LOCUS       NM_001368641            2269 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus tubulin tyrosine ligase-like family, member 10
            (Ttll10), transcript variant 2, mRNA.
ACCESSION   NM_001368641
VERSION     NM_001368641.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2269)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2269)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2269)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   4  (bases 1 to 2269)
  AUTHORS   Ikegami,K. and Setou,M.
  TITLE     TTLL10 can perform tubulin glycylation when co-expressed with TTLL8
  JOURNAL   FEBS Lett 583 (12), 1957-1963 (2009)
   PUBMED   19427864
  REMARK    GeneRIF: TTLL10 can strongly glycylate tubulin in a TTLL8-dependent
            manner. Furthermore, these two TTLL proteins can glycylate
            unidentified 170-, 110-, 75-, 40-, 35-, and 30-kDa acidic proteins.
REFERENCE   5  (bases 1 to 2269)
  AUTHORS   Rogowski,K., Juge,F., van Dijk,J., Wloga,D., Strub,J.M.,
            Levilliers,N., Thomas,D., Bre,M.H., Van Dorsselaer,A., Gaertig,J.
            and Janke,C.
  TITLE     Evolutionary divergence of enzymatic mechanisms for
            posttranslational polyglycylation
  JOURNAL   Cell 137 (6), 1076-1087 (2009)
   PUBMED   19524510
REFERENCE   6  (bases 1 to 2269)
  AUTHORS   Ikegami,K., Horigome,D., Mukai,M., Livnat,I., MacGregor,G.R. and
            Setou,M.
  TITLE     TTLL10 is a protein polyglycylase that can modify nucleosome
            assembly protein 1
  JOURNAL   FEBS Lett 582 (7), 1129-1134 (2008)
   PUBMED   18331838
  REMARK    GeneRIF: Recombinant TTLL10 incorporated glycine into recombinant
            nucleosome assembly protein 1 in vitro.
            GeneRIF: has a polyglycylase (i.e. glycine ligase) activity for
            nucleosome assembly protein 1 (NAP1).
REFERENCE   7  (bases 1 to 2269)
  AUTHORS   van Dijk,J., Rogowski,K., Miro,J., Lacroix,B., Edde,B. and Janke,C.
  TITLE     A targeted multienzyme mechanism for selective microtubule
            polyglutamylation
  JOURNAL   Mol Cell 26 (3), 437-448 (2007)
   PUBMED   17499049
REFERENCE   8  (bases 1 to 2269)
  AUTHORS   Chiellini,C., Costa,M., Novelli,S.E., Amri,E.Z., Benzi,L.,
            Bertacca,A., Cohen,P., Del Prato,S., Friedman,J.M. and Maffei,M.
  TITLE     Identification of cathepsin K as a novel marker of adiposity in
            white adipose tissue
  JOURNAL   J Cell Physiol 195 (2), 309-321 (2003)
   PUBMED   12652657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627204.7.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM690754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-410               AL627204.7         123932-124341       c
            411-491             AL627204.7         123203-123283       c
            492-624             AL627204.7         122990-123122       c
            625-743             AL627204.7         122727-122845       c
            744-870             AL627204.7         122524-122650       c
            871-956             AL627204.7         120965-121050       c
            957-1128            AL627204.7         120359-120530       c
            1129-1300           AL627204.7         119266-119437       c
            1301-1441           AL627204.7         118687-118827       c
            1442-1558           AL627204.7         111777-111893       c
            1559-1652           AL627204.7         111386-111479       c
            1653-2269           AL627204.7         110475-111091       c
FEATURES             Location/Qualifiers
     source          1..2269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 87.82 cM"
     gene            1..2269
