LOCUS       NM_009442               4170 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transcription termination factor, RNA polymerase I
            (Ttf1), transcript variant 1, mRNA.
ACCESSION   NM_009442
VERSION     NM_009442.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4170)
  AUTHORS   Zhang,Z., Wu,Y., Fu,J., Yu,X., Su,Y., Jia,S., Cheng,H., Shen,Y.,
            He,X., Ren,K., Zheng,X., Guan,H., Rao,F. and Zhao,L.
  TITLE     Proteostatic reactivation of the developmental transcription factor
            TBX3 drives BRAF/MAPK-mediated tumorigenesis
  JOURNAL   Nat Commun 15 (1), 4108 (2024)
   PUBMED   38750011
  REMARK    Erratum:[Nat Commun. 2024 Jun 10;15(1):4936. doi:
            10.1038/s41467-024-49330-w.. PMID: 38858379]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4170)
  AUTHORS   Chen,S.Y. and Liu,F.C.
  TITLE     The Fgf9-Nolz1-Wnt2 axis regulates morphogenesis of the lung
  JOURNAL   Development 150 (16) (2023)
   PUBMED   37497597
REFERENCE   3  (bases 1 to 4170)
  AUTHORS   Ishizaki-Asami,R., Uchida,K., Tsuchihashi,T., Shibata,A., Kodo,K.,
            Emoto,K., Mikoshiba,K., Takahashi,T. and Yamagishi,H.
  TITLE     Inositol 1,4,5-trisphosphate receptor 2 as a novel marker of
            vasculature to delineate processes of cardiopulmonary development
  JOURNAL   Dev Biol 458 (2), 237-245 (2020)
   PUBMED   31758944
REFERENCE   4  (bases 1 to 4170)
  AUTHORS   Kim,H.T., Yin,W., Nakamichi,Y., Panza,P., Grohmann,B., Buettner,C.,
            Guenther,S., Ruppert,C., Kobayashi,Y., Guenther,A. and
            Stainier,D.Y.R.
  TITLE     WNT/RYK signaling restricts goblet cell differentiation during lung
            development and repair
  JOURNAL   Proc Natl Acad Sci U S A 116 (51), 25697-25706 (2019)
   PUBMED   31776260
REFERENCE   5  (bases 1 to 4170)
  AUTHORS   Boutin,J., Lessard,F., Tremblay,M.G. and Moss,T.
  TITLE     The Short N-Terminal Repeats of Transcription Termination Factor 1
            Contain Semi-Redundant Nucleolar Localization Signals and P19-ARF
            Tumor Suppressor Binding Sites
  JOURNAL   Yale J Biol Med 92 (3), 385-396 (2019)
   PUBMED   31543703
  REMARK    GeneRIF: The data suggest that the N-terminal repeats of mouse
            TTF1, and by analogy those of human TTF1, cooperate to mediate both
            nucleolar localization and ARF binding
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4170)
  AUTHORS   Gerber,J.K., Gogel,E., Berger,C., Wallisch,M., Muller,F., Grummt,I.
            and Grummt,F.
  TITLE     Termination of mammalian rDNA replication: polar arrest of
            replication fork movement by transcription termination factor TTF-I
  JOURNAL   Cell 90 (3), 559-567 (1997)
   PUBMED   9267035
REFERENCE   7  (bases 1 to 4170)
  AUTHORS   Sander,E.E. and Grummt,I.
  TITLE     Oligomerization of the transcription termination factor TTF-I:
            implications for the structural organization of ribosomal
            transcription units
  JOURNAL   Nucleic Acids Res 25 (6), 1142-1147 (1997)
   PUBMED   9092622
REFERENCE   8  (bases 1 to 4170)
  AUTHORS   Langst,G., Blank,T.A., Becker,P.B. and Grummt,I.
  TITLE     RNA polymerase I transcription on nucleosomal templates: the
            transcription termination factor TTF-I induces chromatin remodeling
            and relieves transcriptional repression
  JOURNAL   EMBO J 16 (4), 760-768 (1997)
   PUBMED   9049305
REFERENCE   9  (bases 1 to 4170)
  AUTHORS   Evers,R. and Grummt,I.
