LOCUS       NM_001003910            4365 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus tetratricopeptide repeat domain 41 (Ttc41), transcript
            variant 3, mRNA.
ACCESSION   NM_001003910
VERSION     NM_001003910.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4365)
  AUTHORS   van den Akker,E., Vankan-Berkhoudt,Y., Valk,P.J., Lowenberg,B. and
            Delwel,R.
  TITLE     The common viral insertion site Evi12 is located in the
            5'-noncoding region of Gnn, a novel gene with enhanced expression
            in two subclasses of human acute myeloid leukemia
  JOURNAL   J Virol 79 (9), 5249-5258 (2005)
   PUBMED   15827139
REFERENCE   2  (bases 1 to 4365)
  AUTHORS   Ruiz,S., Segrelles,C., Bravo,A., Santos,M., Perez,P., Leis,H.,
            Jorcano,J.L. and Paramio,J.M.
  TITLE     Abnormal epidermal differentiation and impaired
            epithelial-mesenchymal tissue interactions in mice lacking the
            retinoblastoma relatives p107 and p130
  JOURNAL   Development 130 (11), 2341-2353 (2003)
   PUBMED   12702649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152453.4, AK133195.1, AK166553.1 and BG072108.2.
            
            On Apr 27, 2007 this sequence version replaced NM_001003910.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and it encodes the longest protein (isoform 3).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               AC152453.4         94561-94767         c
            208-1685            AK133195.1         148-1625
            1686-2181           AK133195.1         1627-2122
            2182-2421           AC152453.4         66784-67023         c
            2422-2620           AC152453.4         63579-63777         c
            2621-2799           AC152453.4         55974-56152         c
            2800-4277           AK166553.1         116-1593
            4278-4365           BG072108.2         1-88                c
FEATURES             Location/Qualifiers
     source          1..4365
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 43.07 cM"
     gene            1..4365
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /note="tetratricopeptide repeat domain 41"
                     /db_xref="GeneID:103220"
                     /db_xref="MGI:MGI:2387653"
     exon            1..207
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /inference="alignment:Splign:2.1.0"
     exon            208..1182
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..4343
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /note="isoform 3 is encoded by transcript variant 3;
                     tetratricopeptide repeat protein GNN; TPR repeat protein
                     GNN; grp94-neighboring nucleotidase; TPR repeat protein
                     41; tetratricopeptide repeat protein 41"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 41 isoform 3"
                     /protein_id="NP_001003910.2"
                     /db_xref="CCDS:CCDS24098.1"
                     /db_xref="GeneID:103220"
                     /db_xref="MGI:MGI:2387653"
                     /translation="MSDEASETGQRYNGQPILKRQKPILPYICSTLDFQEERDFLAKS
                     IFPRLNDICSSRGTYFKAVDLRWSAVKAHKSFTSNQFRQYSCLQSQHLKLSLDYVNRC
                     FPFFIGLLGQTYGDFLPDYTPFLLSQVKDFESLSKGEQNLYIAAKNGYPWVLKTPNCS
                     LTEFEIIQAVFRKKSQFQFFYFRTSNSLLRTFNEEEEEEEEKLSSAYLLNEQGKMKVG
                     KLKAKIIGKGLPVRFYRDLEELGDMVWKDWSAVVEKLYPFTTIMGNIDYKHSFENLYH
                     EEFVENCKQVFVTSKESNRTFEILERFAIKDLDLDLDTDSTIAGSGLDSILRINSLPT
                     CKSILLLSGERGCGKSTLIANWVSNFQSKHPGVLMIPYFVGSTCESCDIMSVIHYFVM
                     ELQHRANGPRLEMDFLNEDSNVLVFSLLVEVFIAAISLKPCILVLDGIEELIGIYGIS
                     GQKAKDFSWLPRSLPPHCKFILSSVSSSLSCKSLCARPDVKIVELNSIGDEDTKFNIF
                     RQHLSPADQERFGQSKPILRKKPNLSPLKLAIIASELQECKIYRNEFQCLREYLEVAS
