LOCUS       NM_009441               7295 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus tetratricopeptide repeat domain 3 (Ttc3), mRNA.
ACCESSION   NM_009441
VERSION     NM_009441.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7295)
  AUTHORS   Endo,R., Chen,Y.K., Burke,J., Takashima,N., Suryawanshi,N.,
            Hui,K.K., Miyazaki,T. and Tanaka,M.
  TITLE     Dysregulation of ribosome-associated quality control elicits
            cognitive disorders via overaccumulation of TTC3
  JOURNAL   Proc Natl Acad Sci U S A 120 (12), e2211522120 (2023)
   PUBMED   36917672
  REMARK    GeneRIF: Dysregulation of ribosome-associated quality control
            elicits cognitive disorders via overaccumulation of TTC3.
REFERENCE   2  (bases 1 to 7295)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7295)
  AUTHORS   Guedj,F., Pennings,J.L., Massingham,L.J., Wick,H.C., Siegel,A.E.,
            Tantravahi,U. and Bianchi,D.W.
  TITLE     An Integrated Human/Murine Transcriptome and Pathway Approach To
            Identify Prenatal Treatments For Down Syndrome
  JOURNAL   Sci Rep 6, 32353 (2016)
   PUBMED   27586445
  REMARK    GeneRIF: USP16 and TTC3 were dysregulated in all affected human
            cells and two mouse models of Down syndrome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7295)
  AUTHORS   Scekic-Zahirovic,J., Sendscheid,O., El Oussini,H., Jambeau,M.,
            Sun,Y., Mersmann,S., Wagner,M., Dieterle,S., Sinniger,J.,
            Dirrig-Grosch,S., Drenner,K., Birling,M.C., Qiu,J., Zhou,Y., Li,H.,
            Fu,X.D., Rouaux,C., Shelkovnikova,T., Witting,A., Ludolph,A.C.,
            Kiefer,F., Storkebaum,E., Lagier-Tourenne,C. and Dupuis,L.
  TITLE     Toxic gain of function from mutant FUS protein is crucial to
            trigger cell autonomous motor neuron loss
  JOURNAL   EMBO J 35 (10), 1077-1097 (2016)
   PUBMED   26951610
REFERENCE   5  (bases 1 to 7295)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   6  (bases 1 to 7295)
  AUTHORS   Pletcher,M.T., Wiltshire,T., Cabin,D.E., Villanueva,M. and
            Reeves,R.H.
  TITLE     Use of comparative physical and sequence mapping to annotate mouse
            chromosome 16 and human chromosome 21
  JOURNAL   Genomics 74 (1), 45-54 (2001)
   PUBMED   11374901
REFERENCE   7  (bases 1 to 7295)
  AUTHORS   Lopes,C., Rachidi,M., Gassanova,S., Sinet,P.M. and Delabar,J.M.
  TITLE     Developmentally regulated expression of mtprd, the murine ortholog
            of tprd, a gene from the Down syndrome chromosomal region 1
  JOURNAL   Mech Dev 84 (1-2), 189-193 (1999)
   PUBMED   10473140
REFERENCE   8  (bases 1 to 7295)
  AUTHORS   Cabin,D.E., McKee-Johnson,J.W., Matesic,L.E., Wiltshire,T.,
            Rue,E.E., Mjaatvedt,A.E., Huo,Y.K., Korenberg,J.R. and Reeves,R.H.
  TITLE     Physical and comparative mapping of distal mouse chromosome 16. 5
            p5
  JOURNAL   Genome Res 8 (9), 940-950 (1998)
   PUBMED   9750193
REFERENCE   9  (bases 1 to 7295)
  AUTHORS   Tsukahara,F., Urakawa,I., Hattori,M., Hirai,M., Ohba,K.,
            Yoshioka,T., Sakaki,Y. and Muraki,T.
