LOCUS       NM_029282               3831 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus TELO2 interacting protein 1 (Tti1), mRNA.
ACCESSION   NM_029282 XM_006500332
VERSION     NM_029282.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3831)
  AUTHORS   Rao,F., Cha,J., Xu,J., Xu,R., Vandiver,M.S., Tyagi,R., Tokhunts,R.,
            Koldobskiy,M.A., Fu,C., Barrow,R., Wu,M., Fiedler,D., Barrow,J.C.
            and Snyder,S.H.
  TITLE     Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death
            pathway by regulating CK2 phosphorylation of Tti1/Tel2
  JOURNAL   Mol Cell 54 (1), 119-132 (2014)
   PUBMED   24657168
  REMARK    GeneRIF: IP7, formed by IP6K2, binds CK2 to enhance its
            phosphorylation of the Tti1/Tel2 complex, thereby stabilizing
            DNA-PKcs and ATM. This process stimulates p53 phosphorylation at
            serine 15 to activate the cell death program.
            Erratum:[Mol Cell. 2020 Aug 20;79(4):702. doi:
            10.1016/j.molcel.2020.07.021.. PMID: 32822581]
REFERENCE   2  (bases 1 to 3831)
  AUTHORS   Nakahara,M., Tateyama,H., Araki,M., Nakagata,N., Yamamura,K. and
            Araki,K.
  TITLE     Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from
            MSM/Ms mice
  JOURNAL   Mamm Genome 24 (5-6), 228-239 (2013)
   PUBMED   23604909
REFERENCE   3  (bases 1 to 3831)
  AUTHORS   Takai,H., Xie,Y., de Lange,T. and Pavletich,N.P.
  TITLE     Tel2 structure and function in the Hsp90-dependent maturation of
            mTOR and ATR complexes
  JOURNAL   Genes Dev 24 (18), 2019-2030 (2010)
   PUBMED   20801936
REFERENCE   4  (bases 1 to 3831)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   5  (bases 1 to 3831)
  AUTHORS   Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J.,
            Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M.
  TITLE     High-throughput sequence identification of gene coding variants
            within alcohol-related QTLs
  JOURNAL   Mamm Genome 12 (8), 657-663 (2001)
   PUBMED   11471062
REFERENCE   6  (bases 1 to 3831)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669824.13, AL845511.6 and AL663092.15.
            
            On or before Oct 5, 2017 this sequence version replaced
            XM_006500332.2, NM_029282.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128940.1, SRR7345562.4369987.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AL669824.13        17790-17850         c
            62-2401             AL845511.6         15291-17630         c
            2402-2590           AL845511.6         8892-9080           c
            2591-2739           AL845511.6         5349-5497           c
            2740-2880           AL845511.6         3653-3793           c
            2881-3085           AL663092.15        207180-207384       c
            3086-3173           AL663092.15        206794-206881       c
            3174-3831           AL663092.15        195629-196286       c
FEATURES             Location/Qualifiers
     source          1..3831
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.68 cM"
     gene            1..3831
                     /gene="Tti1"
                     /gene_synonym="2610036D13Rik"
                     /note="TELO2 interacting protein 1"
                     /db_xref="GeneID:75425"
                     /db_xref="MGI:MGI:1922675"
     exon            1..61
                     /gene="Tti1"
                     /gene_synonym="2610036D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            62..2401
                     /gene="Tti1"
                     /gene_synonym="2610036D13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..3360
                     /gene="Tti1"
                     /gene_synonym="2610036D13Rik"
                     /note="TEL2-interacting protein 1 homolog; Tel2
                     interacting protein 1 homolog"