                     VQELWELILKRWVEDYSWTLKPKDTTLDTVIPGPSGWVVDVLCLLCISHCGLAEDELL
                     QLLDTMGYRDHHKVTAVHWAAFRQATKTWIQEKPNGLLYFQHQSLRSAVEHKLLGVST
                     PVRESNPNVAQNSVNHKKAHFHQVLMRFFQRQTIFWRVYQELPWHMKMSGYWEGLCNF
                     ITNPSITDFISKIQNPSLWTRLHLVHYWDVLLEAGNDVSEAFLLSVAKIEGEQFQKLK
                     KRTTLSVLECSLSEITAADKGRIILFIGSFLKLMGKINEAEKLFLSAEDLLLQSPSMT
                     EMLLRAQNAIGELYLEIGMTPKGLTYFQKAWSNLLRFTLSDLKISQELMKQKVKVMNN
                     LAKSAPGEFLKENHVLEYATEISKYVTGNPRDHATMKYTEGVLMLASGNAALAKLKFQ
                     ECLTIRRWLFGNKNILVGEIMEFLADLLFFLLGENEKSQKKQAIEYYKQVIKIKEKAD
                     TVATCKLVRKHLSISLSDTLCKLAGQLLSGDFCHHATMEAVSYLYRSLDLRAAHLGPT
                     HASIEGILHLLREIQRSRGRRSWPQSMNHLFPNGSRNGFSLWENVPKLNFHSAQSSDT
                     VNTAMCMNIRRFQRVKSTQPSLVSDKPKYVPGKGKKTLAPILCKSAEEKFQRQASDSQ
                     IWNSPRRQPARKKAACPLKTVSLIDKNGLVRLSRQSVSSAELDSRKGLITSICRQPLQ
                     LPHNVDNPWKSISELVSEKWLFHTPQYCFTPQKPGFPRRSQIESKLLKTSDDPNKE"
     exon            1183..1369
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1584
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1745
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..2181
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2421
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2620
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2799
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2939
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3111
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3259
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /inference="alignment:Splign:2.1.0"
     exon            3260..3412
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /inference="alignment:Splign:2.1.0"
     exon            3413..3546
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3676
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /inference="alignment:Splign:2.1.0"
     exon            3677..4365
                     /gene="Ttc41"
                     /gene_synonym="Gnn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttccggct tctagcgaac gtttagtccg tgactagggg aaacggtagc caagacaatg
       61 cgtcctttac ccttttctcg tctacgacgc gggtcacgtt acgagtcctt tcagcgctac
      121 gttcgccgtc acctttcttt tgggcgtttc ttttcgcaaa agagaaattt gtgaggggtt
      181 gaatatccgg aatgcgtttg gatggtgatt gcttaaccat tgcatccctt ccacaagaaa
      241 caatttaaag aagtgatttg aatgaaactg accaattgct tatagcaaac acagttaaaa
      301 gaagacccaa actgtggacc ttggcgactg ggccaggatg gaacttcctt tcttctaagt
      361 gcgacatcat cctggagccg agtgaaatga gcgacgaggc aagtgagacc ggacaaagat
      421 acaacggtca acccatttta aagcgccaga aacccatcct accttacata tgttccactc
      481 tagattttca agaagagaga gactttttgg ccaaaagcat cttccctcgg cttaatgaca
      541 tctgcagctc ccggggcacc tacttcaaag ctgtggactt gagatggtca gctgtgaagg
      601 cccataagtc cttcaccagc aaccagttcc gacagtactc ctgtctccag tctcaacacc
      661 tgaaactctc cctggactac gtgaacagat gcttcccgtt tttcatcggc ctgctggggc
      721 agacctacgg agatttcctc cccgactaca cacctttcct gttatcccaa gtgaaggact
      781 tcgaaagttt atccaaggga gaacagaatc tatacattgc tgccaaaaat ggttaccctt
      841 gggttctcaa gactcccaac tgcagcctga cagagttcga gatcatccaa gcagtattcc
      901 ggaagaaatc tcaatttcaa tttttctact tccggacatc aaattcgctg ctgcgaactt
      961 ttaatgagga agaggaggag gaagaggaga agctgtcctc agcatatctg ttgaacgaac
     1021 aggggaagat gaaggttgga aagctcaagg ctaagatcat tggcaaaggg cttcctgtca
     1081 gattctacag agacctggag gaactggggg atatggtttg gaaggactgg tcggctgttg
     1141 tggaaaagct ctatccattc actacgatca tgggaaatat agactacaaa cacagtttcg
     1201 agaatttgta tcatgaagag tttgtggaga actgcaagca agtttttgtt acttccaagg
     1261 agtcaaacag aacctttgaa atattggaaa gatttgctat aaaagatctt gatcttgatc
