LOCUS       NM_144927               2181 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus TELO2 interacting protein 2 (Tti2), transcript variant
            2, mRNA.
ACCESSION   NM_144927 XM_985831 XM_985868 XM_985901 XM_985940 XM_985975
VERSION     NM_144927.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2181)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2181)
  AUTHORS   Rao,F., Cha,J., Xu,J., Xu,R., Vandiver,M.S., Tyagi,R., Tokhunts,R.,
            Koldobskiy,M.A., Fu,C., Barrow,R., Wu,M., Fiedler,D., Barrow,J.C.
            and Snyder,S.H.
  TITLE     Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death
            pathway by regulating CK2 phosphorylation of Tti1/Tel2
  JOURNAL   Mol Cell 54 (1), 119-132 (2014)
   PUBMED   24657168
  REMARK    Erratum:[Mol Cell. 2020 Aug 20;79(4):702. doi:
            10.1016/j.molcel.2020.07.021.. PMID: 32822581]
REFERENCE   3  (bases 1 to 2181)
  AUTHORS   Takai,H., Xie,Y., de Lange,T. and Pavletich,N.P.
  TITLE     Tel2 structure and function in the Hsp90-dependent maturation of
            mTOR and ATR complexes
  JOURNAL   Genes Dev 24 (18), 2019-2030 (2010)
   PUBMED   20801936
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045392.1, AK084242.1 and AW120801.1.
            
            On Dec 20, 2007 this sequence version replaced NM_144927.2.
            
            Transcript Variant: This variant (2) encodes the shorter protein
            (isoform a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.885400.1,
                                           SRR7345562.4300763.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-505               AK045392.1         5-509
            506-737             AK084242.1         496-727
            738-1819            AK045392.1         743-1824
            1820-2181           AW120801.1         1-362               c
FEATURES             Location/Qualifiers
     source          1..2181
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 18.03 cM"
     gene            1..2181
                     /gene="Tti2"
                     /note="TELO2 interacting protein 2"
                     /db_xref="GeneID:234138"
                     /db_xref="MGI:MGI:2384576"
     exon            1..1184
                     /gene="Tti2"
                     /inference="alignment:Splign:2.1.0"
     CDS             535..2073
                     /gene="Tti2"
                     /note="isoform a is encoded by transcript variant 2"
                     /codon_start=1
                     /product="TELO2-interacting protein 2 isoform a"
                     /protein_id="NP_659176.2"
                     /db_xref="CCDS:CCDS22221.1"
                     /db_xref="GeneID:234138"
                     /db_xref="MGI:MGI:2384576"
                     /translation="MKLDSAEEKSGVGCSLPAEGSPPALEPAFSKILNRLSRPKSSGQ
                     GGARNAALKDLGALIEAAEGDRFFEGSGSGGSLRGMPEILGQVVRALEKFAAPEEKAD
                     GVEEHPEVPEKATEVGSLFLKLLGKVEAAKSSPDCPAWKTGLRHMSGPVYIFAITHRL
                     KQPWTSPASQHVAGEVLSLLLRVTECSSVAGFLCGENEDDRGRFAVVLGLLKPHLNKE
                     TWKKNPAVKHVFSWTLQQVTQPWLNQHLEKILPPSLLISDDYQTENKILGVQCLHHIV
                     VTVPAADLLQYNRAQVLYHALFNHLYMPEHHLIQAVLLCLLDLFPVLEKALHWKGDTA
                     RVTTHCHEVLQLILTHMEPEHRLLLRRTYARHLPAFVKRLGILTVRHLKRLEQVILGY
                     LEVYDEPEDETRLKILETLKLVMQYTWPRIPCRVVVLLKALLKLICDISRDTIPTTEA
                     AKSTMLQEATDCLILLDHCSQGQVKGLLAKIAVSCEDSTVVSCIRKVQQGSADSPGDD
                     TEGD"
     exon            1185..1371