                     /codon_start=1
                     /product="TELO2-interacting protein 1 homolog"
                     /protein_id="NP_083558.1"
                     /db_xref="CCDS:CCDS16983.1"
                     /db_xref="GeneID:75425"
                     /db_xref="MGI:MGI:1922675"
                     /translation="MAVFDTPEEAFGVLRPVCVQLTKTQTVENVEHLQTQLQAISDTA
                     LQELQQYILFPLRFALKTPGPKRERLVQSVVECLTFVLSSTCVREQELLQELFSELSA
                     CLYSPSSQKPAALSEELKLAVIQGLSTLMHSAYRDIILTFYEPSILPRLGFAVSLLLG
                     LAEQEKSKQIKIAALQCLQVLLLQCDCQDHPRPLDELEQQQLGDLLASFLPGISTALT
                     RIITGDFKQGHSIVVSSLKVFYKTVGFIMADEQLTRIPKAQAKPVVEHRVAALMIHRE
                     ADWVKSTGDKLAIFIKKIIDCVSVHPHWKVRLELVEFVEILLLKCTQSLVESTGPLLK
                     VLVGLVNDESPEVQARCSTVLRRLADQKVVVGSRALADILSESLHSLATSLPRLMNTQ
                     DDQGKFSTLSLLLGYLKLLGPKVHVILNSVAHVQRLSRALIQVLELEVTDVKMVEERR
                     WNSDNLSASAEVSAARPWSRVQRRYFRCFTDERVFLLLRKICQLLGYYGDLYLLVDHF
                     MELYHTSVVYRKQAAMILNELVVGAAGLDVEDIHNKCPSMGPEELREIVKSILEEYTS
                     QENWYLITCFEAEEGEEVMMKQQGFQAVTSGVHTCQVVSFPALSKPSPTICSMNSNIW
                     QICIQLEGIGQFAYALGKDFRLLLMSALYPILEKAGDPTLLISQVATSTMVDICHACG
                     YNSVQHLINQNSDYLVNGISLNLRHLALHPHAPKVLEAMLRNADASLLPLVADVVQDV
                     LATLDQFYDKRAASFVSVLHALLAALAHWFPDSGSTGQLQQRSLEEEGRQLPAAGEAS
                     TTAEDIEQFVLSYLQEKDVAEGNVSDLEAEEEVQSAPPKVDENDTLPDVEPPLPTHIQ
                     IAKDVMERCIHLSADKNLKIRLKVLDVLGLCVEVLQTHKNQLLPLAHRAWPSLVHRLT
                     SDDPLAVLRAFKVLQTLGSRCGDFLRSRFCKDVLPKLTSSLITQAPISARAGPVYSHT
                     LAFKLQLAVLQGLGPLCENLDLGEGDLNKVADACVIYLSTKQPVKLQEAARSVFLHLM
                     RVDPDSTWLLLHELYCPVQQFTAPHPSLHPVQLQGATQPQNPYATNVCHLLLQLQ"
     exon            2402..2590
                     /gene="Tti1"
                     /gene_synonym="2610036D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2739
                     /gene="Tti1"
                     /gene_synonym="2610036D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2880
                     /gene="Tti1"
                     /gene_synonym="2610036D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..3085
                     /gene="Tti1"
                     /gene_synonym="2610036D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3173
                     /gene="Tti1"
                     /gene_synonym="2610036D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..3831
                     /gene="Tti1"
                     /gene_synonym="2610036D13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3810..3815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tti1"
                     /gene_synonym="2610036D13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3831
                     /gene="Tti1"
                     /gene_synonym="2610036D13Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtcgtcatt tccgcctagg gtgcaggagg cgggagagtg agggaaagac tggaagacga
       61 gcctgcagga tgtttcctcg gtgagaggaa ggcggttgta caatggcggt gtttgacact
      121 cctgaggagg cttttggcgt cttacgtccg gtctgtgttc agctcacaaa gacccagaca
      181 gtggagaatg tggagcatct gcagacacag ttacaagcca taagtgacac tgctcttcag
      241 gaactacagc agtacatcct cttccctttg cgatttgccc tgaagacccc agggcccaaa
      301 agagagcgcc tggtgcagag tgtggtggaa tgtctcacct ttgtcctctc ttccacatgt
      361 gtgagagagc aggagcttct gcaggaactc ttctcggagc tttctgcctg tctgtactct
      421 cccagctccc agaaacccgc agctttgtca gaggagttga aattggctgt catccaggga
      481 cttagcacct taatgcactc agcttacagg gacatcattc tgacttttta tgagccctcc
      541 attctgcctc gtttaggatt tgctgtgtct ttactgttag gattggcaga gcaggagaag
      601 tcaaaacaga ttaaaattgc tgccttacag tgtctgcagg ttctcctcct tcagtgtgat
      661 tgtcaggacc atccaaggcc cttggatgaa ctggagcagc agcagctggg ggatttgttg
      721 gcatctttct tacctgggat ctcaactgcg ctgaccagaa tcatcacagg agactttaaa
