LOCUS       NM_001013026            4555 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus transcription termination factor, RNA polymerase II
            (Ttf2), mRNA.
ACCESSION   NM_001013026 XM_131118 XM_207781
VERSION     NM_001013026.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4555)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4555)
  AUTHORS   Tiozzo,C., Danopoulos,S., Lavarreda-Pearce,M., Baptista,S.,
            Varimezova,R., Al Alam,D., Warburton,D., Virender,R., De Langhe,S.,
            Di Cristofano,A., Bellusci,S. and Minoo,P.
  TITLE     Embryonic epithelial Pten deletion through Nkx2.1-cre leads to
            thyroid tumorigenesis in a strain-dependent manner
  JOURNAL   Endocr Relat Cancer 19 (2), 111-122 (2012)
   PUBMED   22167068
  REMARK    Erratum:[Endocr Relat Cancer. 2013 Apr;20(2):X1. Virender, Rehan
            [corrected to Rehan, Virender]]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4555)
  AUTHORS   Cederbaum,A.I.
  TITLE     Cytochrome P450 2E1-dependent oxidant stress and upregulation of
            anti-oxidant defense in liver cells
  JOURNAL   J Gastroenterol Hepatol 21 Suppl 3, S22-S25 (2006)
   PUBMED   16958665
  REMARK    Review article
REFERENCE   4  (bases 1 to 4555)
  AUTHORS   Penha-Goncalves,C., Moule,C., Smink,L.J., Howson,J., Gregory,S.,
            Rogers,J., Lyons,P.A., Suttie,J.J., Lord,C.J., Peterson,L.B.,
            Todd,J.A. and Wicker,L.S.
  TITLE     Identification of a structurally distinct CD101 molecule encoded in
            the 950-kb Idd10 region of NOD mice
  JOURNAL   Diabetes 52 (6), 1551-1556 (2003)
   PUBMED   12765969
REFERENCE   5  (bases 1 to 4555)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087352.1, BC096625.1 and BC087733.1.
            
            On Jul 25, 2009 this sequence version replaced NM_001013026.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087352.1, BC096625.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK087352.1         1-14
            15-4284             BC096625.1         13-4282
            4285-4555           BC087733.1         4292-4562
FEATURES             Location/Qualifiers
     source          1..4555
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 43.86 cM"
     gene            1..4555
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /note="transcription termination factor, RNA polymerase
                     II"
                     /db_xref="GeneID:74044"
                     /db_xref="MGI:MGI:1921294"
     exon            1..44
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..3433
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /note="transcription release factor 2; RNA polymerase II
                     termination factor"
                     /codon_start=1
                     /product="transcription termination factor 2"
                     /protein_id="NP_001013044.2"
                     /db_xref="CCDS:CCDS17679.1"
                     /db_xref="GeneID:74044"
                     /db_xref="MGI:MGI:1921294"
                     /translation="MDLVKCPEHGDACFLKTGVRDGPNKGKSFYVCRTNTCGFVQATD
                     IPVSHCLLHEEFVVELQGLFLPQDKKEWRLFFRCARTKAEGKQWCGNVPWRQDPNPKE
                     LSVTSKPQQPSESQLHSPSQPRNPFRVLNKNQKTLERKQFVEEGERKTADKKLRENNE
                     QLLDQRKEQKPKSNSRMEKDPSSDLVATRQSGGDREEQEKSKFQPKTKKAEGMASKQG
                     HGEVLQGIPKGPHMSESESRGVPNKPETLREKETQLLVPSVPGQNPESKVQKEGHVSR
                     EPLKNGEAPSAQVTQRGLAQGPLQGPSKTWRPVPEAPAAPELCSGMAHHATSSSEDSE
                     DDGVSSRPGSPLLFDSTVDSQKKGSLQHSDQSVQRQMPAASGVSKKGDSSDPAAQRAN
                     LTTQLKQKKGTLAAVNIQALPDKGEKLLKQIQALEDALSALALSPEQGTKEKCSAQEP
                     EQSNITKAAAAPLHLVPPQPLPRPLIQPASSLGLKAGRQETPEGASQCSGGHMNQHHL
                     YNVWKITSEAIDELHRSLKSCPGETAVAEDPAGLKVPLLLHQKQALAWLLWRESQKPQ
                     GGILADDMGLGKTLTMIALILTKKNQQKSKEKERSEPVTWLSKNDSSVFTSSGTLIVC
                     PASLIHHWKNEVEKRVTSNRLRIYLYHGPNRSRHAKVLSTYDIVITTYSLLAKEIPTT
