LOCUS       NM_001080949            1849 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tetratricopeptide repeat domain 5 (Ttc5), transcript
            variant 1, mRNA.
ACCESSION   NM_001080949
VERSION     NM_001080949.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1849)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1849)
  AUTHORS   Hu,X. and Mullins,R.D.
  TITLE     LC3 and STRAP regulate actin filament assembly by JMY during
            autophagosome formation
  JOURNAL   J Cell Biol 218 (1), 251-266 (2019)
   PUBMED   30420355
REFERENCE   3  (bases 1 to 1849)
  AUTHORS   Pressly,J.D., Hama,T., Brien,S.O., Regner,K.R. and Park,F.
  TITLE     TRIP13-deficient tubular epithelial cells are susceptible to
            apoptosis following acute kidney injury
  JOURNAL   Sci Rep 7, 43196 (2017)
   PUBMED   28256593
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1849)
  AUTHORS   Maniam,S., Coutts,A.S., Stratford,M.R., McGouran,J., Kessler,B. and
            La Thangue,N.B.
  TITLE     Cofactor Strap regulates oxidative phosphorylation and
            mitochondrial p53 activity through ATP synthase
  JOURNAL   Cell Death Differ 22 (1), 156-163 (2015)
   PUBMED   25168243
REFERENCE   5  (bases 1 to 1849)
  AUTHORS   Adams,C.J., Pike,A.C., Maniam,S., Sharpe,T.D., Coutts,A.S.,
            Knapp,S., La Thangue,N.B. and Bullock,A.N.
  TITLE     The p53 cofactor Strap exhibits an unexpected TPR motif and
            oligonucleotide-binding (OB)-fold structure
  JOURNAL   Proc Natl Acad Sci U S A 109 (10), 3778-3783 (2012)
   PUBMED   22362889
REFERENCE   6  (bases 1 to 1849)
  AUTHORS   Jansson,M., Durant,S.T., Cho,E.C., Sheahan,S., Edelmann,M.,
            Kessler,B. and La Thangue,N.B.
  TITLE     Arginine methylation regulates the p53 response
  JOURNAL   Nat Cell Biol 10 (12), 1431-1439 (2008)
   PUBMED   19011621
REFERENCE   7  (bases 1 to 1849)
  AUTHORS   Adams,C.J., Graham,A.L., Jansson,M., Coutts,A.S., Edelmann,M.,
            Smith,L., Kessler,B. and La Thangue,N.B.
  TITLE     ATM and Chk2 kinase target the p53 cofactor Strap
  JOURNAL   EMBO Rep 9 (12), 1222-1229 (2008)
   PUBMED   18833288
REFERENCE   8  (bases 1 to 1849)
  AUTHORS   Xu,D., Zalmas,L.P. and La Thangue,N.B.
  TITLE     A transcription cofactor required for the heat-shock response
  JOURNAL   EMBO Rep 9 (7), 662-669 (2008)
   PUBMED   18451878
REFERENCE   9  (bases 1 to 1849)
  AUTHORS   Demonacos,C., Krstic-Demonacos,M., Smith,L., Xu,D., O'Connor,D.P.,
            Jansson,M. and La Thangue,N.B.
  TITLE     A new effector pathway links ATM kinase with the DNA damage
            response
  JOURNAL   Nat Cell Biol 6 (10), 968-976 (2004)
   PUBMED   15448695
REFERENCE   10 (bases 1 to 1849)
  AUTHORS   Demonacos,C., Krstic-Demonacos,M. and La Thangue,N.B.
  TITLE     A TPR motif cofactor contributes to p300 activity in the p53
            response
  JOURNAL   Mol Cell 8 (1), 71-84 (2001)
   PUBMED   11511361
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027184.15, BY278375.1, AK161279.1, AK133953.1, AK044781.1 and
            AC140280.3.