      781 caaggtcaca gcattgtcgt gtcttctcta aaggtctttt acaagacagt gggcttcatc
      841 atggctgatg aacagctcac aaggattcca aaggcccaag caaaacctgt agttgagcac
      901 agagtagcag ccctgatgat tcacagagaa gcagactggg taaaaagtac tggtgacaag
      961 ctggccatct ttattaaaaa gataattgac tgtgtctccg ttcacccaca ctggaaggtg
     1021 aggctggaac tggtagagtt tgtggaaatc ctgcttttga agtgcactca gtccctggtt
     1081 gaatccacgg gacccctctt gaaggtgtta gttggcctag tgaatgatga aagtccggaa
     1141 gtccaggccc ggtgcagtac agtgctgagg cgtcttgcag atcagaaagt agtagtgggc
     1201 agcagagcct tggctgacat cttgtcagaa agcctgcatt cactggccac gtctcttccc
     1261 cgcctgatga acacacagga tgatcagggc aaattctcta ccctttccct gttacttggg
     1321 tatctgaaac tgttgggccc caaagtgcat gtgattctca attctgtggc ccatgtgcaa
     1381 cgcctttcca gggccctcat ccaagtactg gagctagagg tgactgatgt caagatggtg
     1441 gaagagcggc gctggaactc tgataacctg agtgcttctg cagaggtctc agctgcacgg
     1501 ccatggagca gagtccagag gcgatacttc cgatgcttca ctgacgagag ggtcttcctg
     1561 ctccttcgga agatctgtca gctcctgggt tattatgggg acctgtattt gcttgtggat
     1621 cactttatgg aactgtacca tacatctgta gtttatcgga agcaagctgc catgatcctt
     1681 aatgaactgg ttgtaggggc tgctggactg gatgtagaag atattcataa caaatgtcca
     1741 agcatgggcc cagaggagtt gagagagatt gtgaaatcta tactagagga atacacaagc
     1801 caagaaaact ggtacttgat tacctgtttt gaagctgagg agggggagga ggtgatgatg
     1861 aagcagcaag gcttccaggc tgtcacatct ggtgtccaca cctgccaagt tgtatctttt
     1921 ccagccctgt caaagccgag tcccactatc tgctccatga acagtaacat ctggcagata
     1981 tgcattcagt tggaagggat tggccagttt gcatatgcat taggaaaaga ctttcgtttg
     2041 cttttgatgt cagctctcta tccaatactg gagaaggcgg gagatccaac cttgcttatt
     2101 agtcaagtgg ctactagcac catggtagat atttgccacg cttgtggcta caactctgta
     2161 caacacctga tcaatcaaaa ttcagactat ttggtgaatg gaatctcttt aaatctgcgt
     2221 cacctcgctc tgcaccctca tgccccaaaa gtcctagaag ccatgcttcg gaacgcggat
     2281 gccagcctac ttcctttggt agcagatgtg gttcaggacg tcctggccac cctggaccaa
     2341 ttttatgata agagagctgc ttcctttgtc agcgttctgc atgctctgct ggcagcatta
     2401 gcacactggt tcccagactc gggttctact gggcaactcc aacagcgtag tttagaagag
     2461 gaggggaggc aactgccagc agctggcgag gctagcacca cagccgagga catcgagcag
     2521 tttgtactga gctacctcca agagaaggat gtggcagagg gaaatgtttc tgaccttgaa
     2581 gctgaagaag aggtgcagtc agcccctccc aaagtggatg agaatgacac ccttccagat
     2641 gtggaaccac cactgccaac gcacatccag atagccaagg acgtgatgga gcgctgcatc
     2701 cacttgtcag cagataaaaa tctgaaaatc cgcctgaagg tcttggatgt gctgggtttg
     2761 tgtgtggagg ttctacagac ccacaagaac cagctccttc ccctagctca tcgggcctgg
     2821 ccttcactcg tacaccgact tacaagtgat gaccccctgg cagtgctcag agccttcaag
     2881 gttttacaga cacttggaag cagatgtggc gattttctcc ggagtcggtt ctgtaaagat
     2941 gtcctgccaa aactgaccag ctccttaatc acccaggccc ccatcagtgc cagggctgga
     3001 ccagtttatt ctcatacact ggccttcaag ctacagctgg ctgtcttgca gggcctgggc
     3061 cccctctgtg aaaatctgga cttgggtgag ggtgacctga ataaagtggc tgatgcctgc
     3121 gtgatttacc tcagtaccaa acagcccgtg aaattacaag aggctgccag gagcgtcttc
     3181 ctccacctga tgagagtaga ccctgactcc acctggctcc tcctgcatga gctgtactgc
     3241 cctgtgcagc aattcacagc cccgcatccc agccttcacc cagtgcagct gcagggggcc
     3301 actcagccac agaaccccta tgccaccaat gtgtgccacc tgcttcttca actgcagtga
     3361 tcctgccaga ccctggcagc cagaaactga gctgagccac ccttcctgga tatagttcgg
     3421 caacacagcg gtgaaggtgg attagacagc gatcaatgta taaattgatc agtcacacga
     3481 ctgcttacaa attggactga aggaaagtag ctcactgtta tttatatttc actctttgtg
     3541 ttttcagatg acattgtctg gtggctctaa gagtttaact ctttagctta ctgtctgcac
     3601 aacccctctg cctcacaagt cccctaaaca catacacaca catcccttgt gttccacacc
     3661 caagtgtgat tctcagcacc cattagtagc tagctcacaa ccatctttgt aactccagtt
     3721 tcaagggatc caaccccctc tcctgacctc aaacaccaga cttgcacatg gtgcacagac
     3781 acactcatga gccaaacact tataagataa ataaatcttt tcaaaaatgt c
//