  TITLE     Molecular characterization of the mouse mtprd gene, a homologue of
            human TPRD: unique gene expression suggesting its critical role in
            the pathophysiology of Down syndrome
  JOURNAL   J Biochem 123 (6), 1055-1063 (1998)
   PUBMED   9603993
REFERENCE   10 (bases 1 to 7295)
  AUTHORS   Wei,J., Hodes,M.E., Wang,Y., Feng,Y., Ghetti,B. and Dlouhy,S.R.
  TITLE     Direct cDNA selection with DNA microdissected from mouse chromosome
            16: isolation of novel clones and construction of a partial
            transcription map of the C3-C4 region
  JOURNAL   Genome Res 6 (8), 678-687 (1996)
   PUBMED   8858343
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC173208.2.
            
            On Jul 27, 2007 this sequence version replaced NM_009441.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB008516.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849381, SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC173208.2         124705-124827
            124-278             AC173208.2         137878-138032
            279-321             AC173208.2         138312-138354
            322-472             AC173208.2         138750-138900
            473-560             AC173208.2         139302-139389
            561-614             AC173208.2         141303-141356
            615-735             AC173208.2         142231-142351
            736-821             AC173208.2         144168-144253
            822-916             AC173208.2         145981-146075
            917-979             AC173208.2         147078-147140
            980-1034            AC173208.2         157280-157334
            1035-1197           AC173208.2         162520-162682
            1198-1243           AC173208.2         163650-163695
            1244-1367           AC173208.2         164799-164922
            1368-1431           AC173208.2         166026-166089
            1432-1492           AC173208.2         169915-169975
            1493-1577           AC173208.2         170248-170332
            1578-1712           AC173208.2         172573-172707
            1713-1793           AC173208.2         173364-173444
            1794-1906           AC173208.2         174214-174326
            1907-2027           AC173208.2         176193-176313
            2028-2150           AC173208.2         178031-178153
            2151-2252           AC173208.2         179053-179154
            2253-2345           AC173208.2         180117-180209
            2346-2410           AC173208.2         180732-180796
            2411-2547           AC173208.2         181757-181893
            2548-2874           AC173208.2         183325-183651
            2875-3126           AC173208.2         185754-186005
            3127-3173           AC173208.2         187082-187128
            3174-3230           AC173208.2         188282-188338
            3231-3301           AC173208.2         189442-189512
            3302-3466           AC173208.2         193151-193315
            3467-4487           AC173208.2         196437-197457
            4488-4553           AC173208.2         198451-198516
            4554-4703           AC173208.2         201965-202114
            4704-4843           AC173208.2         204986-205125
            4844-4912           AC173208.2         206930-206998