     1321 ttgatactga cagtactata gcaggttcgg ggttagactc cattctcaga atcaattccc
     1381 ttccaacttg taagtccatt ttgctcttgt ctggggaacg cggctgtggg aagtccacac
     1441 tgattgccaa ctgggtcagt aatttccaaa gcaaacaccc cggagtgctg atgatcccat
     1501 actttgtggg cagtacgtgt gagagctgtg acatcatgtc tgtgatccac tacttcgtca
     1561 tggagcttca gcacagagcc aacggtcccc ggcttgaaat ggatttcctt aacgaggact
     1621 caaatgtctt ggtcttttca cttctcgtag aagtgttcat agccgccata agcttaaagc
     1681 catgcatcct ggtactagac gggatcgaag agctgatcgg tatctatggg atttcaggtc
     1741 agaaggcgaa agatttctcc tggctgccgc gctccctgcc tcctcactgt aaattcattc
     1801 tgagcagcgt ctcctccagt ctgtcctgca agtcgctgtg tgcccgccct gacgtgaaga
     1861 tcgtggaact caacagcatc ggggacgaag acaccaagtt caacatcttc agacagcacc
     1921 tctcccctgc cgaccaagaa cgcttcgggc agagcaagcc cattttgagg aagaaaccaa
     1981 acctgagccc tctgaagctc gcaatcatcg ccagcgagct gcaggagtgc aaaatctacc
     2041 gcaatgagtt ccagtgtctc cgggagtact tggaggttgc ctctgtgcag gagctctggg
     2101 agttgattct gaagcgctgg gttgaagatt atagttggac tttgaagcct aaagacacaa
     2161 ctctagacac cgtgattcca gggccaagtg gctgggtagt ggatgtgctg tgcttgctct
     2221 gcatctctca ctgcgggctg gctgaggatg aactgctcca gcttttggac acgatgggct
     2281 acagggacca ccacaaagtg acggcggtgc actgggcagc cttccgccaa gccaccaaaa
     2341 cctggatcca ggagaagccc aatggtctcc tctacttcca gcaccagtcc ctaaggagtg
     2401 ccgtggagca caagctgctg ggtgtaagca ctccggtgag agagagcaat cccaatgtgg
     2461 cccagaacag cgtgaatcac aagaaggcac atttccacca ggtcttgatg aggttcttcc
     2521 agcggcaaac catcttctgg agggtgtatc aggagctgcc ctggcacatg aagatgagcg
     2581 ggtattggga aggtctatgt aacttcatca cgaaccccag catcacagat ttcatatcga
     2641 aaatccaaaa cccaagcttg tggaccaggc tgcaccttgt ccactactgg gatgtgctgc
     2701 tggaagccgg caatgacgtg tctgaggctt ttctgctctc tgttgccaag atagaagggg
     2761 aacaattcca gaaactcaag aagcgaacca cactctcagt gctggaatgc agcctgtccg
     2821 agattactgc tgctgataaa ggcagaatta tcctctttat tggaagtttc ctgaagctaa
     2881 tgggcaagat caatgaagct gaaaagctgt tcttgagcgc tgaggacttg ttactacaga
     2941 gcccatccat gacagaaatg ctgctcagag ctcagaatgc cattggggaa ttatatcttg
     3001 agattgggat gactccgaaa ggactcacat attttcagaa agcttggtca aatctgctgc
     3061 ggtttacact cagcgaccta aagatcagcc aggaattgat gaagcagaaa gttaaagtga
     3121 tgaataacct ggcaaaatcg gcgcctgggg aattcttaaa agaaaaccac gttctggaat
     3181 atgctaccga aatctccaag tacgtgactg gtaatccccg tgatcatgct accatgaaat
     3241 atactgaagg tgttctcatg ttggcttccg gaaacgcagc cctggcaaaa ctcaagtttc
     3301 aagagtgttt aactatcaga agatggctat ttggcaataa aaacatacta gttggagaaa
     3361 ttatggaatt cttagcagat ttactatttt ttctactagg agaaaatgaa aaatctcaaa
     3421 agaagcaagc aattgaatat tataaacaag tcataaaaat caaggagaag gcagatacgg
     3481 tggccacctg caagcttgtg aggaagcatc tgagtataag cctcagcgac accttgtgta
     3541 aactagcagg ccagctgttg tcaggtgact tctgccatca tgccacaatg gaggcagtca
     3601 gctatttgta taggtcactt gatttaaggg cagctcacct ggggcctacc cacgcttcca
     3661 ttgagggaat actacacctt ttaagggaaa tccagaggtc ccggggcagg aggtcttggc
     3721 ctcaaagcat gaaccatcta ttccctaacg gttctaggaa tggcttttca ttatgggaga
     3781 atgtgcctaa attaaacttc cacagcgctc agagttctga cacggtaaac actgcaatgt
     3841 gtatgaatat acgtaggttt cagagagtta aaagcacaca gccttctctg gtttcagata
     3901 aaccaaaata tgttcccggc aaaggaaaga agaccttggc tccaattctg tgcaagtctg
     3961 ctgaggaaaa gttccaacgt caggcttcag actcacaaat atggaatagt ccaagaagac
     4021 aacctgccag gaaaaaggca gcctgtcccc ttaagacggt ctcgctcatt gacaagaacg
     4081 gcttggtgag actctcaagg cagagtgttt cttctgctga gctggacagc agaaagggcc
     4141 tgatcacttc catctgccgg caacccctgc agctacctca taatgtggac aatccctgga
     4201 agtccatatc ggaactcgtg tcagaaaagt ggctcttcca cactcctcag tactgcttca
     4261 ctcctcagaa gccaggcttc ccaagaagat ctcagattga atcaaaattg ctgaagacct
     4321 cagatgaccc caataaggaa taaaaataat tttgggctgt tttgt
//
