LOCUS       NM_028209               2569 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tetratricopeptide repeat domain 4 (Ttc4), transcript
            variant 1, mRNA.
ACCESSION   NM_028209
VERSION     NM_028209.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2569)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2569)
  AUTHORS   Dmitriev,R.I., Pestov,N.B., Shakhparonov,M.I. and Okkelman,I.A.
  TITLE     Two distinct nuclear localization signals in mammalian MSL1
            regulate its function
  JOURNAL   J Cell Biochem 115 (11), 1967-1973 (2014)
   PUBMED   24913909
  REMARK    GeneRIF: Studies identi fi ed a novel signal of nuclear
            localization (NLS) in all MSL1 protein isoforms and found that the
            combination of both NLS allows for its intra-nuclear focal
            accumulation and nuclear transport of TTC4 while all MSL1 isoforms
            affect H4K16Ac.
REFERENCE   3  (bases 1 to 2569)
  AUTHORS   Dmitriev,R.I., Okkelman,I.A., Abdulin,R.A., Shakhparonov,M.I. and
            Pestov,N.B.
  TITLE     Nuclear transport of protein TTC4 depends on the cell cycle
  JOURNAL   Cell Tissue Res 336 (3), 521-527 (2009)
   PUBMED   19390865
  REMARK    GeneRIF: The nuclear transport of TTC4 is apparently a complex
            process dependent on interactions with other proteins during the
            progression of the cell cycle.
REFERENCE   4  (bases 1 to 2569)
  AUTHORS   Dmitriev,R.I., Korneenko,T.V., Bessonov,A.A., Shakhparonov,M.I.,
            Modyanov,N.N. and Pestov,N.B.
  TITLE     Characterization of hampin/MSL1 as a node in the nuclear
            interactome
  JOURNAL   Biochem Biophys Res Commun 355 (4), 1051-1057 (2007)
   PUBMED   17335777
REFERENCE   5  (bases 1 to 2569)
  AUTHORS   Lee,Y.J., Park,C.W., Hahn,Y., Park,J., Lee,J., Yun,J.H., Hyun,B.
            and Chung,J.H.
  TITLE     Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely
            linked to Peg1/Mest(1)
  JOURNAL   FEBS Lett 472 (2-3), 230-234 (2000)
   PUBMED   10788617
REFERENCE   6  (bases 1 to 2569)
  AUTHORS   Jurecic,R., Nachtman,R.G., Colicos,S.M. and Belmont,J.W.
  TITLE     Identification and cloning of differentially expressed genes by
            long-distance differential display
  JOURNAL   Anal Biochem 259 (2), 235-244 (1998)
   PUBMED   9618202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY060470.1, AK133931.1, AK012652.1 and AK005923.1.
            
            On Feb 2, 2010 this sequence version replaced NM_028209.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133931.1, AK088684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BY060470.1         1-36
            37-499              AK133931.1         2-464
            500-500             AK012652.1         446-446
            501-1340            AK133931.1         466-1305
            1341-1341           AK005923.1         1342-1342
            1342-2569           AK133931.1         1307-2534
FEATURES             Location/Qualifiers
     source          1..2569
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 49.68 cM"
     gene            1..2569
                     /gene="Ttc4"
                     /gene_synonym="2810002P21Rik; L62"
                     /note="tetratricopeptide repeat domain 4"
                     /db_xref="GeneID:72354"
                     /db_xref="MGI:MGI:1919604"
     exon            1..192
                     /gene="Ttc4"
                     /gene_synonym="2810002P21Rik; L62"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1242
                     /gene="Ttc4"
                     /gene_synonym="2810002P21Rik; L62"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tetratricopeptide repeat protein 4; TPR repeat protein 4"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 4 isoform 1"
                     /protein_id="NP_082485.1"
                     /db_xref="CCDS:CCDS18424.1"
                     /db_xref="GeneID:72354"
                     /db_xref="MGI:MGI:1919604"
                     /translation="MESSEPEPTEDASMDAFLEKFQSQPYRGGFREDQWEEEFDKIPL
                     FMKKAPSEIDPEEFPDLACLQSMIFDDDRYPEEQAKTYKDEGNDYFKEKDYKKAVLSY
                     SEGLKKKCADPDLNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAIIRGALC
                     HLELKHFAEAVNWCDEGLQIDAKEKKLLEIRAKADKLKRMEERDLRKAKLKEKKEQHQ
                     NEALLQAIKARNIRLVSESAGEDEDSASNGPAEILLDGLSSENPYGARLSIDDQGRLS
                     WPVLFLYPEYAQSDFISAFHEDTRFIDHLMAMFSEAPSWDSEHKYHPENLEVYFEDED
                     RAELYQVSPDSTLLQVLQHPRCCVKALTPAFLVCVGSSPFCRNYLQGKKVHR"
     exon            193..310
                     /gene="Ttc4"
                     /gene_synonym="2810002P21Rik; L62"
                     /inference="alignment:Splign:2.1.0"
     exon            311..472
                     /gene="Ttc4"