            4913-5009           AC173208.2         208393-208489
            5010-5110           AC173208.2         210677-210777
            5111-5201           AC173208.2         211287-211377
            5202-5303           AC173208.2         211897-211998
            5304-5644           AC173208.2         213728-214068
            5645-5771           AC173208.2         216188-216314
            5772-5906           AC173208.2         216462-216596
            5907-5999           AC173208.2         220869-220961
            6000-7295           AC173208.2         221892-223187
FEATURES             Location/Qualifiers
     source          1..7295
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 55.18 cM"
     gene            1..7295
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /note="tetratricopeptide repeat domain 3"
                     /db_xref="GeneID:22129"
                     /db_xref="MGI:MGI:1276539"
     exon            1..123
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            124..278
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..6074
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /EC_number="2.3.2.27"
                     /note="mtprd; TPR repeat protein D; RING-type E3 ubiquitin
                     transferase TTC3"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TTC3"
                     /protein_id="NP_033467.2"
                     /db_xref="CCDS:CCDS37407.1"
                     /db_xref="GeneID:22129"
                     /db_xref="MGI:MGI:1276539"
                     /translation="MDDFAEGGLSLADDILLEDYPYEDDCICTPDFTTDDYVRVTQLY
                     YEGVGMQYKDYAQSEKNLEYDICNIWCSKPLSILQDYCDAIKLYIFWPLLFQHQHSSI
                     ISRLHPCVEAIRSRAAEISLKKLQHLELMEDIVDLAKKVANDSFLIEGLLKIGYKIEN
                     KILAMEDALNWIKYTGDVTILPKLGSVDNCWPMLSIFFTEYKYHITRVVTENCNLLEE
                     FRRHSCMQCVKQGELMKMRGNEEFSKEKFEIAVIYYTRAIEYRPENHLLYGNRALCFL
                     RMGQFRNALSDGKRAIVLKNTWPKGHYRYCDALCMLGEYDWALQANIKAQKLCKNDPE
                     GIKDLIQQHVKLQKQIEDLQGRTSNKNPIKAFYESRAYIPRNSSAPAFRTSLNFVETE
                     RGFRKTKYKMANGGDQNQKVADEALKGDDCDCHPEFLPPPSQPPRHKGKQKSRNNESE
                     KPSSNSEVSLQVDLKSILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYTALLEQRCRS
                     AAQAFTELLNGLDPQKIKQLNLAMINYVLVVYGLAVSLLGIGRPEELSEAENQFKRII
                     EHYPNEGLDCLAYCGIGKVYLKKNRFLEALNHFEKAKTLISRLPGILTWPTSNVIIEE
                     SKPEKVKVMLEKFVEECKFPPVPDAVCCYQKCRGYSKIQIYLTDPDFKGFIRISCCQY
                     CKVEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPDCEGIISKIIIYSSGGQVKCEFEH
                     KVIKEKVPSRPVLKQKCSSLEKLRLKEDKKLKRKIQKQEAKKLAQERMEEDLRESNPP
                     KNEEPEETSDSAQRCQFLDDRILQCIKQNADKIKSVVLNTSTLLKELLSWKVLSTEDY
                     TTCFSSKNFVHEAVDYVIGHLIQEKNRVKTRIFLHVLSELKELDPKLAPWIQRLNSFG
                     LDAIGPFFTRYGASLKELDFHVVTVLWDEKYGHKLGSIEGKQLDYFFEPASAMEARCL
                     IWLLEEHRDKFPALHSALDEFFDIMDSRCTVLRKQDSDEMPFGCIKVKNKGKKKKPKD
                     SKPMLVGSGAASVAPSSEAVTPEDHSRRNSDSAGPFAVPDHLRQDVEEFEALYDQHSS
                     EYVVRNKKLWDINPKQKCSTLYDYFSQLLEEHGPLDMSDRMFSEEYEFFPEETRQILE
                     KAGGLKSFLLGCPRFVVIDNCIALKKVASRLKKKRKKKNMKAKVEDISKTGEYLRVKL
                     PLNPTAREFQPDVKSEALSEDVKSIPGPADSSTLAAEDLKAQLDSDSSSGSASEDSRL
