LOCUS       NP_033471                830 aa            linear   ROD 02-MAY-2024
DEFINITION  dual specificity protein kinase TTK isoform 1 [Mus musculus].
ACCESSION   NP_033471
VERSION     NP_033471.2
DBSOURCE    REFSEQ: accession NM_009445.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 830)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 830)
  AUTHORS   Li,L., Sun,Y., Davis,A.E., Shah,S.H., Hamed,L.K., Wu,M.R.,
            Lin,C.H., Ding,J.B. and Wang,S.
  TITLE     Mettl14-mediated m6A modification ensures the cell-cycle
            progression of late-born retinal progenitor cells
  JOURNAL   Cell Rep 42 (6), 112596 (2023)
   PUBMED   37269288
REFERENCE   3  (residues 1 to 830)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 830)
  AUTHORS   Fang,Q., Chen,X.L., Zhang,L., Li,Y.B., Sun,T.Z., Yang,C.X.,
            Chang,J.F., Yang,X.M. and Sun,F.
  TITLE     The essential roles of Mps1 in spermatogenesis and fertility in
            mice
  JOURNAL   Cell Death Dis 12 (6), 531 (2021)
   PUBMED   34031364
  REMARK    GeneRIF: The essential roles of Mps1 in spermatogenesis and
            fertility in mice.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 830)
  AUTHORS   Schukken,K.M., Zhu,Y., Bakker,P.L., Koster,M.H., Harkema,L.,
            Youssef,S.A., de Bruin,A. and Foijer,F.
  TITLE     Acute systemic loss of Mad2 leads to intestinal atrophy in adult
            mice
  JOURNAL   Sci Rep 11 (1), 68 (2021)
   PUBMED   33420244
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 830)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   7  (residues 1 to 830)
  AUTHORS   Pritsker,M., Doniger,T.T., Kramer,L.C., Westcot,S.E. and
            Lemischka,I.R.
  TITLE     Diversification of stem cell molecular repertoire by alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14290-14295 (2005)
   PUBMED   16183747
REFERENCE   8  (residues 1 to 830)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (residues 1 to 830)
  AUTHORS   Hwang,S.Y., Oh,B., Knowles,B.B., Solter,D. and Lee,J.S.
  TITLE     Expression of genes involved in mammalian meiosis during the
            transition from egg to embryo
  JOURNAL   Mol Reprod Dev 59 (2), 144-158 (2001)
   PUBMED   11389549
REFERENCE   10 (residues 1 to 830)
  AUTHORS   Douville,E.M., Afar,D.E., Howell,B.W., Letwin,K., Tannock,L.,
            Ben-David,Y., Pawson,T. and Bell,J.C.
  TITLE     Multiple cDNAs encoding the esk kinase predict transmembrane and
            intracellular enzyme isoforms
  JOURNAL   Mol Cell Biol 12 (6), 2681-2689 (1992)
   PUBMED   1375325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124011.4.
            
            On Nov 2, 2007 this sequence version replaced NP_033471.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058851.1, SRR17253011.4489224.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..830
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 45.61 cM"
     Protein         1..830
                     /product="dual specificity protein kinase TTK isoform 1"
                     /EC_number="2.7.12.1"
                     /note="dual specificity protein kinase TTK"
                     /calculated_mol_wt=93408
     Region          <59..>167
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          105..134
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          139..167
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          496..764
                     /region_name="PKc_Mps1"
                     /note="Catalytic domain of the Dual-specificity Mitotic
                     checkpoint protein kinase, Monopolar spindle 1 (also
                     called TTK); cd14131"
                     /db_xref="CDD:271033"
     Site            order(504..508,512,524,526,559,575..578,581,583,620,622,
                     624..625,627,637,640,658..661)
                     /site_type="active"
                     /db_xref="CDD:271033"
     Site            order(504..508,512,524,526,559,575..578,581,620,622,
                     624..625,627,637)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271033"
     Site            order(508,581,583,620,622,624,640,658..661)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271033"
     Site            order(510,526,528,541,544,573,636)
                     /site_type="other"
                     /note="secondary chemical binding site [chemical binding]"
                     /db_xref="CDD:271033"
     Site            636..661
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271033"
     CDS             1..830
                     /gene="Ttk"
                     /gene_synonym="esk; Esk1; Mps1; PYT"
                     /coded_by="NM_009445.3:80..2572"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS52874.1"
                     /db_xref="GeneID:22137"
                     /db_xref="MGI:MGI:1194921"
ORIGIN      
        1 meaeeligss vtidsimskm rdiknkined ctdelslski cadhtetvnq imrvgntpen
       61 wlnfllklek nssplnddll nkligrysqa ievlppdkyg qnesfariqv rlaelkaiqe
      121 pddardyfqm arenckkfaf vhvsfaqfel sqgnlkkseq llhkavetga vplqmletam
      181 rnlhlqkkql lpeedkksvs astvlsaqep fssslgnvqn rsiscesrgq agaarvlyge
      241 nlppqdaevr hqnpfkqtha akrscpfgrv pvnllnspdf yvktdssavt qlttrkgsgp
      301 drdailpgsr prgsdsyelr glkpiqtiyl kdslvsneks selmsdlial ksktdssltk
      361 leetkpeiae rrpmqwqstr kpecvfqnpa afaplrhvpd vtpkadkesp pisvpkwldp
      421 ksacetpsss slddymkcfk tpvvkndfpp acpsstpysq larlqqqqqq glstplqslq
      481 isgsssinec isvngriysi lkqigsggss kvfqvlnekk qinaikyvnl edadsqties
      541 yrneiaflnk lqqhsdkiir lydyeiteqy iymvmecgni dlnswlkkkk sinpwerksy
      601 wknmleavhi ihqhgivhsd lkpanfvivd gmlklidfgi anqmqpdtts ivkdsqvgtv
      661 nymapeaird msssrenski rtkvsprsdv wslgcilyym tygrtpfqhi inqvsklhai
      721 inpaheiefp eisekdlrdv lkcclvrnpk erisipellt hpyvqiqphp gsqmargatd
      781 emkyvlgqlv glnspnsilk taktlyeryn cgegqdssss ktfdkkrerk
//
