LOCUS       NM_028341               2556 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus tetratricopeptide repeat domain 39C (Ttc39c), mRNA.
ACCESSION   NM_028341 XM_978181 XM_978221 XM_978264 XM_978300
VERSION     NM_028341.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2556)
  AUTHORS   Hayes,C.S., Labuzan,S.A., Menke,J.A., Haddock,A.N. and Waddell,D.S.
  TITLE     Ttc39c is upregulated during skeletal muscle atrophy and modulates
            ERK1/2 MAP kinase and hedgehog signaling
  JOURNAL   J Cell Physiol 234 (12), 23807-23824 (2019)
   PUBMED   31188487
  REMARK    GeneRIF: The results of this study demonstrate that muscle cell
            differentiation is sensitive to abnormal Ttc39c expression and that
            normal Ttc39c expression appears to be necessary for proper MAP
            Kinase and Hedgehog signal transduction in developing muscle cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139027.12 and AC102055.13.
            
            On Dec 27, 2022 this sequence version replaced NM_028341.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013267.1, BC020021.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-682               AC139027.12        89643-90324         c
            683-731             AC139027.12        48801-48849         c
            732-860             AC139027.12        46606-46734         c
            861-975             AC139027.12        43799-43913         c
            976-1330            AC139027.12        38096-38450         c
            1331-1499           AC139027.12        35627-35795         c
            1500-1593           AC139027.12        13643-13736         c
            1594-1701           AC139027.12        8640-8747           c
            1702-1811           AC139027.12        4957-5066           c
            1812-1935           AC139027.12        3569-3692           c
            1936-2033           AC139027.12        631-728             c
            2034-2138           AC102055.13        36064-36168
            2139-2177           AC102055.13        37157-37195
            2178-2556           AC102055.13        37851-38229
FEATURES             Location/Qualifiers
     source          1..2556
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 6.71 cM"
     gene            1..2556
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /note="tetratricopeptide repeat domain 39C"
                     /db_xref="GeneID:72747"
                     /db_xref="MGI:MGI:1919997"
     exon            1..682
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             525..2267
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /note="TPR repeat protein 39C"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 39C"
                     /protein_id="NP_082617.2"
                     /db_xref="CCDS:CCDS29065.1"
                     /db_xref="GeneID:72747"
                     /db_xref="MGI:MGI:1919997"
                     /translation="MAGSEEQWPRRREDGDPDAAAAPLQDAELALAGINMLLNNGFRE
                     SDQLFKQYRNHSPLMSFGASFVSFLNAMMTFEEEKMQLACDDLKTTEKLCESEEAGVI
                     ETIKNKIKKNVDARKSTPSMVDRLQRQIIIADCQVYLAVLSFVKQELSAYIKGGWILR
                     KAWKIYSKCYVDINALQELYQKKLTEEPLASDAANDNHVVAEGVTEESLSRLKGAVSF
                     GYGLFHLCISMVPPNLLKIINLLGFPGDRLQGLSSLTYASESKDMKAPLATLALLWYH
                     TVVRPFFALDGSDNKGGLDEAKAILLRKESAYPNSSLFMFFKGRIQRLECQINSALTS
                     FHTALELAVDQREIQHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWSQCYYAYLTA
                     VCQGATGDVDGAQLVLKEVQKLFKRKNNQIEQFSVKKAERFRKQTPTRALCVLASIEV
                     LYLWKALPNCSFPNLQRMSQACHEVDDSSVVGLKHLLLGAIHKCLGNSQDALQFFQRA
                     ARDELCRQSNSYVPPYACYELGCLLLDSAETVGRGRTLLLQAKEDFSGYDFENRLHVR
                     IHAALASLRELVPQ"
     exon            683..731
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            732..860
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            861..975
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1330
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1499
