LOCUS       NP_659176                512 aa            linear   ROD 09-FEB-2025
DEFINITION  TELO2-interacting protein 2 isoform a [Mus musculus].
ACCESSION   NP_659176 XP_990925 XP_990962 XP_990995 XP_991034 XP_991069
VERSION     NP_659176.2
DBSOURCE    REFSEQ: accession NM_144927.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 512)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 512)
  AUTHORS   Rao,F., Cha,J., Xu,J., Xu,R., Vandiver,M.S., Tyagi,R., Tokhunts,R.,
            Koldobskiy,M.A., Fu,C., Barrow,R., Wu,M., Fiedler,D., Barrow,J.C.
            and Snyder,S.H.
  TITLE     Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death
            pathway by regulating CK2 phosphorylation of Tti1/Tel2
  JOURNAL   Mol Cell 54 (1), 119-132 (2014)
   PUBMED   24657168
  REMARK    Erratum:[Mol Cell. 2020 Aug 20;79(4):702. doi:
            10.1016/j.molcel.2020.07.021.. PMID: 32822581]
REFERENCE   3  (residues 1 to 512)
  AUTHORS   Takai,H., Xie,Y., de Lange,T. and Pavletich,N.P.
  TITLE     Tel2 structure and function in the Hsp90-dependent maturation of
            mTOR and ATR complexes
  JOURNAL   Genes Dev 24 (18), 2019-2030 (2010)
   PUBMED   20801936
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045392.1, AK084242.1 and AW120801.1.
            
            On or before May 4, 2006 this sequence version replaced
            XP_991034.1, XP_991069.1, XP_990995.1, XP_990925.1, XP_990962.1,
            NP_659176.1.
            
            Transcript Variant: This variant (2) encodes the shorter protein
            (isoform a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.885400.1,
                                           SRR7345562.4300763.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 18.03 cM"
     Protein         1..512
                     /product="TELO2-interacting protein 2 isoform a"
                     /calculated_mol_wt=56571
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGV4.1)"
     Region          <217..385
                     /region_name="Tti2"
                     /note="Tti2 family; pfam10521"
                     /db_xref="CDD:431336"
     CDS             1..512
                     /gene="Tti2"
                     /coded_by="NM_144927.3:535..2073"
                     /note="isoform a is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS22221.1"
                     /db_xref="GeneID:234138"
                     /db_xref="MGI:MGI:2384576"
ORIGIN      
        1 mkldsaeeks gvgcslpaeg sppalepafs kilnrlsrpk ssgqggarna alkdlgalie
       61 aaegdrffeg sgsggslrgm peilgqvvra lekfaapeek adgveehpev pekatevgsl
      121 flkllgkvea aksspdcpaw ktglrhmsgp vyifaithrl kqpwtspasq hvagevlsll
      181 lrvtecssva gflcgenedd rgrfavvlgl lkphlnketw kknpavkhvf swtlqqvtqp
      241 wlnqhlekil ppsllisddy qtenkilgvq clhhivvtvp aadllqynra qvlyhalfnh
      301 lympehhliq avllclldlf pvlekalhwk gdtarvtthc hevlqlilth mepehrlllr
      361 rtyarhlpaf vkrlgiltvr hlkrleqvil gylevydepe detrlkilet lklvmqytwp
      421 ripcrvvvll kallklicdi srdtipttea akstmlqeat dclilldhcs qgqvkgllak
      481 iavscedstv vscirkvqqg sadspgddte gd
//