  TITLE     Molecular coevolution of mammalian ribosomal gene terminator
            sequences and the transcription termination factor TTF-I
  JOURNAL   Proc Natl Acad Sci U S A 92 (13), 5827-5831 (1995)
   PUBMED   7597036
REFERENCE   10 (bases 1 to 4170)
  AUTHORS   Evers,R., Smid,A., Rudloff,U., Lottspeich,F. and Grummt,I.
  TITLE     Different domains of the murine RNA polymerase I-specific
            termination factor mTTF-I serve distinct functions in transcription
            termination
  JOURNAL   EMBO J 14 (6), 1248-1256 (1995)
   PUBMED   7720715
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163606.1, BC059011.1, BE332152.1 and BU757299.1.
            
            On Aug 4, 2006 this sequence version replaced NM_009442.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059011.1, SRR1660815.142024.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AK163606.1         2-34
            34-3616             BC059011.1         1-3583
            3617-4079           BE332152.1         12-474
            4080-4170           BU757299.1         1-91                c
FEATURES             Location/Qualifiers
     source          1..4170
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.38 cM"
     gene            1..4170
                     /gene="Ttf1"
                     /gene_synonym="TTF-1; TTF-I"
                     /note="transcription termination factor, RNA polymerase I"
                     /db_xref="GeneID:22130"
                     /db_xref="MGI:MGI:105044"
     exon            1..41
                     /gene="Ttf1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            42..1331
                     /gene="Ttf1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..2628
                     /gene="Ttf1"
                     /gene_synonym="TTF-1; TTF-I"
                     /note="isoform a is encoded by transcript variant 1;
                     transcription termination factor I; RNA polymerase I
                     termination factor; transcription termination factor 1"
                     /codon_start=1
                     /product="transcription termination factor 1 isoform a"
                     /protein_id="NP_033468.2"
                     /db_xref="CCDS:CCDS38089.1"
                     /db_xref="GeneID:22130"
                     /db_xref="MGI:MGI:105044"
                     /translation="MKGGTSKFKTHTETLYKKKKWSSVSEKRPQKCPSQCLESKQPQV
                     SVLGKRRRASQTPAQETLESEWPQKAKRKKRRREPQTPAQETLESEWPQKAKKKKRRG
                     EPQTPTQESLESEQPPVSLLGKRRRESQTPAQENSESEQPRKAKRRRKKRKGSQQPTS
                     SLLKTPETFLKAKKTTSAHKKKKNSVLEVDMETGIILVDKENMENLLETSRKDVDIVY
                     VDMSKGQRSAKVRETGELPAAKPQEHGCRELLGDVRSRKKQKHLQKVAPWDVVQGSQP
                     ESISLPPSEPLSSEDLEGKSTEAAVFCKKKSKKNVFRSQELEPIPDSLDDSETISERL
                     DSTHHGGAVGAGEECESTKESHSIKKKSKKKKHKSVALATSSDSASVTDSKAKNALVD
                     SSEGSGAVREEDVDHRPAEAEAQACSTEKHREAMQRLEPTHEEESNSESASNSAARHI
                     SEDRRESDDSDVDLGSAVRQLREFIPDIQERAATTIRRMYRDDLGRFKEFKAQGVAIR
                     FGKFSAKENKQIEKNVQDFLSLTGIESADKLLYTDRYPEEKTLITNLKRKHAFRLHIG
                     KGIARPWKLVYYRAKKIFDVNNYKGRYNEEDTKKLKAYHSLHGNDWKKIGAMVARSSL
                     SVALKFSQIGGTRNQGAWSKAETQRLIKAVEDVILKKMSPQELRELDSKLQEDPEGRL