                     /gene="Ttll10"
                     /gene_synonym="4833412E22Rik; 4930595O22Rik; Ttll5"
                     /note="tubulin tyrosine ligase-like family, member 10"
                     /db_xref="GeneID:330010"
                     /db_xref="MGI:MGI:1921855"
     exon            1..410
                     /gene="Ttll10"
                     /gene_synonym="4833412E22Rik; 4930595O22Rik; Ttll5"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..2191
                     /gene="Ttll10"
                     /gene_synonym="4833412E22Rik; 4930595O22Rik; Ttll5"
                     /EC_number="6.-.-.-"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tubulin tyrosine ligase-like family, member 5; protein
                     polyglycylase TTLL10; tubulin--tyrosine ligase-like
                     protein 10"
                     /codon_start=1
                     /product="protein polyglycylase TTLL10 isoform 2"
                     /protein_id="NP_001355570.1"
                     /db_xref="CCDS:CCDS89873.1"
                     /db_xref="GeneID:330010"
                     /db_xref="MGI:MGI:1921855"
                     /translation="MALHPQAGRPHRDGSEAQAEATAQDLGRLPSPSKVGAAVCPIQG
                     LGHRAARRPRRGIGTTSASRVPRPGALMPATRNRPRFIHCRGQPPRTRVSSKRSKRSR
                     IHPCHTEVPGWTHEKQMGSSVKERLRPELSQLDQDADDLEEEEAARLPVTSPDGLLME
                     GDKQPSPGQGPFFYIGGTNGASIISNYCESKGWQRTQDSHCEDYKLKWCEIKCRDNYC
                     SFREGQQLLFQLPNNKLLTTKIGLLSALREHARTLSKARMLPSTQTKVLKMEEFFPET
                     YRLDIRDERQAFFALFDETQMWICKPTASNQGKGIFLIRSQEEAAALQAKTQSIEDDP
                     IYRKMPFRAPQARVVQRYVQNPLLLDGKKFDVRSYMLIACAMPYMVFFGHGYARLTLS
                     LYNPHSSDLSGHLTNQFMQKKSPLYTLLKESTVWTMEHLNRYINDKFRKTKGLPRDWV
                     FTTFTKRMQQIMSHCFLAVKSKLECKLGYFDLIGCDFLIDENFKVWLLEMNANPALHT
                     NCEVLKAVIPGVVIETLDLALETCQKSLHSQKMLPLLSQRRFVLLYNGETTDLWPRLA
                     SSRPLNRLPNPHPNPNPNPHPHPHPHPNPNPHPHPHPNANPHPPRPTCEAASSALSSA
                     RAAISERPGARKSMPSRGAPVCTPRKSRLSDSSGSSIAESEPSLCSGSLEGSRDTARE
                     PSLGPPEEEREEEQRSTSHRGS"
     exon            411..491
                     /gene="Ttll10"
                     /gene_synonym="4833412E22Rik; 4930595O22Rik; Ttll5"
                     /inference="alignment:Splign:2.1.0"
     exon            492..624
                     /gene="Ttll10"
                     /gene_synonym="4833412E22Rik; 4930595O22Rik; Ttll5"
                     /inference="alignment:Splign:2.1.0"
     exon            625..743
                     /gene="Ttll10"
                     /gene_synonym="4833412E22Rik; 4930595O22Rik; Ttll5"
                     /inference="alignment:Splign:2.1.0"
     exon            744..870
                     /gene="Ttll10"
                     /gene_synonym="4833412E22Rik; 4930595O22Rik; Ttll5"
                     /inference="alignment:Splign:2.1.0"
     exon            871..956
                     /gene="Ttll10"
                     /gene_synonym="4833412E22Rik; 4930595O22Rik; Ttll5"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1128
                     /gene="Ttll10"
                     /gene_synonym="4833412E22Rik; 4930595O22Rik; Ttll5"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1300
                     /gene="Ttll10"
                     /gene_synonym="4833412E22Rik; 4930595O22Rik; Ttll5"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1441
                     /gene="Ttll10"
                     /gene_synonym="4833412E22Rik; 4930595O22Rik; Ttll5"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1558
                     /gene="Ttll10"
