRRHAPEEGEARVVRRLPPALPLAQPRPAARALS
                     QLVKARGRSRSRVYRRSAGSMRPVTVDSSKARTSLDALKISLRQLRWKEFPFGRRLPC
                     DIYWHGVSFRDSDILSGQVNKFPGMTEMVRKVTLSRALRIMQNLFPEEYNFYPRSWIL
                     PEEFQLFVSQVQTVKEGDPSWKPTFIVKPDSGCQGDGIYLIKDPCDGRLTGTLHNRPA
                     VVQEYIRKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEPNPQNLHH
                     VFMHLTNYSLNIHSGKFVHSDSASTGSKRTFSSILCRLSSKGVDIKKVWSDIISLVIK
                     TVIALTPELKVFYQSDIPTGRPGPTCFQILGFDILLMKNLKPMLLEVNANPSMRIEHE
                     YELSPGVFENIPSLVDEEVKVAVIRDTLRLMDPLKKKKEIHFPDIYMDRKHRIPPVSD
                     RMSSWKHKGSSLSIVRSQQMEKSFTSKEDLNCDPTGGDSEPNPEAHLPSICLKQVFPK
                     YAKQFNYLRLVDRMANLFIRFLGIKGTMKLGPTGFRTFIRNCKLSSSSLSMAAVDILY
                     IDITRRWNSVTVDQRDSGMCLQAFVEAFFFLAQRKFKLQPLHEQVASLIDLCEYHLSV
                     LDEKRLLCHRGRPLQRNPPQMNRPEHSATGSSAPRVIGASKLSQS"
     exon            650..746
                     /gene="Ttll11"
                     /gene_synonym="4932702F08Rik; 4933424A20Rik; D2Ertd624e"
                     /inference="alignment:Splign:2.1.0"
     exon            747..880
                     /gene="Ttll11"
                     /gene_synonym="4932702F08Rik; 4933424A20Rik; D2Ertd624e"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1456
                     /gene="Ttll11"
                     /gene_synonym="4932702F08Rik; 4933424A20Rik; D2Ertd624e"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1552
                     /gene="Ttll11"
                     /gene_synonym="4932702F08Rik; 4933424A20Rik; D2Ertd624e"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1668
                     /gene="Ttll11"
                     /gene_synonym="4932702F08Rik; 4933424A20Rik; D2Ertd624e"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1767
                     /gene="Ttll11"
                     /gene_synonym="4932702F08Rik; 4933424A20Rik; D2Ertd624e"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..2013
                     /gene="Ttll11"
                     /gene_synonym="4932702F08Rik; 4933424A20Rik; D2Ertd624e"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2120
                     /gene="Ttll11"
                     /gene_synonym="4932702F08Rik; 4933424A20Rik; D2Ertd624e"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..3373
                     /gene="Ttll11"
                     /gene_synonym="4932702F08Rik; 4933424A20Rik; D2Ertd624e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3356..3361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttll11"
                     /gene_synonym="4932702F08Rik; 4933424A20Rik; D2Ertd624e"
                     /note="hexamer: AATAAA"
     polyA_site      3373
                     /gene="Ttll11"
                     /gene_synonym="4932702F08Rik; 4933424A20Rik; D2Ertd624e"
                     /note="major polyA site"
ORIGIN      
        1 gtcccttgcg gggccccgtc ccgaggcggc gactatccct gtcaaccggg gcctgagaga
       61 tcatggcaac gggctcgggc ggggagcgcg tggcggcggc ggcggcggcg acggcggcgg
      121 cagtttggtc gcgggccggg acggcggagc agcggcggcg gcggtggctg tggcgccggc
      181 accggccctg agcgtcatgc ggcgcagcag cccggagaag aagccggagg ctgagtggga
      241 ggcggacgcg gcggcggcgg cggcggcgac agcagcggcg accgagtcgc taccggcgga
      301 gactgagaag cagcagggcg tggacgctgg cgcggccggg gatccagagc gcctggagct
      361 ggaggagcag cccaaggacg tgggccggat cccgaccccg acgcgacgcc acgcgcccga
      421 ggaaggagag gcccgcgtcg tccggcggct gccaccagcg ctgcccctgg cccagccgag
      481 gccggcggcg cgggccctga gccagctcgt gaaggcacgg ggccggagcc ggagccgggt