                     EVASPDSPTPLCEDASPSPTPAPEEAKPTYWAQSHLVTGFCTYLPFQGFGITQRPAYI
                     NMVPSLSQFTSIYTPLANISSEYPMQRSMPVVPSFVASNRADENAAAYFESPNLNTEH
                     DSGDHMASETQILEDTLGVCVRSQGSAADADPALSEPEGNSEHSGSSDSLWEASLENV
                     SGTTDAPAAPSVAIQVSRSMVHQEVNTEPYEPFETQQGDLSQKEKECHLLREQLKVAC
                     ENCEQIELRSSQEIKDLEEKLQRHTEENKISKTELDWFLQDLDREIKKWQQEKKEIQE
                     RLKALKKKIKKVINTSEMPAQKNDGFDKECEPHPDQSLGFSSALTDEKTKVEESVRKG
                     KELYEESHQRAVAAEVSVLENWKEREVCKLQGVASQSEAYLKSLKLMSSDSATYPDVE
                     YDILSWESFLSTVREEIESKKSQFEEHIKAIKNGSRLSDLSSVQLSEVSFPGCSTIHP
                     QFLSESSGHEDPGLVACVDSMTGAVLNDPYMDSASGCPEEVPELSLGSPTHQPEVTQQ
                     LELKGASQVSPSEQSPEADEKLSGQATRSSQSPKKPSNSIIEHLSVIFPCYTSTELAG
                     FIKKVRNKTKNSFSGLTIEEIVEKVTEHIVDEQKKKKPNPGKDKKTSEAHSAASVAKS
                     SQSPPLAAAGPSARTKGQKKDDVPAPDGNSCEICHEIFKSKNMRVLKCGHKFHKGCFK
                     QWLKGQSTCPTCGSSDLLSEE"
     exon            279..321
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            322..472
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            473..560
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            561..614
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            615..735
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            736..821
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            822..916
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            917..979
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1034
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1197
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1243
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1367
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1431
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1492
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1577
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1712
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1793
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1906
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2027
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2150
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2252
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2345
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2410
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2547
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2874
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3126
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            3127..3173
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..3230
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3301
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..3466
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..4487
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            4488..4553
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            4554..4703
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            4704..4843
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            4844..4912
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            4913..5009