                     /gene="Tti2"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1464
                     /gene="Tti2"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1652
                     /gene="Tti2"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1796
                     /gene="Tti2"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1959
                     /gene="Tti2"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2167
                     /gene="Tti2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2146..2151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tti2"
                     /note="hexamer: ATTAAA"
     polyA_site      2167
                     /gene="Tti2"
                     /note="major polyA site"
ORIGIN      
        1 ggccggaagt tgcggaatac agctaccgta ctggaagagc gcttggtttc gggagccttt
       61 ttggtgtcac ggttcagtag tttgtcttta aaattaactg tttttttttt cttttttgag
      121 ttttcggaaa gacaaatttc gctacgtgtt aggagcttga ggctctccta tttttttttc
      181 gagacagggt ttctctgtgt atccctggct gtcctggaac tcactctgta gaccaggctg
      241 gcctcgaact cagaaatctg cctgcctctg cctcctgaag cgtgcgccac cactgcccgg
      301 cttgaggctc tcttcttaca gccactttac tgggtggatt gacactcgat ccttgcgtca
      361 agacagtgag acatctcgcc ttttagctgt gcctggtttt agttctgttc gttgggggac
      421 accgagcccc ggacgacctt ccctccgaga ctccagacac catccccatt tggtctctgt
      481 ccccccccgg ggggggcggg gggggcgagc ccagcccctc cggtgcgact aggaatgaag
      541 ctggacagtg ccgaagagaa gtcgggggtc ggctgctccc tgcctgcaga gggctctccc
      601 ccggccctcg aaccagcctt ctccaagatt ctgaaccgtc tcagccgccc aaagtcatca
      661 ggacagggcg gcgcaagaaa tgcggctctt aaagacctcg gcgctttaat agaagccgcc
      721 gaaggtgaca gattctttga ggggagtggg agtgggggat ccctccgggg gatgcccgag
      781 atcctggggc aggtggtgag agccctggag aagttcgcag cacccgagga gaaggcagat
      841 ggggtcgaag agcatcccga agtgcccgag aaggcgactg aagttggctc actgtttcta
      901 aagctgttgg ggaaggttga agctgccaag agttctcccg actgccctgc gtggaagaca
      961 ggcctccgtc acatgtcagg acccgtgtat atttttgcca tcactcacag attgaagcag
     1021 ccatggacca gtccagcatc tcagcatgtt gctggtgagg tgctgtcttt attgcttaga
     1081 gttactgagt gcagttctgt ggcaggattc ctatgcggag aaaatgaaga cgatcgaggg
     1141 agatttgctg tggtcttggg gcttcttaag ccccatttga ataaggaaac ctggaagaag
     1201 aatcctgctg tcaaacatgt tttctcgtgg actctccaac aagtcactca gccctggctg
     1261 aatcagcatc tagaaaagat acttcctccg tctttgctca tctcagatga ctatcagaca
     1321 gagaataaaa tcctgggtgt ccagtgcctc catcacattg tggttactgt gccagctgcg
     1381 gacttgctgc agtataacag agcccaggtc ctgtaccacg ccctcttcaa tcacctgtac
     1441 atgcctgagc accacctcat tcaggctgtg ctcctgtgcc tcctagactt gttccctgtc
     1501 ctagagaagg ctctgcactg gaagggagac acagctcgag tcaccacaca ctgtcatgaa
     1561 gtgttacagc tgatcctcac gcacatggaa ccagagcacc gcctcctcct acggaggacc
     1621 tatgccagac acctgccagc cttcgtgaag aggttgggga tcctaactgt ccggcacttg
     1681 aagaggctgg agcaagttat ccttggttat ctggaggttt atgatgaacc agaagatgaa
     1741 actaggttga agatcctgga aaccctgaaa cttgtcatgc agtatacttg gcccagaatt
     1801 ccctgcagag ttgtggtctt actgaaggct ctcctgaaac tcatatgtga tatatcgagg
     1861 gatacgatcc ccacaaccga ggccgctaag agtacaatgc tccaggaagc cacagactgc
     1921 ctgattctcc tggaccactg ttcccagggg caggtgaagg gtcttctggc taaaattgca
     1981 gtatcctgtg aagacagcac agtggtgagc tgcatcagga aggtgcagca gggctctgca
     2041 gattctcctg gcgatgacac tgaaggtgac taaccagcag gaaaggccgc tctccttatc
     2101 ccagatcaca tggatgtagt tatgggggta aaaatctatt tttgtattaa aatattataa
     2161 gttgaaaaaa aaaaaaaaaa a
//