      541 ctaccggcgg agcgcaggct cgatgcggcc ggtcaccgtg gacagctcca aggcccgcac
      601 ctccctggac gcgctcaaga tcagtcttcg ccagctcagg tggaaggagt tcccatttgg
      661 ccggcgcttg ccttgtgata tctactggca tggagtttca tttcgtgaca gtgacatact
      721 ctccggtcaa gtgaacaaat ttccaggcat gacggagatg gtgcgtaagg tcaccttgag
      781 ccgagcactg aggatcatgc agaacctgtt tccagaggag tacaacttct accctcgctc
      841 ctggatcctg ccagaagagt tccagctctt tgtgtctcag gtccaaacgg tgaaagaagg
      901 tgacccctcc tggaagccca cttttattgt gaaaccggat agtggttgtc agggtgatgg
      961 aatctacctc attaaggatc cctgtgatgg tcgcctgact gggaccctcc ataacaggcc
     1021 ggcagtggtc caggagtaca tccgcaagcc cctcctcatc gacaaactca agttcgacat
     1081 ccgtctgtat gtcttgctga agtccttgga tcccttagag atttatattg ccaaagatgg
     1141 actctctagg ttttgtacag agccatatca agaacctaac ccccagaatc tgcaccatgt
     1201 ctttatgcac ctgaccaact actccctgaa tatccacagc ggcaagtttg tccactctga
     1261 cagcgccagc acgggcagca agaggacttt ctctagcatt ctttgtagac tgtcttccaa
     1321 aggtgtggac atcaagaagg tctggtctga tatcatctcc ttagttatta agactgtcat
     1381 cgccctgacc ccagagctca aagttttcta ccagtcagac atcccaacag ggaggccggg
     1441 gcccacctgc ttccagattc taggctttga cattcttctg atgaaaaact tgaagcctat
     1501 gctacttgaa gtgaatgcaa accccagcat gcgaattgag catgaatacg aactctctcc
     1561 aggagtgttt gaaaatatcc ccagcctggt ggatgaagag gtaaaggtgg ctgtgatcag
     1621 agacacgctg cgcctcatgg acccgctgaa gaagaaaaag gagatccact ttccagatat
     1681 ctatatggac agaaaacaca gaattcctcc agtttctgac agaatgtctt catggaagca
     1741 taagggttcc tcgctttcca tagtcaggtc tcagcagatg gaaaagtctt tcacttcaaa
     1801 ggaagatctg aactgtgacc cgactggtgg tgactccgag cccaaccctg aagcccatct
     1861 gccctccatt tgcctcaagc aggtgttccc caagtatgcc aagcagttca actacttgcg
     1921 cctcgtggac aggatggcca atttgttcat ccgatttctg ggaatcaagg ggacgatgaa
     1981 gttgggacca actggctttc ggaccttcat aaggaactgc aaactcagca gcagcagcct
     2041 gtccatggca gctgtggaca tcctctacat agacatcaca aggaggtgga actcggtgac
     2101 cgtggaccag cgggactcag ggatgtgtct gcaggcattt gtcgaagctt tcttcttcct
     2161 ggcccagagg aagttcaagc tgcaacctct ccatgagcag gtggcgtcct tgattgacct
     2221 gtgtgaatac cacctgtccg tgctggatga aaaacgcttg ctgtgccatc ggggccggcc
     2281 cctccaaaga aatccgcccc agatgaaccg cccagagcat tcagccacag gcagctctgc
     2341 accccgagta atcggggcta gcaagctctc tcaatcctga catgctctgt cctgaaggcc
     2401 actctgtcct ggaagaaggc gtgcctgtgg gggctgagta ccctgggctc cccccacccc
     2461 catctgttgg gagccactag ggttccagct gcaatcacct gtgcgtcctc tctgtgttcc
     2521 gtagggcatt ttgcctcaca cggccaatcc ttgcctgtcc ccttcccagc acttcatggt
     2581 gacccaccct gtttgggaat catcagtgga tatatgacat ccaagatgtg acagatggca
     2641 ccgactattc tgggctcctg ggaagcacca actggggcag tttttgctgt gcttggggcg
     2701 gcatgggaat ggagggggag gggaaggtga aggacagacc atcctaaggt aaagagctgt
     2761 ggatgtggag aacagtcaca ccggggtctg agagcctgct ggtcagagct tagcatcatc
     2821 gcatgtcttt ccttctgccc attgcctgaa acgaagttga aatacgaaga aggtggacac
     2881 ctccgatcat gtgctgcacg ggtgtccttt acagacttac ctcacttttt tgttaacttg
     2941 cctgttgccg caatgtttaa tactaatcaa gaaataatta agaaataata cagtaaggtc
     3001 ttcagtctcc ccatccaggt tccaggggac ccctgcaacg gtgggggact gacccaatgg
     3061 ccaagagcca ctgtgtaccc aacactgtgc tgtgagccct gagtgagggg aggggcttca
     3121 gaggggagag cataaggccc ccatgatagc aggacaagca gacgtgtgtg tagagcatat
     3181 ggtagcctag accagaacaa ccagtgttct cgagtgtcta ctccgagggg cagaggtgaa
     3241 aggccttggt tgctgttcct tggaacccaa gtgggtttcc cagaagtccc aaatgagaag
     3301 tgtgtgggga cattctttaa ccagccttga gctgtacagc tgtagaaagc tattaaataa
     3361 agctttgact tga
//