                     SIVREKLYKGISWVEVEARVETRNWMQCKSKWTEILTKRMTHGGFVYRGVNALQAKIT
                     LIERLYELNVNDANEIDWEDLASAIGDVPPPFVQAKFYKLKAACVPFWQKKTFPEIID
                     YLYKNSLPLLKEKLDKKMKKKDGQIQTPAAPKQDFLFKDIFHCDDDSDEGSPEEPSAS
                     DVQ"
     exon            1332..1558
                     /gene="Ttf1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1744
                     /gene="Ttf1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1823
                     /gene="Ttf1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1954
                     /gene="Ttf1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2189
                     /gene="Ttf1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2279
                     /gene="Ttf1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2345
                     /gene="Ttf1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2431
                     /gene="Ttf1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2609
                     /gene="Ttf1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..4153
                     /gene="Ttf1"
                     /gene_synonym="TTF-1; TTF-I"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacacttccg ggttggaaga cgagcgctac attgtcgctg gggacaggat gaaagggggc
       61 acaagcaaat ttaagaccca cactgaaact ttgtacaaga aaaagaaatg gtcttctgtg
      121 tctgaaaaaa gacctcagaa atgtccctct cagtgcttgg agagcaagca gcctcaggta
      181 tctgtgttgg ggaagaggag gagggcgtcc cagacaccag cccaggagac cttagagagt
      241 gagtggcctc aaaaggccaa gaggaagaag aggaggaggg aaccccagac accagcccag
      301 gagaccttag agagtgagtg gcctcaaaag gccaagaaga agaagagaag gggggaaccc
      361 cagacaccaa cccaagagag tttggagagt gagcagcctc cagtgtcctt gctggggaag
      421 agaaggaggg aatcccagac accagcccag gagaactcgg agagtgagca gcctcggaaa
      481 gccaagagaa ggaggaagaa aaggaaaggg tcccagcaac caacttcctc ccttctgaaa
      541 actccagaaa cctttcttaa agctaagaaa accacttctg cccacaagaa gaaaaagaat
      601 agtgttctgg aggtggatat ggaaactggg atcatccttg tagataaaga aaacatggag
      661 aacctgctag agacttctag aaaggatgtg gatattgttt atgttgatat gagcaaggga
      721 caaaggtcag caaaagtgcg tgaaacagga gagctgcccg ctgctaagcc acaggaacat
      781 ggctgtcgag agctgctcgg tgacgtcagg agcagaaaga aacaaaagca cctccagaaa
      841 gttgcaccct gggatgttgt tcaggggagc cagcctgaga gtatctccct gcccccatca
      901 gagcccttgt cttctgaaga tttagaaggc aaaagcacag aagcagcagt gttttgtaaa
      961 aagaagtcta aaaaaaacgt gttcaggagc caggaattgg agcccatccc cgacagtctt
     1021 gatgactcgg agaccatctc tgagagactt gatagcacac accatggagg agctgtcggg
     1081 gctggagaag aatgtgagag caccaaagaa tcccacagta tcaaaaaaaa gtccaagaaa
     1141 aagaagcaca agtctgttgc tcttgccaca tctagtgaca gtgcctcagt gacagacagc
     1201 aaggctaaga atgccctggt ggactcctca gaaggcagtg gtgctgtgag ggaagaggac
     1261 gtggaccaca ggccagcaga ggcagaagcc caggcttgtt ccactgagaa gcacagggaa
     1321 gccatgcaga ggttagaacc tacccatgaa gaagaaagca attcggaatc agctagcaat
     1381 tctgcagcaa gacacatatc tgaggacagg agagagtctg atgactcgga tgttgatttg
     1441 ggctctgcag tgagacagct gcgagagttc attcctgaca tacaggaaag ggcggccacc
     1501 accatcagac gcatgtatcg ggatgaccta gggcgcttca aagaatttaa ggcacaaggt