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1593
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1701
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1811
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1935
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2033
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2138
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2177
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2556
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2441..2446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2462
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
     regulatory      2534..2539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2556
                     /gene="Ttc39c"
                     /gene_synonym="1700008N02Rik; 2810439F02Rik"
                     /note="major polyA site"
ORIGIN      
        1 aagggttctg acacgcgtgg cccaagccaa agccacctgg gtgtccagcc gcgctccgtc
       61 gcagcaaacc aggagttctc tgaccccgag ttaagctctc ctgcccctcc cagtgcgtcc
      121 agggttcatc ctgtcctgga gggttggcca ttggggcctc ccgtgggtgt cctcagcctg
      181 ggcgctagcc tgggggcctc tggggccggt tccggggcct ggaggggctg caggaagcgg
      241 aggtagctcg ggacgcctgg atcgaagcgg gcgcagacac ccgaaacggc tggggtggcc
      301 gcgagccggc tgctgagtaa tcccgggcgg cgggtggggg cggccgggcg cccacgttcc
      361 ccgcgccgca gcccggcggc ggctccgcct tcgcgtccat ccccgccccc tgccggctgc
      421 tgtgctctgc tccccgcagg tcggagccgg gctccgggag cgcgggccgc tgcagccgcc
      481 tcctccggca cctcgcctcg gcccactcga ggcctcgtgt gcccatggcc ggctcggagg
      541 agcagtggcc gcggcggagg gaggacggcg acccggacgc cgcagcggcg cccctgcagg
      601 acgcggagct ggccttggct ggcatcaata tgcttctcaa caacggcttc agggagtcgg
      661 atcagctttt caaacaatac agaaatcata gtccactaat gagttttgga gccagcttcg
      721 tcagcttttt gaacgccatg atgacattcg aggaggagaa aatgcagttg gcgtgcgatg
      781 acttaaagac tacagagaag ctgtgtgaga gtgaagaggc tggtgtaatc gaaacaatta
      841 agaacaaaat taagaagaac gttgatgccc ggaaatccac cccctccatg gtcgatcgac
      901 ttcagaggca gatcatcatc gctgactgcc aggtttacct ggcagtgctt tcctttgtga
      961 aacaagagtt gtcggcctac ataaaaggtg ggtggatcct taggaaagcc tggaagattt
     1021 acagtaagtg ctatgtggac atcaacgccc ttcaggaact gtatcagaag aagctgacgg
     1081 aagagccctt ggcttctgat gctgcaaatg ataaccacgt tgtggccgaa ggggtgaccg
     1141 aggagtcctt aagcagactg aaaggggctg tgagctttgg atatggcctt ttccaccttt
     1201 gcatatccat ggtgccccca aacctgctca aaatcatcaa cctgctgggc tttcctggag
     1261 accgcctaca gggcctttct tcactgacgt atgcgagcga aagtaaggac atgaaggccc
     1321 ctttagctac attagccctg ctgtggtacc acactgtggt ccgcccattt tttgctttgg
     1381 acggcagtga caacaaaggg ggcttggatg aagctaaggc aattcttctc agaaaggaat
     1441 ctgcttaccc caactcttcc ctcttcatgt ttttcaaggg acggatccag cggttagagt
     1501 gtcaaatcaa cagtgccttg acttccttcc acactgctct ggagctggct gtggaccaga
     1561 gggagatcca gcacgtctgt ctgtatgaaa ttggctggtg cagcatgatt gaactcaact
     1621 tcaaggatgc atttgattcc ttcgagaggc tgaagaacga gtcccggtgg tcccagtgct
     1681 actacgcata tctgactgca gtttgtcagg gagccactgg tgatgtggat ggggcacaac
     1741 ttgttcttaa agaagtccag aagctgttca aaaggaaaaa caaccagatt gaacagtttt
     1801 ctgtgaagaa ggctgagcga tttcggaagc aaaccccaac cagagcgctg tgtgtgctgg
     1861 cctccattga agtgctctac ttgtggaaag cccttccaaa ctgctccttc cccaacctgc
     1921 agaggatgag tcaagcttgc catgaagtgg acgattcatc tgtcgttgga ttaaagcatt
     1981 tgctccttgg tgccatacac aaatgtctag gaaactcaca agatgctctt cagttcttcc
     2041 agcgagctgc tagagatgag ctatgtcggc agagtaactc gtacgtcccg ccatatgcgt
     2101 gctatgagct tggctgtctc ctactggaca gcgcagagac tgtgggaaga ggcagaactc
     2161 tacttcttca ggcaaaggag gatttttctg gctacgactt tgaaaacaga ttgcacgtcc
     2221 gcatccacgc tgctctggcc tccctaaggg aacttgttcc tcagtgataa actcccagtg
     2281 gcccctccgt cccctccacc cagagtcagc actatgaaag ctgaggagaa aactctcttg
     2341 aagatcagct tttcttctgg agaccacctg ggccagggat gggtttcctg gtgtcactga
     2401 catactaaag attcctcttt taaacatgta gctatggagt aataaagatg tccataacga
     2461 gagcaatgcc cgacctggga gagggttaag tgaccttgtt caaactattt agttttgtga
     2521 tttattattt ttaaataaaa tcaaactaaa tattca
//
