LOCUS       NM_183096               2450 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus tetratricopeptide repeat domain 29 (Ttc29), mRNA.
ACCESSION   NM_183096
VERSION     NM_183096.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2450)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2450)
  AUTHORS   Liu,C., He,X., Liu,W., Yang,S., Wang,L., Li,W., Wu,H., Tang,S.,
            Ni,X., Wang,J., Gao,Y., Tian,S., Zhang,L., Cong,J., Zhang,Z.,
            Tan,Q., Zhang,J., Li,H., Zhong,Y., Lv,M., Li,J., Jin,L., Cao,Y. and
            Zhang,F.
  TITLE     Bi-allelic Mutations in TTC29 Cause Male Subfertility with
            Asthenoteratospermia in Humans and Mice
  JOURNAL   Am J Hum Genet 105 (6), 1168-1181 (2019)
   PUBMED   31735294
REFERENCE   3  (bases 1 to 2450)
  AUTHORS   Lores,P., Dacheux,D., Kherraf,Z.E., Nsota Mbango,J.F., Coutton,C.,
            Stouvenel,L., Ialy-Radio,C., Amiri-Yekta,A., Whitfield,M.,
            Schmitt,A., Cazin,C., Givelet,M., Ferreux,L., Fourati Ben
            Mustapha,S., Halouani,L., Marrakchi,O., Daneshipour,A., El
            Khouri,E., Do Cruzeiro,M., Favier,M., Guillonneau,F., Chaudhry,M.,
            Sakheli,Z., Wolf,J.P., Patrat,C., Gacon,G., Savinov,S.N.,
            Hosseini,S.H., Robinson,D.R., Zouari,R., Ziyyat,A., Arnoult,C.,
            Dulioust,E., Bonhivers,M., Ray,P.F. and Toure,A.
  TITLE     Mutations in TTC29, Encoding an Evolutionarily Conserved Axonemal
            Protein, Result in Asthenozoospermia and Male Infertility
  JOURNAL   Am J Hum Genet 105 (6), 1148-1167 (2019)
   PUBMED   31735292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117544.8, AC140845.2 and AC133181.2.
            
            On Nov 19, 2009 this sequence version replaced NM_183096.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048386.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               AC117544.8         12799-13005         c
            208-271             AC117544.8         12276-12339         c
            272-384             AC117544.8         8330-8442           c
            385-483             AC117544.8         7462-7560           c
            484-567             AC117544.8         5514-5597           c
            568-791             AC140845.2         66454-66677
            792-977             AC140845.2         72078-72263
            978-1190            AC140845.2         97098-97310
            1191-1276           AC140845.2         102657-102742
            1277-1368           AC140845.2         136028-136119
            1369-1492           AC140845.2         145824-145947
            1493-1721           AC133181.2         16235-16463
            1722-1788           AC133181.2         75752-75818
            1789-2450           AC133181.2         76346-77007
FEATURES             Location/Qualifiers
     source          1..2450
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 36.86 cM"
     gene            1..2450
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /note="tetratricopeptide repeat domain 29"
                     /db_xref="GeneID:73301"
                     /db_xref="MGI:MGI:1920551"
     exon            1..207
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            208..271
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            272..384
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            385..483
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..1807
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /note="TPR repeat protein 29"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 29"
                     /protein_id="NP_898919.3"
                     /db_xref="CCDS:CCDS22428.1"
                     /db_xref="GeneID:73301"
                     /db_xref="MGI:MGI:1920551"
                     /translation="MATFPPLPMTHTRLAILARQKLPCSSKKIPRAQLIKEKEDIDYY
                     LEQNFKGLSKEEVAAHRNSYKKSICVDMLRDGFHKSFTELFALMEQWDKLREAAKAQS
                     LFWQQRPLEDQPDKLDNFYHYLTRAEAAERKGYYEEVYNNLYALACYFDNSEDKWVRN
                     HFYERCFNIAQLIKADGGKKEAEAESHMGLLFEEEGELLKAAEHYEAFHELTHGRLWK
                     DGTGQLLNLVACESLVRTYRLLSDRMLENKDYKQAIKILIKASEIAREGNDRSMEGEA