                     KQEGEVPGANLSVEGTSAPLLQVVWARIILDEAHNVKNPRVQTSIAVCKLQAQARWAV
                     TGTPIQNNLLDMYSLMKFLRCSPFDEFSLWKSQVDNGSMKGGERLSILTKSLLLRRTK
                     DQLDSTGKPLVALPARRCQLHRLKLSEDERAVYDIFLARSRSALQSYLKRQEGRGSHH
                     GRSPDNPFSRVAQEFGSSVSQGCPAADSQRPSTVHVLSQLLRLRQCCCHLSLLKSALD
                     PTELESEGLVLSLEEQLSALTLSKVDVSEPSPTVSLNGTCFKAELFDDTRRSTKVSSL
                     LAELEAIQKGPGSQKSVIVSQWTSMLQVVALHLKKNRLTYATIDGSVNPKQRMDLVEA
                     FNHSQGPQVMLISLLAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQKKDVV
                     IHRFVCEGTVEEKILQLQEKKKDLAKQVLSGSEGPVTKLTLADLKILFGI"
     exon            45..147
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            148..234
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            235..304
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            305..1219
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1334
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1517
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1645
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1727
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1847
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1998
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2104
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2286
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2440
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2532
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2615
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2749
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2920
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..2979
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3130
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3213
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3288
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     exon            3289..4541
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4520..4525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /note="hexamer: AATAAA"
     polyA_site      4541
                     /gene="Ttf2"
                     /gene_synonym="4632434F22Rik; 8030447N19"
                     /note="major polyA site"
ORIGIN      
        1 gcttcctggc tgcggtatgg acctggttaa gtgtccggag cacggggacg cctgcttctt
       61 aaagaccggc gtccgcgatg gcccgaataa gggaaagagc ttctacgtgt gccggacgaa
      121 cacatgcggc ttcgtgcagg ccaccgatat tcctgtttct cactgtttat tgcatgagga
      181 gtttgtggtc gagcttcagg gtttgtttct accacaggac aagaaagaat ggaggctgtt
      241 cttccgatgt gctagaacca aggcggaggg gaagcagtgg tgtggaaacg tcccatggcg
      301 gcaggatcct aaccctaaag aactctctgt aaccagtaag cctcagcagc catctgagtc
      361 acagcttcac tctcccagcc agccgagaaa cccatttagg gtgcttaaca agaatcaaaa
      421 aacactcgaa cgaaaacagt ttgtcgaaga aggtgagaga aagacagctg ataagaagct
      481 gagagaaaac aatgagcagc tcttggatca aaggaaagaa cagaagccca aatctaacag
      541 caggatggag aaggacccct catctgacct ggtggcaact agacagtctg gaggtgacag
      601 ggaagaacaa gagaaatcaa agttccagcc caaaactaag aaagctgaag gaatggcttc
      661 caagcaaggc catggagagg tgcttcaagg aatacccaag ggtcctcaca tgtcagagag
      721 tgagagtcga ggggtcccga acaagccaga gactctgaga gaaaaggaaa cccagctttt
      781 ggtgccaagt gttcctggtc agaacccaga aagcaaggtc cagaaagagg gacacgtcag
      841 cagggagccc ctcaagaacg gggaggcccc tagtgcacag gtcacccaga gggggctcgc
      901 tcaggggcct ctccagggac catccaagac ttggaggcct gttcctgaag caccagcagc
      961 acctgagctt tgctcgggaa tggcccacca tgccacctcc agcagtgagg acagcgaaga
     1021 tgatggtgtt tccagtaggc cggggtcccc acttctcttt gactcgactg tggactcaca
     1081 gaagaagggg agccttcagc attctgacca gagtgtgcag agacagatgc ctgctgcttc
     1141 aggtgtttcc aagaagggag attcctctga cccagcagcc cagcgtgcaa acctaacaac
     1201 acagctgaaa caaaagaagg gtaccctggc tgcagtgaac atccaggctc tccctgataa
     1261 gggtgagaag ttgcttaagc aaatccaggc tttggaggac gcactcagtg ctctggctct
     1321 ctccccagaa caaggaacta aagagaagtg cagcgctcag gaaccagagc agagcaacat