     1561 gtggctatta gatttggcaa attttctgct aaagaaaata aacaaataga aaaaaatgtg
     1621 caagatttcc tatccctgac tggaattgag agtgcagaca agctgctgta cacagacaga
     1681 tacccagagg aaaagactct gatcaccaac ctaaaacgga agcatgcctt cagactgcac
     1741 attgggaagg gcatcgctcg gccctggaag ctcgtgtact accgtgcaaa gaagatcttt
     1801 gatgtgaata actacaaagg caggtacaat gaagaagata ctaagaagct gaaggcatac
     1861 cattccctcc atggaaacga ctggaaaaag attggggcca tggtggcccg aagcagcctc
     1921 tcagtcgccc tcaagttctc tcagattggt ggtactagaa accaaggtgc ttggagtaag
     1981 gcagaaaccc agaggctaat caaggctgtg gaggacgtga tcctaaagaa gatgtctccc
     2041 caggagttaa gagaactgga ttctaaactc caggaagacc ctgagggtcg cctgtcaatt
     2101 gtccgggaaa aactctacaa gggcatatct tgggtggagg tggaagctag agtggagacc
     2161 cggaactgga tgcagtgcaa aagtaagtgg acagagattc ttaccaaaag gatgacccat
     2221 ggtgggttcg tgtatcgtgg ggtcaatgct ctacaggcca aaatcaccct tattgaaagg
     2281 ttgtatgaac taaatgtgaa tgatgctaat gaaatagact gggaagatct tgctagcgcc
     2341 ataggggatg tccctccacc ttttgttcag gcaaaatttt ataagctgaa agctgcctgc
     2401 gttccctttt ggcagaaaaa gacttttcca gaaatcattg actacttata taagaacagt
     2461 ctgcctttgc tgaaggaaaa gttagacaag aaaatgaaga aaaaagacgg ccagatccaa
     2521 acacctgcag ctcccaaaca agactttctg ttcaaagaca tcttccattg cgatgatgac
     2581 agtgatgaag ggagcccaga ggagcccagc gcctctgatg tgcagtgact ggatcgtctc
     2641 ttcctcaaac tgctctctgt tcccttggac ctgtgttgtg cattggctat agatcccgct
     2701 cgcatgtgat acctctcctg tgctgggcac cgagtcacac ggtgttctgc tggagcattg
     2761 gtagtctgca tcggagccca actggtagcc ttgaagagtc tgtcagctga acacagcccc
     2821 actggattct caggactggg tgaaaggggt gctctttggt caatcaggag agtcaaccca
     2881 actgtagggg cttcagagaa gaaaacttag ggtttgggta agaagaagta ttccatgaga
     2941 tctgtgcact atggagatag gtgggggagt gggaagtggg gtcacaggat tgaagccaac
     3001 ctgggctaca tagttcctcc agcatataca cacacagtgg gatgctggag catcctccaa
     3061 aaggagaagt gcattgccca gagagcagga gagtactgca gagaagctct agctctgcaa
     3121 gccccaattt ccctgtgttc cttctagctg ttcccatact caggctgtct gttgttgccc
     3181 tgcagagaaa tgtgtccatg tgtgaccctt agcagaacac tgctgcaagg gagtctggga
     3241 cacccaaatg ttcagacatt cagacttctg ccccatctgt gctggggaga cagaagggaa
     3301 agtgaggcta atgaaaccgc ccatatactg ctgtctacgt tggtgccact cagcaatctt
     3361 ctgtctcccg agaactctca gacatgattt ctgtggcact attagaaggt ggactagagg
     3421 gctggtgaga tggctcagtg ggtaagagca cccgattgct ctcccgaagg tccggagttc
     3481 aaatcccagc aaccacatgg tggctcacaa ccatctgtaa caagatctga ctccctcttc
     3541 tggagtgtct gaagacagct acagtgtact tacatataat aaataaataa atctttaaaa
     3601 aaaaaaaaaa aaaaaaagaa ggtggactag aaggagcttc tgcttgccat gtacctagca
     3661 cttccccaga tgtgcagata acggagtagt caggtggaat gcactaatgc acccagcatt
     3721 catgtggggt aggaggagcg ggaggtcaaa gtggtcctta caaatagcag gctctaggcc
     3781 agggtggcct atagatgact ctggctctaa caaacacaca aataaaacat tgtgtgaatg
     3841 atggtatttt agtacatggt tctctaccca gcccctctgt ccctcaggca ttctagactc
     3901 tgtgctgaca ggactaaatt gctcctacaa aaataatagt actaatgtat aagccaattc
     3961 tatatttgtg atagaagaaa aaatgaatat tctttaacag gaagtatgtt cctagaatgg
     4021 gatatcatat ggtaaattac agtgataaca atagatctgg ttgacatgac gttatatttt
     4081 tgtgaagtat ttcaaaagaa tatatatttt ctcagtttta taaaaatgaa aaataaaaga
     4141 aattggttgt ttaaaaaaaa aaaaaaaaaa
//