                     /gene_synonym="2810002P21Rik; L62"
                     /inference="alignment:Splign:2.1.0"
     exon            473..550
                     /gene="Ttc4"
                     /gene_synonym="2810002P21Rik; L62"
                     /inference="alignment:Splign:2.1.0"
     exon            551..675
                     /gene="Ttc4"
                     /gene_synonym="2810002P21Rik; L62"
                     /inference="alignment:Splign:2.1.0"
     exon            676..762
                     /gene="Ttc4"
                     /gene_synonym="2810002P21Rik; L62"
                     /inference="alignment:Splign:2.1.0"
     exon            763..980
                     /gene="Ttc4"
                     /gene_synonym="2810002P21Rik; L62"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1062
                     /gene="Ttc4"
                     /gene_synonym="2810002P21Rik; L62"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1145
                     /gene="Ttc4"
                     /gene_synonym="2810002P21Rik; L62"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..2569
                     /gene="Ttc4"
                     /gene_synonym="2810002P21Rik; L62"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttc4"
                     /gene_synonym="2810002P21Rik; L62"
                     /note="hexamer: ATTAAA"
     polyA_site      2119
                     /gene="Ttc4"
                     /gene_synonym="2810002P21Rik; L62"
                     /note="major polyA site"
ORIGIN      
        1 aaaaggaagg gcatccctgc cgccggaagg agcggcgcgt ttcttggtcc cgggactgaa
       61 gcgccgaagt tgcgagctgc catggagagt tctgagcctg agcctacaga ggacgcttcc
      121 atggacgcgt tcctggaaaa gtttcagagc cagccttacc gcggcggctt ccgcgaggat
      181 cagtgggagg aggaatttga caagattccc ctatttatga aaaaagcgcc atcagaaatt
      241 gaccccgagg agtttcctga cttggcctgc ctccagtcga tgatttttga tgatgatcga
      301 tatccagaag agcaagccaa gacctataaa gatgagggca atgactactt taaagaaaaa
      361 gactataaga aagctgtgct ttcatacagt gaagggttga agaagaagtg tgcagaccct
      421 gatttgaatg ctgtcctgta taccaaccgg gcagcagcac agtactatct cggcaatgtt
      481 cgttcttccc tcaatgatgt gctggctgcc aagaagctaa agcccggtca cctgaaagcc
      541 atcataagag gtgccctgtg ccatcttgaa ctgaaacact ttgctgaggc tgtgaactgg
      601 tgtgatgagg gactacaaat tgatgccaaa gagaagaaac ttctagaaat aagggcaaaa
      661 gcagacaagc taaagaggat ggaagagagg gatctgagga aggcaaagtt gaaagaaaag
      721 aaggaacagc atcagaatga ggctctgctc caggccatca aggctaggaa catcaggctt
      781 gtctctgaat cagccggtga ggatgaagat tcagcctcca atggtccagc tgagatactc
      841 ctggatgggc tcagctctga gaacccctat ggagccaggc taagtataga tgaccagggc
      901 aggctgagct ggcctgtgct gttcctgtac ccggagtacg cgcaatcaga cttcatctct
      961 gcttttcatg aggacaccag gtttattgac catctaatgg cgatgtttag tgaagcaccc
     1021 tcctgggact cagagcacaa gtaccaccca gagaatctgg aggtctactt cgaggatgag
     1081 gacagggcgg aactatacca ggtgtctccc gatagcaccc tgttgcaggt gctgcagcac
     1141 cccaggtgct gcgtgaaggc ccttaccccg gcattcctgg tctgtgtagg atcctcgcct
     1201 ttctgtagga attacctcca ggggaagaag gtgcacaggt aacatgggag ccagaccctg
     1261 gggtctcttc cctcaacttc ctctgctgga ctttgtacac gggaatcatc tggcctagag
     1321 tgtagcactc tatcctcagg gacagtggtt cccagcctct tgttggggaa gaagctgcag
     1381 gaccccctga acctaagcct gtctggctga gtgctgggct ccagctgggc cgcactctcc
     1441 tcagattcac agccctgccc tggccagtac atctttggag tccatctctg aaaaaatcat
     1501 ccactgcagt taccagaata gctggccttg gtaactccct agcccagaga ctgtcgcagg
     1561 atgcagtgac agtcttaacc tttgtggcat cgggcacata cagaaggcac aactccaagg
     1621 caataaacca gccctgcaca tactctaagg ccttaaggct tgaaagactg gctcagttgc
     1681 ttcaccagcc tggaggaaag ctaagatgct gtggatgcca tgaagtgact gcagccatga
     1741 agccacatcc tgttctgttg actgtataaa cttggatcct gggactactc agagccctac
     1801 tggattctct acttctcaat gcccatgcaa gggcttgtgc cacatctgac agaagcttga
     1861 ggagtcaatg ggcagtggtt tgcaagtagg cttgtgttgt tttcccttta ttgtgaggtc
     1921 tcatttctga aataggagta gtcctggtgt ctgagcaaag cccacagcag ctggcctaaa
     1981 gccattgttt gttacatgag tggcaaatgt gtttgtagta aacacttgag atttggggga
     2041 ttgttcgtca atataggaaa actgactaat acattattaa actgaaacca gctggtggcc
     2101 ttcagatggg ctaatatgag atcttgtgtt gtttgtgtcc ttgtttcttg aagagaaatt
     2161 gtttgaaata tttagggaga caagtgcagc tttctttacc agagcaggtc cctgtaaatc
     2221 cactaaaccc tacccccaac acacacacac acacacacac acacacacac acacacacac
     2281 acgttttgga aatactgcag acattctctc ctcagtcaga gactttcctc tgacttcctt
     2341 tttaagaact caaagtctat gtgaggggcc taaaagtgtc tctgttctgt gggtgtggtc
     2401 ttaagaccct catcctagct gcgtggaagt cagtcttcca ctagcaacct tcaaatgaag
     2461 atgtagaact ctcagctctg cgtgcaccat gcttgcctgg atgctgccat gttcctgcct
     2521 tgacgttaat ggactgaacc tgtaagccag ccaattaaat tttgtcctt
//