                     /gene_synonym="4833412E22Rik; 4930595O22Rik; Ttll5"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1652
                     /gene="Ttll10"
                     /gene_synonym="4833412E22Rik; 4930595O22Rik; Ttll5"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..2269
                     /gene="Ttll10"
                     /gene_synonym="4833412E22Rik; 4930595O22Rik; Ttll5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2242..2247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttll10"
                     /gene_synonym="4833412E22Rik; 4930595O22Rik; Ttll5"
                     /note="hexamer: TATAAA"
     polyA_site      2269
                     /gene="Ttll10"
                     /gene_synonym="4833412E22Rik; 4930595O22Rik; Ttll5"
                     /note="major polyA site"
ORIGIN      
        1 acacagaggc cacactcgtc gaggccagaa cagtcttggc cgaagaaaac tcactaggca
       61 gagacgggat gcaaagatgg ccctacaccc acaggccgga aggcctcaca gagatggaag
      121 tgaggcacaa gctgaagcca cagcccagga cttggggagg cttccttccc caagcaaagt
      181 gggtgcagct gtctgtccca ttcaagggct gggacatcgg gctgctcgaa gaccccgaag
      241 gggtataggg actacatctg cctcaagggt tcctcgccct ggtgccctta tgcctgcaac
      301 acgaaaccgt ccaagattca tccactgccg gggtcagccc cctcgaaccc gtgtcagctc
      361 caagagatcc aaacggtcca gaatccatcc gtgccacact gaggtgccag gctggaccca
      421 tgagaaacag atggggagca gcgtcaagga aaggctccgg cctgagctaa gtcagctgga
      481 ccaagatgca gacgacctgg aggaagaaga agctgccaga ctcccagtga cctccccgga
      541 cgggctcctg atggaaggag acaagcagcc cagtcccggt cagggccctt tcttctacat
      601 tggaggcacc aacggagcat caataatcag caactactgt gagagcaagg gctggcaacg
      661 cactcaggac agccactgtg aggactacaa gctaaagtgg tgtgagatca agtgcaggga
      721 caactactgc agctttcggg aaggccagca gttgctgttc cagctcccca acaacaagct
      781 tcttacgacc aagatcgggt tgctcagtgc tctgcgggag cacgcacgca ctttgagcaa
      841 agccaggatg ctgcccagta cccaaaccaa ggtcctgaaa atggaagagt tttttccaga
      901 gacctatcgg ctggacatca gagacgagag gcaggctttc ttcgctctat ttgatgaaac
      961 ccagatgtgg atctgcaaac ctacggcctc caaccaggga aagggcatct ttctgatcag
     1021 gagccaggag gaggctgctg ccctgcaggc caagacccag agcattgagg atgaccccat
     1081 ctaccgcaag atgcccttcc gtgcaccaca ggcgcgagtg gtgcagagat atgtccagaa
     1141 cccgctgctg ctagatggga agaagtttga tgtgcgctcc tacatgctca ttgcctgtgc
     1201 catgccttac atggtctttt ttggccatgg ctatgcccgc ctcaccctca gcctgtataa
     1261 ccctcattcc agtgacctca gtggtcattt gaccaatcag ttcatgcaga agaagagccc
     1321 cctgtacacg ctgctgaagg agagcaccgt gtggaccatg gagcacctca accgatacat
     1381 caatgacaaa tttaggaaga ccaagggcct ccccagagat tgggtcttca ccaccttcac
     1441 gaagcggatg cagcagatca tgtcccactg cttcctggct gtcaagtcca agctggagtg
     1501 caagctgggc tactttgacc tcattggctg tgacttcctg attgatgaaa acttcaaggt
     1561 gtggctgctg gagatgaacg ccaaccctgc cctgcatacc aactgtgaag tcctgaaggc
     1621 agtgatcccc ggagtggtta tagagacctt ggacctggcg cttgagacct gccaaaagag
     1681 cttgcacagt cagaagatgc tgcctctgct gtcacagcgt cgctttgtgc tcctttacaa
     1741 cggggagact acggacttgt ggccgcgctt ggcgagctcg cgcccactta accgcttgcc
     1801 taaccctcac cctaacccta accctaaccc tcaccctcac cctcaccctc accctaaccc
     1861 taaccctcac cctcaccctc accctaacgc taaccctcac cctccccggc ccacctgtga
     1921 agccgcatcc tctgcgcttt cctccgcacg ggccgctatc tcagaacggc ctggtgcacg
     1981 caagtcgatg ccctccaggg gagctcccgt gtgcacaccc cgcaaatcgc ggctgtctga
     2041 ctcgagcggt agctccatag cggagtctga gccctctctc tgttctgggt ccctggaagg
     2101 cagcagggac acagcccggg aaccctccct gggtccgccc gaggaggagc gcgaggagga
     2161 acagagaagt acgagccatc gaggctccta gcagccgcag catccagcgg ccctgcacct
     2221 tgctgtgccc tctccgggac ctataaaagc tactttgtga caaacgcaa
//
