LOCUS       NP_001161947             446 aa            linear   ROD 04-JUN-2024
DEFINITION  tetratricopeptide repeat protein 23 isoform 2 [Mus musculus].
ACCESSION   NP_001161947
VERSION     NP_001161947.1
DBSOURCE    REFSEQ: accession NM_001168475.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 446)
  AUTHORS   Ikegami,K., Saigoh,K., Fujioka,A., Nagano,M., Kitajima,K., Sato,C.,
            Masubuchi,S., Kusunoki,S. and Shigeyoshi,Y.
  TITLE     Effect of expression alteration in flanking genes on phenotypes of
            St8sia2-deficient mice
  JOURNAL   Sci Rep 9 (1), 13634 (2019)
   PUBMED   31541165
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 446)
  AUTHORS   Breslow,D.K., Hoogendoorn,S., Kopp,A.R., Morgens,D.W., Vu,B.K.,
            Kennedy,M.C., Han,K., Li,A., Hess,G.T., Bassik,M.C., Chen,J.K. and
            Nachury,M.V.
  TITLE     A CRISPR-based screen for Hedgehog signaling provides insights into
            ciliary function and ciliopathies
  JOURNAL   Nat Genet 50 (3), 460-471 (2018)
   PUBMED   29459677
REFERENCE   3  (residues 1 to 446)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   4  (residues 1 to 446)
  AUTHORS   Alvarez-Dominguez,J.R., Hu,W., Yuan,B., Shi,J., Park,S.S.,
            Gromatzky,A.A., van Oudenaarden,A. and Lodish,H.F.
  TITLE     Global discovery of erythroid long noncoding RNAs reveals novel
            regulators of red cell maturation
  JOURNAL   Blood 123 (4), 570-581 (2014)
   PUBMED   24200680
REFERENCE   5  (residues 1 to 446)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120124.10, AK141754.1 and AK005431.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1. Variants 2
            and 5 both encode the same isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141754.1, SRR7345562.2654244.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 37.06 cM"
     Protein         1..446
                     /product="tetratricopeptide repeat protein 23 isoform 2"
                     /note="tetratricopeptide repeat protein 23; TPR repeat
                     protein 23"
                     /calculated_mol_wt=49721
     Region          87..116
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          100..385
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Site            order(138,141..142,145..146,148,187,190..191,194..195,
                     197..198,229,232..233,236..237,240)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          138..165
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          185..215
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          228..254
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..446
                     /gene="Ttc23"
                     /gene_synonym="1600012K10Rik"
                     /coded_by="NM_001168475.1:457..1797"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS52270.1"
                     /db_xref="GeneID:67009"
                     /db_xref="MGI:MGI:1914259"
ORIGIN      
        1 mqesqdthms shldevvaav svtsknripn kllqtalfqp preklhlcee raksysssre
       61 ykqaiqelvr cvaltricyg dwhwklaeay vnlaqgylql kglslqakqh aekakeilan
      121 siespchnkt difkcslelf ytlgrallsl qkfkdasenl ikaerlskem lqcgnivkee
      181 wieiqsrikl sfaqlyqgqk rskeafpfyq kaleyteitk dekslecvqv lrelagveqa
      241 lglyaaaish fsrahliils kdpspeeaad sahfiaraaa asgmhdhrdv aekyfqesmt
      301 sikdsegaer akflsiqdef csflqttgqk eraamilres leakvgafgd fspevaetyr
      361 algradlaqg nnsgayaklk kcvqietfly gsqdkktlat qhtidtlski seaagksrqs
      421 vkakvafcts apqygmpgkg rhsvad
//
