LOCUS       NM_001033149            4793 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus tetratricopeptide repeat domain 9 (Ttc9), mRNA.
ACCESSION   NM_001033149 XM_126933
VERSION     NM_001033149.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4793)
  AUTHORS   Lim,L.W., Shrestha,S., Or,Y.Z., Tan,S.Z., Chung,H.H., Sun,Y.,
            Lim,C.L., Khairuddin,S., Lufkin,T. and Lin,V.C.
  TITLE     Tetratricopeptide repeat domain 9A modulates anxiety-like behavior
            in female mice
  JOURNAL   Sci Rep 6, 37568 (2016)
   PUBMED   27869229
  REMARK    GeneRIF: TTC9A modulates the anxiety-related behaviors through
            modulation of estrogen action on the serotonergic system in the
            dorsal raphe nucleus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4793)
  AUTHORS   Shrestha,S., Sun,Y., Lufkin,T., Kraus,P., Or,Y., Garcia,Y.A.,
            Guy,N., Ramos,P., Cox,M.B., Tay,F. and Lin,V.C.
  TITLE     Tetratricopeptide repeat domain 9A negatively regulates estrogen
            receptor alpha activity
  JOURNAL   Int J Biol Sci 11 (4), 434-447 (2015)
   PUBMED   25798063
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4793)
  AUTHORS   Shrestha,S., Cao,S. and Lin,V.C.
  TITLE     The local microenvironment instigates the regulation of mammary
            tetratricopeptide repeat domain 9A during lactation and involution
            through local regulation of the activity of estrogen receptor alpha
  JOURNAL   Biochem Biophys Res Commun 426 (1), 65-70 (2012)
   PUBMED   22917536
  REMARK    GeneRIF: Together with the observation that TTC9A is a direct
            ERalpha target gene, this study proposes that the fall and rise of
            TTC9A levels during lactation and involution is caused by the
            changes of ERalpha activity that is in turn regulated by the
            factors in the microenvironment.
REFERENCE   4  (bases 1 to 4793)
  AUTHORS   Cao,S., Iyer,J.K. and Lin,V.
  TITLE     Identification of tetratricopeptide repeat domain 9, a hormonally
            regulated protein
  JOURNAL   Biochem Biophys Res Commun 345 (1), 310-317 (2006)
   PUBMED   16678794
  REMARK    GeneRIF: Though the function of TTC9 is not yet clear, the
            susceptibility of its protein level to biological and chemical
            agents suggests that TTC9 is a biologically significant protein.
REFERENCE   5  (bases 1 to 4793)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC125351.3, AK133456.1 and
            BE947764.1.
            
            On Sep 19, 2015 this sequence version replaced NM_001033149.2.
            
            Summary: This gene encodes a protein that contains three
            tetratricopeptide repeats. The human gene has been shown to be
            hormonally regulated in breast cancer cells and may play a role in
            cancer cell invasion and metastasis. [provided by RefSeq, Sep
            2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172918.1, AK133456.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC125351.3         40838-40957
            121-2162            AK133456.1         2-2043
            2163-4468           AC125351.3         74531-76836
            4469-4773           BE947764.1         21-325              c
            4774-4774           AC125351.3         77142-77142
            4775-4793           BE947764.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..4793
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 37.85 cM"
     gene            1..4793
                     /gene="Ttc9"
                     /note="tetratricopeptide repeat domain 9"
                     /db_xref="GeneID:69480"
                     /db_xref="MGI:MGI:1916730"
     exon            1..553
                     /gene="Ttc9"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..816
                     /gene="Ttc9"