     1381 caccaaagct gctgctgccc ctctccactt ggtacctccc cagccccttc ccaggcccct
     1441 catccagcct gcaagctctc taggactaaa ggcaggccgc caggaaactc ctgagggagc
     1501 cagccagtgc tcaggaggcc atatgaacca acatcatctt tataatgtgt ggaaaatcac
     1561 gagtgaagcc atagatgagc tgcatcggtc actgaagtct tgtccgggtg aaacagcagt
     1621 agcagaagac ccagctggct tgaaggtccc cttgctactg caccagaagc aggcattagc
     1681 ctggttactg tggagggaaa gtcagaagcc acaaggaggg atcctggcgg atgatatggg
     1741 cttaggaaag actctgacaa tgattgcact catcctaacc aagaagaatc agcagaaaag
     1801 caaggaaaag gagagaagcg agcctgtgac gtggctttcc aagaatgact cctctgtctt
     1861 tacttccagt ggaacactga tcgtctgccc cgcttccctg atccatcact ggaagaacga
     1921 agtagagaaa cgtgtaacca gcaacagact cagaatctat ctctaccatg ggccaaaccg
     1981 gagtcggcac gcaaaagtac tctctacgta tgacatcgtg attactactt acagccttct
     2041 ggccaaggag attcctacaa cgaagcaaga gggagaggtc ccaggagcaa acctcagtgt
     2101 ggagggtacc tcagcacctt tgcttcaggt agtctgggct cggatcattt tggatgaagc
     2161 tcataacgtg aaaaaccctc gagtacagac atccattgct gtgtgtaagc tccaagccca
     2221 ggcccggtgg gctgtcactg gaacccccat tcagaacaac ctgttggata tgtattcact
     2281 gatgaagttt ctccgttgct ccccatttga tgagttcagt ctttggaaga gccaggttga
     2341 caatggttca atgaaaggag gggaacggtt aagcatttta accaagagcc ttttgctgag
     2401 gagaacaaaa gaccagctgg attccactgg taaacctctg gtagcactgc ctgcacgtag
     2461 atgccagctg caccggttaa agctttctga ggacgagcgg gccgtttatg acatctttct
     2521 tgcaaggtca aggtcagctc tccagtccta tctaaagaga caagaaggta gaggcagcca
     2581 ccatggaaga agccctgata atccattcag tagagtggct caggagtttg gatccagtgt
     2641 gtcccagggc tgccctgcgg cagactccca aagacccagc accgtccatg tcctgtccca
     2701 gcttctgcgg cttcgccagt gctgctgcca tctttctctg ctgaagtcgg ctctggaccc
     2761 cacagaactg gagagcgaag gccttgtcct gtccctggaa gaacagctca gtgctctgac
     2821 cttgtccaag gtcgatgtct cagagccatc acccacggtt agccttaatg gcacatgttt
     2881 caaggcggag ctttttgatg acacacgaag gagcaccaag gtgtcttctc tgctggcaga
     2941 actggaggcg atccaaaaag gcccagggtc ccaaaagagt gtcattgtct ctcagtggac
     3001 cagcatgctg caggtagtag cactgcacct caagaagaac cgactgactt acgccaccat
     3061 cgatggctct gtcaacccca aacagagaat ggacctggtg gaggcattta accactccca
     3121 gggacctcag gtcatgctga tctccctctt ggctggcggt gttggactta acctgactgg
     3181 aggaaaccac cttttccttc tggacatgca ctggaatccc tcacttgaag accaagcttg
     3241 tgaccggatt taccgagtag gacagaagaa ggatgttgtc atacacaggt ttgtctgtga
     3301 ggggacagtg gaagagaaga tcttacagct ccaagaaaaa aagaaagatt tggcaaaaca
     3361 ggtcctttct ggatccgaag gacctgtcac caagctcaca ctggctgacc tcaagatcct
     3421 ctttggcatc tagcttcgtc tgctggagtg atgctctttc catgatcctg gagtcttaga
     3481 tttcatccta ctcgaagtga ggcttgttcc tatgctagga attgaggatg ggttaccagg
     3541 ttaacaaacc agttagtcag tcagcttgtg taatgtgggc catagaaacc cattggttat
     3601 ttcagaatta agcctggcat gttagtgcat gcctgtaatc cagcaagaag atggagaggt
     3661 ccactttggc ctgttgtaga ctctttctca aaacaaacca caaagtgctc tggaaggcag
     3721 ccatgtagtc catacttccc agcacctgaa aggctgagtg gggattgtga gttagaggcc
     3781 agtttatgcc acagagtaca tttcaggcca gcctgggcta cagaatgaga ccgtgtctta
     3841 gaaaaacaaa gtaaaaccag tgaagctttg gcgttggatg gcctggaagc tgagtctgga
     3901 agaactgtgt aagtgctggg tgtgatgctc agggagccat tacaagcata gtgacacatg
     3961 cttagaatgc tggcactttg taggcaaagg caagaggatc tcgagtctaa ggttagcctg
     4021 ggtaacagtg agttctttag cagccttaat tacatgggaa gaccctgtct gtcaaacagc
     4081 ctcaaagccc tgtgctgcca tgtttgggac tgatggcgga cctggtctta ttaccttgcc
     4141 tatgtaggct ctgtcctgtt tccctgctgg caggctgcgt cttgtaagcc tctttgtaac
     4201 caaccatccc tatgaggctg gctgaatcta ggcaggttta gggtcaagat atttcatata
     4261 tcttgagttg agtattaatc atggtatcat ctagcatctc tcatttagcc tgtgcatcat
     4321 ggtttcattt agggatatat caacatcagt gtgactgtgt cactcagttt catcactgta
     4381 tcatttgata tcacagtatt tcatatagta tttgtcttat ttaatgttta tgtccatttc
     4441 agttgccagt ggcatttaat ctgttgtgtc acttagtttc tgccattgta ccacattgtg
     4501 ttatcattgg tatggtctta ataaacgcct tcggccgtgc aaaaaaaaaa aaaaa
//