                     SYYLGLAHLASGEYETALTVLNRYSEISTSLDDDHGLGRAYEAIAKALQSQGETTEAI
                     NYLEKFVTIARNNLQSLDMIRACTMLGDIYNEKGQYSKASEYFQQAFSTAMELMKTAL
                     MDETKVHYGIARAHQMMLAMKGYIESADSNGLNCLLSWKETRTQIEYDPILGESRRAT
                     EDNIYQLPDAEEETRRSPENQ"
     exon            484..567
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            568..791
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            792..977
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1190
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1276
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1368
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1492
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1721
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1788
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..2450
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2423..2428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2450
                     /gene="Ttc29"
                     /gene_synonym="1700031F13Rik"
                     /note="major polyA site"
ORIGIN      
        1 gccaggccaa caatctggga tgagagtacc gcgcccagca cccaccgcct gcagaagctt
       61 agtcagggac acagaatcac aggcccagag ctagttttct aaggtttgtg gggcaaggct
      121 ggggacagga cctggtcagc tcccagaaga gtgggcggct cttcctttcc aagaacccct
      181 tcttccatta cttgggcccc agcttggtat tttgcttaca gaattttcag acaggcctct
      241 aagagcccag agcaatcggt tatctgcaaa tgtggatggc tctgtattca catactttgc
      301 ataaggacag actttttaca acaggactgt gtggcctgga ggccctgacc taagaggggc
      361 tcaacttctg gacatttcat taagcccccc aatggctacc tttcccccac ttcccatgac
      421 tcatacaagg cttgcgatct tagccaggca gaagctacca tgctcttcaa aaaaaatccc
      481 aagggcccag ttgatcaaag agaaagagga catagattat tacctggaac agaatttcaa
      541 agggctgtcg aaagaagagg tggctgccca caggaactca tacaagaaga gcatctgcgt
      601 ggacatgctg cgagatgggt tccacaagtc cttcaccgag ctctttgcac tgatggaaca
      661 gtgggataag ctccgggaag ctgcgaaggc acagtccctc ttctggcagc agaggcctct
      721 ggaggaccag ccggacaagc tagacaattt ctaccactac ctgaccaggg ccgaggctgc
      781 cgagaggaaa ggatactatg aggaggtata taacaacctg tatgctctgg cctgttattt
      841 cgataattct gaagacaagt gggtgaggaa tcacttctac gaacggtgtt ttaatattgc
      901 tcagctgatc aaagctgacg gcgggaagaa agaggcagag gccgagtcac acatgggact
      961 tcttttcgag gaagagggtg agctcctgaa ggctgcagag cactatgaag cattccatga
     1021 actgacacac ggacggctct ggaaggatgg tacgggccag cttctcaact tggtggcctg
     1081 tgaaagtctc gtgaggacct acagattgct ctcagacagg atgctggaaa acaaagacta
     1141 caaacaggcc atcaaaatcc taataaaagc ttctgaaata gccagagaag gcaatgacag
     1201 aagcatggaa ggggaggctt cttactacct gggcttggcc cacttggctt ctggagaata
     1261 tgaaaccgca ctaacagtgc tgaatcggta cagtgagatc tccacaagtc tggatgacga
     1321 tcatggcctg gggagagcct atgaggctat cgccaaggcc ctgcagagcc aaggggagac
     1381 aacagaagca attaattacc tggagaagtt cgtgacaatt gcaagaaaca acttgcaaag
     1441 cctcgatatg attcgagcat gcacgatgct cggcgacatc tacaatgaaa aggggcaata
     1501 cagcaaggct tccgagtact tccaacaagc tttcagcacc gcgatggagc tcatgaaaac
     1561 ggcgctcatg gatgaaacca aagtccacta tgggatagcc agagcgcacc agatgatgct
     1621 ggcgatgaag ggttacatcg aatctgccga ctcgaatggc ctcaactgcc tgctgtcctg
     1681 gaaggagact agaactcaaa tcgagtacga cccgattcta ggagagtcta gaagagccac
     1741 agaagataac atatatcaac tcccagatgc tgaggaagaa acaagaaggt ctccagaaaa
     1801 tcaataacac ggaactgaag tggctcaacg tcaaagcagg aagaaactta gcacatagcc
     1861 ttagacctca ttagacagga gcacgtaaca gctgataggg agttgtaaaa agaagattac
     1921 agttgtcttt attgaatttt gtgctgccgt aactatggca agcttatgaa gatgaagtac
     1981 agcttagatg gttagaacga tcagcactta ctcataagat aaactttaga atgtcccctc
     2041 ctacatgcta ctccacaaga actccaggag tttaaatctg aactgtttct gattgcaaaa
     2101 tgtttacgag ttaaagacat ctttcacact gcatgataat ctgctaaaat ctcagggaaa
     2161 cctcagcaga cacaaagggc catgagcagt ctgtgcttgt attgctaagc actgctaaat
     2221 ttgctttatg tgtagaaact taaattcatg gcacgcttag ctgacaggac acagcctaac
     2281 atacccacgt gcctcgaggc aggggggaaa tccttcagtc tcaggaacct ttgctggttt
     2341 gcttgcaact gaaagaccgc agcttccctc tgaaacctct ggaactcctc ccgtgaatcc
     2401 ataagggtag tacattacca agaataaaga ctttcttcct tttcaatgca
//