                     /note="TPR repeat protein 9A"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 9A"
                     /protein_id="NP_001028321.1"
                     /db_xref="CCDS:CCDS26024.1"
                     /db_xref="GeneID:69480"
                     /db_xref="MGI:MGI:1916730"
                     /translation="MERKGLAARSSGNPSPPALGEGPRPVPPPCVPSGGGAPERGQAG
                     TAAEPAELIRRAHEFKSQGAQCYKDKKFREAIGKYHRALLELKGLLPSQEERDARPAS
                     SAGVPKSSRLSEEQSKTVEAIEIDCYNSLAACLLQAELVNYERVKEYCLKVLKKEGEN
                     FKALYRSGVAFYHLGDYDKALYYLKEARTRQPTDTNVIRYIQLTEMKLSRCSQREKEA
                     M"
     exon            554..736
                     /gene="Ttc9"
                     /inference="alignment:Splign:2.1.0"
     exon            737..4778
                     /gene="Ttc9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2146..2151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttc9"
                     /note="hexamer: ATTAAA"
     polyA_site      2166
                     /gene="Ttc9"
                     /note="major polyA site"
     regulatory      2184..2189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttc9"
                     /note="hexamer: ATTAAA"
     polyA_site      2210
                     /gene="Ttc9"
                     /note="major polyA site"
     regulatory      4685..4690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttc9"
                     /note="hexamer: AAGAAA"
     polyA_site      4711
                     /gene="Ttc9"
     regulatory      4754..4759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttc9"
                     /note="hexamer: CATAAA"
     polyA_site      4778
                     /gene="Ttc9"
                     /note="major polyA site"
ORIGIN      
        1 gagctgcctc gggcggctgg cgaaaaggat gggagtgcgg ggcaagcgcg cggcgcccag
       61 ggtaacggcc gcggcagagt ctgcggggcg cgaagccagc gctccgcgct tttaaagccc
      121 ggatcgcgac gcgctctagg cgcgggcggc ggccggatgg agaggaaggg cttggcggcc
      181 cgatcctcgg ggaaccctag cccgcctgcg ctgggtgagg gaccgcggcc cgtgccgccg
      241 ccgtgcgtcc cgagcggcgg aggagccccg gagcggggcc aggctggaac ggcggccgag
      301 cccgcggagc ttatccggcg cgcacacgag ttcaagagcc aaggggcgca gtgctacaag
      361 gacaagaaat tccgcgaagc catcggcaaa taccaccggg cgttgctgga gctgaaggga
      421 ttgctgccgt cacaagagga gcgggacgca cggccagcct cctcggcagg ggttcccaaa
      481 tccagccgcc tctcagagga gcagagcaag acggttgaag ccattgagat cgactgttac
      541 aacagcctgg cagcctgcct gctccaggcc gagctggtaa attatgagcg agtcaaggag
      601 tattgcctga aggtcctgaa gaaggaagga gagaacttca aagctcttta caggtctggt
      661 gtggccttct atcatcttgg ggactatgat aaagctctct actacctaaa agaagcaagg
      721 acccgacaac ccacagacac caatgtgatt cggtacatcc agctgacgga gatgaagctc
      781 agcagatgtt cccaaaggga gaaagaagcc atgtaacaag gaagcctctc tcaagccaca
      841 ctcgtacctg accagggact tccaggcacc ggtggtggag agtcccgacg tgggctctct
      901 ccctctcttc ccggttcttc ctgtacttct cctgttgctc attctgttgc tccccaactc
      961 ttgtctgtaa gaaggtgaga ggcggtcttg gaccttcgtg agcagcccag acgtggactt
     1021 gtccttttct ctagtaggtc agcaaatggg acagctaggg aagtcttgtg gaccggggat
     1081 ggttctgtgg ctttgacttg gcccagtgtt tctgagcctg gcaggtgtat ggtgcccaca
     1141 gcctggaccc ttctactcct tcccagtgga tcagagcatc ttgaggagac tgtgatgaac
     1201 gtaagaagcg ctgggcgaac taatgctgag gatgtgaatt tccttctgcc ccctcagtca
     1261 gtcacctgag ctcctgccac acccccggac ttgtccaggc ttgtactttg ttttctccca
     1321 ctgtgaggtc aggtctttgc caggattcac atgcctttaa ggcccactct cagtgccctc
     1381 tggtgaccac acataccatt ctcccacccc cagctagccg gcagctgtaa cagcagaagg
     1441 gcagggtgaa atgagccaaa ggttgggggc agagcagact gagtaggtga cagaggaggg
     1501 aaagaaagag cattgggtgg actgagggat taggactaat taatgtaaat aaaaactaac
     1561 tcacaggcat ccattcctgt catttcccgt ggagacagtc cactccctta tttctgttcc
     1621 ctccttgtcc ctcaggcaga gtgacctaca gcttccggta aagacagtga ggggcactta