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            5010..5110
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            5111..5201
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            5202..5303
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            5304..5644
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            5645..5771
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            5772..5906
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            5907..5999
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            6000..7295
                     /gene="Ttc3"
                     /gene_synonym="2610202A04Rik; D16Ium21; D16Ium21e;
                     mKIAA4119; TPRD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accctaagcc acgtgacccg cccgcctcag gagccgcgga gcgttcgctc tgcgggtctg
       61 gttgacgtgg agggccggag gcgtcggcag cccgcgtctg aggctcgcgg gctgcgggcc
      121 cgggactgtg cagcatggat gactttgctg agggaggtct cagtttggca gatgatatct
      181 tactggaaga ttacccttat gaggatgact gtatctgtac tcctgacttt accactgacg
      241 attatgttcg agtaacccag ctttactatg aaggcgtggg tatgcaatat aaagattatg
      301 cccaaagtga gaaaaattta gaatatgaca tctgcaatat ctggtgcagt aagccactct
      361 ccatcctgca agattactgt gatgccatta agctgtacat cttctggcca cttctttttc
      421 aacatcaaca cagttctata atatcaagat tgcacccctg tgtagaagcc atccgttctc
      481 gtgctgctga gataagtttg aagaaattac aacatcttga gttgatggaa gacattgtgg
      541 atttggcaaa gaaagttgca aatgattcat tccttattga aggcttattg aaaattggtt
      601 ataaaataga aaataaaatc ttggcaatgg aagatgcttt aaattggata aaatacacgg
      661 gtgatgtaac aattctacct aaattaggat cagttgacaa ttgctggccc atgctaagta
      721 ttttctttac tgaatataag taccatatta ctagagttgt aactgaaaat tgcaacttgc
      781 tagaagaatt tagaaggcat agttgcatgc agtgtgtgaa gcaaggagaa ctcatgaaaa
      841 tgagaggaaa tgaagagttc tcaaaggaaa agtttgaaat agctgttatt tattacacca
      901 gagccattga atatagacct gaaaaccatc ttctttatgg taaccgagct ctctgttttc
      961 ttcgtatggg gcagtttaga aatgcactta gcgatggaaa gagggccatt gttttgaaga
     1021 acacctggcc aaagggtcat tatcgttatt gtgatgctct ttgtatgctg ggggaatatg
     1081 actgggccct gcaagcaaac ataaaagctc aaaaactctg taaaaatgac cctgagggaa
     1141 tcaaggatct aattcagcag catgtaaagt tacaaaaaca aatagaagac ctacaaggtc
     1201 ggacatcaaa taagaatcca attaaagctt tttatgaaag cagggcttac atacctagaa
     1261 actcatcagc acctgctttt aggacatcac ttaactttgt ggaaacagaa agaggtttca
     1321 gaaaaactaa gtacaaaatg gcaaatggtg gcgatcagaa tcaaaaggtg gcagatgagg
     1381 ctttgaaggg ggacgattgt gactgtcatc ctgaatttct gccacctcca agtcagcctc
     1441 caagacacaa aggaaaacaa aaatcacgaa acaatgaatc agaaaagccc agttctaatt
     1501 cagaagtgag tttacaagta gatttgaaaa gcattttgga gaaacagttt tcaaaatctt
     1561 ccagagctgc acaccaggat tttgctaaca tcatgaaaat gctaaggagc ttgattcagg
     1621 atgggtacac ggccctgtta gagcagcgct gccgcagcgc tgcccaggcc tttacagagc
     1681 tgctcaatgg tttagaccct cagaaaataa agcaattgaa cctggccatg attaattatg
     1741 tattagtagt ctatggactt gccgtttctc tccttggaat aggacgacca gaggagctgt
     1801 ctgaagccga aaaccagttt aagaggatta tcgaacacta tcccaatgag gggctggact
     1861 gcttggccta ctgcggaata ggaaaagtgt atttgaaaaa gaacagattt ctcgaagctc
     1921 ttaatcactt tgaaaaggca aagactttaa ttagtcgtct ccctggaatt ctaacttggc
     1981 ccacaagtaa tgtgattatt gaagaatcta agccagaaaa agtcaaggtg atgttagaga