            
            On Oct 1, 2013 this sequence version replaced NM_001080949.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157777.1, AK044781.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC027184.15        141816-141817
            3-23                BY278375.1         3-23
            24-1746             AK161279.1         2-1724
            1747-1832           AK133953.1         1733-1818
            1833-1847           AK044781.1         1822-1836
            1848-1849           AC140280.3         191643-191644       c
FEATURES             Location/Qualifiers
     source          1..1849
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.24 cM"
     gene            1..1849
                     /gene="Ttc5"
                     /note="tetratricopeptide repeat domain 5"
                     /db_xref="GeneID:219022"
                     /db_xref="MGI:MGI:2683584"
     exon            1..83
                     /gene="Ttc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1355
                     /gene="Ttc5"
                     /note="isoform a is encoded by transcript variant 1;
                     tetratricopeptide repeat protein 5; TPR repeat protein 5;
                     stress-responsive activator of p300; protein Strap"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 5 isoform a"
                     /protein_id="NP_001074418.1"
                     /db_xref="CCDS:CCDS36905.1"
                     /db_xref="GeneID:219022"
                     /db_xref="MGI:MGI:2683584"
                     /translation="MMADEEEEAKHVLQKLQGLVDRLYCFRDSYFETHSVEDAGRKQQ
                     DVQEEMEKTLQQMEEVLGSAQVEAQALMLKGKALNVTPDYSPEAEVLLSKAVKLEPEL
                     VEAWNQLGEVYWKKGDVASAHTCFSGALTHCKNKVSLQNLSMVLRQLQTDSGDEHSRH
                     VMDSVRQAKLAVQMDVLDGRSWYILGNAYLSLYFNTGQNPKISQQALSAYAQAEKVDR
                     KASSNPDLHLNRATLHKYEESYGEALEGFSQAAALDPVWPEPQQREQQLLEFLSRLTS
                     LLESKGKTKPKKLQSMLGSLRPAHLGPCGDGRYQSASGQKMTLELKPLSTLQPGVNSG
                     TVVLGKVVFSLTTEEKVPFTFGLVDSDGPCYAVMVYNVVQSWGVLIGDSVAIPEPNLR
                     HHQIRHKGKDYSFSSVRVETPLLLVVNGKPQNSSSQASATVASRPQCE"
     exon            84..216
                     /gene="Ttc5"
                     /inference="alignment:Splign:2.1.0"
     exon            217..428
                     /gene="Ttc5"
                     /inference="alignment:Splign:2.1.0"
     exon            429..579
                     /gene="Ttc5"
                     /inference="alignment:Splign:2.1.0"
     exon            580..671
                     /gene="Ttc5"
                     /inference="alignment:Splign:2.1.0"
     exon            672..728
                     /gene="Ttc5"
                     /inference="alignment:Splign:2.1.0"
     exon            729..875
                     /gene="Ttc5"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1090
                     /gene="Ttc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1235
                     /gene="Ttc5"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1849
                     /gene="Ttc5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1818..1823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttc5"
                     /note="hexamer: ATTAAA"
     polyA_site      1839
                     /gene="Ttc5"
                     /note="major polyA site"
ORIGIN      
        1 agttggggga ggagacgctg agagcggctg ggatgatggc tgatgaagag gaagaagcga
       61 agcacgtctt gcagaaattg cagggactgg tggatcggct ctactgtttt cgagacagtt
      121 actttgagac acatagtgtc gaagatgcag gacggaagca gcaggatgta caggaagaga
      181 tggagaagac cctgcagcag atggaggaag tactcggttc tgcccaggtt gaggcacagg
      241 ctctgatgct gaaggggaag gcactgaatg tgactcctga ttatagccct gaggccgagg
      301 tgcttctctc caaggccgtg aagctggagc ctgagctggt ggaagcctgg aaccagctgg
      361 gtgaggtgta ctggaagaaa ggagatgtcg cgtctgccca cacctgcttc tcaggagccc
      421 tcacccactg caagaacaaa gtctctctgc agaacttgtc catggtgctc cgccagctgc
      481 agaccgactc tggagatgaa cattctcgcc acgtcatgga cagcgtccgg caggctaagt
      541 tggccgtgca gatggatgtc cttgatggcc gctcctggta tatcctgggg aatgcatatc
      601 tttctcttta tttcaatact ggccagaacc ctaagatctc ccagcaagcc ctcagtgcct
      661 atgctcaagc agagaaggtg gacaggaaag catctagcaa ccctgacctt catctcaaca
      721 gggcgacgtt acataaatat gaggagagtt atggggaggc ccttgagggt ttctctcagg
      781 ctgcagcgct ggaccctgtg tggccagagc cccagcaacg agaacagcaa ctcctggaat
      841 tcctcagtag gctaaccagc ctcctggaga gcaaggggaa gacaaagccc aagaagctgc
      901 agagcatgct gggaagcttg cgcccagctc atctgggccc ctgtggtgat gggcgctatc
      961 agtcggcctc tgggcagaag atgaccctgg agcttaagcc actgagcacc ctgcagcctg
     1021 gtgtgaacag tggcaccgtg gtcctgggaa aggtggtgtt cagcctgacc acagaggaga
     1081 aagtcccctt cacgtttggc ttggtagatt cggatggtcc ctgctatgca gtgatggtgt
     1141 ataatgtggt gcagagctgg ggagtgctca tcggggactc tgtagctatt cctgagccca
     1201 accttcggca tcatcaaatc cggcacaagg gaaaggacta ttccttctcc agcgtgcgtg
     1261 tggaaacgcc tcttctgctg gtggtgaatg gaaagccaca gaactccagc agtcaagcct
     1321 ctgccacagt agcttcaagg ccgcagtgtg aatgaccttg tagaggcaat gaagtctcat
     1381 agctaagctc accctgcgag ttggaaatgg ggacttctct tcccctgccc tggaacatag
     1441 ttgagtctct ttccttttcc ctgctgtatt ccagccctct tcagagccat tgggaccctt
     1501 gtttattctt cctgcctctt caaaggtgcc gacttaaaga gcaaagaact catagaactg
     1561 ttgggaccat gtcatgagag actcaggacc taaagtcctg agaggttttg acagtccacg
     1621 agatccctgt tctcgcctcc ttcctgagtc caatatgtat gtacatatca gtttactatt
     1681 tattgttgag ggggctcaac tttctaatgg cttcattttt gagcagtgtt tttttttttt
     1741 tttttttaat ttttatgttt aagttccgat tgtcttaaaa aaaaaatgtt ctttctcgtc
     1801 cttagggcta gaacaaaatt aaatttgttt ggaaaagaat ttaccctat
//