     1681 gaccaagact atatacatca ggttggccac agcctctgtg cttagtggag tgggctggga
     1741 ttgtagaaac tgccccagga cttggctttg tgggaatttg tacaccccac ctcccttttt
     1801 gacaaaatta tctgaactca atatctagtg cataaagaat ttttgtcaaa tgggtacatt
     1861 tcgactgcag actgactctc ctgccttaaa ccaatcgggt ccccgcctgg tctcctgaca
     1921 catatgcttt ttatgctatg ccacattgaa acatgtcccg agggctcact ggtcccccac
     1981 catagtgcaa tataggacag agtcccagtc ttcatgaaga tagggaagtt gggaaatcca
     2041 tatgagatta ttaccaatga caccgttaag atatatgatg cttaaacctt ttcaaagcac
     2101 tttcatgtat ttttcgtgtg acttagtgag acactattat ataaaattaa aatatataaa
     2161 atgcaataat gttaatagga tttattaaat gcactatctt cagatcatta cacggacaat
     2221 ctcatttctt tcatatactc attctgtggg atcttattcc caggtgatgg agaagccagg
     2281 aaaattaatg ttcttgaggt cacatggcct tgcaggatat ggctaggact gaaccagatc
     2341 tgactggttc cagagctctg gctactgact atcttatgct tagctgcctc tctgttgaat
     2401 agttacactg tttgagagca gaacaatttc cataaagttg aaacatgatt cacacatcaa
     2461 tcctcccacc cccttatatt tacataggca agagagaaag agaccaaaag ccagactccc
     2521 tagtggcttg agcagtgacc ccccaggaaa aagacaatag gcctggcaat tacatctgtg
     2581 tgctggccgt tctatttgct gatggatcag catgaatctg aacaatccac ctggccttcc
     2641 tcactgaatg gccagcagtg agaaaggatc ccaagtatag gcggagacta aagggaaaca
     2701 caaagttaat tgtgtgttat ttcttcaagc tgttgctttg ccagttgcaa gatccagaag
     2761 ccagcagccc agctcatatc cacacagctc ccccaaacac tcccagtata tgtgtgtggg
     2821 ggtgctgcag gaaggtgcta gaaatatcca gagtcccacc atggctctgg agaagaagaa
     2881 aaggaaaaag ccatcccagg accactttcc ctgactttag aacatattct gtcttcttcc
     2941 tccaaaatgg cttctcctaa ccccaacccc agactcctct cagccctggc atatgcctgc
     3001 acccatcccc tcagccctca gtgccatccc taagctcaga ggtcataagc tgacaaacgg
     3061 ttaagatctg aaggatgaaa atgaggtcag aggtggttta cagaatgagt ttaaactggc
     3121 aggcacctcc tttgctcttc aatgcattag gaatggtttt ggtacgaatt tccagtggag
     3181 gggagggaga gaacgcttgc ttggatgaat gtgtcggggg aagggctata gtcataggaa
     3241 taaaaccatt gccactccaa agagaacgtt tgaaaaagca caataagtga ctcagataca
     3301 gacacccgtg ggaactccat tcactgtgac ccagacttta atgacccacc cacacacacc
     3361 tcaaaaagga aaccgtctgg ggtattagtt aacacaaggg gtggcaggga tgaattttct
     3421 gttcatttgt cagcagagtc tccagagagc tgtttctctt ccttcttcca cgtctcccga
     3481 aatcaaggac tgtactctac ctgcagactt ggtgggtgcc accgttgaac tgtgcagaca
     3541 aacactcagc gcgggtctgc cctacacggt catctgcctg gacttatgtg aaagaccctt
     3601 tggcacacaa cttagacttt gtgttgttat aaaagccaca cacatgcgtt tgtagaccac
     3661 gtaaggaaag ttaagggtga ctcttagctc gtcacactag caccaagagg acactgtcag
     3721 ccttcctgta agtctttcat tctccctggt ataactgtgt gcgcacatac tctcaccggc
     3781 ttttggtttt tgcttttttg tttgtttgtt tttgttttct aatgaagaaa actgggtcgt
     3841 gctgtatata gtctttaatg acttactttt caaatgtgta tttatatttt agaatatgca
     3901 atatatgcac agatctataa aattcaaata gtatacaaac tctgtagttg aaagtaactc
     3961 ttcttccctg tgtgcccaca gcaaagtacc ctctggtttc ttgtgtaacc ccttcaagag
     4021 attctcgttt ttcaaagatg tgtatatcct tttatcactc acaagtggta gcatgtcaga
     4081 tgcttccccc acccccactg ctttatgtaa tatgtcatgg gcatttcggc atgtctcttg
     4141 gacttttctt cagcatcttc atggtatgcg tggatcttta ttttgtaacc catccacaaa
     4201 cacagatgag ttcacctgtt tccagtcttt actgtaaata atgttgtaac tgacattctt
     4261 gtcgctaaat tttgcacatg tctgtggcga gttccttagg atataatccg agaaggaaat
     4321 tgcgtgacta tttttaagga ttttgataca tgttgccaat accctgtaga gagtttatac
     4381 ccagacactg ttctgtttgc agccccagag caccctgctc tctggactct aaaaagcact
     4441 aggttttatc acttatcaaa tctttgccaa tttgataggc aaataacagt acgtcaatgg
     4501 tatttcaact tattgcttta acattccttg gttatcagtg actaacattt tcatatgctt
     4561 attgaccatt tgaatttctt tctttgtgaa tttcctattt gtttgatatt gatatgttta
     4621 tctttatcta tatttatgtt tatctttatg atctatttgt aactttaaga atattatttt
     4681 tgtcaagaaa tgcaacagat acgctttcca agtgctttgc tttcagattt catttatggt
     4741 gctttttaac atacataaac tcctaattct gcaactaaaa aaaaaaaaaa aaa
//