     2041 agtttgttga agaatgcaag tttcccccag tgccagatgc tgtttgttgc tatcagaagt
     2101 gccgtggata ttctaaaatt cagatttact taactgatcc agactttaag ggttttatac
     2161 gaattagctg ttgccaatac tgtaaggtag aatttcatat gaactgctgg aaaaagttaa
     2221 aaacaacaac ttttaatgat aaaattgaca aggattttct acaaggaatc tgtctcactc
     2281 ccgattgtga gggaatcatt tctaagatta tcatctacag cagtggaggt caagttaaat
     2341 gtgaatttga acacaaggtc ataaaagaaa aggttccttc aagacctgtt ctgaaacaga
     2401 aatgttccag cctagagaag ttaagactga aagaagacaa aaaattgaag agaaagatcc
     2461 aaaagcaaga ggcaaaaaag ttagcacaag aaagaatgga agaggactta agagaaagca
     2521 atccacctaa aaatgaagag ccagaagaaa cctcagacag tgctcagcgt tgtcagtttc
     2581 ttgatgacag aatcctgcag tgcataaagc agaatgctga caagattaaa tctgttgtat
     2641 tgaatacatc cacgcttctc aaagagctgc tctcttggaa ggttctgagc acggaagact
     2701 atacaacatg cttttctagc aaaaattttg tccatgaagc agtggactat gttatcggtc
     2761 acttgatcca agagaagaac agagtaaaga cacggatatt tctgcatgtt ttgagtgagc
     2821 ttaaagagtt agaccccaag ttggctccct ggatccagag actgaatagt tttggcttgg
     2881 atgccatagg accctttttc actcggtacg gagcatctct caaggagctt gatttccacg
     2941 tcgtgactgt cctctgggat gagaagtacg gccataaact gggctctata gaaggaaagc
     3001 agcttgatta cttctttgag ccagcatcgg caatggaagc acgctgttta atatggcttc
     3061 tggaagagca cagggacaag tttccggcct tgcacagtgc cttagacgag ttctttgata
     3121 taatggacag ccgatgcact gtactaagga agcaagacag cgatgaaatg ccgtttggtt
     3181 gtatcaaggt aaaaaacaaa ggcaagaaaa agaagccaaa agattcaaag ccaatgttag
     3241 tgggatctgg agctgcatca gtagcaccga gcagtgaggc tgtcactcca gaagaccata
     3301 gcaggcgcaa ttcagattct gcaggaccat ttgcagtgcc tgaccacctt cggcaagatg
     3361 tggaagaatt tgaagctctt tatgaccagc acagcagcga gtatgttgtc cgaaataaga
     3421 agctctggga tattaacccc aaacagaaat gttcgactct gtatgattat ttctctcagt
     3481 tgttggaaga gcacggcccc ttggatatga gtgacaggat gttctctgag gaatatgagt
     3541 tcttccctga agaaactcga cagatactgg agaaggcagg agggctgaag tcgttcctcc
     3601 tgggctgtcc tcgatttgtt gtgatcgaca actgcattgc attgaaaaaa gttgcctcaa
     3661 gactcaagaa aaaaagaaag aagaaaaaca tgaaagctaa agttgaagac atttcaaaaa
     3721 caggagaata tttacgagtt aaactaccac taaatccaac tgctagggaa tttcaaccag
     3781 atgtaaagtc tgaagcactg tctgaggatg tgaagtccat accaggacct gccgactcct
     3841 caaccctagc tgcggaggat ctgaaggccc agctggactc tgatagctct tctgggtcag
     3901 cttcggagga cagcagactg gaagtggcct ctcctgactc tcctacacca ctctgtgagg
     3961 atgcttctcc ttcccccacg ccagctcctg aagaagccaa accaacatac tgggctcaat
     4021 cacacttggt cacaggattc tgcacatacc ttccttttca aggatttggc atcacccagc
     4081 gaccagcgta cattaacatg gtacctagcc tgtcgcagtt cactagcatt tacacacctt
     4141 tggccaacat ttcttctgag tatccaatgc aaagatccat gccagtggtg ccatcttttg
     4201 tagccagcaa cagagcagat gaaaatgccg ctgcatactt tgagagtcct aatctgaata
     4261 ctgagcacga ctctggtgac cacatggcct ctgaaacaca gatcctggag gatactttgg
     4321 gagtgtgtgt caggtcccag ggcagcgcag ctgatgctga tccagctctg agtgagcctg
     4381 agggaaacag cgaacacagt gggagctctg acagcctgtg ggaagcttct ctagaaaatg
     4441 tcagtggaac aacagatgct ccagctgctc catcggttgc catacaggtg tctaggagca
     4501 tggtacatca ggaagtcaac actgagccgt atgagccgtt tgaaacacag cagggggacc
     4561 tttcccagaa ggaaaaggag tgccacctac tcagagagca gctgaaggta gcatgtgaga
     4621 actgcgagca gatagaactc aggagctcac aagagatcaa ggacctggag gaaaagctgc
     4681 aacggcacac agaggaaaac aagatctcaa agacggaatt agactggttc ctccaagatt
     4741 tggacagaga gattaaaaag tggcaacaag agaaaaaaga aatccaagaa agattaaaag
     4801 ccctgaagaa aaaaattaaa aaggttatca ataccagtga aatgcctgcc cagaaaaatg
     4861 atggattcga taaggaatgt gaaccacatc cggaccagtc ccttggattc agcagtgcac
     4921 tcacagatga gaagacaaaa gtagaagagt ctgtcaggaa agggaaagag ctctatgaag
     4981 agagtcacca gagagccgtg gctgcagagg tatctgttct tgaaaactgg aaagagcgag
     5041 aagtgtgcaa actacagggt gtggcgtcac aatcagaagc ctatcttaaa agcctcaagc
     5101 tgatgagcag tgattctgca acgtatcccg atgtggagta tgatatactt tcatgggagt
     5161 catttctttc tactgtaaga gaagagatcg agagcaaaaa gtctcagttt gaagagcata
     5221 ttaaggccat taagaatggt tctcgactca gtgacctttc cagtgtgcag ctttctgagg
     5281 tttcatttcc tggttgttcg acgatccatc ctcagttcct ctctgagtct tcaggccatg
     5341 aggatcccgg actggtggct tgtgtagaca gcatgactgg agcagtcctc aatgatcctt
     5401 acatggactc tgctagtggc tgcccagagg aggttccaga actgtcgctg ggatcaccca
     5461 cccatcagcc agaagttact caacagcttg agctcaaggg ggctagccag gtgtctccat
     5521 cagaacagag ccctgaggcc gacgagaaac tatctggaca ggctactcgg tcaagccagt
     5581 ctccaaaaaa gccttccaac agtattattg aacacctgtc agtgatattc ccatgttata
     5641 ccagcactga gcttgctggg tttattaaga aagttagaaa caaaaccaag aactcattct
     5701 cgggattaac tattgaggag attgtggaga aagtgacaga acacattgtc gatgagcaaa
     5761 agaagaaaaa gccaaatcca ggaaaagaca agaagacatc tgaggctcat tcggctgcct
     5821 ctgtggccaa gtcctcccag agtccaccct tggcagctgc tggaccatca gctagaacca
     5881 aaggccagaa aaaagatgat gtccctgcac cagatggaaa ttcctgtgag atatgccatg
     5941 aaatattcaa gtcaaaaaac atgcgtgtgc taaaatgtgg gcacaagttt cacaaagggt
     6001 gctttaagca gtggctgaaa gggcagagca cgtgccccac ctgtggcagc agtgacctgc
     6061 tgtcagaaga gtaactgttg caccatcgtc acagacccag cccaggagaa gatgggaacc
     6121 tccttcctgt tgctgtaggt agtcactcct cactaatgca ccatgcactt catgagttaa
     6181 agaacaacag tgtcctgtta ccagtgtaaa aacagcaaac atggaagctc tcacactgtg
     6241 catcacaaag ctaacaaatg gaaatctgaa ttgcagtctg tcccaggttc caggcaggtg
     6301 acagccatgt gtgtctgcaa tgctgtcacc atggtcctgc actgtcgtgg ctgctgcagg
     6361 atactctgag atgagcaggt tctttggaaa gaactgctga gctcctcaaa gcagtgctga
     6421 gattgtaaag gctctcagcc tcctcagttc ctcatgtggc actgtagcat ccccgtcata
     6481 aatttttaaa gtgcttatga ttcaattaat ctacattttg gtaatcaatt ataaaatact
     6541 ttttaaatta gtattggcta tttttttttt ttaccctggg aagatgctgt ctgctcacag
     6601 gagtcccaca cttggcactt acactaaggt taccatgtaa gtctcatgag tcagcagtgc
     6661 ttggaagtgc acagctggct agtgctgaaa acaggacata gtgcccagcg cagggcagcc
     6721 accctcaccc tccttcctta tccttccacc agaagagaaa tgtaccacag tcctgatgtg
     6781 ttggtgttaa cattgttctg tttgactttt gtgtaaagta atgcatgcaa tcttgtaatg
     6841 tggcctgaaa acaagctaac tgtattagaa actattcaaa aactaggtat ttttagtgac
     6901 ctgtaggcag tggcaaatac agacatgtga accttgaata cattacattt ctctcaaaca
     6961 caaagaaaca aacaaaaaac ttttccagcg tgttctctgc tgccctggag atgccgtcac
     7021 cttccacccg tgtctgtgtg agttgtggtg tcttagtgac ttagtatgta gctcactcct
     7081 tattctgaga cattgtctgt ggtgtccctg aaacatggtg tccatgctgt aacagtggag
     7141 tgcagtacat gcctgagtac acacagcagc ttatagtatc tgtcgggtac aaagaagagt
     7201 agctgttgag acagagagct gtgcttcgtg tcagagcctg tgaacatgcc ttacacttgt
     7261 ccagtaactg tcaataaaga acattataaa aggtc
//
